1 files changed, 0 insertions, 427 deletions
diff --git a/web/tutorial/ppt/WebQTLDemo_files/slide0049.htm b/web/tutorial/ppt/WebQTLDemo_files/slide0049.htm
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--- a/web/tutorial/ppt/WebQTLDemo_files/slide0049.htm
+++ /dev/null
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-</layer></div>
-</layer><script>
-	mytop = 0.17 * g_height; myleft = 0.17 * g_width; myheight = 0.16 * g_height; mywidth = 0.04 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.08 * g_height; mywidth = 0.04 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:300%;color:#F6BF69'>B<br>
-</span></div>
-</layer><script>
-	mytop = 0.08 * g_height; myleft = 0 * g_width; myheight = 0.08 * g_height; mywidth = 0.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:300%;color:#F6BF69;mso-special-format:lastCR;
-display:none'><br>
-</span></div>
-</layer></div>
-</layer><script>
-	mytop = 0.77 * g_height; myleft = 0.05 * g_width; myheight = 0.26 * g_height; mywidth = 1.04 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div><script>
-	mytop = 0.02 * g_height; myleft = 0.01 * g_width; myheight = 0.22 * g_height; mywidth = 1.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.14 * g_height; mywidth = 1.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 1.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script><span
-style='text-align:left'><span style='font-size:233%;color:#E2EBF0'>D</span><span
-style='font-size:233%;color:#E9EB5D'> </span><span style='font-size:200%;
-color:#E9EB5D'>and </span><span style='font-size:233%;color:#F6BF69'>B</span><span
-style='font-size:233%;color:#E9EB5D'> </span><span style='font-size:200%;
-color:#E9EB5D'>may be SNP-like variants in the promoter </span></span></layer><script>
-	mytop = 0.08 * g_height; myleft = 0 * g_width; myheight = 0.05 * g_height; mywidth = 1 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script><span
-style='text-align:left'><span style='font-size:200%;color:#E9EB5D'>itself (cis
-QTL) or in </span><span style='font-size:200%;color:#EAEC5E'>upstream genes
-(trans QTLs)</span><span style='font-size:300%;color:#E9EB5D;display:none'><br>
-</span></span></layer></div>
-</layer><script>
-	mytop = 0.14 * g_height; myleft = 0 * g_width; myheight = 0.08 * g_height; mywidth = 0.89 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:300%;color:#E9EB5D;mso-special-format:lastCR;
-display:none'><br>
-</span></div>
-</layer></div>
-</layer></div>
-</layer><script>
-	mytop = 0.07 * g_height; myleft = 0.04 * g_width; myheight = 0.16 * g_height; mywidth = 0.22 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.05 * g_height; mywidth = 0.22 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:17;
-mso-text-indent-alt:17'><span style='font-size:200%;color:#E9EB5D'>UPSTREAM<br>
-</span></div>
-</layer><script>
-	mytop = 0.05 * g_height; myleft = 0 * g_width; myheight = 0.05 * g_height; mywidth = 0.22 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:17;
-mso-text-indent-alt:17'><span style='font-size:200%;color:#E9EB5D'>modulators<br>
-</span></div>
-</layer><script>
-	mytop = 0.1 * g_height; myleft = 0.01 * g_width; myheight = 0.05 * g_height; mywidth = 0.2 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:17;
-mso-text-indent-alt:17'><span style='font-size:200%;color:#E9EB5D;mso-special-format:
-lastCR;display:none'><br>
-</span></div>
-</layer></div>
-</layer><script>
-	mytop = 0.07 * g_height; myleft = 0.44 * g_width; myheight = 0.18 * g_height; mywidth = 0.17 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div><script>
-	mytop = 0 * g_height; myleft = 0.01 * g_width; myheight = 0.16 * g_height; mywidth = 0.14 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.08 * g_height; mywidth = 0.14 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:16;mso-text-indent-alt:
-16'><span style='font-size:300%;color:#E2EBF0'>High<br>
-</span></div>
-</layer><script>
-	mytop = 0.08 * g_height; myleft = 0 * g_width; myheight = 0.08 * g_height; mywidth = 0.14 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:16;mso-text-indent-alt:
-16'><span style='font-size:300%;color:#E2EBF0;mso-special-format:lastCR;
-display:none'><br>
-</span></div>
-</layer></div>
-</layer></div>
-</layer><script>
-	mytop = 0.63 * g_height; myleft = 0.08 * g_width; myheight = 0.18 * g_height; mywidth = 0.06 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div><script>
-	mytop = 0 * g_height; myleft = 0.01 * g_width; myheight = 0.16 * g_height; mywidth = 0.04 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.08 * g_height; mywidth = 0.04 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:300%;color:#E2EBF0'>D<br>
-</span></div>
-</layer><script>
-	mytop = 0.08 * g_height; myleft = 0 * g_width; myheight = 0.08 * g_height; mywidth = 0.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:300%;color:#E2EBF0;mso-special-format:lastCR;
-display:none'><br>
-</span></div>
-</layer></div>
-</layer></div>
-</layer><script>
-	mytop = 0.63 * g_height; myleft = 0.15 * g_width; myheight = 0.18 * g_height; mywidth = 0.06 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div><script>
-	mytop = 0 * g_height; myleft = 0.01 * g_width; myheight = 0.16 * g_height; mywidth = 0.04 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.08 * g_height; mywidth = 0.04 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:300%;color:#F6BF69'>B<br>
-</span></div>
-</layer><script>
-	mytop = 0.08 * g_height; myleft = 0 * g_width; myheight = 0.08 * g_height; mywidth = 0.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:300%;color:#F6BF69;mso-special-format:lastCR;
-display:none'><br>
-</span></div>
-</layer></div>
-</layer></div>
-</layer><script>
-	mytop = 0.71 * g_height; myleft = 0.07 * g_width; myheight = 0.12 * g_height; mywidth = 0.16 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div><script>
-	mytop = 0 * g_height; myleft = 0.01 * g_width; myheight = 0.1 * g_height; mywidth = 0.14 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.05 * g_height; mywidth = 0.14 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:200%;color:#E9EB5D'><i>cis QTL</i></span><span
-style='font-size:200%;color:#E9EB5D;display:none'><br>
-</span></div>
-</layer><script>
-	mytop = 0.05 * g_height; myleft = 0 * g_width; myheight = 0.05 * g_height; mywidth = 0.12 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:200%;color:#E9EB5D;mso-special-format:lastCR;
-display:none'><br>
-</span></div>
-</layer></div>
-</layer></div>
-</layer><script>
-	mytop = 0.57 * g_height; myleft = -0.01 * g_width; myheight = 0.07 * g_height; mywidth = 1.01 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div><script language=JavaScript><!--
-xx = -0.01 * g_width;
-yy = 0.57 * g_height;
-ht = 0.07 * g_height;
-wd = 1.01 * g_width;
-document.write(
-'<img border=0 src="slide0017_image079.gif" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' );
-//-->
-</script></div>
-</layer><script>
-	mytop = 0.44 * g_height; myleft = 0.47 * g_width; myheight = 0.12 * g_height; mywidth = 0.09 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.09 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:233%;color:#F6BF69'>Low<br>
-</span></div>
-</layer><script>
-	mytop = 0.06 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.07 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17'><span style='font-size:233%;color:#F6BF69;mso-special-format:lastCR;
-display:none'><br>
-</span></div>
-</layer></div>
-</layer><script>
-	mytop = 0.58 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 1.14 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div><script>
-	mytop = 0 * g_height; myleft = 0.01 * g_width; myheight = 0.04 * g_height; mywidth = 1.13 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%;mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:
-17;mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt:17'><span
-style='font-family:Gadget;font-size:167%;color:white'>&gt;&gt;&gt;&gt;PROMOTER--ATG-Exon1-Intron1-Exon2-Intron2
- etc-3'UTR &gt;&gt;&gt;&gt;&gt;</span></div>
-</layer></div>
-</layer><script>
-	mytop = 0.37 * g_height; myleft = 0.08 * g_width; myheight = 0.2 * g_height; mywidth = 0.13 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div><script language=JavaScript><!--
-xx = 0.08 * g_width;
-yy = 0.37 * g_height;
-ht = 0.2 * g_height;
-wd = 0.13 * g_width;
-document.write(
-'<img border=0 src="slide0017_image080.gif" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' );
-//-->
-</script></div>
-</layer><script>
-	mytop = 0.39 * g_height; myleft = 0.1 * g_width; myheight = 0.12 * g_height; mywidth = 0.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.05 * g_height; mywidth = 0.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:17;
-mso-text-indent-alt:17'><span style='font-family:Palatino;font-size:233%;
-color:white'><b>&#4;<br>
-</b></span></div>
-</layer><script>
-	mytop = 0.06 * g_height; myleft = 0 * g_width; myheight = 0.05 * g_height; mywidth = 0.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:17;
-mso-text-indent-alt:17'><span style='font-family:Palatino;font-size:233%;
-color:white;mso-special-format:lastCR;display:none'><b><br>
-</b></span></div>
-</layer></div>
-</layer><script>
-	mytop = 0.4 * g_height; myleft = 0.17 * g_width; myheight = 0.12 * g_height; mywidth = 0.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
-normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
-no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%;
-mso-text-raise:0%'><script>
-	mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.05 * g_height; mywidth = 0.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:17;
-mso-text-indent-alt:17'><span style='font-family:Palatino;font-size:233%;
-color:white'><b>&#4;<br>
-</b></span></div>
-</layer><script>
-	mytop = 0.06 * g_height; myleft = 0 * g_width; myheight = 0.05 * g_height; mywidth = 0.03 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div style='text-align:center;mso-line-spacing:" 0 0";mso-margin-left-alt:17;
-mso-text-indent-alt:17'><span style='font-family:Palatino;font-size:233%;
-color:white;mso-special-format:lastCR;display:none'><b><br>
-</b></span></div>
-</layer></div>
-</layer><script>
-	mytop = 0.33 * g_height; myleft = 0.08 * g_width; myheight = 0.2 * g_height; mywidth = 0.13 * g_width;
-	document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' );
-</script>
-<div><script language=JavaScript><!--
-xx = 0.08 * g_width;
-yy = 0.33 * g_height;
-ht = 0.2 * g_height;
-wd = 0.13 * g_width;
-document.write(
-'<img border=0 src="slide0017_image081.gif" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' );
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-   <td align=left colspan=1><font face=Helvetica size=3>This slide is
-   illustrates two categories of QTLs that modulate variability in transcript
-   abundance.</font><br>
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-   <td align=left colspan=1><font face=Helvetica size=3>1. cis QTLs are defined
-   as QTLs that are closely linked to the gene whose transcript is the measured
-   trait. For example, a polymorphism in the promoter that affects the binding
-   of a transcription factor. However, cis QTLs can be far upstream or
-   downstream polymorphisms in enhancers. They may also be polymorphisms in
-   neigghboring genes.</font><br>
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-   </td>
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-   <td align=left colspan=1><font face=Helvetica size=3>2. trans QTLs map far
-   enough away from the location of the gene that gives rise to the transcript
-   that is being measured so that we can be quite certain that the QTL is not
-   IN the gene itself. The most blatant type of trans-QTL would be a
-   polymorphism in a transcription factor. BUT in the majority of cases, the
-   trans QTLs can be far removed in a mechanistic sense from the actual events
-   modulating transcript abundance. That is why there are three overlappoing
-   arrows above.<span style="mso-spacerun: yes">&nbsp; </span>The way in which
-   an upstream polymorphism influences a downstream difference in mRNA
-   abundance can be very indirect. Effects can :</font><br>
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-   style="mso-spacerun: yes">&nbsp;&nbsp; </span>a.<span style="mso-spacerun:
-   yes">&nbsp; </span>cross tissue types (a polymorphic liver enzyme may affect
-   CNS gene expression)</font><br>
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-   style="mso-spacerun: yes">&nbsp;&nbsp; </span>b.<span style="mso-spacerun:
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-   during development but has permanent effects in adults),</font><br>
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-   style="mso-spacerun: yes">&nbsp;&nbsp; </span>c.<span style="mso-spacerun:
-   yes">&nbsp; </span>may be contingent on environmental factors (heat shock
-   may trigger the expression of a polymorphic factor that affects mRNA
-   abundance).</font><br>
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