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mso-text-indent-alt:0'><span style='font-family:Verdana;font-size:64%'><i>Genetic
versus Physical maps for App expression</i></span><span style='font-family:
Verdana;font-size:73%;mso-special-format:lastCR;display:none'><i><br>
</i></span></div>

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style='text-align:left'><span style='font-size:117%;color:#E9EB5D'><i>The
difference between genetic and physical scale is analogous to measuring the </i></span></span></layer><script>
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   <td align=left colspan=1><font face=Verdana size=3>The map on the top has an
   X-axis scale based on frequency of recombinations events between markers (B
   to D transitions, see slide 19 for a color-coded example). These so-called
   genetic maps are scaled in centimorgan (recombinations per 100 gametes). In
   contrast, the physical map shown below the genetic map has an X-axis scale
   based on DNA length measured in nucleotides or base-pairs. Notice the large
   difference between the two maps in the size of Chr 19 (large on the genetic
   scale but small on the physical scale).</font><br>
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   <td align=left colspan=1><font face=Verdana size=3>Also notice the large
   difference in the width of the chromosome 7 QTL peak. In mice,
   recombinations occur with higher frequency toward the telomeric side (right
   side) of each chromosome. As a result, genetic maps are stretched out more
   toward the telomere relative to a physical map. The QTL on distal Chr 7 is
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   genetic map.</font><br>
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   <td align=left colspan=1><font face=Verdana size=3>The physical scale is
   becoming more useful than the genetic scale primarily because many other
   data types can be easily superimposed on a physical map. You will see more
   examples in the next several slides.</font><br>
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