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| -rw-r--r-- | wqflask/maintenance/generate_kinship_from_bimbam.py | 59 |
1 files changed, 59 insertions, 0 deletions
diff --git a/wqflask/maintenance/generate_kinship_from_bimbam.py b/wqflask/maintenance/generate_kinship_from_bimbam.py new file mode 100644 index 00000000..f322341d --- /dev/null +++ b/wqflask/maintenance/generate_kinship_from_bimbam.py @@ -0,0 +1,59 @@ +#!/usr/bin/python + +""" +Generate relatedness matrix files for GEMMA from BIMBAM genotype/phenotype files + +This file goes through all of the BIMBAM files in the bimbam diretory +and uses GEMMA to generate their corresponding kinship/relatedness matrix file + +""" + +from __future__ import print_function, division, absolute_import +import sys +sys.path.append("..") +import os +import glob + +class GenerateKinshipMatrices(object): + def __init__(self, group_name, geno_file, pheno_file): + self.group_name = group_name + self.geno_file = geno_file + self.pheno_file = pheno_file + + def generate_kinship(self): + gemma_command = "/gnu/store/xhzgjr0jvakxv6h3blj8z496xjig69b0-profile/bin/gemma -g " + self.geno_file + " -p " + self.pheno_file + " -gk 1 -outdir /home/zas1024/genotype_files/genotype/bimbam/ -o " + self.group_name + print("command:", gemma_command) + os.system(gemma_command) + + @classmethod + def process_all(self, geno_dir, bimbam_dir): + os.chdir(geno_dir) + for input_file in glob.glob("*"): + if not input_file.endswith(('geno', '.geno.gz')): + continue + group_name = ".".join(input_file.split('.')[:-1]) + geno_input_file = os.path.join(bimbam_dir, group_name + "_geno.txt") + pheno_input_file = os.path.join(bimbam_dir, group_name + "_pheno.txt") + convertob = GenerateKinshipMatrices(group_name, geno_input_file, pheno_input_file) + try: + convertob.generate_kinship() + except EmptyConfigurations as why: + print(" No config info? Continuing...") + continue + except Exception as why: + + print(" Exception:", why) + print(traceback.print_exc()) + print(" Found in row %s at tabular column %s" % (convertob.latest_row_pos, + convertob.latest_col_pos)) + print(" Column is:", convertob.latest_col_value) + print(" Row is:", convertob.latest_row_value) + break + + +if __name__=="__main__": + Geno_Directory = """/home/zas1024/genotype_files/genotype/""" + Bimbam_Directory = """/home/zas1024/genotype_files/genotype/bimbam/""" + GenerateKinshipMatrices.process_all(Geno_Directory, Bimbam_Directory) + + #./gemma -g /home/zas1024/genotype_files/genotype/bimbam/BXD_geno.txt -p /home/zas1024/genotype_files/genotype/bimbam/BXD_pheno.txt -gk 1 -o BXD
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