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17;mso-text-indent-alt:17;position:absolute;top:0%;left:0%;width:100.0%;
height:48.48%'><span style='font-family:Times;font-size:117%;color:white;
display:none'><br>
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<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:51.51%;left:0%;width:100.0%;
height:48.48%'><span style='font-family:Times;font-size:117%;color:white;
mso-special-format:lastCR;display:none'><br>
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<div style='position:absolute;top:2.12%;left:-2.64%;width:105.82%;height:11.13%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:0%;left:0%;width:100.0%;height:88.88%'>
<div style='text-align:center;mso-line-spacing:"%0 0 0";mso-margin-left-alt:
16;mso-text-indent-alt:16;position:absolute;top:0%;left:0%;width:100.0%;
height:67.85%'><span style='font-family:Arial;font-size:267%;color:#E9EB5D'><i>How
to make recombinant inbred strains (RI)</i></span><span style='font-family:
Arial;font-size:150%;color:aqua;display:none'><br>
</span></div>
<div style='text-align:center;mso-line-spacing:"%0 0 0";mso-margin-left-alt:
16;mso-text-indent-alt:16;position:absolute;top:60.71%;left:6.25%;width:87.48%;
height:39.28%'><span style='font-family:Arial;font-size:150%;color:aqua;
mso-special-format:lastCR;display:none'><br>
</span></div>
</div>
</div>
<img border=0 src="slide0016_image025.gif" style='position:absolute;top:28.79%;
left:45.43%;width:18.14%;height:1.06%'><img border=0
src="slide0016_image026.gif" style='position:absolute;top:20.31%;left:28.21%;
width:1.98%;height:11.83%'>
<div style='position:absolute;top:15.01%;left:25.03%;width:19.47%;height:10.07%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:8.77%;left:6.8%;width:93.19%;
height:78.94%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>C57BL/6J (B)<br>
</span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:51.11%;left:0%;width:83.21%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99;mso-special-format:lastCR;
display:none'><br>
</span></div>
</div>
</div>
<img border=0 src="slide0016_image027.gif" style='position:absolute;top:20.31%;
left:30.46%;width:1.98%;height:11.83%'>
<div style='position:absolute;top:15.01%;left:62.25%;width:16.55%;height:10.07%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:8.77%;left:8.0%;width:92.8%;
height:78.94%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>DBA/2J (D)<br>
</span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:51.11%;left:0%;width:82.75%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99;mso-special-format:lastCR;
display:none'><br>
</span></div>
</div>
</div>
<img border=0 src="slide0016_image028.gif" style='position:absolute;top:20.31%;
left:66.62%;width:4.23%;height:11.83%'><img border=0
src="slide0016_image029.gif" style='position:absolute;top:35.51%;left:23.97%;
width:50.86%;height:1.23%'><img border=0 src="slide0016_image030.gif"
style='position:absolute;top:35.68%;left:24.1%;width:.66%;height:4.06%'><img
border=0 src="slide0016_image031.gif" style='position:absolute;top:35.68%;
left:40.92%;width:.52%;height:4.06%'><img border=0 src="slide0016_image032.gif"
style='position:absolute;top:35.68%;left:57.61%;width:.52%;height:4.06%'><img
border=0 src="slide0016_image033.gif" style='position:absolute;top:35.68%;
left:74.3%;width:.52%;height:3.88%'>
<div style='position:absolute;top:42.75%;left:5.69%;width:6.75%;height:12.72%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:8.33%;left:19.6%;width:70.58%;
height:81.94%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:49.15%'><span
style='font-family:Arial;font-size:200%;color:#FFFF99'><b>F1<br>
</b></span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:50.84%;left:0%;width:83.33%;height:49.15%'><span
style='font-family:Arial;font-size:200%;color:#FFFF99;mso-special-format:lastCR;
display:none'><b><br>
</b></span></div>
</div>
</div>
<img border=0 src="slide0016_image034.gif" style='position:absolute;top:39.92%;
left:22.25%;width:4.23%;height:11.83%'><img border=0
src="slide0016_image035.gif" style='position:absolute;top:39.92%;left:38.94%;
width:4.23%;height:11.83%'><img border=0 src="slide0016_image036.gif"
style='position:absolute;top:39.92%;left:55.62%;width:4.23%;height:11.83%'><img
border=0 src="slide0016_image037.gif" style='position:absolute;top:39.39%;
left:72.84%;width:4.23%;height:11.83%'><img border=0
src="slide0016_image038.gif" style='position:absolute;top:43.46%;left:43.97%;
width:11.12%;height:3.53%'><img border=0 src="slide0016_image039.gif"
style='position:absolute;top:60.95%;left:20.66%;width:9.8%;height:3.53%'>
<div style='position:absolute;top:71.73%;left:58.41%;width:20.52%;height:27.03%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:12.41%;left:6.45%;width:87.09%;
height:82.35%'>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:17;
mso-text-indent-alt:17;position:absolute;top:0%;left:0%;width:100.0%;
height:69.84%'><span style='position:absolute;top:0%;left:0%;width:99.25%'><span
style='font-family:Arial;font-size:117%;color:#FFFF99'><b>20 generations </b></span></span><span
style='position:absolute;top:39.77%;left:0%;width:100.0%'><span
style='font-family:Arial;font-size:117%;color:#FFFF99'><b>brother-sister </b></span></span><span
style='position:absolute;top:80.68%;left:0%;width:100.0%'><span
style='font-family:Arial;font-size:117%;color:#FFFF99'><b>matings</b></span><span
style='font-family:Arial;font-size:233%;color:#FFFF99;display:none'><b><br>
</b></span></span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:17;
mso-text-indent-alt:17;position:absolute;top:73.8%;left:0%;width:100.0%;
height:26.98%'><span style='font-family:Arial;font-size:233%;color:#FFFF99;
mso-special-format:lastCR;display:none'><b><br>
</b></span></div>
</div>
</div>
<img border=0 src="slide0016_image040.gif" style='position:absolute;top:60.95%;
left:50.72%;width:9.93%;height:3.53%'><img border=0 src="slide0016_image041.gif"
style='position:absolute;top:62.72%;left:54.03%;width:4.37%;height:28.97%'><img
border=0 src="slide0016_image042.gif" style='position:absolute;top:61.13%;
left:79.86%;width:10.86%;height:3.53%'><img border=0
src="slide0016_image043.gif" style='position:absolute;top:62.36%;left:83.97%;
width:4.1%;height:28.79%'>
<div style='position:absolute;top:92.93%;left:21.72%;width:9.4%;height:10.07%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:8.77%;left:12.67%;width:84.5%;
height:78.94%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>BXD1</span><span
style='font-family:Arial;font-size:150%;color:#484848;display:none'><br>
</span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:51.11%;left:0%;width:83.33%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#484848;mso-special-format:lastCR;
display:none'><br>
</span></div>
</div>
</div>
<div style='position:absolute;top:92.75%;left:51.78%;width:9.4%;height:10.07%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:8.77%;left:12.67%;width:84.5%;
height:78.94%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>BXD2<br>
</span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:51.11%;left:0%;width:83.33%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99;mso-special-format:lastCR;
display:none'><br>
</span></div>
</div>
</div>
<div style='position:absolute;top:92.93%;left:80.79%;width:10.99%;height:6.0%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;
mso-text-indent-alt:17;position:absolute;top:14.7%;left:12.04%;width:87.95%;
height:64.7%'><span style='font-family:Arial;font-size:150%;color:#FFFF99'>BXD80</span></div>
</div>
<div style='position:absolute;top:90.45%;left:64.1%;width:17.74%;height:17.84%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:5.94%;left:7.46%;width:92.53%;
height:87.12%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:48.86%'><span
style='font-family:Arial;font-size:300%;color:#FFFF99'>+ � +<br>
</span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:50.0%;left:0%;width:83.87%;height:48.86%'><span
style='font-family:Arial;font-size:300%;color:#FFFF99;mso-special-format:lastCR;
display:none'><br>
</span></div>
</div>
</div>
<div style='position:absolute;top:62.89%;left:4.9%;width:6.75%;height:12.72%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:6.94%;left:19.6%;width:70.58%;
height:81.94%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:49.15%'><span
style='font-family:Arial;font-size:200%;color:#FFFF99'><b>F2<br>
</b></span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:50.84%;left:0%;width:83.33%;height:49.15%'><span
style='font-family:Arial;font-size:200%;color:#FFFF99;mso-special-format:lastCR;
display:none'><b><br>
</b></span></div>
</div>
</div>
<img border=0 src="slide0016_image044.gif" style='position:absolute;top:54.24%;
left:18.01%;width:75.62%;height:1.06%'><img border=0
src="slide0016_image045.gif" style='position:absolute;top:54.06%;left:17.88%;
width:.66%;height:3.88%'><img border=0 src="slide0016_image046.gif"
style='position:absolute;top:54.24%;left:32.45%;width:.52%;height:3.88%'><img
border=0 src="slide0016_image047.gif" style='position:absolute;top:54.24%;
left:48.07%;width:.52%;height:4.06%'><img border=0 src="slide0016_image048.gif"
style='position:absolute;top:54.24%;left:62.78%;width:.52%;height:4.06%'><img
border=0 src="slide0016_image049.gif" style='position:absolute;top:54.24%;
left:77.74%;width:.52%;height:4.06%'><img border=0 src="slide0016_image050.gif"
style='position:absolute;top:54.59%;left:92.71%;width:.52%;height:3.71%'><img
border=0 src="slide0016_image051.gif" style='position:absolute;top:44.87%;
left:49.13%;width:.79%;height:10.07%'><img border=0 src="slide0016_image052.gif"
style='position:absolute;top:57.59%;left:15.89%;width:4.23%;height:11.83%'><img
border=0 src="slide0016_image053.gif" style='position:absolute;top:57.59%;
left:30.86%;width:4.37%;height:11.83%'><img border=0
src="slide0016_image054.gif" style='position:absolute;top:57.59%;left:46.35%;
width:4.23%;height:11.83%'><img border=0 src="slide0016_image055.gif"
style='position:absolute;top:57.59%;left:60.92%;width:4.23%;height:11.83%'><img
border=0 src="slide0016_image056.gif" style='position:absolute;top:57.59%;
left:75.62%;width:4.23%;height:11.83%'><img border=0
src="slide0016_image057.gif" style='position:absolute;top:57.59%;left:90.86%;
width:4.23%;height:11.83%'><img border=0 src="slide0016_image058.gif"
style='position:absolute;top:84.09%;left:56.42%;width:1.98%;height:1.41%'><img
border=0 src="slide0016_image059.gif" style='position:absolute;top:80.21%;
left:25.96%;width:1.98%;height:11.83%'><img border=0
src="slide0016_image060.gif" style='position:absolute;top:84.98%;left:86.09%;
width:1.85%;height:2.12%'>
<div style='position:absolute;top:75.61%;left:1.58%;width:14.17%;height:14.13%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:7.5%;left:.93%;width:97.19%;
height:83.75%'>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:0%;left:7.69%;width:83.65%;
height:32.83%'><span style='font-family:Arial;font-size:150%;color:#FFFF99'><b>BXD
RI<br>
</b></span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:32.83%;left:0%;width:100.0%;
height:32.83%'><span style='font-family:Arial;font-size:150%;color:#FFFF99'><b>Strain
set<br>
</b></span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:67.16%;left:7.69%;width:83.65%;
height:32.83%'><span style='font-family:Arial;font-size:150%;color:#FFFF99;
mso-special-format:lastCR;display:none'><b><br>
</b></span></div>
</div>
</div>
<img border=0 src="slide0016_image061.gif" style='position:absolute;top:12.36%;
left:14.17%;width:10.59%;height:6.36%'><img border=0
src="slide0016_image062.gif" style='position:absolute;top:10.6%;left:76.42%;
width:14.3%;height:8.3%'>
<div style='position:absolute;top:20.84%;left:17.48%;width:9.8%;height:14.13%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:7.5%;left:6.75%;width:86.48%;
height:83.75%'>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:0%;left:7.81%;width:82.81%;
height:32.83%'><span style='font-family:Arial;font-size:150%;color:#FFFF99'>fully<br>
</span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:32.83%;left:0%;width:100.0%;
height:32.83%'><span style='font-family:Arial;font-size:150%;color:#FFFF99'>inbred<br>
</span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:67.16%;left:7.81%;width:82.81%;
height:32.83%'><span style='font-family:Arial;font-size:150%;color:#FFFF99;
mso-special-format:lastCR;display:none'><br>
</span></div>
</div>
</div>
<div style='position:absolute;top:38.16%;left:2.91%;width:12.05%;height:10.07%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:8.77%;left:3.29%;width:92.3%;
height:78.94%'>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:0%;left:0%;width:100.0%;
height:48.88%'><span style='font-family:Arial;font-size:150%;color:#FFFF99'>isogenic<br>
</span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:51.11%;left:8.33%;width:83.33%;
height:48.88%'><span style='font-family:Arial;font-size:150%;color:#FFFF99;
mso-special-format:lastCR;display:none'><br>
</span></div>
</div>
</div>
<div style='position:absolute;top:54.41%;left:1.85%;width:12.45%;height:14.13%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:7.5%;left:2.12%;width:93.61%;
height:83.75%'>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:0%;left:7.95%;width:82.95%;
height:32.83%'><span style='font-family:Arial;font-size:150%;color:#FFFF99'>hetero-<br>
</span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:32.83%;left:0%;width:100.0%;
height:32.83%'><span style='font-family:Arial;font-size:150%;color:#FFFF99'>geneous<br>
</span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:67.16%;left:7.95%;width:82.95%;
height:32.83%'><span style='font-family:Arial;font-size:150%;color:#FFFF99;
mso-special-format:lastCR;display:none'><br>
</span></div>
</div>
</div>
<div style='position:absolute;top:74.91%;left:29.0%;width:22.25%;height:22.08%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:4.0%;left:5.35%;width:88.09%;
height:90.4%'>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:0%;left:0%;width:100.0%;
height:79.64%'><span style='position:absolute;top:0%;left:.67%;width:99.32%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>Recombined </span></span><span
style='position:absolute;top:25.55%;left:.67%;width:99.32%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>chromosomes </span></span><span
style='position:absolute;top:51.11%;left:0%;width:100.0%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>are needed for </span></span><span
style='position:absolute;top:75.55%;left:.67%;width:99.32%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>mapping<br>
</span></span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:80.53%;left:.67%;width:99.32%;
height:19.46%'><span style='font-family:Arial;font-size:150%;color:#FFFF99;
mso-special-format:lastCR;display:none'><br>
</span></div>
</div>
</div>
<div style='position:absolute;top:10.24%;left:25.56%;width:10.46%;height:10.07%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:8.77%;left:12.65%;width:87.34%;
height:78.94%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>female<br>
</span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:51.11%;left:0%;width:84.05%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99;mso-special-format:lastCR;
display:none'><br>
</span></div>
</div>
</div>
<div style='position:absolute;top:10.24%;left:64.5%;width:8.21%;height:10.07%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:8.77%;left:14.51%;width:80.64%;
height:78.94%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99'>male<br>
</span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:51.11%;left:0%;width:84.0%;height:48.88%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99;mso-special-format:lastCR;
display:none'><br>
</span></div>
</div>
</div>
<div style='position:absolute;top:30.56%;left:78.01%;width:19.47%;height:10.07%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:15.78%;left:6.12%;width:93.19%;
height:71.92%'>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:0%;left:0%;width:100.0%;height:41.46%'><span
style='font-family:Arial;font-size:117%;color:#FFFF99'>chromosome pair</span><span
style='font-family:Arial;font-size:150%;color:#FFFF99;display:none'><br>
</span></div>
<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:46.34%;left:0%;width:83.21%;height:53.65%'><span
style='font-family:Arial;font-size:150%;color:#FFFF99;mso-special-format:lastCR;
display:none'><br>
</span></div>
</div>
</div>
<img border=0 src="slide0016_image063.gif" style='position:absolute;top:31.09%;
left:65.82%;width:12.84%;height:2.82%'>
<div style='position:absolute;top:86.21%;left:3.97%;width:10.06%;height:14.48%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='position:absolute;top:4.87%;left:5.26%;width:86.84%;
height:85.36%'>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:0%;left:9.09%;width:83.33%;
height:24.28%'><span style='font-family:Arial;font-size:117%;color:#E9EB5D'>Inbred<br>
</span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:25.71%;left:0%;width:100.0%;
height:24.28%'><span style='font-family:Arial;font-size:117%;color:#E9EB5D'>Isogenic<br>
</span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:50.0%;left:6.06%;width:90.9%;
height:24.28%'><span style='font-family:Arial;font-size:117%;color:#E9EB5D'>siblings</span><span
style='font-family:Arial;font-size:117%;color:aqua;display:none'><br>
</span></div>
<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:
17;mso-text-indent-alt:17;position:absolute;top:75.71%;left:9.09%;width:83.33%;
height:24.28%'><span style='font-family:Arial;font-size:117%;color:aqua;
mso-special-format:lastCR;display:none'><br>
</span></div>
</div>
</div>
<img border=0 src="slide0016_image064.gif" style='position:absolute;top:79.32%;
left:83.7%;width:1.98%;height:11.83%'><img border=0 src="slide0016_image065.gif"
style='position:absolute;top:79.85%;left:53.5%;width:1.98%;height:11.83%'><img
border=0 src="slide0016_image066.gif" style='position:absolute;top:80.21%;
left:23.44%;width:1.98%;height:11.83%'>
<div style='position:absolute;top:18.72%;left:43.04%;width:13.77%;height:9.89%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=O style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
17;position:absolute;top:10.71%;left:9.61%;width:90.38%;height:76.78%'><span
style='font-family:Arial;font-size:300%;color:aqua'>B</span><span
style='font-family:Arial;font-size:300%;color:#FFFF99'>X</span><span
style='font-family:Arial;font-size:300%;color:#FF1911'>D</span></div>
</div>
<img border=0 src="slide0016_image067.gif" style='position:absolute;top:27.2%;
left:32.98%;width:31.39%;height:4.06%'><img border=0
src="slide0016_image068.gif" style='position:absolute;top:66.25%;left:60.92%;
width:1.98%;height:3.18%'><img border=0 src="slide0016_image069.gif"
style='position:absolute;top:64.31%;left:15.89%;width:1.98%;height:5.3%'><img
border=0 src="slide0016_image070.gif" style='position:absolute;top:57.59%;
left:75.62%;width:1.98%;height:5.65%'><img border=0 src="slide0016_image071.gif"
style='position:absolute;top:28.44%;left:48.87%;width:.92%;height:8.12%'><img
border=0 src="slide0016_image072.gif" style='position:absolute;top:62.19%;
left:23.84%;width:3.57%;height:16.96%'><img border=0
src="slide0016_image073.gif" style='position:absolute;top:61.48%;left:63.17%;
width:1.98%;height:8.12%'></div>
<div id=NotesObj style='display:none'>
<table style='color:white' border=0 width="100%">
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<td width="100%"></td>
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<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>The next set of slides
provide a very short interlude on QTL mapping. You will need to do some
independent reading on this topic if this is your first exposure to QTL
mapping. The recombinant inbred strains that we are using in WebQTL and in
this particular demo were generated about 25 years ago by Dr. Ben Taylor at
The Jackson Laboratory. He crossed a female C57BL/6J mouse with a male DBA/2J
mice. At the bottom of this slide we have schematized one chromosome pair
from three out of 80 BXD RI strains.<span style="mso-spacerun: yes">
</span>The dashed vertical lines that lead to the final BXD RI lines involve
20 full sib matings (about 6 years of breeding). Some lines die<span
style="mso-spacerun: yes"> </span>out during inbreeding. For example,
there is no extant BXD3 or BXD4 strain.</font><br>
</td>
</tr>
</table>
</div>
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