| WebQTL Demonstration
One please link to www.webqtl.org/search.html |
| Part 1: How to discover shared expression patterns (slides 2Ð14) | |
| Part 2. Discovering upstream modulators (15Ð25) | |
| Discovering downstream targets |
| "or webqtl.org/search.html..." |
| or webqtl.org/search.html (mirror) |
| Search results |
| "First page of data:" |
| First page of data: The ÒTrait Data FormÓ |
| "Data sources:" |
| Data sources: Phenotpyes and genotypes |
| "Return to Trait Data page" |
| Return to Trait Data page |
| "Discovering shared expression patterns" |
| Discovering shared expression patterns |
| "The App transcript neighborhood" |
| The App transcript neighborhood |
| "Handdrawn sketch of the neighborhood" |
| Handdrawn sketch of the neighborhood |
| "What a network is likely..." |
| What a network is likely to look like (but App will not be center of universe). |
| Are there experimental results to corroborate a link between App with Hsp84-1? |
| "2.45 billion scatter plots" |
| 2.45 billion scatter plots: here is one of the best |
| "Cross-tissue type correlations" |
| Cross-tissue type correlations |
| "Cross-modal correlations:" |
| Cross-modal correlations: From mRNA to to anatomy and to behavior and pharmacology |
| WebQTL link to www.webqtl.org/search.html |
| Discovering shared expression patterns | |
| Discovering upstream modulators (QTLs) | |
| Discovering downstream targets |
| Slide 16 |
| Slide 17 |
| WebQTL to exploring upstream control |
| WebQTL to exploring upstream control. |
| The whole neighborhood is modulated! |
| Which gene is the QTL? |
| Slide 22 |
| Slide 23 |
| Tissue differences in probe performance |
| Is there known biology to link Hars2 with App? |
| WebQTL link to www.webqtl.org/search.html |
| Discovering shared expression patterns | |
| Discovering upstream modulators (QTLs) | |
| Discovering downstream targets |
| Requirement: The gene must be polymorphic to be genetically ÒupstreamÓ |
| Direct correlations between genotypes and traits |
| WhatÕs downstream of Chr 2 near Hars2? |
| WhatÕs downstream of Chr 2 near Hars2? |
| Does Hars2 correlate with Actn2 strongly? |
| Contact for comments and improvements: |