1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
|
<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN">
<HTML>
<HEAD>
<TITLE>SUH BXD Liver Affy Mouse Gene 1.0 ST (Jun11) RMA **</TITLE>
<META http-equiv=Content-Type content="text/html; charset=iso-8859-1">
<META NAME="keywords" CONTENT="genetics, bioinformatics, genome, phenome, gene expression, complex trait analysis, gene mapping, SNP, quantitative trait locus QTL, expression eQTL, WebQTL, Traitnet, Traitnetwork, personalized medicine">
<META NAME="description" CONTENT ="GeneNetwork is a free scientific web resource used to study relationships between differences in genes, environmental factors, phenotypes, and disease risk." >
<META NAME="author" CONTENT ="GeneNetwork developers" >
<META NAME="geo.placename" CONTENT ="Memphis, TN" >
<META NAME="geo.region" CONTENT="US-TN">
<LINK REL="stylesheet" TYPE="text/css" HREF='/css/general.css'>
<LINK REL="stylesheet" TYPE="text/css" HREF='/css/menu.css'>
<link rel="stylesheet" media="all" type="text/css" href="/css/tabbed_pages.css" />
<LINK REL="apple-touch-icon" href="/images/ipad_icon3.png" />
<link type="text/css" href='/css/custom-theme/jquery-ui-1.8.12.custom.css' rel='Stylesheet' />
<script type="text/javascript" src="/javascript/jquery.js"></script>
<SCRIPT SRC="/javascript/webqtl.js"></SCRIPT>
<SCRIPT SRC="/javascript/dhtml.js"></SCRIPT>
<SCRIPT SRC="/javascript/jqueryFunction.js"></SCRIPT>
<script src="/javascript/tabbed_pages.js" type="text/javascript"></script>
<script src="/javascript/jquery-ui-1.8.12.custom.min.js" type="text/javascript"></script>
<script type="text/javascript">
var _gaq = _gaq || [];
_gaq.push(['_setAccount', 'UA-3782271-1']);
_gaq.push(['_trackPageview']);
(function() {
var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true;
ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js';
var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s);
})();
</script>
</HEAD>
<BODY bottommargin="2" leftmargin="2" rightmargin="2" topmargin="2" text=#000000 bgColor=#ffffff >
<TABLE cellSpacing=5 cellPadding=4 width="100%" border=0>
<TBODY>
<!-- Start of header -->
<TR>
<TD width=30 rowSpan=5> </TD>
<TD bgColor=#ffffff NOWRAP="yes" width="100%" class="solidBorder">
<Table width= "100%" cellSpacing=0 cellPadding=0>
<TR>
<TD width= "100%" id="smallsize">
<a href="/">
<IMG src="/images/upload/GeneNet_Banner2009c.png" border="0">
</a>
</TD>
<TD valign="bottom">
<A HREF="http://www.touchgraph.com/TGGoogleBrowser.php?start=genenetwork.org&signed=false" target="_blank">
<IMG SRC="/images/upload/NetworkLogo.png" width="101" height="73" border="0">
</a>
</td>
<TD valign="bottom">
<IMG src="/images/webqtllogo2.gif" alt="WebQTL" border="0">
</TD>
</TR>
</Table>
</TD>
<TD width=30 rowSpan=5> </TD>
</TR>
<TR>
<!--Home Help Search News Papers Policies Accounts Links-->
<TD bgColor=#ddddff NOWRAP="yes" class="solidBorder">
<table width=100% cellSpacing=0 cellPadding=0 border=0>
<tr>
<td aligh=left NOWRAP="yes">
|
<Span Id= "menu_grp1" onmouseover="A_MENUS[0].onmouseover(grpObj['menu_grp1'])" onmouseout="A_MENUS[0].onmouseout(grpObj['menu_grp1'])" style="font-size:12px;font-family:verdana;color:#0000ae">
<Strong>Home</Strong></Span>
|
<Span Id= "menu_grp2" onmouseover="A_MENUS[0].onmouseover(grpObj['menu_grp2'])" onmouseout="A_MENUS[0].onmouseout(grpObj['menu_grp2'])" style="font-size:12px;font-family:verdana;color:#0000ae">
<Strong>Search</Strong></Span>
|
<Span Id= "menu_grp3" onmouseover="A_MENUS[0].onmouseover(grpObj['menu_grp3'])" onmouseout="A_MENUS[0].onmouseout(grpObj['menu_grp3'])" style="font-size:12px;font-family:verdana;color:#0000ae">
<Strong>Help</Strong></Span>
|
<Span Id= "menu_grp4" onmouseover="A_MENUS[0].onmouseover(grpObj['menu_grp4'])" onmouseout="A_MENUS[0].onmouseout(grpObj['menu_grp4'])" style="font-size:12px;font-family:verdana;color:#0000ae">
<A Href="/whats_new.html" style="font-size:12px;font-family:verdana;color:#0000ae">
<Strong>News</Strong></A></Span>
|
<Span Id= "menu_grp5" onmouseover="A_MENUS[0].onmouseover(grpObj['menu_grp5'])" onmouseout="A_MENUS[0].onmouseout(grpObj['menu_grp5'])" style="font-size:12px;font-family:verdana;color:#0000ae">
<A Href="/reference.html" style="font-size:12px;font-family:verdana;color:#0000ae">
<Strong>References</Strong></A></Span>
|
<Span Id= "menu_grp6" onmouseover="A_MENUS[0].onmouseover(grpObj['menu_grp6'])" onmouseout="A_MENUS[0].onmouseout(grpObj['menu_grp6'])" style="font-size:12px;font-family:verdana;color:#0000ae">
<Strong>Policies</Strong></Span>
|
<Span Id= "menu_grp8" onmouseover="A_MENUS[0].onmouseover(grpObj['menu_grp8'])" onmouseout="A_MENUS[0].onmouseout(grpObj['menu_grp8'])" style="font-size:12px;font-family:verdana;color:#0000ae">
<A Href="/links.html" style="font-size:12px;font-family:verdana;color:#0000ae">
<Strong>Links</Strong></A></Span>
|
</td>
<td align="right" NOWRAP="yes">
</td>
</tr>
</table>
</TD>
</TR>
<!-- End of header -->
<!-- Start of body -->
<TR>
<TD bgColor=#eeeeee class="solidBorder">
<Table width= "100%" cellSpacing=0 cellPadding=5>
<TR>
<P class="title">SUH BXD Liver Affy Mouse Gene 1.0 ST (Jun11) RMA **<A HREF="/webqtl/main.py?FormID=editHtml"><img src="/images/modify.gif" alt="modify this page" border= 0 valign="middle"></A><BR><BR>
Accession number: <A HREF="/webqtl/main.py?FormID=sharinginfo&GN_AccessionId=325">GN325</A></P>
<P><B>Saarland University Homburg (SUH) Carbon Tetrachloride-Treated BXD Mouse Affymetrix Mouse Gene 1.0 ST Array data set</B>
<P>This experimental liver gene expression data set (~100 Affymetrix exon-type arrays), was generated by Frank Lammert, Sonja Hillebrandt, Rabea Hall, and colleagues at the Saarland University Medical Center in Homburg, Germany. This work is part of the German Network for Systems Genetics (<A HREF="http://www.helmholtz-hzi.de/en/genesys/genesys/working_packages/wp_8/" target="new">GeNeSys</A>).
<P>Expression data after <A HREF="http://en.wikipedia.org/wiki/Carbon_tetrachloride" target="new">carbon tetrachloride</A> treatment (CCl4, also known as Halon, Freon, carbon tet, or tetrachloromethane) were generated using RNA sample from 30 BXD strains, both parental strains (C57BL/6J, DBA/2J), and B6D2 F1 hybrids. The great majority of cases were females and were treated with carbon tetrachloride injections over a six week period. Three arrays were run for each strain using independent liver samples.
<P>PURPOSE: The overall goal of the project is to understand the etiology of liver fibrogenesis using carbon tetracholoride as a toxin and inducer of liver disease. Liver fibrogenesis, or scarring of the liver, is the common end-stage of chronic liver diseases, in particular after chronic viral infections. In Germany along complications associated with liver fibrosis cause approximately 10,000 deaths per year. In the past decade key molecular pathomechanisms of hepatic fibrogenesis due to chronic viral infections have been identified. Activated hepatic stellate cells (HSCs) drive the process of de novo deposition of abnormal extracellular matrix, which is modulated by complex interactions between cytokines, receptors, and matrix components.
<P>Several studies have demonstrated that the course and progression of the fibrogenic response to chronic liver injury is highly variability among individuals. This marked variabilityhas been attributed to etiology, age, gender, and environmental factors. In humans these genetic disease fibrosis predisposition factors have not yet to be studied systematically.
<P>Our group recently identified a gene variant that contributes to liver fibrogenesis by using QTL mapping in an experimental crosses between fibrosis-susceptible and resistant strains of mice (Hillebrandt et al., <A HREF="http://www.ncbi.nlm.nih.gov/pubmed?term=15995705" target="new">2005</A>). We demonstrated that sequence differences in the <I>HC</I> gene that encodes complement factor C5 (also known as hemolytic complement), are responsible for this strain difference. Common haplotype-tagging polymorphisms of the human HC gene were shown to be associated with advanced fibrosis in chronic hepatitis C virus infection. Thus, the mouse analysis led to the identification of an unknown gene underlying human susceptibility to liver fibrosis, supporting the idea that HC has a causal role in chronic inflammatory disorders and organ fibrogenesis across species.
<P>As part of the GeNeSys program we have studied liver fibrogenesis in the BXD family of strains as a model for chronic liver injury. This expression data set is used to map complex genetic traits that modulate gene expression and determine gene networks during liver fibrogenesis in GRPs.
<P> The following assays are complete or are in progress:
<OL>
<LI>Liver fibrosis studies: Phenotyping protocols include standard histology, morphometry, biochemical quantification of hepatic collagen contents, serum surrogate markers of fibrosis, immunohistochemistry, and expression profiling of proinflammatory and profibrogenic genes by qRT-PCR and Affymetrix microarrays (this data set).
<LI>Characterization of liver cells: Liver immune cell fractions will be isolated and sorted according to SOPs developed in the Lammert laboratory. In addition, in cooperation with the technology platforms of the <A HREF="http://www.systembiologie.de" target="new">HepatoSys Network of Excellence</A>, we will characterize primary HSCs that play critical roles in liver fibrogenesis with respect to proinflammatory responses during chronic liver inflammation.
</OL>
<p><B>PROTOCOL for carbon tetrachloride (CCl4) treatment </B> (parental strains, F1, and BXD lines). Animals were injected with CCl4 (12 x 0.7 mg/kg ip) over a 6-week period on days 1 and 4 of each week. Intraperitoneal injections were begun between the ages of 6-8 weeks. Animals were sacrificed after 6 weeks of treatment at 12 to 14 weeks of age. Untreated control mice from only the two parental strains were also sacrificed at 12-14 weeks of age
<p>
Tissue: Livers were snap frozen in liquid nitrogen immediately after harvesting. RNA was extracted and submitted to the UTHSC Molecular Resource Core for expression profiling. Expression data were generated by Lorne Rose, William Taylor and colleagues. Data were entered into GeneNetwork by Arthur Centeno, June 17, 2011. Data were quality controlled by R. W. Williams. </P>
<P>QC Results: This data set consists of expression data for 33 strains. A total of 166 probe sets are associated with LOD scores above 10 and the highest linkage score of 22 for <I>Rpl3</I> (probe set 10430669). Strain distribution patterns of eQTLs with a Mendelian expression pattern match those of their closest markers perfectly, verifying that there are no errors of strain assignment in this data set.
<P>Analysis of XIST probe set 1060617 confirms that most strains are purely female. However, only males were available for BXD1 and BXD6. BXD28 and BXD33 data are based on the average of two female samples and one male sample. All other strains are purely female.
<p>Data were analyzed by Rabea Hall and Dr. Frank Lammert at the Universitätsklinikum des Saarlandes in Homburg, Germany.
<p>Contacts: rabea.hall at uks.eu, Rabea.Hall at uniklinikum-saarland.de, and frank.lammert at uks.eu
<p><b>Table updated 7-19-2011</b></p>
<blockquote>
<table border="0" cellpadding="0" cellspacing="0" bgcolor="#000000" width="600">
<tr><td>
<table width="600" border="0" cellpadding="5" cellspacing="1" align="left">
<tr bgcolor="royalblue"><td><font color=#FFFFFF>Index</font></td><td><font color=#FFFFFF>Sample ID</font></td><td><font color=#FFFFFF>Strain ID</font></td><td><font color=#FFFFFF>Treatment</font></td></tr>
<tr bgcolor="#eeeeee"><td>1</td><td>504</td><td>B6D2F1 </td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>2</td><td>506</td><td>B6D2F1</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>3</td><td>508</td><td>B6D2F1</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>4</td><td>414</td><td>C57BL/6J</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>5</td><td>488</td><td>C57BL/6J</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>6</td><td>489</td><td>C57BL/6J</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>7</td><td>B6J1 </td><td>C57BL/6J</td><td>untreated control</td></tr>
<tr bgcolor="#eeeeee"><td>8</td><td>B6J2 </td><td>C57BL/6J</td><td>untreated control</td></tr>
<tr bgcolor="#eeeeee"><td>9</td><td>B6J3 </td><td>C57BL/6J</td><td>untreated control</td></tr>
<tr bgcolor="#eeeeee"><td>10</td><td>449</td><td>DBA/2J</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>11</td><td>450</td><td>DBA/2J</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>12</td><td>451</td><td>DBA/2J</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>13</td><td>219.1</td><td>DBA/2J</td><td>untreated control</td></tr>
<tr bgcolor="#eeeeee"><td>14</td><td>219.2</td><td>DBA/2J</td><td>untreated control</td></tr>
<tr bgcolor="#eeeeee"><td>15</td><td>219.3</td><td>DBA/2J</td><td>untreated control</td></tr>
<tr bgcolor="#eeeeee"><td>16</td><td>276</td><td>BXD1</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>17</td><td>278</td><td>BXD1</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>18</td><td>279</td><td>BXD1</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>19</td><td>353</td><td>BXD2</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>20</td><td>357</td><td>BXD2</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>21</td><td>358</td><td>BXD2</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>22</td><td>272</td><td>BXD6</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>23</td><td>273</td><td>BXD6</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>24</td><td>274</td><td>BXD6</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>25</td><td>405</td><td>BXD11</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>26</td><td>406</td><td>BXD11</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>27</td><td>408</td><td>BXD11</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>28</td><td>239</td><td>BXD12</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>29</td><td>240</td><td>BXD12</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>30</td><td>241</td><td>BXD12</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>31</td><td>553</td><td>BXD13</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>32</td><td>554</td><td>BXD13</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>33</td><td>555</td><td>BXD13</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>34</td><td>249</td><td>BXD14</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>35</td><td>250</td><td>BXD14</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>36</td><td>288</td><td>BXD14</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>37</td><td>191</td><td>BXD19</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>38</td><td>644</td><td>BXD19</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>39</td><td>645</td><td>BXD19</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>40</td><td>442</td><td>BXD24a</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>41</td><td>443</td><td>BXD24a</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>42</td><td>444</td><td>BXD24a</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>43</td><td>216</td><td>BXD27</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>44</td><td>218</td><td>BXD27</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>45</td><td>290</td><td>BXD27</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>46</td><td>28</td><td>BXD28</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>47</td><td>71</td><td>BXD28</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>48</td><td>129</td><td>BXD28</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>49</td><td>219</td><td>BXD31</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>50</td><td>220</td><td>BXD31</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>51</td><td>231</td><td>BXD31</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>52</td><td>549</td><td>BXD32</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>53</td><td>550</td><td>BXD32</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>54</td><td>551</td><td>BXD32</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>55</td><td>139</td><td>BXD33</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>56</td><td>140</td><td>BXD33</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>57</td><td>559</td><td>BXD33</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>58</td><td>132</td><td>BXD34</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>59</td><td>146</td><td>BXD34</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>60</td><td>147</td><td>BXD34</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>61</td><td>293</td><td>BXD39</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>62</td><td>597</td><td>BXD39</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>63</td><td>599</td><td>BXD39</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>64</td><td>154</td><td>BXD40</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>65</td><td>570</td><td>BXD40</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>66</td><td>572</td><td>BXD40</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>67</td><td>361</td><td>BXD42</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>68</td><td>362</td><td>BXD42</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>69</td><td>373</td><td>BXD42</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>70</td><td>428</td><td>BXD43</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>71</td><td>429</td><td>BXD43</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>72</td><td>556</td><td>BXD43</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>73</td><td>472</td><td>BXD51</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>74</td><td>473</td><td>BXD51</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>75</td><td>474</td><td>BXD51</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>76</td><td>533</td><td>BXD55</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>77</td><td>534</td><td>BXD55</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>78</td><td>535</td><td>BXD55</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>79</td><td>519</td><td>BXD62</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>80</td><td>520</td><td>BXD62</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>81</td><td>521</td><td>BXD62</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>82</td><td>463</td><td>BXD65</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>83</td><td>464</td><td>BXD65</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>84</td><td>465</td><td>BXD65</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>85</td><td>327</td><td>BXD69</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>86</td><td>346</td><td>BXD69</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>87</td><td>347</td><td>BXD69</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>88</td><td>614</td><td>BXD73</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>89</td><td>616</td><td>BXD73</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>90</td><td>619</td><td>BXD73</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>91</td><td>395</td><td>BXD75</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>92</td><td>482</td><td>BXD75</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>93</td><td>483</td><td>BXD75</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>94</td><td>317</td><td>BXD87</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>95</td><td>319</td><td>BXD87</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>96</td><td>322</td><td>BXD87</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>97</td><td>374</td><td>BXD90</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>98</td><td>388</td><td>BXD90</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>99</td><td>389</td><td>BXD90</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>100</td><td>402</td><td>BXD96</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>101</td><td>403</td><td>BXD96</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>102</td><td>404</td><td>BXD96</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>103</td><td>584</td><td>BXD98</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>104</td><td>585</td><td>BXD98</td><td>CCl4</td></tr>
<tr bgcolor="#eeeeee"><td>105</td><td>607</td><td>BXD98</td><td>CCl4</td></tr>
</table>
</blockquote>
</TR>
</TABLE>
</TD>
</TR>
<!-- End of body -->
<!-- Start of footer -->
<TR>
<TD align=center bgColor=#ddddff class="solidBorder">
<TABLE width="100%">
<TR>
<TD align="left">
<A HREF="http://citg.uthsc.edu/" target="_blank">
<IMG SRC="/images/upload/CITGLogo.png" alt="CITG" border="0"></A>
</TD>
<TD align="left" id="smallsize" style="font-size:11px;font-family:verdana;color:black">
Service initiated June 15, 2001. Site by
<A class="smallsize" HREF="mailto:xzhou15@uthsc.edu">Xiaodong Zhou</A>,
<A class="smallsize" HREF="mailto:lyan6@uthsc.edu">Lei Yan</A>,
<A class="smallsize" HREF="mailto:nliu4@uthsc.edu" target="_blank">Ning Liu</A>,
<A class="smallsize" HREF="mailto:zachary.a.sloan@gmail.com">Zachary Sloan</A>,
<A class="smallsize" HREF="mailto:rudi.alberts@helmholtz-hzi.de">Rudi Alberts</A>,
<A class="smallsize" HREF="mailto:acenteno@uthsc.edu" target="_blank">Arthur Centeno</A>, Jintao Wang, Lu Lu, Kenneth Manly, Robert W. Williams, and <A class="smallsize" HREF="/credit.html">colleagues</A>.
</TD>
<TD align="right">
<A HREF="http://www.python.org/" target="_blank">
<IMG src="/images/upload/PythonLogo.png" alt="Python Powered" border="0"></A>
</TD>
<TD align="right">
<A HREF="http://www.neuinfo.org" target="_blank">
<img src="/images/upload/Nif.png" alt="Registered with Nif" border="0"></A>
</TD>
</TR>
<TR>
<TD>
</TD>
<TD colspan=3 style="font-size:12px;font-family:verdana;color:black">
GeneNetwork support from:
<UL>
<LI><a class="smallsize" target="_blank" href="http://citg.uthsc.edu">The UT Center for Integrative and Translational Genomics</A>
<LI><a class="smallsize" target="_blank" href="http://www.iniastress.org">NIAAA</A> Integrative Neuroscience Initiative on Alcoholism (U01AA13499, U24AA13513, U01AA014425)
<LI><a class="smallsize" target="_blank" href="http://www.drugabuse.gov/about/organization/Genetics/geneexpression/index.html">NIDA</A>, <a class="smallsize" target="_blank" href="http://www.nimh.nih.gov/">NIMH</A>, and <a class="smallsize" target="_blank" href="http://www.niaaa.nih.gov/">NIAAA</A> (P20-DA 21131)
<LI>NCI <a class="smallsize" target="_blank" href="http://emice.nci.nih.gov/">MMHCC</A> (U01CA105417), <a class="smallsize" target="_blank" href="http://www.ncrr.nih.gov/">NCRR</A> <a class="smallsize" target="_blank" href="http://www.nbirn.net/TestBeds/Mouse/index.htm">BIRN</A>, (U24 RR021760)
</UL>
</TD>
</TR>
<TR>
<TD colspan=4 id="smallsize" align="left">
</TD>
</TR>
</TABLE>
</TD>
</TR>
<!-- End of footer -->
</TABLE>
<!-- menu script itself. you should not modify this file -->
<script language="JavaScript" src="/javascript/menu_new.js"></script>
<!-- items structure. menu hierarchy and links are stored there -->
<script language="JavaScript" src="/javascript/menu_items.js"></script>
<!-- files with geometry and styles structures -->
<script language="JavaScript" src="/javascript/menu_tpl.js"></script>
<script language="JavaScript">
<!--//
// Note where menu initialization block is located in HTML document.
// Don't try to position menu locating menu initialization block in
// some table cell or other HTML element. Always put it before </body>
// each menu gets two parameters (see demo files)
// 1. items structure
// 2. geometry structure
new menu (MENU_ITEMS, MENU_POS);
// make sure files containing definitions for these variables are linked to the document
// if you got some javascript error like "MENU_POS is not defined", then you've made syntax
// error in menu_tpl.js file or that file isn't linked properly.
// also take a look at stylesheets loaded in header in order to set styles
//-->
</script>
</BODY>
</HTML>
|
