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<td align=left colspan=1><font face=Helvetica size=2>Part 3.<span
style="mso-spacerun: yes"> </span>Many investigators would like to
discover the set of downstream targets of a gene of interest.</font><br>
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<td align=left colspan=1><font face=Helvetica size=2>In a genetic and
functional sense, that question can only be addressed effectively if there is
genetic variation in the particular gene.<span style="mso-spacerun:
yes"> </span>We know that Fos is an important transcription factor, but
unless it is polymorphic between C57BL/6J and DBA/2J, then it cannot generate
a genetic variance signal with which we can work. We can still study
covariance of Fos and hundreds of other transcripts (an interesting
exercise), but there are no genetic causes-and-effects.</font><br>
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