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author | Frederick Muriuki Muriithi | 2021-10-29 06:34:19 +0300 |
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committer | Frederick Muriuki Muriithi | 2021-10-29 06:34:19 +0300 |
commit | 0bb51bd78479c05839d7b7f9f878db4b5616cfda (patch) | |
tree | db8f19d81f33cb15c75dfe328475eff58aaf6f40 /gn3 | |
parent | 4c73d70d6d844bf2fa3358c71b9e28daff51e69c (diff) | |
download | genenetwork3-0bb51bd78479c05839d7b7f9f878db4b5616cfda.tar.gz |
Implement `tissue_correlation` function
Issue:
https://github.com/genenetwork/gn-gemtext-threads/blob/main/topics/gn1-migration-to-gn2/partial-correlations.gmi
* gn3/computations/partial_correlations.py: New function (tissue_correlation)
* tests/unit/test_partial_correlations.py ->
tests/unit/computations/test_partial_correlations.py: Move module. Implement
tests for new function
Migrate the `cal_tissue_corr` function embedded in the
`web.webqtl.correlation.correlationFunction.batchCalTissueCorr` function in
GN1 and implement tests to ensure it works correctly.
Diffstat (limited to 'gn3')
-rw-r--r-- | gn3/computations/partial_correlations.py | 27 |
1 files changed, 27 insertions, 0 deletions
diff --git a/gn3/computations/partial_correlations.py b/gn3/computations/partial_correlations.py index b3de31c..e73edfd 100644 --- a/gn3/computations/partial_correlations.py +++ b/gn3/computations/partial_correlations.py @@ -7,6 +7,7 @@ GeneNetwork1. from functools import reduce from typing import Any, Tuple, Sequence +from scipy.stats import pearsonr, spearmanr def control_samples(controls: Sequence[dict], sampleslist: Sequence[str]): """ @@ -123,6 +124,32 @@ def find_identical_traits( if len(item[1]) > 1), tuple())) +def tissue_correlation( + primary_trait_values: Tuple[float, ...], + target_trait_values: Tuple[float, ...], + method: str) -> Tuple[float, float]: + """ + Compute the correlation between the primary trait values, and the values of + a single target value. + + This migrates the `cal_tissue_corr` function embedded in the larger + `web.webqtl.correlation.correlationFunction.batchCalTissueCorr` function in + GeneNetwork1. + """ + def spearman_corr(*args): + result = spearmanr(*args) + return (result.correlation, result.pvalue) + + method_fns = {"pearson": pearsonr, "spearman": spearman_corr} + + assert len(primary_trait_values) == len(target_trait_values), ( + "The lengths of the `primary_trait_values` and `target_trait_values` " + "must be equal") + assert method in method_fns.keys(), ( + "Method must be one of: {}".format(",".join(method_fns.keys()))) + + return method_fns[method](primary_trait_values, target_trait_values) + def batch_computed_tissue_correlation( trait_value: str, symbol_value_dict: dict, method: str = "pearson") -> Tuple[dict, dict]: |