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- <layer> <div id=NotesObj style='display:none'> <table style='color:white' border=0 width="100%"> <tr> <td width=5 nowrap></td> <td width="100%"></td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Helvetica size=3>Part 3.<span style="mso-spacerun: yes">&nbsp; </span>Many investigators would like to discover the set of downstream targets of a gene of interest.</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Helvetica size=3>In a genetic and functional sense, that question can only be addressed effectively if there is genetic variation in the particular gene.<span style="mso-spacerun: yes">&nbsp; </span>We know that Fos is an important transcription factor, but unless it is polymorphic between C57BL/6J and DBA/2J, then it cannot generate a genetic variance signal with which we can work. We can still study covariance of Fos and hundreds of other transcripts (an interesting exercise), but there are no genetic causes-and-effects.</font><br> </td> </tr> </table> </div> </layer> <script language=JavaScript><!--
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