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<HTML><HEAD><TITLE>Stuart CXB Mouse Spleen Normative Affy M430 2.0 (Nov 2007) RMA data set</TITLE>
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<P class="title">Stuart CXB Mouse Spleen Normative Affy M430 2.0 (Nov 2007) RMA data set <A HREF="/webqtl/main.py?FormID=editHtml">
<img src="/images/modify.gif" alt="modify this page" border= 0 valign="middle"></A><BR><BR>Accession number: <A HREF="/webqtl/main.py?FormID=sharinginfo&GN_AccessionId=153">GN153</A></P>
<B>This is a new and untested data set from John Stuart and colleagues, VA Medical Center, Memphis, TN.</B>
<P>Please contact Rob Williams (rwilliam@nb.utmem.edu) for access.
<P>The recombinant inbred CXB (BALB/cBy x C57BL/6By) RI set have often been used to study the influence of non-H-2 chromosomal regions on the progression of collagen-induced arthritis (CIA). C57BL/6By mice are of intermediate susceptibility to CIA while BALB/cBy mice are resistant, but are highly susceptible to proteoglycan-induced arthritis. While antigen presentation is H-2 directed, the amount of disease that results is thought to be driven by regions outside of the MHC. CXB strains that are H-2b are predicted to show variation in the frequency and severity of disease relative to C57BL/6By, depending on which BALB/cBy chromosome regions are present. Nine of thirteen CXB strains are H-2b (2, 3, 5, 6, 7, 8, 10, 11 and 13) while one has a recombined H-2 region (CXB9). The four H-2d strains were crossed with C57Bl/6ByJ to generate F1 mice that could present collagen via the B allele at the H-2b locus, while possibly identifying BALB/cBy alleles that would have a dominant effect on disease progression. A number of disease and immunological parameters were collected. (text from Dana Marshall, Jan 2008)
<P>Gene expression analysis was performed using samples from resting naive spleens from adult female adult mice. Information on these cases is provided below.
<P>
<Blockquote>
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<td><font color=#FFFFFF>Index</font></td>
<td><font color=#FFFFFF>Tube ID</font></td>
<td><font color=#FFFFFF>RNA ID</td>
<td><font color=#FFFFFF>Strain</font></td>
<td><font color=#FFFFFF>Age</font></td>
<td><font color=#FFFFFF>Source</font></td>
<td><font color=#FFFFFF>Pool size</td>
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<tr bgcolor="#eeeeee"><td>1</td><td>R2440S1</td><td>R2440S</td><td>BALB/cByJ</td><td>60</td><td>UTHSC</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>2</td><td>R2435S1</td><td>R2435S</td><td>BALB/cByJ</td><td>83</td><td>JAX</td><td>n/a</td>
<tr bgcolor="#eeeeee"><td>3</td><td>R2394S1</td><td>R2394S</td><td>C57BL/6BYJ</td><td>51</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>4</td><td>R2395S1</td><td>R2395S</td><td>C57BL/6BYJ</td><td>51</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>5</td><td>R2410S1</td><td>R2410S</td><td>CXB1</td><td>55</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>6</td><td>R2655S1</td><td>R2655S</td><td>CXB1</td><td>58</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>7</td><td>R2392S1</td><td>R2392S</td><td>CXB2</td><td>53</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>8</td><td>R2393S1</td><td>R2393S</td><td>CXB2</td><td>53</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>9</td><td>R2430S1</td><td>R2430S</td><td>CXB3</td><td>41</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>10</td><td>R2412S1</td><td>R2412S</td><td>CXB3</td><td>47</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>11</td><td>R2432S1</td><td>R2432S</td><td>CXB4</td><td>47</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>12</td><td>R2413S1</td><td>R2413S</td><td>CXB4</td><td>58</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>13</td><td>R2441S1</td><td>R2441S</td><td>CXB5</td><td>67</td><td>UTHSC</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>14</td><td>R2444S1</td><td>R2444S</td><td>CXB5</td><td>80</td><td>UTHSC</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>15</td><td>R2437S1</td><td>R2437S</td><td>CXB6</td><td>47</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>16</td><td>R2414S1</td><td>R2414S</td><td>CXB6</td><td>49</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>17</td><td>R2416S1</td><td>R2416S</td><td>CXB7</td><td>58</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>18</td><td>R2415S1</td><td>R2415S</td><td>CXB7</td><td>63</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>19</td><td>R2418S1</td><td>R2418S</td><td>CXB8</td><td>41</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>20</td><td>R2417S1</td><td>R2417S</td><td>CXB8</td><td>54</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>21</td><td>R2420S1</td><td>R2420S</td><td>CXB9</td><td>53</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>22</td><td>R2419S1</td><td>R2419S</td><td>CXB9</td><td>54</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>23</td><td>R2422S1</td><td>R2422S</td><td>CXB10</td><td>48</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>24</td><td>R2421S1</td><td>R2421S</td><td>CXB10</td><td>53</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>25</td><td>R2423S1</td><td>R2423S</td><td>CXB11</td><td>58</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>26</td><td>R2424S1</td><td>R2424S</td><td>CXB11</td><td>77</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>27</td><td>R2425S1</td><td>R2425S</td><td>CXB12</td><td>47</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>28</td><td>R2442S1</td><td>R2442S</td><td>CXB12</td><td>76</td><td>UTHSC</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>29</td><td>R2427S1</td><td>R2427S</td><td>CXB13</td><td>49</td><td>JAX</td><td>n/a</td></tr>
<tr bgcolor="#eeeeee"><td>30</td><td>R2426S1</td><td>R2426S</td><td>CXB13</td><td>56</td><td>JAX</td><td>n/a</td></tr>
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