Merge branch 'testing' of github.com:genenetwork/genenetwork2

25 files changed, 574 insertions, 194 deletions

diff --git a/wqflask/base/webqtlConfig.py b/wqflask/base/webqtlConfig.py
index e5f10edf..c3f1e76a 100644
--- a/wqflask/base/webqtlConfig.py
+++ b/wqflask/base/webqtlConfig.py
@@ -70,8 +70,8 @@ assert_writable_dir(TMPDIR)
 
 CACHEDIR             = mk_dir(TMPDIR+'/cache/')
 # We can no longer write into the git tree:
-GENERATED_IMAGE_DIR  = mk_dir(TMPDIR+'/generated/')
-GENERATED_TEXT_DIR   = mk_dir(TMPDIR+'/generated_text/')
+GENERATED_IMAGE_DIR  = mk_dir(TMPDIR+'generated/')
+GENERATED_TEXT_DIR   = mk_dir(TMPDIR+'generated_text/')
 
 # Make sure we have permissions to access these
 assert_writable_dir(CACHEDIR)
diff --git a/wqflask/maintenance/convert_geno_to_bimbam.py b/wqflask/maintenance/convert_geno_to_bimbam.py
new file mode 100644
index 00000000..05006d5c
--- /dev/null
+++ b/wqflask/maintenance/convert_geno_to_bimbam.py
@@ -0,0 +1,239 @@
+#!/usr/bin/python
+
+"""
+Convert .geno files to json
+
+This file goes through all of the genofiles in the genofile directory (.geno)
+and converts them to json files that are used when running the marker regression
+code
+
+"""
+
+from __future__ import print_function, division, absolute_import
+import sys
+sys.path.append("..")
+import os
+import glob
+import traceback
+import gzip
+
+#import numpy as np
+#from pyLMM import lmm
+
+import simplejson as json
+
+from pprint import pformat as pf
+
+class EmptyConfigurations(Exception): pass
+
+        
+
+class Marker(object):
+    def __init__(self):
+        self.name = None
+        self.chr = None
+        self.cM = None
+        self.Mb = None
+        self.genotypes = []
+
+class ConvertGenoFile(object):
+
+    def __init__(self, input_file, output_files):
+        
+        self.input_file = input_file
+        self.output_files = output_files
+        
+        self.mb_exists = False
+        self.cm_exists = False
+        self.markers = []
+        
+        self.latest_row_pos = None
+        self.latest_col_pos = None
+        
+        self.latest_row_value = None
+        self.latest_col_value = None
+        
+    def convert(self):
+
+        self.haplotype_notation = {
+            '@mat': "1",
+            '@pat': "0",
+            '@het': "0.5",
+            '@unk': "NA"
+            }
+        
+        self.configurations = {}
+        #self.skipped_cols = 3
+        
+        #if self.input_file.endswith(".geno.gz"):
+        #    print("self.input_file: ", self.input_file)
+        #    self.input_fh = gzip.open(self.input_file)
+        #else:
+        self.input_fh = open(self.input_file)
+        
+        with open(self.output_files[0], "w") as self.geno_fh:
+            #if self.file_type == "geno":
+            self.process_csv()
+            #elif self.file_type == "snps":
+            #    self.process_snps_file()
+
+
+    def process_csv(self):
+        for row_count, row in enumerate(self.process_rows()):
+            row_items = row.split("\t")
+
+            this_marker = Marker()
+            this_marker.name = row_items[1]
+            this_marker.chr = row_items[0]
+            if self.cm_exists and self.mb_exists:
+                this_marker.cM = row_items[2]
+                this_marker.Mb = row_items[3]
+                genotypes = row_items[4:]
+            elif self.cm_exists:
+                this_marker.cM = row_items[2]
+                genotypes = row_items[3:]
+            elif self.mb_exists:
+                this_marker.Mb = row_items[2]
+                genotypes = row_items[3:]
+            else:
+                genotypes = row_items[2:]
+            for item_count, genotype in enumerate(genotypes):
+                if genotype.upper().strip() in self.configurations:
+                    this_marker.genotypes.append(self.configurations[genotype.upper().strip()])
+                else:
+                    this_marker.genotypes.append("NA")
+                
+            #print("this_marker is:", pf(this_marker.__dict__))   
+            #if this_marker.chr == "14":
+            self.markers.append(this_marker.__dict__)
+
+        self.write_to_bimbam()    
+            
+        # with open(self.output_file, 'w') as fh:
+            # json.dump(self.markers, fh, indent="   ", sort_keys=True)
+                
+                # print('configurations:', str(configurations))
+                #self.latest_col_pos = item_count + self.skipped_cols
+                #self.latest_col_value = item
+                
+                #if item_count != 0:
+                #    self.output_fh.write(" ")
+                #self.output_fh.write(self.configurations[item.upper()])
+                    
+            #self.output_fh.write("\n")
+
+    def write_to_bimbam(self):
+        with open(self.output_files[0], "w") as geno_fh:
+            # geno_fh.write(str(len(self.sample_list)) + "\n")
+            # geno_fh.write("2\n")
+            # geno_fh.write("IND")
+            # for sample in self.sample_list:
+                # geno_fh.write(" " + sample)
+            # geno_fh.write("\n")
+            for marker in self.markers:
+                geno_fh.write(marker['name'])
+                geno_fh.write(", X, Y")
+                geno_fh.write(", " + ", ".join(marker['genotypes']))
+                geno_fh.write("\n")
+                
+        #pheno_fh = open(self.output_files[1], 'w')
+        with open(self.output_files[1], "w") as pheno_fh:
+            for sample in self.sample_list:
+                pheno_fh.write("1\n")
+        
+        with open(self.output_files[2], "w") as snp_fh:
+            for marker in self.markers:
+                if self.mb_exists:
+                    snp_fh.write(marker['name'] +", " + str(int(float(marker['Mb'])*1000000)) + ", " + marker['chr'] + "\n")
+                else:
+                    snp_fh.write(marker['name'] +", " + str(int(float(marker['cM'])*1000000)) + ", " + marker['chr'] + "\n")
+        
+            
+    def get_sample_list(self, row_contents):
+        self.sample_list = []
+        if self.mb_exists:
+            if self.cm_exists:
+                self.sample_list = row_contents[4:]
+            else:
+                self.sample_list = row_contents[3:]
+        else:
+            if self.cm_exists:
+                self.sample_list = row_contents[3:]
+            else:
+                self.sample_list = row_contents[2:]
+    
+    def process_rows(self):
+        for self.latest_row_pos, row in enumerate(self.input_fh):
+            #if self.input_file.endswith(".geno.gz"):
+            #    print("row: ", row)
+            self.latest_row_value = row
+            # Take care of headers
+            if not row.strip():
+                continue
+            if row.startswith('#'):
+                continue
+            if row.startswith('Chr'):
+                if 'Mb' in row.split():
+                    self.mb_exists = True
+                if 'cM' in row.split():
+                    self.cm_exists = True
+                self.get_sample_list(row.split())
+                continue
+            if row.startswith('@'):
+                key, _separater, value = row.partition(':')
+                key = key.strip()
+                value = value.strip()
+                if key in self.haplotype_notation:
+                    self.configurations[value] = self.haplotype_notation[key]
+                continue
+            if not len(self.configurations):
+                raise EmptyConfigurations
+            yield row
+
+    @classmethod
+    def process_all(cls, old_directory, new_directory):
+        os.chdir(old_directory)
+        for input_file in glob.glob("*"):
+            if not input_file.endswith(('geno', '.geno.gz')):
+                continue
+            group_name = ".".join(input_file.split('.')[:-1])
+            geno_output_file = os.path.join(new_directory, group_name + "_geno.txt")
+            pheno_output_file = os.path.join(new_directory, group_name + "_pheno.txt")
+            snp_output_file = os.path.join(new_directory, group_name + "_snps.txt")
+            output_files = [geno_output_file, pheno_output_file, snp_output_file]
+            print("%s -> %s" % (
+                os.path.join(old_directory, input_file), geno_output_file))
+            convertob = ConvertGenoFile(input_file, output_files)
+            try:
+                convertob.convert()
+            except EmptyConfigurations as why:
+                print("  No config info? Continuing...")
+                #excepted = True
+                continue
+            except Exception as why:
+
+                print("  Exception:", why)
+                print(traceback.print_exc())
+                print("    Found in row %s at tabular column %s" % (convertob.latest_row_pos,
+                                                                convertob.latest_col_pos))
+                print("    Column is:", convertob.latest_col_value)
+                print("    Row is:", convertob.latest_row_value)
+                break
+            
+    #def process_snps_file(cls, snps_file, new_directory):
+    #    output_file = os.path.join(new_directory, "mouse_families.json")
+    #    print("%s -> %s" % (snps_file, output_file))
+    #    convertob = ConvertGenoFile(input_file, output_file)
+
+
+if __name__=="__main__":
+    Old_Geno_Directory = """/home/zas1024/genotype_files/genotype/"""
+    New_Geno_Directory = """/home/zas1024/genotype_files/genotype/bimbam/"""
+    #Input_File = """/home/zas1024/gene/genotype_files/genotypes/BXD.geno"""
+    #Output_File = """/home/zas1024/gene/wqflask/wqflask/pylmm/data/bxd.snps"""
+    #convertob = ConvertGenoFile("/home/zas1024/gene/genotype_files/genotypes/SRxSHRSPF2.geno", "/home/zas1024/gene/genotype_files/new_genotypes/SRxSHRSPF2.json")
+    #convertob.convert()
+    ConvertGenoFile.process_all(Old_Geno_Directory, New_Geno_Directory)
+    #ConvertGenoFiles(Geno_Directory)
+    
+    #process_csv(Input_File, Output_File)
\ No newline at end of file
diff --git a/wqflask/maintenance/generate_kinship_from_bimbam.py b/wqflask/maintenance/generate_kinship_from_bimbam.py
new file mode 100644
index 00000000..f322341d
--- /dev/null
+++ b/wqflask/maintenance/generate_kinship_from_bimbam.py
@@ -0,0 +1,59 @@
+#!/usr/bin/python
+
+"""
+Generate relatedness matrix files for GEMMA from BIMBAM genotype/phenotype files
+
+This file goes through all of the BIMBAM files in the bimbam diretory
+and uses GEMMA to generate their corresponding kinship/relatedness matrix file
+
+"""
+
+from __future__ import print_function, division, absolute_import
+import sys
+sys.path.append("..")
+import os
+import glob
+
+class GenerateKinshipMatrices(object):
+    def __init__(self, group_name, geno_file, pheno_file):
+        self.group_name = group_name
+        self.geno_file = geno_file
+        self.pheno_file = pheno_file
+    
+    def generate_kinship(self):
+        gemma_command = "/gnu/store/xhzgjr0jvakxv6h3blj8z496xjig69b0-profile/bin/gemma -g " + self.geno_file + " -p " + self.pheno_file + " -gk 1 -outdir /home/zas1024/genotype_files/genotype/bimbam/ -o " + self.group_name
+        print("command:", gemma_command)
+        os.system(gemma_command)
+
+    @classmethod
+    def process_all(self, geno_dir, bimbam_dir):
+        os.chdir(geno_dir)
+        for input_file in glob.glob("*"):
+            if not input_file.endswith(('geno', '.geno.gz')):
+                continue
+            group_name = ".".join(input_file.split('.')[:-1])
+            geno_input_file = os.path.join(bimbam_dir, group_name + "_geno.txt")
+            pheno_input_file = os.path.join(bimbam_dir, group_name + "_pheno.txt")
+            convertob = GenerateKinshipMatrices(group_name, geno_input_file, pheno_input_file)
+            try:
+                convertob.generate_kinship()
+            except EmptyConfigurations as why:
+                print("  No config info? Continuing...")
+                continue
+            except Exception as why:
+
+                print("  Exception:", why)
+                print(traceback.print_exc())
+                print("    Found in row %s at tabular column %s" % (convertob.latest_row_pos,
+                                                                convertob.latest_col_pos))
+                print("    Column is:", convertob.latest_col_value)
+                print("    Row is:", convertob.latest_row_value)
+                break
+    
+    
+if __name__=="__main__":
+    Geno_Directory = """/home/zas1024/genotype_files/genotype/"""
+    Bimbam_Directory = """/home/zas1024/genotype_files/genotype/bimbam/"""
+    GenerateKinshipMatrices.process_all(Geno_Directory, Bimbam_Directory)
+    
+    #./gemma -g /home/zas1024/genotype_files/genotype/bimbam/BXD_geno.txt -p /home/zas1024/genotype_files/genotype/bimbam/BXD_pheno.txt -gk 1 -o BXD
\ No newline at end of file
diff --git a/wqflask/utility/tools.py b/wqflask/utility/tools.py
index 867bc5c8..c5685cdd 100644
--- a/wqflask/utility/tools.py
+++ b/wqflask/utility/tools.py
@@ -113,6 +113,9 @@ def pylmm_command(guess=None):
 def gemma_command(guess=None):
     return assert_bin(get_setting("GEMMA_COMMAND",guess))
 
+def gemma_wrapper_command(guess=None):
+    return assert_bin(get_setting("GEMMA_WRAPPER_COMMAND",guess))
+
 def plink_command(guess=None):
     return assert_bin(get_setting("PLINK_COMMAND",guess))
 
@@ -240,10 +243,11 @@ JS_GUIX_PATH       = get_setting('JS_GUIX_PATH')
 JS_GN_PATH         = get_setting('JS_GN_PATH')
 # assert_dir(JS_GN_PATH)
 
-PYLMM_COMMAND      = pylmm_command()
-GEMMA_COMMAND      = gemma_command()
-PLINK_COMMAND      = plink_command()
-TEMPDIR            = tempdir() # defaults to UNIX TMPDIR
+PYLMM_COMMAND         = pylmm_command()
+GEMMA_COMMAND         = gemma_command()
+GEMMA_WRAPPER_COMMAND = gemma_wrapper_command()
+PLINK_COMMAND         = plink_command()
+TEMPDIR               = tempdir() # defaults to UNIX TMPDIR
 
 # ---- Handle specific JS modules
 JS_TWITTER_POST_FETCHER_PATH = get_setting("JS_TWITTER_POST_FETCHER_PATH",js_path("Twitter-Post-Fetcher"))
diff --git a/wqflask/wqflask/marker_regression/gemma_mapping.py b/wqflask/wqflask/marker_regression/gemma_mapping.py
index 6e2cb972..31e94266 100644
--- a/wqflask/wqflask/marker_regression/gemma_mapping.py
+++ b/wqflask/wqflask/marker_regression/gemma_mapping.py
@@ -1,24 +1,75 @@
 import os, math
 
 from base import webqtlConfig
+from base.trait import GeneralTrait
+from base.data_set import create_dataset
 from utility.tools import flat_files, GEMMA_COMMAND
 
-def run_gemma(this_dataset, samples, vals):
+import utility.logger
+logger = utility.logger.getLogger(__name__ )
+
+def run_gemma(this_dataset, samples, vals, covariates, method):
     """Generates p-values for each marker using GEMMA"""
 
     print("INSIDE GEMMA_MAPPING")
 
-    gen_pheno_txt_file(this_dataset, vals)
+    gen_pheno_txt_file(this_dataset, vals, method)
+
+    if not os.path.isfile("{}{}_output.assoc.txt".format(webqtlConfig.GENERATED_IMAGE_DIR, this_dataset.group.name)):
+        open("{}{}_output.assoc.txt".format(webqtlConfig.GENERATED_IMAGE_DIR, this_dataset.group.name), "w+")
 
-    # use GEMMA_RUN in the next one, create a unique temp file
+    logger.debug("COVARIATES_GEMMA:", covariates)
 
-    gemma_command = GEMMA_COMMAND + ' -bfile %s/%s -k %s/%s.sXX.txt -lmm 1 -maf 0.1 -outdir %s -o %s_output' % (flat_files('mapping'),
-                                                                                    this_dataset.group.name,
-                                                                                    flat_files('mapping'),
-                                                                                    this_dataset.group.name,
-                                                                                    webqtlConfig.GENERATED_IMAGE_DIR,
-                                                                                    this_dataset.group.name)
-    print("gemma_command:" + gemma_command)
+    if covariates != "":
+        gen_covariates_file(this_dataset, covariates)
+        if method == "gemma":
+            #gemma_command = GEMMA_COMMAND + ' -bfile %s/%s -k %s/%s.sXX.txt -lmm 1 -maf 0.1 -c %s/%s_covariates.txt -o %s_output' % (flat_files('mapping'),
+            gemma_command = GEMMA_COMMAND + ' -bfile %s/%s -k %s/%s.cXX.txt -lmm 1 -maf 0.1 -c %s/%s_covariates.txt -outdir %s -o %s_output' % (flat_files('mapping'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('mapping'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('mapping'),
+                                                                                            this_dataset.group.name,
+                                                                                            webqtlConfig.GENERATED_IMAGE_DIR,
+                                                                                            this_dataset.group.name)
+            # use GEMMA_RUN in the next one, create a unique temp file
+        else:
+            logger.debug("FLAT FILES:", flat_files('mapping'))
+            #gemma_command = GEMMA_COMMAND + ' -g %s/%s_geno.txt -p %s/%s_pheno.txt -a %s/%s_snps.txt -k %s/%s.sXX.txt -lmm 1 -maf 0.1 -c %s/%s_covariates.txt -o %s_output' % (flat_files('genotype/bimbam'),
+            gemma_command = GEMMA_COMMAND + ' -g %s/%s_geno.txt -p %s/%s_pheno.txt -a %s/%s_snps.txt -k %s/%s.cXX.txt -lmm 1 -maf 0.1 -c %s/%s_covariates.txt -outdir %s -debug -o %s_output' % (flat_files('genotype/bimbam'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('genotype/bimbam'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('genotype/bimbam'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('genotype/bimbam'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('mapping'),
+                                                                                            this_dataset.group.name,
+                                                                                            webqtlConfig.GENERATED_IMAGE_DIR,
+                                                                                            this_dataset.group.name)
+    else:
+        if method == "gemma":
+            #gemma_command = GEMMA_COMMAND + ' -bfile %s/%s -k %s/%s.sXX.txt -lmm 1 -maf 0.1 -o %s_output' % (flat_files('mapping'),
+            gemma_command = GEMMA_COMMAND + ' -bfile %s/%s -k %s/%s.cXX.txt -lmm 1 -maf 0.1 -outdir %s -o %s_output' % (flat_files('mapping'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('mapping'),
+                                                                                            this_dataset.group.name,
+                                                                                            webqtlConfig.GENERATED_IMAGE_DIR,
+                                                                                            this_dataset.group.name)
+        else:
+            #gemma_command = GEMMA_COMMAND + ' -g %s/%s_geno.txt -p %s/%s_pheno.txt -a %s/%s_snps.txt -k %s/%s.sXX.txt -lmm 1 -maf 0.1 -o %s_output' % (flat_files('genotype/bimbam'),
+            gemma_command = GEMMA_COMMAND + ' -g %s/%s_geno.txt -p %s/%s_pheno.txt -a %s/%s_snps.txt -k %s/%s.cXX.txt -lmm 1 -maf 0.1 -outdir %s -debug -o %s_output' % (flat_files('genotype/bimbam'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('genotype/bimbam'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('genotype/bimbam'),
+                                                                                            this_dataset.group.name,
+                                                                                            flat_files('genotype/bimbam'),
+                                                                                            this_dataset.group.name,
+                                                                                            webqtlConfig.GENERATED_IMAGE_DIR,
+                                                                                            this_dataset.group.name)
+    logger.debug("gemma_command:" + gemma_command)
 
     os.system(gemma_command)
 
@@ -26,27 +77,70 @@ def run_gemma(this_dataset, samples, vals):
 
     return marker_obs
 
-def gen_pheno_txt_file(this_dataset, vals):
+def gen_pheno_txt_file(this_dataset, vals, method):
     """Generates phenotype file for GEMMA"""
 
-    current_file_data = []
-    with open("{}/{}.fam".format(flat_files('mapping'), this_dataset.group.name), "r") as outfile:
-        for i, line in enumerate(outfile):
-            split_line = line.split()
-            current_file_data.append(split_line)
-    
-    with open("{}/{}.fam".format(flat_files('mapping'), this_dataset.group.name), "w") as outfile:
-        for i, line in enumerate(current_file_data):
-            if vals[i] == "x":
-                this_val = -9
+    if method == "gemma":
+        current_file_data = []
+        with open("{}/{}.fam".format(flat_files('mapping'), this_dataset.group.name), "r") as outfile:
+            for i, line in enumerate(outfile):
+                split_line = line.split()
+                current_file_data.append(split_line)
+
+        with open("{}/{}.fam".format(flat_files('mapping'), this_dataset.group.name), "w") as outfile:
+            for i, line in enumerate(current_file_data):
+                if vals[i] == "x":
+                    this_val = -9
+                else:
+                    this_val = vals[i]
+                outfile.write("0" + " " + line[1] + " " + line[2] + " " + line[3] + " " + line[4] + " " + str(this_val) + "\n")
+    else:
+        current_file_data = []
+        with open("{}/{}_pheno.txt".format(flat_files('genotype/bimbam'), this_dataset.group.name), "w") as outfile:
+            for value in vals:
+                if value == "x":
+                    outfile.write("NA\n")
+                else:
+                    outfile.write(value + "\n")
+
+def gen_covariates_file(this_dataset, covariates):
+    covariate_list = covariates.split(",")
+    covariate_data_object = []
+    for covariate in covariate_list:
+        this_covariate_data = []
+        trait_name = covariate.split(":")[0]
+        dataset_ob = create_dataset(covariate.split(":")[1])
+        trait_ob = GeneralTrait(dataset=dataset_ob,
+                                name=trait_name,
+                                cellid=None)
+
+        #trait_samples = this_dataset.group.all_samples_ordered()
+        this_dataset.group.get_samplelist()
+        trait_samples = this_dataset.group.samplelist
+        logger.debug("SAMPLES:", trait_samples)
+        trait_sample_data = trait_ob.data
+        logger.debug("SAMPLE DATA:", trait_sample_data)
+        for index, sample in enumerate(trait_samples):
+            if sample in trait_sample_data:
+                sample_value = trait_sample_data[sample].value
+                this_covariate_data.append(sample_value)
             else:
-                this_val = vals[i]
-            outfile.write("0" + " " + line[1] + " " + line[2] + " " + line[3] + " " + line[4] + " " + str(this_val) + "\n")
+                this_covariate_data.append("-9")
+        covariate_data_object.append(this_covariate_data)
+
+    with open("{}/{}_covariates.txt".format(flat_files('mapping'), this_dataset.group.name), "w") as outfile:
+        for i in range(len(covariate_data_object[0])):
+            for this_covariate in covariate_data_object:
+                outfile.write(str(this_covariate[i]) + "\t")
+            outfile.write("\n")
 
 def parse_gemma_output(this_dataset):
     included_markers = []
     p_values = []
     marker_obs = []
+    previous_chr = 0
+
+    #with open("/home/zas1024/gene/wqflask/output/{}_output.assoc.txt".format(this_dataset.group.name)) as output_file:
     with open("{}{}_output.assoc.txt".format(webqtlConfig.GENERATED_IMAGE_DIR, this_dataset.group.name)) as output_file:
         for line in output_file:
             if line.startswith("chr"):
@@ -54,7 +148,16 @@ def parse_gemma_output(this_dataset):
             else:
                 marker = {}
                 marker['name'] = line.split("\t")[1]
-                marker['chr'] = int(line.split("\t")[0])
+                if line.split("\t")[0] != "X" and line.split("\t")[0] != "X/Y":
+                    marker['chr'] = int(line.split("\t")[0])
+                else:
+                    marker['chr'] = line.split("\t")[0]
+                # try:
+                    # marker['chr'] = int(line.split("\t")[0])
+                # except:
+                    # marker['chr'] = previous_chr + 1
+                # if marker['chr'] != previous_chr:
+                    # previous_chr = marker['chr']
                 marker['Mb'] = float(line.split("\t")[2]) / 1000000
                 marker['p_value'] = float(line.split("\t")[10])
                 if math.isnan(marker['p_value']) or (marker['p_value'] <= 0):
diff --git a/wqflask/wqflask/marker_regression/marker_regression.py b/wqflask/wqflask/marker_regression/marker_regression.py
index 60424468..55bbacac 100644
--- a/wqflask/wqflask/marker_regression/marker_regression.py
+++ b/wqflask/wqflask/marker_regression/marker_regression.py
@@ -92,6 +92,7 @@ class MarkerRegression(object):
         self.num_perm = 0
         self.perm_output = []
         self.bootstrap_results = []
+        self.covariates = start_vars['covariates']
 
         #ZS: This is passed to GN1 code for single chr mapping
         self.selected_chr = -1
@@ -153,11 +154,11 @@ class MarkerRegression(object):
             self.genofile_string = start_vars['genofile']
             self.dataset.group.genofile = self.genofile_string.split(":")[0]
         self.dataset.group.get_markers()
-        if self.mapping_method == "gemma":
+        if self.mapping_method == "gemma" or self.mapping_method == "gemma_bimbam":
             self.score_type = "-log(p)"
             self.manhattan_plot = True
             with Bench("Running GEMMA"):
-                marker_obs = gemma_mapping.run_gemma(self.dataset, self.samples, self.vals)
+                marker_obs = gemma_mapping.run_gemma(self.dataset, self.samples, self.vals, self.covariates, self.mapping_method)
             results = marker_obs
         elif self.mapping_method == "rqtl_plink":
             results = self.run_rqtl_plink()
diff --git a/wqflask/wqflask/marker_regression/marker_regression_gn1.py b/wqflask/wqflask/marker_regression/marker_regression_gn1.py
index 08332e7d..93d75a03 100644
--- a/wqflask/wqflask/marker_regression/marker_regression_gn1.py
+++ b/wqflask/wqflask/marker_regression/marker_regression_gn1.py
@@ -255,6 +255,8 @@ class MarkerRegression(object):
             self.controlLocus = start_vars['control_marker']
         else:
             self.controlLocus = ""
+        if 'covariates' in start_vars.keys():
+            self.covariates = start_vars['covariates']
 
         #try:
         self.selectedChr = int(start_vars['selected_chr'])
@@ -1369,7 +1371,10 @@ class MarkerRegression(object):
 
                 #draw gray blocks for 3' and 5' UTR blocks
                 if cdsStart and cdsEnd:
-
+                    logger.debug("txStart:", txStart)
+                    logger.debug("cdsStart:", cdsStart)
+                    logger.debug("txEnd:", txEnd)
+                    logger.debug("cdsEnd:", cdsEnd)
                     utrStartPix = (txStart-startMb)*plotXScale + xLeftOffset
                     utrEndPix = (cdsStart-startMb)*plotXScale + xLeftOffset
                     if (utrStartPix < xLeftOffset):
@@ -1380,9 +1385,10 @@ class MarkerRegression(object):
                         utrEndPix = xLeftOffset + plotWidth
                     if (utrStartPix > xLeftOffset + plotWidth):
                         utrStartPix = xLeftOffset + plotWidth
-                    canvas.drawRect(utrStartPix, geneYLocation, utrEndPix, (geneYLocation+self.EACH_GENE_HEIGHT*zoom), edgeColor=utrColor, fillColor =utrColor)
+                    #canvas.drawRect(utrStartPix, geneYLocation, utrEndPix, (geneYLocation+self.EACH_GENE_HEIGHT*zoom), edgeColor=utrColor, fillColor =utrColor)
 
-                    if self.DRAW_UTR_LABELS and self.endMb - self.startMb <= self.DRAW_UTR_LABELS_MB:
+                    #if self.DRAW_UTR_LABELS and self.endMb - self.startMb <= self.DRAW_UTR_LABELS_MB:
+                    if self.endMb - self.startMb <= self.DRAW_UTR_LABELS_MB:
                         if strand == "-":
                             labelText = "3'"
                         else:
@@ -1401,10 +1407,11 @@ class MarkerRegression(object):
                         utrEndPix = xLeftOffset + plotWidth
                     if (utrStartPix > xLeftOffset + plotWidth):
                         utrStartPix = xLeftOffset + plotWidth
-                    canvas.drawRect(utrStartPix, geneYLocation, utrEndPix, (geneYLocation+self.EACH_GENE_HEIGHT*zoom), edgeColor=utrColor, fillColor =utrColor)
+                    #canvas.drawRect(utrStartPix, geneYLocation, utrEndPix, (geneYLocation+self.EACH_GENE_HEIGHT*zoom), edgeColor=utrColor, fillColor =utrColor)
 
-                    if self.DRAW_UTR_LABELS and self.endMb - self.startMb <= self.DRAW_UTR_LABELS_MB:
-                        if tstrand == "-":
+                    #if self.DRAW_UTR_LABELS and self.endMb - self.startMb <= self.DRAW_UTR_LABELS_MB:
+                    if self.endMb - self.startMb <= self.DRAW_UTR_LABELS_MB:
+                        if strand == "-":
                             labelText = "5'"
                         else:
                             labelText = "3'"
diff --git a/wqflask/wqflask/network_graph/network_graph.py b/wqflask/wqflask/network_graph/network_graph.py
index 7eb5be61..b42904a4 100644
--- a/wqflask/wqflask/network_graph/network_graph.py
+++ b/wqflask/wqflask/network_graph/network_graph.py
@@ -182,24 +182,18 @@ class NetworkGraph(object):
                     self.edges_list.append(edge_dict)
       
             if trait_db[1].type == "ProbeSet":
-                node_dict = { 'data' : {'id' : str(this_trait.name) + ":" + str(this_trait.dataset.name),
-                                        'name' : str(this_trait.name),
-                                        'dataset' : str(this_trait.dataset.name),
+                node_dict = { 'data' : {'id' : str(this_trait.name) + ":" + str(this_trait.dataset.name), 
                                         'label' : this_trait.symbol,
                                         'symbol' : this_trait.symbol,
                                         'geneid' : this_trait.geneid,
                                         'omim' : this_trait.omim,
                                         'max_corr' : max_corr } }
             elif trait_db[1].type == "Publish":
-                node_dict = { 'data' : {'id' : str(this_trait.name) + ":" + str(this_trait.dataset.name),
-                                        'name' : str(this_trait.name),
-                                        'dataset' : str(this_trait.dataset.name),
+                node_dict = { 'data' : {'id' : str(this_trait.name) + ":" + str(this_trait.dataset.name), 
                                         'label' : this_trait.name,
                                         'max_corr' : max_corr } }
             else:
-                node_dict = { 'data' : {'id' : str(this_trait.name) + ":" + str(this_trait.dataset.name),
-                                        'name' : str(this_trait.name),
-                                        'dataset' : str(this_trait.dataset.name),
+                node_dict = { 'data' : {'id' : str(this_trait.name) + ":" + str(this_trait.dataset.name), 
                                         'label' : this_trait.name,
                                         'max_corr' : max_corr } }
             self.nodes_list.append(node_dict)
diff --git a/wqflask/wqflask/show_trait/show_trait.py b/wqflask/wqflask/show_trait/show_trait.py
index b2dfc4ac..13ad4a8f 100644
--- a/wqflask/wqflask/show_trait/show_trait.py
+++ b/wqflask/wqflask/show_trait/show_trait.py
@@ -133,9 +133,9 @@ class ShowTrait(object):
 
         self.sample_group_types = OrderedDict()
         if len(self.sample_groups) > 1:
-            self.sample_group_types['samples_primary'] = self.dataset.group.name + " Only"
-            self.sample_group_types['samples_other'] = "Non-" + self.dataset.group.name
-            self.sample_group_types['samples_all'] = "All Cases"
+            self.sample_group_types['samples_primary'] = self.dataset.group.name
+            self.sample_group_types['samples_other'] = "Other"
+            self.sample_group_types['samples_all'] = "All"
         else:
             self.sample_group_types['samples_primary'] = self.dataset.group.name
         sample_lists = [group.sample_list for group in self.sample_groups]
diff --git a/wqflask/wqflask/static/new/javascript/get_covariates_from_collection.js b/wqflask/wqflask/static/new/javascript/get_covariates_from_collection.js
index c267b045..92e2b13b 100644
--- a/wqflask/wqflask/static/new/javascript/get_covariates_from_collection.js
+++ b/wqflask/wqflask/static/new/javascript/get_covariates_from_collection.js
@@ -2,8 +2,6 @@
 var add_trait_data, assemble_into_json, back_to_collections, collection_click, collection_list, color_by_trait, create_trait_data_csv, get_this_trait_vals, get_trait_data, process_traits, selected_traits, submit_click, this_trait_data, trait_click,
   __indexOf = [].indexOf || function(item) { for (var i = 0, l = this.length; i < l; i++) { if (i in this && this[i] === item) return i; } return -1; };
 
-console.log("before get_traits_from_collection");
-
 collection_list = null;
 
 this_trait_data = null;
@@ -25,109 +23,30 @@ collection_click = function() {
 };
 
 submit_click = function() {
-  var all_vals, sample, samples, scatter_matrix, this_trait_vals, trait, trait_names, trait_vals_csv, traits, _i, _j, _len, _len1, _ref;
-  selected_traits = {};
-  traits = [];
+  var covariates_string = "";
   $('#collections_holder').find('input[type=checkbox]:checked').each(function() {
-    var this_dataset, this_trait, this_trait_url;
+    var this_dataset, this_trait;
     this_trait = $(this).parents('tr').find('.trait').text();
     console.log("this_trait is:", this_trait);
     this_dataset = $(this).parents('tr').find('.dataset').text();
     console.log("this_dataset is:", this_dataset);
-    this_trait_url = "/trait/get_sample_data?trait=" + this_trait + "&dataset=" + this_dataset;
-    return $.ajax({
-      dataType: "json",
-      url: this_trait_url,
-      async: false,
-      success: add_trait_data
-    });
+    covariates_string += this_trait + ":" + this_dataset + ","
   });
-  console.log("SELECTED_TRAITS IS:", selected_traits);
-  trait_names = [];
-  samples = $('input[name=allsamples]').val().split(" ");
-  all_vals = [];
-  this_trait_vals = get_this_trait_vals(samples);
-  all_vals.push(this_trait_vals);
-  _ref = Object.keys(selected_traits);
-  for (_i = 0, _len = _ref.length; _i < _len; _i++) {
-    trait = _ref[_i];
-    trait_names.push(trait);
-    this_trait_vals = [];
-    for (_j = 0, _len1 = samples.length; _j < _len1; _j++) {
-      sample = samples[_j];
-      if (__indexOf.call(Object.keys(selected_traits[trait]), sample) >= 0) {
-        this_trait_vals.push(parseFloat(selected_traits[trait][sample]));
-      } else {
-        this_trait_vals.push(null);
-      }
-    }
-    all_vals.push(this_trait_vals);
-  }
-  trait_vals_csv = create_trait_data_csv(selected_traits);
-  scatter_matrix = new ScatterMatrix(trait_vals_csv);
-  scatter_matrix.render();
-  return $.colorbox.close();
-};
+  // Trim the last comma
+  covariates_string = covariates_string.substring(0, covariates_string.length - 1)
+  console.log("COVARIATES:", covariates_string)
 
-create_trait_data_csv = function(selected_traits) {
-  var all_vals, index, sample, sample_vals, samples, this_trait_vals, trait, trait_names, trait_vals_csv, _i, _j, _k, _l, _len, _len1, _len2, _len3, _ref;
-  trait_names = [];
-  trait_names.push($('input[name=trait_id]').val());
-  samples = $('input[name=allsamples]').val().split(" ");
-  all_vals = [];
-  this_trait_vals = get_this_trait_vals(samples);
-  all_vals.push(this_trait_vals);
-  _ref = Object.keys(selected_traits);
-  for (_i = 0, _len = _ref.length; _i < _len; _i++) {
-    trait = _ref[_i];
-    trait_names.push(trait);
-    this_trait_vals = [];
-    for (_j = 0, _len1 = samples.length; _j < _len1; _j++) {
-      sample = samples[_j];
-      if (__indexOf.call(Object.keys(selected_traits[trait]), sample) >= 0) {
-        this_trait_vals.push(parseFloat(selected_traits[trait][sample]));
-      } else {
-        this_trait_vals.push(null);
-      }
-    }
-    all_vals.push(this_trait_vals);
-  }
-  console.log("all_vals:", all_vals);
-  trait_vals_csv = trait_names.join(",");
-  trait_vals_csv += "\n";
-  for (index = _k = 0, _len2 = samples.length; _k < _len2; index = ++_k) {
-    sample = samples[index];
-    if (all_vals[0][index] === null) {
-      continue;
-    }
-    sample_vals = [];
-    for (_l = 0, _len3 = all_vals.length; _l < _len3; _l++) {
-      trait = all_vals[_l];
-      sample_vals.push(trait[index]);
-    }
-    trait_vals_csv += sample_vals.join(",");
-    trait_vals_csv += "\n";
-  }
-  return trait_vals_csv;
+  $("input[name=covariates]").val(covariates_string)
+
+  return $.colorbox.close();
 };
 
 trait_click = function() {
   var dataset, this_trait_url, trait;
-  console.log("Clicking on:", $(this));
   trait = $(this).parent().find('.trait').text();
   dataset = $(this).parent().find('.dataset').text();
-  console.log("BEFORE COVAR:", trait + ":" + dataset)
-  $('input[name=covariates]').val(trait + ":" + dataset)
-  console.log("AFTER COVAR:", $('input[name=covariates]').val())
+  $("input[name=covariates]").val(trait + ":" + dataset)
   return $.colorbox.close();
-  // this_trait_url = "/trait/get_sample_data?trait=" + trait + "&dataset=" + dataset;
-  // console.log("this_trait_url", this_trait_url);
-  // $.ajax({
-    // dataType: "json",
-    // url: this_trait_url,
-    // success: get_trait_data
-  // });
-  // return $.colorbox.close();
 };
 
 add_trait_data = function(trait_data, textStatus, jqXHR) {
@@ -140,9 +59,7 @@ add_trait_data = function(trait_data, textStatus, jqXHR) {
 
 get_trait_data = function(trait_data, textStatus, jqXHR) {
   var sample, samples, this_trait_vals, trait_sample_data, vals, _i, _len;
-  console.log("trait:", trait_data[0]);
   trait_sample_data = trait_data[1];
-  console.log("trait_sample_data:", trait_sample_data);
   samples = $('input[name=allsamples]').val().split(" ");
   vals = [];
   for (_i = 0, _len = samples.length; _i < _len; _i++) {
@@ -158,7 +75,6 @@ get_trait_data = function(trait_data, textStatus, jqXHR) {
   }
   $('#hidden_inputs').append('<input type="hidden" name="vals" value="[' + vals.toString() + ']" />');
   this_trait_vals = get_this_trait_vals(samples);
-  console.log("THE LENGTH IS:", $('input[name=vals]').length);
   return color_by_trait(trait_sample_data);
 };
 
@@ -174,7 +90,6 @@ get_this_trait_vals = function(samples) {
       this_trait_vals.push(null);
     }
   }
-  console.log("this_trait_vals:", this_trait_vals);
   this_vals_json = '[' + this_trait_vals.toString() + ']';
   return this_trait_vals;
 };
@@ -231,7 +146,6 @@ back_to_collections = function() {
   return $('#collections_holder').colorbox.resize();
 };
 
-console.log("inside get_traits_from_collection");
 $(".collection_line").on("click", collection_click);
 $("#submit").on("click", submit_click);
 $(".trait").on("click", trait_click);
diff --git a/wqflask/wqflask/static/new/javascript/lodheatmap.js b/wqflask/wqflask/static/new/javascript/lodheatmap.js
index f604cd10..965a1d53 100644
--- a/wqflask/wqflask/static/new/javascript/lodheatmap.js
+++ b/wqflask/wqflask/static/new/javascript/lodheatmap.js
@@ -20,7 +20,7 @@ lodheatmap = function() {
   chrGap = 8;
   titlepos = 20;
   rectcolor = d3.rgb(230, 230, 230);
-  colors = ["blue", "white", "crimson"];
+  colors = ["slateblue", "white", "red"];
   title = "";
   xlab = "Chromosome";
   ylab = "";
diff --git a/wqflask/wqflask/static/new/javascript/network_graph.js b/wqflask/wqflask/static/new/javascript/network_graph.js
index 03ef1c98..0129bcae 100644
--- a/wqflask/wqflask/static/new/javascript/network_graph.js
+++ b/wqflask/wqflask/static/new/javascript/network_graph.js
@@ -6,7 +6,7 @@ window.onload=function() {
       container: $('#cytoscapeweb'), // container to render in
 
       elements: elements_list,
-
+      
       style: [ // the stylesheet for the graph
           {    
             selector: 'node',
@@ -82,7 +82,7 @@ window.onload=function() {
         cy.nodes().qtip({
                             content: function(){
                                 qtip_content = ''
-                                gn_link = '<b>'+'<a href="http://gn2.genenetwork.org/show_trait?trait_id=' + this.data().name + '&dataset=' + this.data().dataset + '" >'+this.data().id +'</a>'+'</b><br>'
+                                gn_link = '<b>'+'<a href="http://gn2.genenetwork.org/show_trait?trait_id=' + this.data().id + '&dataset=' + this.data().dataset + '" >'+this.data().id +'</a>'+'</b><br>'
                                 qtip_content += gn_link
                                 if (typeof(this.data().geneid) !== 'undefined'){
                                     ncbi_link = '<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=' + this.data().geneid + '" >NCBI<a>'+'<br>'
diff --git a/wqflask/wqflask/static/new/javascript/show_trait.js b/wqflask/wqflask/static/new/javascript/show_trait.js
index f232c6eb..f08965e9 100644
--- a/wqflask/wqflask/static/new/javascript/show_trait.js
+++ b/wqflask/wqflask/static/new/javascript/show_trait.js
@@ -74,11 +74,14 @@
         return open_trait_selection();
       };
     })(this));
-    d3.select("#select_covariate").on("click", (function(_this) {
+    d3.select("#select_covariates").on("click", (function(_this) {
       return function() {
         return open_covariate_selection();
       };
     })(this));
+    $("#remove_covariates").click(function () {
+        $("input[name=covariates]").val("") 
+    });
     d3.select("#clear_compare_trait").on("click", (function(_this) {
       return function() {
         return $('.scatter-matrix-container').remove();
@@ -101,15 +104,15 @@
       })(this));
     };
     open_covariate_selection = function() {
-      return $('#collections_holder').load('/collections/list?select_covariates #collections_list', (function(_this) {
+      return $('#collections_holder').load('/collections/list #collections_list', (function(_this) {
         return function() {
           $.colorbox({
             inline: true,
             href: "#collections_holder",
             onComplete: function(){
-                console.log("before get script")
+                console.log("before get cov script")
                 $.getScript("/static/new/javascript/get_covariates_from_collection.js");
-                console.log("after get script")
+                console.log("after get cov script")
             }
           });
           return $('a.collection_name').attr('onClick', 'return false');
@@ -199,16 +202,16 @@
     };
     make_table = function() {
       var header, key, row, row_line, table, the_id, the_rows, value, _i, _len, _ref, _ref1;
-      header = "<thead><tr><th style=\"padding-left: 5px;\">Statistic</th>";
+      header = "<thead><tr><th style=\"text-align: right; padding-left: 5px;\">Statistic</th>";
       _ref = js_data.sample_group_types;
       for (key in _ref) {
         if (!__hasProp.call(_ref, key)) continue;
         value = _ref[key];
         the_id = process_id("column", key);
         if (Object.keys(_ref).length > 1) {
-            header += "<th id=\"" + the_id + "\" style=\"padding-left: 5px;\">" + value + "</th>";
+            header += "<th id=\"" + the_id + "\" style=\"text-align: right; padding-left: 5px;\">" + value + "</th>";
         } else {
-            header += "<th id=\"" + the_id + "\" style=\"padding-left: 5px;\">Value</th>";
+            header += "<th id=\"" + the_id + "\" style=\"text-align: right; padding-left: 5px;\">Value</th>";
         }
       }
 
@@ -221,16 +224,16 @@
         }
         row_line = "<tr>";
         if (row.url != null) {
-          row_line += "<td id=\"" + row.vn + "\"><a href=\"" + row.url + "\" style=\"color: #000000;\">" + row.pretty + "</a></td>";
+          row_line += "<td id=\"" + row.vn + "\" align=\"right\"><a href=\"" + row.url + "\" style=\"color: #000000;\">" + row.pretty + "</a></td>";
         } else {
-          row_line += "<td id=\"" + row.vn + "\">" + row.pretty + "</td>";
+          row_line += "<td id=\"" + row.vn + "\" align=\"right\">" + row.pretty + "</td>";
         }
         _ref1 = js_data.sample_group_types;
         for (key in _ref1) {
           if (!__hasProp.call(_ref1, key)) continue;
           value = _ref1[key];
           the_id = process_id(key, row.vn);
-          row_line += "<td id=\"" + the_id + "\">foo</td>";
+          row_line += "<td id=\"" + the_id + "\" align=\"right\">foo</td>";
         }
         row_line += "</tr>";
         the_rows += row_line;
diff --git a/wqflask/wqflask/static/new/javascript/show_trait_mapping_tools.js b/wqflask/wqflask/static/new/javascript/show_trait_mapping_tools.js
index d6cd8134..e11aaf4a 100644
--- a/wqflask/wqflask/static/new/javascript/show_trait_mapping_tools.js
+++ b/wqflask/wqflask/static/new/javascript/show_trait_mapping_tools.js
@@ -237,6 +237,21 @@
     };
   })(this));
 
+  $("#gemma_bimbam_compute").on("click", (function(_this) {
+    return function() {
+      var form_data, url;
+      console.log("RUNNING GEMMA");
+      //$("#static_progress_bar_container").modal();
+      url = "/loading";
+      $('input[name=method]').val("gemma_bimbam");
+      $('input[name=maf]').val($('input[name=maf_gemma]').val());
+      form_data = $('#trait_data_form').serialize();
+      console.log("form_data is:", form_data);
+      return submit_special(url);
+      //return do_ajax_post(url, form_data);
+    };
+  })(this));
+
   $("#interval_mapping_compute").on("click", (function(_this) {
     return function() {
       var form_data, url;
diff --git a/wqflask/wqflask/static/new/packages/DataTables/css/jquery.dataTables.css b/wqflask/wqflask/static/new/packages/DataTables/css/jquery.dataTables.css
index a5b9f09c..f376d15e 100644
--- a/wqflask/wqflask/static/new/packages/DataTables/css/jquery.dataTables.css
+++ b/wqflask/wqflask/static/new/packages/DataTables/css/jquery.dataTables.css
@@ -80,7 +80,7 @@ table.dataTable tbody tr {
   background-color: #ffffff;
 }
 table.dataTable tbody tr.selected {
-  background-color: #abb9d3;
+  background-color: #ffee99;
 }
 table.dataTable tbody th,
 table.dataTable tbody td {
@@ -111,13 +111,13 @@ table.dataTable.stripe tbody tr.odd, table.dataTable.display tbody tr.odd {
   background-color: #f9f9f9;
 }
 table.dataTable.stripe tbody tr.odd.selected, table.dataTable.display tbody tr.odd.selected {
-  background-color: #abb9d3;
+  background-color: #FFEE99;
 }
 table.dataTable.hover tbody tr:hover, table.dataTable.display tbody tr:hover {
   background-color: whitesmoke;
 }
 table.dataTable.hover tbody tr:hover.selected, table.dataTable.display tbody tr:hover.selected {
-  background-color: #a9b7d1;
+  background-color: #FFEE99;
 }
 table.dataTable.order-column tbody tr > .sorting_1,
 table.dataTable.order-column tbody tr > .sorting_2,
@@ -143,7 +143,7 @@ table.dataTable.display tbody tr.odd > .sorting_3, table.dataTable.order-column.
   background-color: whitesmoke;
 }
 table.dataTable.display tbody tr.odd.selected > .sorting_1, table.dataTable.order-column.stripe tbody tr.odd.selected > .sorting_1 {
-  background-color: #a6b3cd;
+  background-color: #ffe047;
 }
 table.dataTable.display tbody tr.odd.selected > .sorting_2, table.dataTable.order-column.stripe tbody tr.odd.selected > .sorting_2 {
   background-color: #a7b5ce;
@@ -161,7 +161,7 @@ table.dataTable.display tbody tr.even > .sorting_3, table.dataTable.order-column
   background-color: #fdfdfd;
 }
 table.dataTable.display tbody tr.even.selected > .sorting_1, table.dataTable.order-column.stripe tbody tr.even.selected > .sorting_1 {
-  background-color: #acbad4;
+  background-color: #ffe047;
 }
 table.dataTable.display tbody tr.even.selected > .sorting_2, table.dataTable.order-column.stripe tbody tr.even.selected > .sorting_2 {
   background-color: #adbbd6;
@@ -179,7 +179,7 @@ table.dataTable.display tbody tr:hover > .sorting_3, table.dataTable.order-colum
   background-color: #eeeeee;
 }
 table.dataTable.display tbody tr:hover.selected > .sorting_1, table.dataTable.order-column.hover tbody tr:hover.selected > .sorting_1 {
-  background-color: #a1aec7;
+  background-color: #ffe047;
 }
 table.dataTable.display tbody tr:hover.selected > .sorting_2, table.dataTable.order-column.hover tbody tr:hover.selected > .sorting_2 {
   background-color: #a2afc8;
diff --git a/wqflask/wqflask/static/packages/bootstrap/css/bootstrap.css b/wqflask/wqflask/static/packages/bootstrap/css/bootstrap.css
index 91aaa98f..e6abe790 100644
--- a/wqflask/wqflask/static/packages/bootstrap/css/bootstrap.css
+++ b/wqflask/wqflask/static/packages/bootstrap/css/bootstrap.css
@@ -3803,7 +3803,7 @@ select[multiple].input-group-sm > .input-group-btn > .btn {
 .nav-pills > li.active > a:hover,
 .nav-pills > li.active > a:focus {
   color: #fff;
-  background-color: #428bca;
+  background-color: #3071a9; /* Tab cell background color */
 }
 .nav-stacked > li {
   float: none;
@@ -4485,7 +4485,7 @@ fieldset[disabled] .navbar-inverse .btn-link:focus {
   z-index: 2;
   color: #fff;
   cursor: default;
-  background-color: #428bca;
+  background-color: #3071a9;
   border-color: #428bca;
 }
 .pagination > .disabled > span,
@@ -4667,7 +4667,7 @@ a.badge:focus {
 }
 a.list-group-item.active > .badge,
 .nav-pills > .active > a > .badge {
-  color: #428bca;
+  color: #3071a9;
   background-color: #fff;
 }
 .nav-pills > li > a > .badge {
diff --git a/wqflask/wqflask/static/packages/bootstrap/css/non-responsive.css b/wqflask/wqflask/static/packages/bootstrap/css/non-responsive.css
index 9da73a8f..d352390f 100644
--- a/wqflask/wqflask/static/packages/bootstrap/css/non-responsive.css
+++ b/wqflask/wqflask/static/packages/bootstrap/css/non-responsive.css
@@ -97,7 +97,7 @@ body {
 .navbar .navbar-nav .open .dropdown-menu > .active > a:hover,
 .navbar .navbar-nav .open .dropdown-menu > .active > a:focus {
   color: #fff !important;
-  background-color: #428bca !important;
+  background-color: #3071a9 !important;
 }
 .navbar .navbar-nav .open .dropdown-menu > .disabled > a,
 .navbar .navbar-nav .open .dropdown-menu > .disabled > a:hover,
diff --git a/wqflask/wqflask/templates/collections/list.html b/wqflask/wqflask/templates/collections/list.html
index cc60ecff..ad72052e 100644
--- a/wqflask/wqflask/templates/collections/list.html
+++ b/wqflask/wqflask/templates/collections/list.html
@@ -65,11 +65,6 @@
             {% endfor %}
             </tbody>
         </table>
-        {% if "color_by_trait" in params %}
-        <script language="javascript" type="text/javascript" src="/static/new/javascript/get_traits_from_collection.js"></script>
-        {% else %}
-        <script language="javascript" type="text/javascript" src="/static/new/javascript/get_covariates_from_collection.js"></script>
-        {% endif %}
         </div>
     </div>
 
diff --git a/wqflask/wqflask/templates/gsearch_gene.html b/wqflask/wqflask/templates/gsearch_gene.html
index c2f687fd..6f2ad0b8 100644
--- a/wqflask/wqflask/templates/gsearch_gene.html
+++ b/wqflask/wqflask/templates/gsearch_gene.html
@@ -27,8 +27,8 @@
               <button class="btn btn-default" id="export_traits">Download CSV</button>
             </form>
             <br />
-            <div style="width: 2000px;">
-              <table width="2000px" id="trait_table" class="display dataTable nowrap" style="float: left;">
+            <div style="width: 100%;">
+              <table width="100%" id="trait_table" class="display dataTable nowrap" style="float: left;">
                 <thead>
                   <tr>
                     <th></th>
diff --git a/wqflask/wqflask/templates/marker_regression_gn1.html b/wqflask/wqflask/templates/marker_regression_gn1.html
index 5afd134a..c6c6bc23 100644
--- a/wqflask/wqflask/templates/marker_regression_gn1.html
+++ b/wqflask/wqflask/templates/marker_regression_gn1.html
@@ -27,6 +27,7 @@
         <input type="hidden" name="num_bootstrap" value="{{ nboot }}">
         <input type="hidden" name="do_control" value="{{ doControl }}">
         <input type="hidden" name="control_marker" value="{{ controlLocus }}">
+        <input type="hidden" name="covariates" values="{{ covariates }}">
         <input type="hidden" name="mapmethod_rqtl_geno" value="{{ mapmethod_rqtl_geno }}">
         <input type="hidden" name="mapmodel_rqtl_geno" value="{{ mapmodel_rqtl_geno }}">
         <input type="hidden" name="pair_scan" value="{{ pair_scan }}">
diff --git a/wqflask/wqflask/templates/search_result_page.html b/wqflask/wqflask/templates/search_result_page.html
index 93e24cc7..9ad8a53e 100644
--- a/wqflask/wqflask/templates/search_result_page.html
+++ b/wqflask/wqflask/templates/search_result_page.html
@@ -234,6 +234,7 @@
                 "autoWidth": false,
                 "deferRender": true,
                 "bSortClasses": false,
+                "scrollX": true,
                 "scrollY": "600px",
                 "scrollCollapse": false,
                 "scroller": true,
@@ -306,6 +307,7 @@
                 "autoWidth": false,
                 "deferRender": true,
                 "bSortClasses": false,
+                "scrollY": "600px",
                 "scrollCollapse": false,
                 "scroller": false,
                 "paging": false,
diff --git a/wqflask/wqflask/templates/show_trait.html b/wqflask/wqflask/templates/show_trait.html
index 7c4dbc60..c2724fea 100644
--- a/wqflask/wqflask/templates/show_trait.html
+++ b/wqflask/wqflask/templates/show_trait.html
@@ -142,6 +142,7 @@
     <script type="text/javascript" src="/static/new/javascript/scatter-matrix.js"></script>
     <script type="text/javascript" src="/static/new/javascript/draw_probability_plot.js"></script>  
     <script type="text/javascript" src="/static/new/javascript/compare_traits_scatterplot.js"></script>
+    <script language="javascript" type="text/javascript" src="/static/new/javascript/get_covariates_from_collection.js"></script>
 
     <script type="text/javascript" src="/static/new/javascript/show_trait_mapping_tools.js"></script>
     <script type="text/javascript" src="/static/new/javascript/show_trait.js"></script>
diff --git a/wqflask/wqflask/templates/show_trait_calculate_correlations.html b/wqflask/wqflask/templates/show_trait_calculate_correlations.html
index 0e15ce9c..c5f815ce 100644
--- a/wqflask/wqflask/templates/show_trait_calculate_correlations.html
+++ b/wqflask/wqflask/templates/show_trait_calculate_correlations.html
@@ -105,7 +105,7 @@
         <div class="form-group">
             <label for="corr_sample_method" class="col-xs-1 control-label"></label>
             <div class="col-xs-4 controls">
-                <button class="btn corr_compute submit_special btn-primary" data-url="/corr_compute" title="Compute Correlation">
+                <button class="btn corr_compute submit_special btn-success" data-url="/corr_compute" title="Compute Correlation">
                     <i class="icon-ok-circle icon-white"></i> Compute
                 </button>
             </div>
diff --git a/wqflask/wqflask/templates/show_trait_mapping_tools.html b/wqflask/wqflask/templates/show_trait_mapping_tools.html
index bded60d2..c24a5853 100644
--- a/wqflask/wqflask/templates/show_trait_mapping_tools.html
+++ b/wqflask/wqflask/templates/show_trait_mapping_tools.html
@@ -4,7 +4,6 @@
         <div class="tabbable"> <!-- Only required for left/right tabs -->
 
             <ul class="nav nav-pills">
-                {# if use_pylmm_rqtl and not use_plink_gemma and dataset.group.species != "human" #}
                 {% if dataset.group.mapping_id == "1" %}
                 <li class="active">
                     <a href="#interval_mapping" data-toggle="tab">Interval Mapping</a>
@@ -15,12 +14,14 @@
                 <li>
                     <a href="#rqtl_geno" data-toggle="tab">R/qtl</a>
                 </li>
+                <li>
+                    <a href="#gemma" data-toggle="tab">GEMMA</a>
+                </li>
                 {% endif %}
-                {# if use_plink_gemma #}
                 {% for mapping_method in dataset.group.mapping_names %}
                 {% if mapping_method == "GEMMA" %}
                 <li class="active">
-                    <a href="#gemma" data-toggle="tab">GEMMA</a>
+                    <a href="#gemma_plink" data-toggle="tab">GEMMA</a>
                 </li>
                 {% elif mapping_method == "PLINK" %}
                 <li>
@@ -122,7 +123,7 @@
                         </div>
                         <div class="form-group">
                             <div style="padding-left:15px;" class="controls">
-                                <button id="interval_mapping_compute" class="btn submit_special btn-primary" data-url="/marker_regression" title="Compute Interval Mapping">
+                                <button id="interval_mapping_compute" class="btn submit_special btn-success" data-url="/marker_regression" title="Compute Interval Mapping">
                                     <i class="icon-ok-circle icon-white"></i> Compute
                                 </button>
                             </div>
@@ -179,7 +180,7 @@
 -->
                         <div class="form-group">
                             <div style="padding-left:15px;" class="controls">
-                                <button id="pylmm_compute" class="btn submit_special btn-primary" title="Compute Marker Regression">
+                                <button id="pylmm_compute" class="btn submit_special btn-success" title="Compute Marker Regression">
                                     <i class="icon-ok-circle icon-white"></i> Compute
                                 </button>
                             </div>
@@ -286,36 +287,75 @@
 
                         <div class="form-group">
                             <div style="padding-left:15px;" class="controls">
-                                <button id="rqtl_geno_compute" class="btn submit_special btn-primary" data-url="/marker_regression" title="Compute Marker Regression">
+                                <button id="rqtl_geno_compute" class="btn submit_special btn-success" data-url="/marker_regression" title="Compute Marker Regression">
                                     <i class="icon-ok-circle icon-white"></i> Compute
                                 </button>
                             </div>
                         </div>
                     </div>
                 </div>
+                <div class="tab-pane" id="gemma">
+                    <div style="padding-top: 10px;" class="form-horizontal">
+                        <div class="mapping_method_fields form-group">
+                            <label for="maf_gemma" class="col-xs-5 control-label">Minor allele threshold</label>
+                            <div style="margin-left: 20px;" class="col-xs-3 controls">
+                                <input name="maf_gemma" value="0.01" type="text" class="form-control">
+                            </div>
+                        </div>
+                    </div>
+
+                    <div style="padding-top: 5px; padding-bottom: 5px; padding-left: 20px;" class="form-horizontal">
+                        <div class="mapping_method_fields form-group">
+                            <button type="button" id="select_covariates" class="btn btn-default">
+                                Select Covariates
+                            </button>
+                            <button type="button" id="remove_covariates" class="btn btn-default">
+                                Remove Covariates
+                            </button>
+                        </div>
+                    </div>
+
+                    <div class="form-group">
+                        <div class="col-xs-4 controls">
+                            <button id="gemma_bimbam_compute" class="btn submit_special btn-success" data-url="/marker_regression" title="Compute Marker Regression">
+                                Compute
+                            </button>
+                        </div>
+                    </div>
+                </div>
                 {% endif %}
-                {# if use_plink_gemma #}
-                {% if dataset.group.mapping_id == "2" or dataset.group.mapping_id == "4" %}
-                <div class="tab-pane active" id="gemma">
-                    <div style="padding: 20px" class="form-horizontal">
+                {% for mapping_method in dataset.group.mapping_names %}
+                {% if mapping_method == "GEMMA" %}
+                <div class="tab-pane active" id="gemma_plink">
+                    <div style="padding-top: 10px;" class="form-horizontal">
                         <div class="mapping_method_fields form-group">
-                            <label for="maf_gemma" class="col-xs-3 control-label">Minor allele threshold</label>
+                            <label for="maf_gemma" class="col-xs-5 control-label">Minor allele threshold</label>
                             <div style="margin-left: 20px;" class="col-xs-3 controls">
                                 <input name="maf_gemma" value="0.01" type="text" class="form-control">
                             </div>
                         </div>
                     </div>
 
+                    <div style="padding-top: 5px; padding-bottom: 5px; padding-left: 20px;" class="form-horizontal">
+                        <div class="mapping_method_fields form-group">
+                            <button type="button" id="select_covariates" class="btn btn-default">
+                                Select Covariates
+                            </button>
+                            <button type="button" id="remove_covariates" class="btn btn-default">
+                                Remove Covariates
+                            </button>
+                        </div>
+                    </div>
+
                     <div class="form-group">
-                        <label for="gemma_compute" class="col-xs-1 control-label"></label>
-                        <div style="margin-left:20px;" class="col-xs-4 controls">
-                            <button id="gemma_compute" class="btn submit_special btn-primary" data-url="/marker_regression" title="Compute Marker Regression">
+                        <div class="col-xs-4 controls">
+                            <button id="gemma_compute" class="btn submit_special btn-success" data-url="/marker_regression" title="Compute Marker Regression">
                                 Compute
                             </button>
                         </div>
                     </div>
                 </div>
-                {% if dataset.group.mapping_id == "4" %}
+                {% elif mapping_method == "PLINK" %}
                 <div class="tab-pane" id="plink">
                     <div style="padding: 20px" class="form-horizontal">
                         <div class="mapping_method_fields form-group">
@@ -329,14 +369,14 @@
                     <div class="form-group">
                         <label for="plink_compute" class="col-xs-1 control-label"></label>
                         <div style="margin-left:20px;" class="col-xs-4 controls">
-                            <button id="plink_compute" class="btn submit_special btn-primary" data-url="/marker_regression" title="Compute Marker Regression">
+                            <button id="plink_compute" class="btn submit_special btn-success" data-url="/marker_regression" title="Compute Marker Regression">
                                 Compute
                             </button>
                         </div>
                     </div>
                 </div>
                 {% endif %}
-                {% endif %}
+                {% endfor %}
             </div>
         </div>
     </div>
diff --git a/wqflask/wqflask/views.py b/wqflask/wqflask/views.py
index 83496000..2d4fd0f2 100644
--- a/wqflask/wqflask/views.py
+++ b/wqflask/wqflask/views.py
@@ -514,6 +514,7 @@ def loading_page():
         'bootCheck',
         'bootstrap_results',
         'LRSCheck',
+        'covariates',
         'maf',
         'manhattan_plot',
         'control_marker',
@@ -569,6 +570,7 @@ def marker_regression_page():
         'bootCheck',
         'bootstrap_results',
         'LRSCheck',
+        'covariates',
         'maf',
         'manhattan_plot',
         'control_marker',