Douglas M. Ruden a,*, Lang Chen b, Debra Possidente c, Bernard Possidente d, Parsa Rasouli a, Luan Wanga, Xiangyi Lu a, Mark D. Garfinkel e, Helmut V.B. Hirsch d, Grier P. Page f a Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, United States b Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United States c Department of Biological Sciences, University at Albany, SUNY, Albany, NY, United States d Department of Biology, Skidmore College, Saratoga Springs, NY, United States e Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL, United States f Statistics and Epidemiology Unit, RTI International, Atlanta, GA, United States