From b2feda451ccfbeaed02dce9088d6dd228cf15861 Mon Sep 17 00:00:00 2001 From: Bonface Date: Tue, 13 Feb 2024 23:52:26 -0600 Subject: Update dataset RTF Files. --- .../datasets/JAX_D2_Mono1vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf | 1 - 1 file changed, 1 deletion(-) delete mode 100644 general/datasets/JAX_D2_Mono1vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf (limited to 'general/datasets/JAX_D2_Mono1vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf') diff --git a/general/datasets/JAX_D2_Mono1vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf b/general/datasets/JAX_D2_Mono1vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf deleted file mode 100644 index 1c50734..0000000 --- a/general/datasets/JAX_D2_Mono1vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf +++ /dev/null @@ -1 +0,0 @@ -

To understand the function of these infiltrating monocyte-like cells, we used RNA-sequencing to profile their transcriptomes. Based on their pro-inflammatory molecular signatures, we hypothesized and confirmed that monocyte-platelet interactions occur in glaucomatous tissue. Furthermore, to test monocyte function we used two approaches to inhibit their entry into the optic nerve head: (1) treatment with DS-SILY, a peptidoglycan that acts as a barrier to platelet adhesion to the vessel wall and to monocytes, and (2) genetic targeting of Itgam (CD11b, an immune cell receptor that enables immune cell extravasation).

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