Merge pull request #1 from genenetwork/testing

Updating my testing branch

1 files changed, 181 insertions, 0 deletions

diff --git a/wqflask/utility/gen_geno_ob.py b/wqflask/utility/gen_geno_ob.py
new file mode 100644
index 00000000..23b0b650
--- /dev/null
+++ b/wqflask/utility/gen_geno_ob.py
@@ -0,0 +1,181 @@
+from __future__ import absolute_import, division, print_function
+
+import utility.logger
+logger = utility.logger.getLogger(__name__ )
+
+class genotype(object):
+    """
+    Replacement for reaper.Dataset so we can remove qtlreaper use while still generating mapping output figure
+    """
+
+    def __init__(self, filename):
+        self.group = None
+        self.type = "riset"
+        self.prgy = []
+        self.nprgy = 0
+        self.mat = -1
+        self.pat = 1
+        self.het = 0
+        self.unk = "U"
+        self.filler = False
+        self.mb_exists = False
+
+        #ZS: This is because I'm not sure if some files switch the column that contains Mb/cM positions; might be unnecessary
+        self.cm_column = 2
+        self.mb_column = 3
+
+        self.chromosomes = []
+
+        self.read_file(filename)
+
+    def __iter__(self):
+        return iter(self.chromosomes)
+
+    def __getitem__(self, index):
+        return self.chromosomes[index]
+
+    def __len__(self):
+        return len(self.chromosomes)
+
+    def read_rdata_output(self, qtl_results):
+        #ZS: This is necessary because R/qtl requires centimorgan marker positions, which it normally gets from the .geno file, but that doesn't exist for HET3-ITP (which only has RData), so it needs to read in the marker cM positions from the results
+        self.chromosomes = [] #ZS: Overwriting since the .geno file's contents are just placeholders
+
+        this_chr = "" #ZS: This is so it can track when the chromosome changes as it iterates through markers
+        chr_ob = None
+        for marker in qtl_results:
+            locus = Locus(self)
+            if (str(marker['chr']) != this_chr) and this_chr != "X": #ZS: This is really awkward but works as a temporary fix
+                if this_chr != "":
+                    self.chromosomes.append(chr_ob)
+                this_chr = str(marker['chr'])
+                if this_chr == "20":
+                    this_chr = "X"
+                chr_ob = Chr(this_chr, self)
+            if 'chr' in marker:
+                locus.chr = str(marker['chr'])
+            if 'name' in marker:
+                locus.name = marker['name']
+            if 'Mb' in marker:
+                locus.Mb = marker['Mb']
+            if 'cM' in marker:
+                locus.cM = marker['cM']
+            chr_ob.loci.append(locus)
+
+        self.chromosomes.append(chr_ob)
+
+        return self
+
+    def read_file(self, filename):
+        with open(filename, 'r') as geno_file:
+            lines = geno_file.readlines()
+
+            this_chr = "" #ZS: This is so it can track when the chromosome changes as it iterates through markers
+            chr_ob = None
+            for line in lines:
+                if line[0] == "#":
+                    continue
+                elif line[0] == "@":
+                    label = line.split(":")[0][1:]
+                    if label == "name":
+                        self.group = line.split(":")[1].strip()
+                    elif label == "filler":
+                        if line.split(":")[1].strip() == "yes":
+                            self.filler = True
+                    elif label == "type":
+                        self.type = line.split(":")[1].strip()
+                    elif label == "mat":
+                        self.mat = line.split(":")[1].strip()
+                    elif label == "pat":
+                        self.pat = line.split(":")[1].strip()
+                    elif label == "het":
+                        self.het = line.split(":")[1].strip()
+                    elif label == "unk":
+                        self.unk = line.split(":")[1].strip()
+                    else:
+                        continue
+                elif line[:3] == "Chr":
+                    header_row = line.split("\t")
+                    if header_row[2] == "Mb":
+                        self.mb_exists = True
+                        self.mb_column = 2
+                        self.cm_column = 3
+                    elif header_row[3] == "Mb":
+                        self.mb_exists = True
+                        self.mb_column = 3
+                    elif header_row[2] == "cM":
+                        self.cm_column = 2
+
+                    if self.mb_exists:
+                        self.prgy = header_row[4:]
+                    else:
+                        self.prgy = header_row[3:]
+                    self.nprgy = len(self.prgy)
+                else:
+                    if line.split("\t")[0] != this_chr:
+                        if this_chr != "":
+                            self.chromosomes.append(chr_ob)
+                        this_chr = line.split("\t")[0]
+                        chr_ob = Chr(line.split("\t")[0], self)
+                    chr_ob.add_marker(line.split("\t"))
+
+            self.chromosomes.append(chr_ob)
+
+class Chr(object):
+    def __init__(self, name, geno_ob):
+        self.name = name
+        self.loci = []
+        self.mb_exists = geno_ob.mb_exists
+        self.cm_column = geno_ob.cm_column
+        self.mb_column = geno_ob.mb_column
+        self.geno_ob = geno_ob
+
+    def __iter__(self):
+        return iter(self.loci)
+
+    def __getitem__(self, index):
+        return self.loci[index]
+
+    def __len__(self):
+        return len(self.loci)
+
+    def add_marker(self, marker_row):
+        self.loci.append(Locus(self.geno_ob, marker_row))
+
+class Locus(object):
+    def __init__(self, geno_ob, marker_row = None):
+        self.chr = None
+        self.name = None
+        self.cM = None
+        self.Mb = None
+        self.genotype = []
+        if marker_row:
+            self.chr = marker_row[0]
+            self.name = marker_row[1]
+            try:
+                self.cM = float(marker_row[geno_ob.cm_column])
+            except:
+                self.cM = float(marker_row[geno_ob.mb_column]) if geno_ob.mb_exists else 0
+            try:
+                self.Mb = float(marker_row[geno_ob.mb_column]) if geno_ob.mb_exists else None
+            except:
+                self.Mb = self.cM
+
+            geno_table = {
+                geno_ob.mat: -1,
+                geno_ob.pat: 1,
+                geno_ob.het: 0,
+                geno_ob.unk: "U"
+            }
+
+            self.genotype = []
+            if geno_ob.mb_exists:
+                start_pos = 4
+            else:
+                start_pos = 3
+
+            for allele in marker_row[start_pos:]:
+                if allele in geno_table.keys():
+                    self.genotype.append(geno_table[allele])
+                else: #ZS: Some genotype appears that isn't specified in the metadata, make it unknown
+                    self.genotype.append("U")
\ No newline at end of file