From 007264d03484ed62a06c6bc5747881c409250561 Mon Sep 17 00:00:00 2001
From: Pjotr Prins
Date: Tue, 1 Nov 2022 13:38:30 +0100
Subject: search: add Ashbrook paper

---
 topics/features/genenetwork/search.gmi | 4 ++++
 1 file changed, 4 insertions(+)

(limited to 'topics')

diff --git a/topics/features/genenetwork/search.gmi b/topics/features/genenetwork/search.gmi
index 71718fa..003a887 100644
--- a/topics/features/genenetwork/search.gmi
+++ b/topics/features/genenetwork/search.gmi
@@ -18,6 +18,10 @@ brca - only renders 2 results, why not BRCA2?
 
 Keywords like tissue appear to be case sensitive. Should not be the case.
 
+In the paper `New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork' the authors reanalyzed an older experimental data in the GeneNetwork database.
+They discovered QTLs on mouse chromosomes 3, 5, 9, 11, and 14, not found in the original study
+and found new candidate genes included Slitrk6 and Cdk14. Slitrk6, in a Chromosome14 QTL for locomotion, was found to be part of a co-expression network involved in voluntary movement and associated with neuropsychiatric phenotypes. Cdk14, one of only three genes in a Chromosome5 QTL, is associated with handling induced convulsions after ethanol treatment, that is regulated by the anticonvulsant drug valproic acid\cite{PMC9024903}.
+
 ## Future
 
 * Add human SNP search and synteny
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