aboutsummaryrefslogtreecommitdiff
path: root/gn3/api
diff options
context:
space:
mode:
Diffstat (limited to 'gn3/api')
-rw-r--r--gn3/api/gemma.py54
1 files changed, 54 insertions, 0 deletions
diff --git a/gn3/api/gemma.py b/gn3/api/gemma.py
index 372ef82..ed698d3 100644
--- a/gn3/api/gemma.py
+++ b/gn3/api/gemma.py
@@ -505,3 +505,57 @@ def compute_k_gwa_with_loco_only(chromosomes, maf, token):
status=128,
# use better message
message="Metadata file non-existent!")
+
+
+@gemma.route("/k-gwa-compute/covars/loco/<chromosomes>/maf/<maf>/<token>",
+ methods=["POST"])
+def compute_k_gwa_with_loco_and_cavar(chromosomes, maf, token):
+ """k-gwa-compute; Loco with covars; lmm defaults to 9!
+
+ """
+ working_dir = os.path.join(current_app.config.get("TMPDIR"), token)
+ _dict = jsonfile_to_dict(os.path.join(working_dir, "metadata.json"))
+ try:
+ genofile, phenofile, snpsfile, covarfile = [
+ os.path.join(working_dir, _dict.get(x))
+ for x in ["geno", "pheno", "snps", "covar"]
+ ]
+ if not do_paths_exist([genofile, phenofile, snpsfile]):
+ raise FileNotFoundError
+ gemma_kwargs = {"g": genofile, "p": phenofile, "a": snpsfile}
+ gemma_k_cmd = generate_gemma_cmd(
+ gemma_cmd=current_app.config.get("GEMMA_"
+ "WRAPPER_CMD"),
+ output_dir=current_app.config.get('TMPDIR'),
+ token=token,
+ gemma_kwargs=gemma_kwargs,
+ chromosomes=chromosomes)
+ gemma_kwargs["c"] = covarfile
+ gemma_kwargs["maf"] = float(maf)
+ gemma_kwargs["lmm"] = _dict.get("lmm", 9)
+ gemma_gwa_cmd = generate_gemma_cmd(
+ gemma_cmd=current_app.config.get("GEMMA_"
+ "WRAPPER_CMD"),
+ output_dir=current_app.config.get('TMPDIR'),
+ token=token,
+ gemma_kwargs=gemma_kwargs,
+ gemma_wrapper_kwargs={
+ "loco":
+ ("--input "
+ f"{os.path.join(working_dir, gemma_k_cmd.get('output_file'))}"
+ )
+ })
+ return jsonify(unique_id=queue_cmd(
+ conn=redis.Redis(),
+ email=(request.get_json() or {}).get('email'),
+ job_queue=current_app.config.get("REDIS_JOB_QUEUE"),
+ cmd=(f"{gemma_k_cmd.get('gemma_cmd')} && "
+ f"{gemma_gwa_cmd.get('gemma_cmd')}")),
+ status="queued",
+ output_file=gemma_gwa_cmd.get("output_file"))
+ # pylint: disable=W0703
+ except Exception:
+ return jsonify(
+ status=128,
+ # use better message
+ message="Metadata file non-existent!")