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"""
This module will contain functions to be used in computation of the data used to
generate various kinds of heatmaps.
"""
from functools import reduce
from typing import Any, Dict, Sequence
from gn3.computations.slink import slink
from gn3.db.traits import retrieve_trait_data, retrieve_trait_info
from gn3.computations.correlations2 import compute_correlation
def export_trait_data(
trait_data: dict, strainlist: Sequence[str], dtype: str = "val",
var_exists: bool = False, n_exists: bool = False):
"""
Export data according to `strainlist`. Mostly used in calculating
correlations.
DESCRIPTION:
Migrated from
https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L166-L211
PARAMETERS
trait: (dict)
The dictionary of key-value pairs representing a trait
strainlist: (list)
A list of strain names
type: (str)
... verify what this is ...
var_exists: (bool)
A flag indicating existence of variance
n_exists: (bool)
A flag indicating existence of ndata
"""
def __export_all_types(tdata, strain):
sample_data = []
if tdata[strain]["value"]:
sample_data.append(tdata[strain]["value"])
if var_exists:
if tdata[strain]["variance"]:
sample_data.append(tdata[strain]["variance"])
else:
sample_data.append(None)
if n_exists:
if tdata[strain]["ndata"]:
sample_data.append(tdata[strain]["ndata"])
else:
sample_data.append(None)
else:
if var_exists and n_exists:
sample_data += [None, None, None]
elif var_exists or n_exists:
sample_data += [None, None]
else:
sample_data.append(None)
return tuple(sample_data)
def __exporter(accumulator, strain):
# pylint: disable=[R0911]
if strain in trait_data["data"]:
if dtype == "val":
return accumulator + (trait_data["data"][strain]["value"], )
if dtype == "var":
return accumulator + (trait_data["data"][strain]["variance"], )
if dtype == "N":
return accumulator + (trait_data["data"][strain]["ndata"], )
if dtype == "all":
return accumulator + __export_all_types(trait_data["data"], strain)
raise KeyError("Type `%s` is incorrect" % dtype)
if var_exists and n_exists:
return accumulator + (None, None, None)
if var_exists or n_exists:
return accumulator + (None, None)
return accumulator + (None,)
return reduce(__exporter, strainlist, tuple())
def trait_display_name(trait: Dict):
"""
Given a trait, return a name to use to display the trait on a heatmap.
DESCRIPTION
Migrated from
https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L141-L157
"""
if trait.get("db", None) and trait.get("trait_name", None):
if trait["db"]["dataset_type"] == "Temp":
desc = trait["description"]
if desc.find("PCA") >= 0:
return "%s::%s" % (
trait["db"]["displayname"],
desc[desc.rindex(':')+1:].strip())
return "%s::%s" % (
trait["db"]["displayname"],
desc[:desc.index('entered')].strip())
prefix = "%s::%s" % (
trait["db"]["dataset_name"], trait["trait_name"])
if trait["cellid"]:
return "%s::%s" % (prefix, trait["cellid"])
return prefix
return trait["description"]
def cluster_traits(traits_data_list: Sequence[Dict]):
"""
Clusters the trait values.
DESCRIPTION
Attempts to replicate the clustering of the traits, as done at
https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/heatmap/Heatmap.py#L138-L162
"""
def __compute_corr(tdata_i, tdata_j):
if tdata_i[0] == tdata_j[0]:
return 0.0
corr_vals = compute_correlation(tdata_i[1], tdata_j[1])
corr = corr_vals[0]
if (1 - corr) < 0:
return 0.0
return 1 - corr
def __cluster(tdata_i):
return tuple(
__compute_corr(tdata_i, tdata_j)
for tdata_j in enumerate(traits_data_list))
return tuple(__cluster(tdata_i) for tdata_i in enumerate(traits_data_list))
def heatmap_data(formd, search_result, conn: Any):
"""
heatmap function
DESCRIPTION
This function is an attempt to reproduce the initialisation at
https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/heatmap/Heatmap.py#L46-L64
and also the clustering and slink computations at
https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/heatmap/Heatmap.py#L138-L165
with the help of the `gn3.computations.heatmap.cluster_traits` function.
It does not try to actually draw the heatmap image.
PARAMETERS:
TODO: Elaborate on the parameters here...
"""
threshold = 0 # webqtlConfig.PUBLICTHRESH
cluster_checked = formd.formdata.getvalue("clusterCheck", "")
strainlist = [
strain for strain in formd.strainlist if strain not in formd.parlist]
genotype = formd.genotype
def __retrieve_traitlist_and_datalist(threshold, fullname):
trait = retrieve_trait_info(threshold, fullname, conn)
return (
trait,
export_trait_data(retrieve_trait_data(trait, conn), strainlist))
traits_details = [
__retrieve_traitlist_and_datalist(threshold, fullname)
for fullname in search_result]
traits_list = map(lambda x: x[0], traits_details)
traits_data_list = map(lambda x: x[1], traits_details)
return {
"target_description_checked": formd.formdata.getvalue(
"targetDescriptionCheck", ""),
"cluster_checked": cluster_checked,
"slink_data": (
slink(cluster_traits(traits_data_list))
if cluster_checked else False),
"sessionfile": formd.formdata.getvalue("session"),
"genotype": genotype,
"nLoci": sum(map(len, genotype)),
"strainlist": strainlist,
"ppolar": formd.ppolar,
"mpolar":formd.mpolar,
"traits_list": traits_list,
"traits_data_list": traits_data_list
}
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