This December 2008 data set provides estimates of mRNA expression in normal hearts of 31 strains of rats including the hypertensive SHR strain (aka HSR), the normotensive BN strain, and 29 HXB/BXH recombinant inbred strains. Most strains were sampled in quadruplicate (6-week-old males). Animals and tissues were generated by Michal Pravenec and colleagues at the Czech Academy of Sciences (CAS). RNA samples were processed at the Max-Delbrück-Center (MDC), Berlin Buch by Norbert Hübner and colleagues. Transcriptome mapping was carried out by Timothy Aitman and colleagues at the Imperial College, London (ICL). Samples were hybridized individually to a total of approximately XXX Affymetrix RAE230A array processed using the RMA protocol. The expression values of each array have been logged and adjusted to a mean of 8 and a standard deviation of 2 (mean and variance stabilized). This data set complements the kidney and fat data set exploited by Hübner and colleagues 2005.

These data may also be viewed using the eQTL Explorer Java application by John Mangion, Tim Aitman, and colleagues (Mueller et al. 2006).

Genome-wide co-expression analysis in multiple tissues.

And see closely associate set of papers:

1. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.
2. Heritability and tissue specificity of expression quantitative trait loci.
3. Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.
4. New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.
5. The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.
6. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
7. Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.
8. Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans.