(define-module (gn runner gemma) #:use-module (json) #:use-module (gn data genotype) #:use-module (ice-9 match) #:use-module (ice-9 format) #:use-module (ice-9 iconv) #:use-module (ice-9 receive) #:use-module (ice-9 string-fun) #:use-module (rnrs base) #:export ( run-gemma )) (define (run-gemma population data-id name trait-name traits) (define bxd-inds (geno-inds-bxd "BXD.json")) (assert (= 235 (length bxd-inds))) (if name (display (string-append "WE HAVE OUR BXD DATASET " name " and trait " trait-name " for precompute!\n"))) (display data-id) (display traits) (newline) ;; ---- write phenotype file (let* [(sys-tmpdir (getenv "TMPDIR")) (tmpdir (mkdtemp (string-append sys-tmpdir "/run-gemma-XXXXXX"))) (pheno-fn (string-append tmpdir "/pheno.txt")) (k-json-fn (string-append tmpdir "/K.json")) (gwa-json-fn (string-append tmpdir "/GWA.json"))] (call-with-output-file pheno-fn (lambda (port) (for-each (lambda (ind) (begin (let* [(value (assoc-ref traits ind)) (outvalue (if value value "NA"))] (display outvalue) (newline) (display outvalue port) (newline port)))) bxd-inds))) ;; set up with ./.guix-shell -- guile -L . -s ./scripts/precompute/precompute-hits.scm ;; ---- to start GEMMA precompute inside container ;; env TMPDIR=. LD_LIBRARY_PATH=$GUIX_ENVIRONMENT/lib/ guile -L . -s ./scripts/precompute/precompute-hits.scm ;; --- First we compute K - control output goes to K.json (let [(err (system (string-append "env GEMMA_COMMAND=gemma /gemma-wrapper/bin/gemma-wrapper --population \"" population "\" --name \"" name "\" --trait \"" trait-name "\" --verbose --loco --json --debug --parallel -- -gk -g BXD.8_geno.txt.gz -p " pheno-fn " -a BXD.8_snps.txt > " k-json-fn )))] (if (not (= err 0)) (exit err))) (let [(err (system (string-append "env GEMMA_COMMAND=gemma /gemma-wrapper/bin/gemma-wrapper --population \"" population "\" --name \"" name "\" --trait \"" trait-name "\" --verbose --loco --json --debug --parallel --input " k-json-fn " -- -g BXD.8_geno.txt.gz -p " pheno-fn " -a BXD.8_snps.txt -lmm 2 -maf 0.1 > " gwa-json-fn)))] (if (not (= err 0)) (exit err))) (delete-file pheno-fn) (delete-file gwa-json-fn) (delete-file k-json-fn) (rmdir tmpdir) ) )