From d029d5d7f8ead1f1de8d318045004a4a6f68f5fb Mon Sep 17 00:00:00 2001 From: Bonface Date: Fri, 9 Feb 2024 09:41:28 -0600 Subject: Update dataset RTF Files. --- general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/summary.rtf | 1 + 1 file changed, 1 insertion(+) create mode 100644 general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/summary.rtf (limited to 'general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/summary.rtf') diff --git a/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/summary.rtf b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/summary.rtf new file mode 100644 index 0000000..0639fe7 --- /dev/null +++ b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/summary.rtf @@ -0,0 +1 @@ +

Although mice are the most widely used mammalian model organism, genetic studies have suffered from limited mapping resolution due to extensive linkage disequilibrium (LD) that is characteristic of crosses among inbred strains. Carworth Farms White (CFW) mice are a commercially available outbred mouse population that exhibit rapid LD decay in comparison to other available mouse populations. We performed a genome-wide association study (GWAS) of behavioral, physiological and gene expression phenotypes using 1,200 male CFW mice. We used genotyping by sequencing (GBS) to obtain genotypes at 92,734 SNPs. We also measured gene expression using RNA sequencing in three brain regions. Our study identified numerous behavioral, physiological and expression quantitative trait loci (QTLs). We integrated the behavioral QTL and eQTL results to implicate specific genes, including Azi2 in sensitivity to methamphetamine and Zmynd11 in anxiety-like behavior. The combination of CFW mice, GBS and RNA sequencing constitutes a powerful approach to GWAS in mice. Full article available here.

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