aboutsummaryrefslogtreecommitdiff
path: root/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0024.htm
diff options
context:
space:
mode:
Diffstat (limited to 'web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0024.htm')
-rwxr-xr-xweb/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0024.htm167
1 files changed, 167 insertions, 0 deletions
diff --git a/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0024.htm b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0024.htm
new file mode 100755
index 00000000..bf2b9b3c
--- /dev/null
+++ b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0024.htm
@@ -0,0 +1,167 @@
+<html> <head> <meta name=ProgId content=PowerPoint.Slide> <meta name=Generator content="Microsoft Macintosh PowerPoint 11"> <title>PowerPoint Presentation - Complex trait analysis, develop-ment, and genomics</title> <link title="Presentation File" type="application/powerpoint" rel=alternate href="webqtl_demo2.ppt.ppt"> <script>
+if ( ! top.PPTPRESENTATION ) {
+ window.location.replace( "endshow.htm" );
+}
+</script> <meta name=Description content="Aug-15-05: Evaluating Ctbp2 as a candidate QTL for App"> <style media=print> <!--.sld {left:0px !important; width:6.0in !important; height:4.5in !important; font-size:76% !important;} --> </style> <script language=Javascript src=script.js></script>
+<script language=JavaScript>
+function font_size() {
+ var min = window.innerWidth/20;
+ if ( min > window.innerHeight/20 )
+ min = window.innerHeight/20;
+
+ return min+"pt";
+}
+var SoundEnabled = navigator.plugins && navigator.plugins["LiveAudio"];
+function restore() {
+ self.location.reload();
+}
+function set_size() {
+ document.SlideLayer.width = window.innerWidth;
+ document.SlideLayer.height = window.innerHeight;
+}
+document.captureEvents(Event.MOUSEDOWN);
+document.captureEvents(Event.KEYPRESS);
+document.onkeypress = _KPH ;
+document.onmousedown = _KPH ;
+ parent.base.highlite();
+</script><script language=JavaScript><!--
+function DoOnLoad() {
+ LoadNavSld("slide0024.htm");
+}//-->
+</script> </head> <body onresize="restore()" onload="DoOnLoad()" style='font-size:&{font_size()};' bgcolor="#000000"> <script>
+
+g_origHeight = 566;
+g_origWidth = 755;
+g_width = window.innerWidth - 10;
+g_height = window.innerHeight - 10;
+
+g_top = 0;
+g_left = 0;
+
+if ( g_width < ( g_origWidth * g_height /g_origHeight ) )
+ g_height = g_width * g_origHeight / g_origWidth;
+else
+ g_width = g_origWidth * g_height / g_origHeight;
+
+g_top = (window.innerHeight - g_height) / 2;
+g_left = (window.innerWidth - g_width) / 2;
+
+document.write( '<layer id=SlideLayer BGCOLOR=#484848 background="" top=' + g_top + ' left=' + g_left + ' height=' + g_height + ' width=' + g_width + ' >' );
+document.SlideLayer.clip.top = 0;
+document.SlideLayer.clip.left = 0;
+document.SlideLayer.clip.height = g_height;
+document.SlideLayer.clip.width = g_width;
+function new_font_size() {
+ var size = 11 * g_width / g_origWidth;
+ if ( size < 1 ) size = 1;
+ return size+"pt";
+}
+</script> <div id=SlideObj class=sld style='position:relative;font-size:&{new_font_size()};'><script>
+ mytop = 0 * g_height; myleft = 0 * g_width; myheight = 1 * g_height; mywidth = 1 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div><script language=JavaScript><!--
+ht = g_height;
+wd = g_width;
+document.write(
+'<img src="master03_background.png" height=' + ht + ' width=' + wd + '>' );
+//-->
+</script></div> </layer><script>
+ mytop = 0 * g_height; myleft = 0.01 * g_width; myheight = 0.07 * g_height; mywidth = 1.06 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div><script>
+ mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 1.05 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div style='text-align:left;font-family:"Gill Sans";font-weight:normal; font-style:normal;text-decoration:none;text-shadow:none;text-effect:none; mso-fareast-hint:no;layout-flow:horizontal;color:#E9EB5D;font-size:293%; mso-text-raise:0%;mso-line-spacing:"-358 0 -1";mso-margin-left-alt:233; mso-text-indent-alt:0;mso-line-spacing:"-358 0 -1";mso-margin-left-alt:233; mso-text-indent-alt:0'><span style='font-family:Verdana;font-size:64%'>Evaluating </span><span style='font-family:Verdana;font-size:64%'><i>Ctbp2</i></span><span style='font-family:Verdana;font-size:64%'> as a candidate QTL for </span><span style='font-family:Verdana;font-size:64%'><i>App</i></span><span style='font-family:Verdana;font-size:73%;mso-special-format:lastCR;display: none'><i><br> </i></span></div> </layer></div> </layer><script>
+ mytop = 0.94 * g_height; myleft = 0.03 * g_width; myheight = 0.04 * g_height; mywidth = 0.96 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div><script language=JavaScript><!--
+xx = 0.03 * g_width;
+yy = 0.94 * g_height;
+ht = 0.04 * g_height;
+wd = 0.96 * g_width;
+document.write(
+'<img border=0 src="slide0010_image082.png" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' );
+//-->
+</script></div> </layer><script>
+ mytop = 0.07 * g_height; myleft = 0.03 * g_width; myheight = 0.4 * g_height; mywidth = 0.48 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div><script language=JavaScript><!--
+xx = 0.03 * g_width;
+yy = 0.07 * g_height;
+ht = 0.4 * g_height;
+wd = 0.48 * g_width;
+document.write(
+'<img border=0 src="slide0010_image083.png" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' );
+//-->
+</script></div> </layer><script>
+ mytop = 0.52 * g_height; myleft = 0.55 * g_width; myheight = 0.37 * g_height; mywidth = 0.35 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div style='text-align:left;font-family:Verdana;font-weight:normal;font-style: normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint: no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%; mso-text-raise:0%'><script>
+ mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.33 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script><span style='text-align:left'><span style='font-size:233%;color:#E9EB5D'>This is</span><span style='font-size:233%;color:#E9EB5D'><i> the </i></span></span></layer><script>
+ mytop = 0.06 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.34 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script><span style='text-align:left'><span style='font-size:233%;color:#E9EB5D'><i>Ctbp2 </i></span><span style='font-size:233%;color:#E9EB5D'>cis QTL, </span></span></layer><script>
+ mytop = 0.12 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.35 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script><span style='text-align:left'><span style='font-size:233%;color:#E9EB5D'>but is detected </span></span></layer><script>
+ mytop = 0.18 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.33 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script><span style='text-align:left'><span style='font-size:233%;color:#E9EB5D'>only in the </span></span></layer><script>
+ mytop = 0.25 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.35 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script><span style='text-align:left'><span style='font-size:233%;color:#E9EB5D'>Rosen striatum </span></span></layer><script>
+ mytop = 0.31 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.33 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script><span style='text-align:left'><span style='font-size:233%;color:#E9EB5D'>data set.</span><span style='font-size:233%;color:#E9EB5D;mso-special-format:lastCR;display:none'><i><br> </i></span></span></layer></div> </layer><script>
+ mytop = 0.16 * g_height; myleft = 0.56 * g_width; myheight = 0.12 * g_height; mywidth = 0.48 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div style='text-align:left;font-family:Verdana;font-weight:normal;font-style: normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint: no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%; mso-text-raise:0%'><script>
+ mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.45 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script><span style='text-align:left'><span style='font-size:233%;color:#E9EB5D'>This is</span><span style='font-size:233%;color:#E9EB5D'><i> the App QTL </i></span></span></layer><script>
+ mytop = 0.06 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.48 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script><span style='text-align:left'><span style='font-size:233%;color:#E9EB5D'>in the INIA data set. </span><span style='font-size:233%;color:#E9EB5D;mso-special-format: lastCR;display:none'><i><br> </i></span></span></layer></div> </layer><script>
+ mytop = 0.39 * g_height; myleft = 0.03 * g_width; myheight = 0.53 * g_height; mywidth = 0.48 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div><script language=JavaScript><!--
+xx = 0.03 * g_width;
+yy = 0.39 * g_height;
+ht = 0.53 * g_height;
+wd = 0.48 * g_width;
+document.write(
+'<img border=0 src="slide0010_image084.png" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' );
+//-->
+</script></div> </layer><script>
+ mytop = 0.1 * g_height; myleft = 0.35 * g_width; myheight = 0.72 * g_height; mywidth = 0 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div><script language=JavaScript><!--
+xx = 0.35 * g_width;
+yy = 0.1 * g_height;
+ht = 0.72 * g_height;
+wd = 0 * g_width;
+document.write(
+'<img border=0 src="slide0010_image085.png" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' );
+//-->
+</script></div> </layer><script>
+ mytop = 0.1 * g_height; myleft = 0.31 * g_width; myheight = 0.72 * g_height; mywidth = 0 * g_width;
+ document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
+</script> <div><script language=JavaScript><!--
+xx = 0.31 * g_width;
+yy = 0.1 * g_height;
+ht = 0.72 * g_height;
+wd = 0 * g_width;
+document.write(
+'<img border=0 src="slide0010_image086.png" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' );
+//-->
+</script></div> </layer></div> </LAYER>
+ <layer> <div id=NotesObj style='display:none'> <table style='color:white' border=0 width="100%"> <tr> <td width=5 nowrap></td> <td width="100%"></td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>This slide illustrates one reason why Ctbp2 should be considered a high priority positional candidate gene that may modulate the expression level of App.<span style="mso-spacerun: yes">&nbsp; </span>Ctbp2 is a strong cis QTL in some brain regions (here the data are taken from the striatum).<span style="mso-spacerun: yes">&nbsp; </span>If Ctbp2 contains variants that modulate its own expression then these expression differences may produce many downstream effects. Of course, we now want to know much more about the known biology of Ctbp2. What kind of gene is it? To begin to answer that question we can use a number of resources listed in the LINKS page.</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>Notes:</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Arial size=3>1.</font><font face=Verdana size=3> The App QTL is bimodal. Perhaps there are actually two causal factors in this region--one close to 123 Mb and the other close to 127 Mb.</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>2. The precision of QTL mapping depends on several factors, including the effect size and interactions among QTLs modulating a trait, the number of genetic individuals that are studied, and the distribution of recombinations in the study population.<span style="mso-spacerun: yes">&nbsp; </span>In the case above, the QTL(s) are likely to be confined to the interval from 120 to 132 Mb. The bootstrap test (yellow bars shown in some of the previous slides) can be usual for estimating the consistency of QTL peaks.</font><br> </td> </tr> </table> </div> </layer> <script language=JavaScript><!--
+//-->
+</script><script language=JavaScript><!--
+function playList() {
+
+}
+//-->
+</script> </body> </html> \ No newline at end of file
generated by cgit v1.2.3 (git 2.44.0) at 2024-11-26 10:16:44 +0000