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+# Copyright (C) University of Tennessee Health Science Center, Memphis, TN.
+#
+# This program is free software: you can redistribute it and/or modify it
+# under the terms of the GNU Affero General Public License
+# as published by the Free Software Foundation, either version 3 of the
+# License, or (at your option) any later version.
+#
+# This program is distributed in the hope that it will be useful,
+# but WITHOUT ANY WARRANTY; without even the implied warranty of
+# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
+# See the GNU Affero General Public License for more details.
+#
+# This program is available from Source Forge: at GeneNetwork Project
+# (sourceforge.net/projects/genenetwork/).
+#
+# Contact Drs. Robert W. Williams and Xiaodong Zhou (2010)
+# at rwilliams@uthsc.edu and xzhou15@uthsc.edu
+#
+#
+#
+# This module is used by GeneNetwork project (www.genenetwork.org)
+#
+# Created by GeneNetwork Core Team 2010/08/10
+#
+# Last updated by GeneNetwork Core Team 2010/10/20
+
+import string
+import sys,os
+
+import cPickle
+
+import reaper
+from htmlgen import HTMLgen2 as HT
+
+from base import webqtlConfig
+from utility import webqtlUtil
+from dbFunction import webqtlDatabaseFunction
+from base.templatePage import templatePage
+from base.webqtlDataset import webqtlDataset
+from base.webqtlTrait import webqtlTrait
+from utility.THCell import THCell
+from utility.TDCell import TDCell
+
+#########################################
+# Probe Infomation Page
+#########################################
+
+class ShowProbeInfoPage(templatePage):
+
+ def __init__(self, fd):
+
+ templatePage.__init__(self, fd)
+
+ if not self.openMysql():
+ return
+
+ fd.readGenotype()
+ TD_LR = HT.TD(height=200,width="100%",bgColor='#eeeeee')
+ self.database = fd.formdata.getfirst('database')
+ self.ProbeSetID = fd.formdata.getfirst('ProbeSetID')
+ self.CellID = fd.formdata.getfirst('CellID')
+
+ self.db = webqtlDataset(self.database, self.cursor)
+ thisTrait = webqtlTrait(db= self.db, cursor=self.cursor, name=self.ProbeSetID) #, cellid=CellID)
+ thisTrait.retrieveInfo()
+
+ try:
+ self.cursor.execute('SELECT ProbeFreeze.Name FROM ProbeFreeze,ProbeSetFreeze WHERE ProbeFreeze.Id = ProbeSetFreeze.ProbeFreezeId and ProbeSetFreeze.Name = "%s"' % self.db.name)
+ self.probeDatabase = self.cursor.fetchall()[0][0]
+ self.probeInfoDatabase = 'Probe'
+ except:
+ heading = 'Probe Information'
+ intro = ['Trying to retrieve the probe information for ProbeSet ',HT.Span('%s' % self.ProbeSetID, Class="fwb cdg"),' in Database ',HT.Href(text='%s' % self.db.fullname,url=webqtlConfig.infopagehref % self.database)]
+ detail = ['The information you just requested is not available at this time.']
+ self.error(heading=heading,intro=intro,detail=detail)
+ return
+
+
+ form = HT.Form(cgi= os.path.join(webqtlConfig.CGIDIR, webqtlConfig.SCRIPTFILE), enctype='multipart/form-data', name='showDatabase', submit=HT.Input(type='hidden'))
+ hddn = {'FormID':'showDatabase','ProbeSetID':'_','database':'_','CellID':'_','RISet':fd.RISet, 'incparentsf1':'on'}
+ if fd.RISet == 'BXD':
+ hddn['parentsf1']='ON'
+
+ for key in hddn.keys():
+ form.append(HT.Input(name=key, value=hddn[key], type='hidden'))
+
+
+ #Buttons on search page
+ linkinfo ="%s/probeInfo.html" % webqtlConfig.PORTADDR
+ mintmap = ""
+ probeinfo = HT.Input(type='button' ,name='mintmap',value='Info', onClick="openNewWin('%s');" % linkinfo, Class="button")
+ cormatrix = HT.Href(url="#redirect", onClick="databaseFunc(document.getElementsByName('showDatabase')[0], 'corMatrix');")
+ cormatrix_img = HT.Image("/images/correlation_matrix1_final.jpg", alt="Correlation Matrix and PCA", title="Correlation Matrix and PCA", style="border:none;")
+ cormatrix.append(cormatrix_img)
+ heatmap = HT.Href(url="#redirect", onClick="databaseFunc(document.getElementsByName('showDatabase')[0], 'heatmap');")
+ heatmap_img = HT.Image("/images/heatmap2_final.jpg", name='mintmap', alt="QTL Heat Map and Clustering", title="QTL Heatmap and Clustering", style="border:none;")
+ heatmap.append(heatmap_img)
+ if self.ProbeSetID[-2:] in ('_A', '_B'):
+ thisProbeSetID = self.ProbeSetID[:-2]
+ else:
+ thisProbeSetID = self.ProbeSetID
+ thisurl = 'http://www.ensembl.org/Mus_musculus/featureview?type=AffyProbe&id=%s' % thisProbeSetID
+ verifyButton = HT.Input(type="button",value="Verify Ensembl",onClick= "openNewWin('%s')" % thisurl, Class="button")
+
+ addselect = HT.Input(type='button' ,name='addselect',value='Add to Collection', onClick="addRmvSelection('%s', this.form, 'addToSelection');" % fd.RISet,Class="button")
+ selectall = HT.Input(type='button' ,name='selectall',value='Select All', onClick="checkAll(this.form);",Class="button")
+ selectpm = HT.Input(type='button' ,name='selectall',value='Select PM', onClick="checkPM(this.form);",Class="button")
+ selectmm = HT.Input(type='button' ,name='selectall',value='Select MM', onClick="checkMM(this.form);",Class="button")
+ selectinvert = HT.Input(type='button' ,name='selectinvert',value='Select Invert', onClick="checkInvert(this.form);",Class="button")
+ reset = HT.Input(type='reset',name='',value='Select None',Class="button")
+ chrMenu = HT.Input(type='hidden',name='chromosomes',value='all')
+ probedata = HT.Input(type='hidden',name='probedata',value='all')
+
+ url_rudi_track = self.getProbeTrackURL(self.probeDatabase, self.ProbeSetID)
+ if url_rudi_track:
+ rudi_track = HT.Input(type='button', name='ruditrack', value='Probe Track', onClick="openNewWin('%s')"%url_rudi_track, Class="button")
+ else: rudi_track = None
+
+ pinfopage = "/probeInfo.html"
+
+ #updated by NL: 07-22-2011 get chosenStrains
+ _f1, _f12, _mat, _pat = webqtlUtil.ParInfo[fd.RISet]
+ chosenStrains="%s,%s"%(_mat,_pat)
+ tblobj = {}
+ tblobj['header']=[]
+
+ tblobj['header'].append([
+ THCell(HT.TD("", Class="cbrb cw fwb fs13 b1", rowspan=2,nowrap='ON'), sort=0),
+ THCell(HT.TD(HT.Href(target="_PROBEINFO", url=pinfopage+"#probe", text=HT.Span('Probe', Class="cw fwb fs13")), HT.Sup(HT.Italic('1')), Class="cbrb cw fwb fs13 b1",align='center',rowspan=2,nowrap='ON'), text="probe", idx=1),
+ THCell(HT.TD(HT.Href(text=HT.Span('Sequence', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#Sequence"),HT.Sup(HT.Italic('2')), Class="cbrb cw fwb fs13 b1", align='center',rowspan=2,nowrap='ON'), text="seq", idx=2),
+ THCell(HT.TD(HT.Href(text=HT.Span('bl2seq', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#bl2seq"),HT.Sup(HT.Italic('3')), Class="cbrb cw fwb fs13 b1", align='center',rowspan=2,nowrap='ON'), sort=0),
+ THCell(HT.TD(HT.Href(text=HT.Span('Exons', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#Exon"),HT.Sup(HT.Italic('4')), Class="cbrb cw fwb fs13 b1",align='center',rowspan=2,nowrap='ON'), sort=0),
+ THCell(HT.TD(HT.Href(text=HT.Span('Tm °C', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#Tm"),HT.Sup(HT.Italic('5')), Class="cbrb cw fwb fs13 b1",align='center',rowspan=2,nowrap='ON'), text="tm", idx=5),
+ THCell(HT.TD(HT.Href(text=HT.Span('Stacking Energy K', HT.Sub('B'),'T', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#KBT"),HT.Sup(HT.Italic('6')), Class="cbrb cw fwb fs13 b1",align='center',colspan=2,NOWRAP="yes",nowrap='ON'), sort=0),
+ THCell(HT.TD(HT.Href(text=HT.Span('Mean', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#Mean"),HT.Sup(HT.Italic('7')), Class="cbrb cw fwb fs13 b1",align='center',rowspan=2,nowrap='ON'), text="mean", idx=8),
+ THCell(HT.TD(HT.Href(text=HT.Span('Stdev', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#Stdev"),HT.Sup(HT.Italic('8')), Class="cbrb cw fwb fs13 b1",align='center',rowspan=2,nowrap='ON'), text="std", idx=9),
+ THCell(HT.TD(HT.Href(text=HT.Span('Probe h2', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#h2"),HT.Sup(HT.Italic('9')), Class="cbrb cw fwb fs13 b1",align='center',rowspan=2,NOWRAP="yes"), text="h2", idx=10),
+ THCell(HT.TD(HT.Href(text=HT.Span('Probe Location', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#location"), HT.Sup(HT.Italic('10')),Class="cbrb cw fwb fs13 b1",align='center',colspan=3)),
+ THCell(HT.TD(HT.Href(text=HT.Span('SNPs', HT.BR(), '(Across all strains)', Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#snps"), HT.Sup(HT.Italic('11')),Class="cbrb cw fwb fs13 b1",align='center',rowspan=2,NOWRAP="yes")),
+ THCell(HT.TD(HT.Href(text=HT.Span('SNPs', HT.BR(),'(Different alleles only between %s and %s)'%(_mat,_pat), Class="cw fwb fs13"), target="_PROBEINFO", url=pinfopage+"#snps"), HT.Sup(HT.Italic('11')),Class="cbrb cw fwb fs13 b1",align='center',rowspan=2,NOWRAP="yes"))
+
+ ])
+
+ tblobj['header'].append([
+ THCell(HT.TD(HT.Span('GSB', Class="cw fwb fs13"),align='center', Class="cbrb ffl fwb fs13 b1",), text="gsb", idx=6),
+ THCell(HT.TD(HT.Span('NSB', Class="cw fwb fs13"),align='center', Class="cbrb ffl fwb fs13 b1",), text="nsb", idx=7),
+ THCell(HT.TD(HT.Span('Chr', Class="cw fwb fs13"), align='center', Class="cbrb ffl2 fwb fs13 b1",)),
+ THCell(HT.TD(HT.Span('Start', Class="cw fwb fs13"),align='center', Class="cbrb ffl fwb fs13 b1",)),
+ THCell(HT.TD(HT.Span('End', Class="cw fwb fs13"),align='center', Class="cbrb ffl fwb fs13 b1",)),
+ ])
+
+ tblobj['body'] = []
+
+ blatbutton = ''
+
+ fetchField = ['Probe.Name','Probe.Sequence','Probe.ExonNo','Probe.Tm', 'Probe.E_GSB','Probe.E_NSB', 'ProbeH2.h2', 'ProbeH2.weight']
+
+ query = "SELECT %s FROM (Probe, ProbeSet, ProbeFreeze) left join ProbeH2 on ProbeH2.ProbeId = Probe.Id and ProbeH2.ProbeFreezeId = ProbeFreeze.Id WHERE ProbeSet.Name = '%s' and Probe.ProbeSetId = ProbeSet.Id and ProbeFreeze.Name = '%s' order by Probe.SerialOrder" % (string.join(fetchField,','), self.ProbeSetID, self.probeDatabase)
+ self.cursor.execute(query)
+ results = self.cursor.fetchall()
+
+ blatsequence = ""
+
+ # add by NL: get strains' name in SnpPattern database table
+ strainsInSnpPatternDBtable=self.getStrainNameIndexPair() # after snpBrowserPage.py change to MVC, this function can be removed in this class and called from other class;
+ allStrainNameList=[v[0] for v in strainsInSnpPatternDBtable]
+
+ speciesid = webqtlDatabaseFunction.retrieveSpeciesId(cursor=self.cursor,RISet=fd.RISet)
+ for result in results:
+ """
+ ProbeId, CellID,Sequence,ExonNo,Tm, E_GSB,E_NSB = map(self.nullRecord,result)
+ h2 = ''
+ query = "SELECT h2 FROM ProbeH2 WHERE ProbeFreezeId = '%s' and ProbeId=%s" % (self.probeDatabase, ProbeId)
+ self.cursor.execute(query)
+ results = self.cursor.fetchall()
+ """
+
+ CellID,Sequence,ExonNo,Tm, E_GSB,E_NSB,h2, weight = map(self.nullRecord,result)
+
+
+ Average = ''
+ STDEV = ''
+ mean = -10000.0
+ stdev = -10000.0
+ try:
+ thisTrait.cellid = CellID
+ thisTrait.retrieveData()
+
+ mean, median, var, stdev, sem, N = reaper.anova(thisTrait.exportInformative()[1])
+
+ if mean:
+ Average = '%2.2f' % mean
+ if stdev:
+ STDEV = '%2.2f' % stdev
+ except:
+ pass
+
+ if CellID == self.CellID:
+ bkColor = "cbrdull fs11 b1"
+ else:
+ bkColor = "fs11 b1"
+ seqcolor= ''
+
+ if thisTrait.blatseq:
+ blatsequence = thisTrait.blatseq
+ if int(CellID[-1]) % 2 == 1:
+ seqcolor= 'cdg'
+ else:
+ if int(CellID[-1]) % 2 == 1:
+ seqcolor= 'cdg'
+ blatsequence += string.strip(Sequence)
+
+ if thisTrait.genbankid and (int(CellID[-1]) % 2 == 1):
+ probeurl = 'http://www.ncbi.nlm.nih.gov/blast/bl2seq/wblast2.cgi?one=%s&sseq=%s' % (thisTrait.genbankid, Sequence)
+ probefy1 = HT.Input(type="button",value="Blast",onClick= "openNewWin('%s')" % probeurl, Class="buttonsmaller")
+ else:
+ probefy1 = ''
+
+ traitName = str(thisTrait)
+
+ #XZ, Aug 08, 2011: Note that probesets on some affy chips are not name as "xxx_at" (i.e., Affy Mouse Gene 1.0 ST (GPL6246)).
+ #EnsemblProbeSetID = self.ProbeSetID[0:self.ProbeSetID.index('_at')+3]
+ EnsemblProbeSetID = self.ProbeSetID
+ if '_at' in self.ProbeSetID:
+ EnsemblProbeSetID = self.ProbeSetID[0:self.ProbeSetID.index('_at')+3]
+
+ self.cursor.execute('''
+ SELECT EnsemblProbeLocation.*
+ FROM EnsemblProbeLocation, EnsemblProbe, EnsemblChip, GeneChipEnsemblXRef, ProbeFreeze
+ WHERE EnsemblProbeLocation.ProbeId=EnsemblProbe.Id and EnsemblProbe.ChipId=GeneChipEnsemblXRef.EnsemblChipId and
+ GeneChipEnsemblXRef.GeneChipId=ProbeFreeze.ChipId and EnsemblProbe.Name=%s and EnsemblProbe.ProbeSet=%s and
+ ProbeFreeze.Name=%s group by Chr, Start, End'''
+ ,(CellID, EnsemblProbeSetID, self.probeDatabase))
+ LocationFields = self.cursor.fetchall()
+
+ Chr=''
+ Start=''
+ End=''
+ if (len(LocationFields)>=1):
+ Chr,Start,End,Strand,MisMatch,ProbeId = map(self.nullRecord,LocationFields[0])
+ Start /= 1000000.0
+ End /= 1000000.0
+ if (len(LocationFields)>1):
+ self.cursor.execute('''
+ SELECT ProbeSet.Chr, ProbeSet.Mb FROM ProbeSet, ProbeFreeze
+ WHERE ProbeSet.ChipId=ProbeFreeze.ChipId and ProbeSet.Name=%s and ProbeFreeze.Name=%s'''
+ ,(self.ProbeSetID, self.probeDatabase))
+ ProbeSetChr, ProbeSetMb = map(self.nullRecord,self.cursor.fetchall()[0])
+
+ self.cursor.execute('''
+ SELECT EnsemblProbeLocation.*, ABS(EnsemblProbeLocation.Start/1000000-%s) as Mb
+ FROM EnsemblProbeLocation, EnsemblProbe, EnsemblChip, GeneChipEnsemblXRef, ProbeFreeze
+ WHERE EnsemblProbeLocation.ProbeId=EnsemblProbe.Id and EnsemblProbe.ChipId=GeneChipEnsemblXRef.EnsemblChipId and
+ GeneChipEnsemblXRef.GeneChipId=ProbeFreeze.ChipId and EnsemblProbe.Name=%s and EnsemblProbe.ProbeSet=%s and
+ EnsemblProbeLocation.Chr=%s and ProbeFreeze.Name=%s order by Mb limit 1'''
+ ,(ProbeSetMb, CellID, EnsemblProbeSetID, ProbeSetChr, self.probeDatabase))
+ NewLocationFields = self.cursor.fetchall()
+ if (len(NewLocationFields)>0):
+ Chr,Start,End,Strand,MisMatch,ProbeId,Mb = map(self.nullRecord,NewLocationFields[0])
+ Start /= 1000000.0
+ End /= 1000000.0
+
+ snp_collection = []
+ snpDiff_collection=[]
+
+ startIndex=3
+ if Chr != '' and Start != '' and End != '' and speciesid != None:
+
+ self.cursor.execute('''
+ SELECT a.SnpName, a.Id, b.* FROM SnpAll a, SnpPattern b
+ WHERE a.Chromosome=%s and a.Position>=%s and a.Position<=%s
+ and a.SpeciesId=%s and a.Id=b.SnpId'''
+ ,(Chr, Start, End, speciesid)) #chr,Start, End, 1))
+ snpresults = self.cursor.fetchall()
+
+ index1=allStrainNameList.index(_mat) #_mat index in results
+ index2=allStrainNameList.index(_pat) #_pat index in results
+
+ for v in snpresults:
+ #updated by NL: 07-22-2011 check 'limit to' to get snpBrowser snpresults
+ snp_collection.append(HT.Href(text=v[0], url=os.path.join(webqtlConfig.CGIDIR,
+ "main.py?FormID=SnpBrowserResultPage&submitStatus=1&customStrain=1")+ "&geneName=%s" % v[0], Class="fs12 fwn", target="_blank"))
+ snp_collection.append(HT.BR())
+ #updated by NL: 07-27-2011 link snp info for different allele only
+ strain1_allele=v[startIndex+index1]
+ strain2_allele=v[startIndex+index2]
+
+ if strain1_allele!=strain2_allele:
+ snpDiff_collection.append(HT.Href(text=v[0], url=os.path.join(webqtlConfig.CGIDIR,
+ "main.py?FormID=SnpBrowserResultPage&submitStatus=1&customStrain=1&diffAlleles=1&chosenStrains=%s"%chosenStrains)+ "&geneName=%s" % v[0], Class="fs12 fwn", target="_blank"))
+ snpDiff_collection.append(HT.BR())
+
+
+ tr = []
+ tr.append(TDCell(HT.TD(HT.Input(type="checkbox", Class='checkbox', name="searchResult",value=traitName, onClick="highlight(this)"), align="right", Class=bkColor, nowrap="on"), text=traitName))
+
+ tr.append(TDCell(HT.TD(HT.Href(text=CellID, url = "javascript:showDatabase2('%s','%s','%s');" % (self.database,self.ProbeSetID,CellID),Class="fs12 fwn"),Class=bkColor), traitName, traitName.upper()))
+
+ tr.append(TDCell(HT.TD(Sequence, Class=bkColor + " %s ffmono fs14" % seqcolor),Sequence,Sequence.upper()))
+ tr.append(TDCell(HT.TD(probefy1,align='center',Class=bkColor)))
+ tr.append(TDCell(HT.TD(ExonNo,align='center',Class=bkColor)))
+
+ try:
+ TmValue = float(Tm)
+ except:
+ TmValue = 0.0
+ tr.append(TDCell(HT.TD(Tm,align='center',Class=bkColor), Tm, TmValue))
+
+ try:
+ E_GSBValue = float(E_GSB)
+ except:
+ E_GSBValue = -10000.0
+ tr.append(TDCell(HT.TD(E_GSB,align='center',Class=bkColor), E_GSB, E_GSBValue))
+
+ try:
+ E_NSBValue = float(E_NSB)
+ except:
+ E_NSBValue = -10000.0
+ tr.append(TDCell(HT.TD(E_NSB,align='center',Class=bkColor), E_NSB, E_NSBValue))
+
+ tr.append(TDCell(HT.TD(Average,align='center',Class=bkColor), Average, mean))
+ tr.append(TDCell(HT.TD(STDEV,align='center',Class=bkColor), STDEV, stdev))
+
+ try:
+ h2Value = float(h2)
+ except:
+ h2Value = -10000.0
+ tr.append(TDCell(HT.TD(h2,align='center',Class=bkColor), h2, h2Value))
+
+ tr.append(TDCell(HT.TD(Chr,align='left',Class=bkColor)))
+ tr.append(TDCell(HT.TD(Start,align='left',Class=bkColor)))
+ tr.append(TDCell(HT.TD(End,align='left',Class=bkColor)))
+
+ snp_td = HT.TD(align='left',Class=bkColor)
+ for one_snp_href in snp_collection:
+ snp_td.append(one_snp_href)
+
+ tr.append(TDCell(snp_td))
+
+ #07-27-2011:add by NL: show SNP results for different allele only
+ snpDiff_td= HT.TD(align='left', valign='top', Class=bkColor)
+ for one_snpDiff_href in snpDiff_collection:
+ snpDiff_td.append(one_snpDiff_href)
+ tr.append(TDCell(snpDiff_td))
+
+ tblobj['body'].append(tr)
+
+ # import cPickle
+ filename = webqtlUtil.genRandStr("Probe_")
+ objfile = open('%s.obj' % (webqtlConfig.TMPDIR+filename), 'wb')
+ cPickle.dump(tblobj, objfile)
+ objfile.close()
+ # NL, 07/27/2010. genTableObj function has been moved from templatePage.py to webqtlUtil.py;
+ div = HT.Div(webqtlUtil.genTableObj(tblobj=tblobj, file=filename, sortby=("", ""), tableID = "sortable", addIndex = "1"), Id="sortable")
+
+ #UCSC
+ _Species = webqtlDatabaseFunction.retrieveSpecies(cursor=self.cursor, RISet=fd.RISet)
+ if _Species == "rat":
+ thisurl = webqtlConfig.UCSC_BLAT % ('rat', 'rn3', blatsequence)
+ elif _Species == "mouse":
+ thisurl = webqtlConfig.UCSC_BLAT % ('mouse', 'mm9', blatsequence)
+ else:
+ thisurl = ""
+ if thisurl:
+ blatbutton = HT.Input(type='button' ,name='blatPM',value='Verify UCSC', onClick="window.open('%s','_blank')" % thisurl,Class="button")
+ else:
+ blatbutton = ""
+
+ #GenBank
+ genbankSeq = ""
+ if thisTrait.genbankid:
+ self.cursor.execute("SELECT Sequence FROM Genbank WHERE Id = '%s'" % thisTrait.genbankid )
+ genbankSeq = self.cursor.fetchone()
+ if genbankSeq:
+ genbankSeq = genbankSeq[0]
+
+ if genbankSeq:
+ if _Species == "rat":
+ thisurl2 = webqtlConfig.UCSC_BLAT % ('rat', 'rn3', genbankSeq)
+ if _Species == "mouse":
+ thisurl2 = webqtlConfig.UCSC_BLAT % ('mouse', 'mm9', genbankSeq)
+ else:
+ thisurl2 = ''
+ if thisurl2:
+ blatbutton2 = HT.Input(type='button' ,name='blatPM',value='Verify GenBank', onClick="window.open('%s','_blank')" % thisurl2,Class="button")
+ else:
+ blatbutton2 = ""
+
+ #Snp
+ snpBrowser = ""
+ if thisTrait.symbol and _Species == 'mouse':
+ self.cursor.execute("select geneSymbol from GeneList where geneSymbol = %s", thisTrait.symbol)
+ geneName = self.cursor.fetchone()
+ if geneName:
+ snpurl = os.path.join(webqtlConfig.CGIDIR, "main.py?FormID=snpBrowser") + "&geneName=%s" % geneName[0]
+ else:
+ if thisTrait.chr and thisTrait.mb:
+ snpurl = os.path.join(webqtlConfig.CGIDIR, "main.py?FormID=snpBrowser") + \
+ "&chr=%s&start=%2.6f&end=%2.6f" % (thisTrait.chr, thisTrait.mb-0.002, thisTrait.mb+0.002)
+ else:
+ snpurl = ""
+
+ if snpurl:
+ snpBrowser = HT.Input(type="button",value="SNP Browser",onClick= \
+ "openNewWin('%s')" % snpurl, Class="button")
+
+ else:
+ snpBrowser = ""
+ #end if
+
+ heading = HT.Paragraph('Probe Information', Class="title")
+ intro = HT.Paragraph('The table below lists information of all probes of probe set ',HT.Span(self.ProbeSetID, Class="fwb fs13"),' from database ', HT.Span(self.probeDatabase, Class="fwb fs13"), ".")
+ buttons = HT.Paragraph(probedata,probeinfo,heatmap,cormatrix,blatbutton,blatbutton2,verifyButton,snpBrowser, HT.P(),selectall,selectpm,selectmm,selectinvert,reset,addselect)
+ if rudi_track:
+ buttons.append(rudi_track)
+ form.append(buttons,div,HT.P())
+
+ TD_LR.append(heading,intro,form, HT.P())
+ self.dict['basehref'] = ''
+ self.dict['body'] = str(TD_LR)
+ self.dict['title'] = self.db.shortname + ' : ' + self.ProbeSetID +' / Probe Information'
+ # updated by NL, javascript function xmlhttpPost(strURL, div, querystring) and function updatepage(Id, str)
+ # have been moved to dhtml.js
+ self.dict['js1'] = ''
+
+ def nullRecord(self,x):
+ if x or x == 0:
+ return x
+ else:
+ return ""
+
+##########################
+# UCSC Probe track by Ridi Albert
+##########################
+ def convertChipName2Rudi(self, officialName):
+ rudiName = None
+ if officialName == 'Hu6800':
+ rudiName = "ANHuGeneFL"
+ else:
+ rudiName = officialName.replace('_','')
+ rudiName = rudiName.replace('-','')
+ rudiName = "AN%s"%rudiName
+ return rudiName
+
+ def getProbeTrackURL(self, probesetfreeze_id, probeset_id):
+ try:
+ self.cursor.execute('SELECT GeneChip.Name, GeneChip.SpeciesId FROM ProbeFreeze,GeneChip WHERE ProbeFreeze.ChipId = GeneChip.Id and ProbeFreeze.Name = "%s"' % probesetfreeze_id)
+ chipname, species = self.cursor.fetchall()[0]
+ except:
+ return None
+
+ if not species:
+ return None
+
+ chipname_in_url = self.convertChipName2Rudi(chipname)
+ orgs = {1:"mouse", 2:"rat"}
+ dbs = {1:"mm8", 2:"mm6"}
+
+ try:
+ url = webqtlConfig.UCSC_RUDI_TRACK_URL%(orgs[species], dbs[species],chipname_in_url, probeset_id)
+ except:
+ url = ''
+
+ return url
+
+
+ #NL 05-13-2011: get field_names in query
+ def getStrainNameIndexPair(self):
+
+ strainNameIndexPair=[]
+ query ='SELECT * FROM SnpPattern limit 1'
+ self.cursor.execute(query)
+
+ num_fields = len(self.cursor.description)
+ field_names = [i[0] for i in self.cursor.description]
+ strainsNameList=field_names[1:]
+
+ # index for strain name starts from 1
+ for index, name in enumerate(strainsNameList):
+ index=index+1
+ strainNameIndexPair.append((name,index))
+
+ return strainNameIndexPair
+
+
+