1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
|
<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN">
<HTML><HEAD><TITLE>OX UK HS ILM6v1.1 Liver (May 2010) RankInv</TITLE>
<META http-equiv=Content-Type content="text/html; charset=iso-8859-1">
<LINK REL="stylesheet" TYPE="text/css" HREF='/css/general.css'>
<LINK REL="stylesheet" TYPE="text/css" HREF='/css/menu.css'>
<link rel="stylesheet" media="all" type="text/css" href="/css/tabbed_pages.css" />
<script type="text/javascript" src="/javascript/jquery.js"></script>
<SCRIPT SRC="/javascript/webqtl.js"></SCRIPT>
<SCRIPT SRC="/javascript/dhtml.js"></SCRIPT>
<script src="/javascript/tabbed_pages.js" type="text/javascript"></script>
</HEAD>
<BODY bottommargin="2" leftmargin="2" rightmargin="2" topmargin="2" text=#000000 bgColor=#ffffff >
<TABLE cellSpacing=5 cellPadding=4 width="100%" border=0>
<TBODY>
<TR>
<script language="JavaScript" src="/javascript/header.js"></script>
</TR>
<TR>
<TD bgColor=#eeeeee class="solidBorder">
<Table width= "100%" cellSpacing=0 cellPadding=5>
<TR>
<!-- split from Here -->
<!-- Body Start from Here -->
<P class="title">OX UK HS ILM6v1.1 Liver (May 2010) RankInv (accession number: <A HREF="/webqtl/main.py?FormID=sharinginfo&GN_AccessionId=269">GN269</A>) <A HREF="/webqtl/main.py?FormID=editHtml">
<img src="/images/modify.gif" alt="modify this page" border= 0 valign="middle"></A></P>
<p><blockquote>
<p class="subtitle">Summary:</p>
<p>A proportion of the genetic variants underlying complex phenotypes do so through their effects on gene expression, so an important challenge in complex trait analysis is to discover the genetic basis for the variation in transcript abundance. So far, the potential of mapping both quantitative trait loci (QTLs) and expression quantitative trait loci (eQTLs) in rodents has been limited by the low mapping resolution inherent in crosses between inbred strains. We provide a megabase resolution map of thousands of eQTLs in hippocampus, lung, and liver samples from heterogeneous stock (HS) mice in which 843 QTLs have also been mapped at megabase resolution. We exploit dense mouse SNP data to show that artifacts due to allele-specific hybridization occur in _30% of the cis-acting eQTLs and, by comparison with exon expression data, we show that alternative splicing of the 3_ end of the genes accounts for <1% of cis-acting eQTLs. Approximately one third of cis-acting eQTLs and one half of trans-acting eQTLs are tissue specific. We have created an important systems biology resource for the genetic analysis of complex traits in a key model organism.</p>
<p class="subtitle">Animals and Tissue Used to Generate This Set of Data:</p>
<p>Organism: Mus musculus. Tissue: Liver. Array design: A-MEXP-533 - Illumina Mouse-6 v1 Expression BeadChip</p>
<p class="subtitle">Data Source Acknowledgements:</p>
<p>
<p>Citations: High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Huang GJ, Shifman S, Valdar W, Johannesson M, Yalcin B, Taylor MS, Taylor JM, Mott R, Flint J. Genome Res 19(6):1133-40 (Genome Res), PubMed 19376938<p>
Contact: Richard Mott. Email: Richard.Mott at well.ox.ac.uk University of Oxford</p>
<p>Data entered by A. Centeno on May 20, 2010</p>
</blockquote></p>
</TR></TABLE>
</TD>
</TR>
<TR>
<TD align=center bgColor=#ddddff class="solidBorder">
<!--Start of footer-->
<TABLE width="100%">
<script language='JavaScript' src='/javascript/footer.js'></script>
<TR>
<TD colspan=4 class="fs12" align="left">
</TD>
</TR>
</TABLE>
<!--End of footer-->
</TD>
</TR>
</TABLE>
<!-- /Footer -->
<!-- menu script itself. you should not modify this file -->
<script language="JavaScript" src="/javascript/menu_new.js"></script>
<!-- items structure. menu hierarchy and links are stored there -->
<script language="JavaScript" src="/javascript/menu_items.js"></script>
<!-- files with geometry and styles structures -->
<script language="JavaScript" src="/javascript/menu_tpl.js"></script>
<script language="JavaScript">
<!--//
// Note where menu initialization block is located in HTML document.
// Don't try to position menu locating menu initialization block in
// some table cell or other HTML element. Always put it before </body>
// each menu gets two parameters (see demo files)
// 1. items structure
// 2. geometry structure
new menu (MENU_ITEMS, MENU_POS);
// make sure files containing definitions for these variables are linked to the document
// if you got some javascript error like "MENU_POS is not defined", then you've made syntax
// error in menu_tpl.js file or that file isn't linked properly.
// also take a look at stylesheets loaded in header in order to set styles
//-->
</script>
</BODY>
</HTML>
|
