Summary of Part 2
1. Covered the basics of QTL
analysis and mapping.
2. Reviewed difference between
genetic and physical maps.
3. Discussed interpreting features
of QTL maps including the LRS function, the additive effect function,
the bootstrap bars, and the permutation thresholds.
4. Illustrated techniques to
generate a list of positional candidates.
5. Discussed some factors used to
evaluate candidate genes.
What does a QTL signify? A good QTL is a claim that a particular chromosomal region contains a causal source of variation in the phenotype. The importance of this hypothesis depends on the quality and relevance of
the phenotype and the statistical strength of the QTL. As usual, test and be skeptical.