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* Python-Rpy2 performance issues with genenetwork2
At one point, genenetwork2 was down. A possible cause was that it
wrote into the log file in an infinite loop due to rpy2, so a solution
was to empty it. Currently, as a work around, rpy2 is disabled by
removing it's imports. This affects WGCNA/ CTL imports and commenting
out Biweight Midcorrelation option in the trait page. See:
- [[https://github.com/genenetwork/genenetwork2/commit/1baf5f7611909c651483208184c5fbf7d4a7a088][1baf5f7]]
- [[https://github.com/genenetwork/genenetwork2/commit/afee4d625248565857df98d3510f680ae6204864][afee4d6]]
- [[https://github.com/genenetwork/genenetwork2/commit/c458bf0ad731e5e5fd9cbd0686936b3a441bae63][c458bf0]]
- [[https://github.com/genenetwork/genenetwork2/commit/d31f3f763471b19559ca74e73b52b3cb5e7153ce][d31f3f7]]
** Reproducing the problem
I went back to commit #b8408cea. With regards to logs, I never
experienced any log issue. Perhaps it's because of how I start my
server:
: env SERVER_PORT=5004 TMPDIR=/home/bonface/tmp WEBSERVER_MODE=DEBUG LOG_LEVEL=DEBUG GENENETWORK_FILES=/home/bonface/data/genotype_files/ GN2_PROFILE=/home/bonface/opt/python3-genenetwork2 ./scripts/run_debug.sh
However, when loading the homepage, I occasionally ran into this trace:
#+begin_export ascii
DEBUG:wqflask.views:.check_access_permissions: @app.before_request check_access_permissions
DEBUG:wqflask.views:.shutdown_session: remove db_session
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: Error: ignoring SIGPIPE signal
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: In addition:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: Warning messages:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: 1:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: In (function (package, help, pos = 2, lib.loc = NULL, character.only = FALSE, :
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: library '/home/bonface/R/x86_64-unknown-linux-gnu-library/4.0' contains no packages
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: 2:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: In (function (package, help, pos = 2, lib.loc = NULL, character.only = FALSE, :
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: library '/home/bonface/R/x86_64-unknown-linux-gnu-library/4.0' contains no packages
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: Fatal error: unable to initialize the JIT
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]:
*** caught segfault ***
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: address (nil), cause 'memory not mapped'
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]:
Possible actions:
1: abort (with core dump, if enabled)
2: normal R exit
3: exit R without saving workspace
4: exit R saving workspace
Selection:
#+end_export
This blocks the flask service. Seems to be related to: [[https://github.com/rpy2/rpy2/issues/769][rpy2-issue#769]]
and [[https://github.com/rpy2/rpy2/issues/809][rpy2-issue#809]]. I tried to reproduce this problem using some endpoint:
#+begin_src python
@app.route("/test")
def test():
from rpy2 import robjects as ro
from rpy2 import rinterface
from threading import Thread
def rpy2_init_simple():
rinterface.initr_simple()
thread = Thread(target=rpy2_init_simple)
thread.start()
return "This is a test after importing rpy2"
#+end_src
which generates this trace:
#+begin_export ascii
/home/bonface/opt/python3-genenetwork2/lib/python3.8/site-packages/rpy2/rinterface.py:955: UserWarning: R is not initialized by the main thread.
Its taking over SIGINT cannot be reversed here, and as a
consequence the embedded R cannot be interrupted with Ctrl-C.
Consider (re)setting the signal handler of your choice from
the main thread.
warnings.warn(
DEBUG:wqflask.views:.shutdown_session: remove db_session
#+end_export
Modifying the endpoint to:
#+begin_src python
@app.route("/test")
def test():
import wqflask.correlation.show_corr_results
import wqflask.ctl.ctl_analysis
import time
from wqflask.correlation.correlation_functions import cal_zero_order_corr_for_tiss
print("Sleeping for 3 seconds")
time.sleep(3)
return "This is a test after importing rpy2"
#+end_src
and refreshing the page a couple of times, I get:
#+begin_export ascii
DEBUG:wqflask.views:.check_access_permissions: @app.before_request check_access_
permissions
Sleeping for 3 seconds
DEBUG:wqflask.views:.shutdown_session: remove db_session
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: Error: ignoring SIGPI
PE signal
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: In addition:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: Warning messages:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: 1:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: In (function (package
, help, pos = 2, lib.loc = NULL, character.only = FALSE, :
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: library '/home/bonfa
ce/R/x86_64-unknown-linux-gnu-library/4.0' contains no packages
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: 2:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: In (function (package
, help, pos = 2, lib.loc = NULL, character.only = FALSE, :
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]:
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: library '/home/bonfa
ce/R/x86_64-unknown-linux-gnu-library/4.0' contains no packages
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]:
*** caught segfault ***
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]: address (nil), cause
'memory not mapped'
WARNING:rpy2.rinterface_lib.callbacks:R[write to console]:
Possible actions:
1: abort (with core dump, if enabled)
2: normal R exit
3: exit R without saving workspace
4: exit R saving workspace
Selection: [2021-06-16 13:11:00 +0300] [18657] [INFO] Handling signal: winch
[2021-06-16 13:11:00 +0300] [18657] [INFO] Handling signal: winch
[2021-06-16 13:13:02 +0300] [18657] [INFO] Handling signal: winch
#+end_export
However, this seems to be non-deterministic, in the sense that I can't really pin what causes the above. I've tried to write a Locust Test that simulates users hitting that endpoint:
#+begin_src python
"""Load test a single trait page"""
from locust import HttpUser, task, between
class LoadTest(HttpUser):
wait_time = between(1, 2.5)
@task
def fetch_trait(self):
"""Fetch a single trait"""
self.client.get("/test")
#+end_src
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