[ { "level": "domainexpert", "domain": "gn", "query": [ "What are the potential benefits and risk associated with gene editing technologies like CRISPRR-Cas9?", "How does epigenetics inluence gene expression without changing the underlying DNA sequence?", "Describe the role of mitochondrial DNA in heredity and how it differs from nuclear DNA.", "What are the ethical considerations surrounding prenatal genetic testing and the selective termination of pregnancies based on genetic factors?", "Create a how-to guide for genetic sequencing.", "Which genes give a predisposition to developing T1D?", "What is ensembl", "Which database can I use for genetic, genomics, phenotype, and disease-related data generated from rat research?", "What is RGD?", "What resources can I use to do pathway analyses?", "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?", "Why is genetic tracing matrilineal rather than patrilineal?", "Explain the process of DNA replication and how it ensures accurate copying of genetic information during cell division.", "What are the potential benefits and risks associated with gene editing technologies like CRISPR-Cas9?", "How does one tell the difference between X and Y DNA, with repsect to DNA tracing and determining QTLs?", "For text and biological resources, do you mean add some books (on biology stuff) or/and web resources (as ensembl) on your system?", "what is ensembl?", "What is the difference between QTL mapping and GWAS?", "How do I determine which gene in my QTL is causal for the trait?", "Why do males have two Y chromosomes and females only one?", "How does one tell the difference between X and Y DNA, with respect to DNA tracing and determining QTLs", "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?", "How can I add a new species to the GeneNetwork database?", "which genes are typically associated with diabetes in QTL analyses?", "In which diseases is the gene TCF7L2 involved?", "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?", "Can you explain what a ribosomal binding site at a high level and make it accessable to a non-expert?", "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?", "Can you explain the difference between sequencing with short reads vs long reads? Please make you answer accessible to a non-expert.", "Can you explain why using a pangenome-based reference might be more useful than simply using a single linear reference? Please make you answer accessible to a non-expert.", "Is all genetic regulation done through DNA (e.g., prompters, repressors, activators) or are there other forms of genetic regulation? Please make you answer accessible to a non-expert.", "What are the different relationship between traits?", "Can landscape of QTL and GWAS hits be used to find relationships between traits?" ] }, { "level": "domainexpert", "domain": "diabetes", "query": [ "How is gene expression in the liver affected by diabetes?", "Is any of the genes SH2B3, IFIH1 or ERBB3 related to diabetes?", "nutrition is a factor for diabetes. how can genomics be use to better understand nutritional factors of diabetes", "nutrition is a factor for diabetes. construct an abstract about how can genomics be use to better understand nutritional factors of diabetes", "Is the gene TCF7L2 involved in diabetes?", "Is any of the genes SH2B3, IFIH1 or ERBB3 related to diabetes?", "How can I use genenetwork to find genes related with diabetes in humans?", "How can I use the GeneNetwork tool to find genes related with diabetes in humans?", "what are confounding factors in diabetes?", "How is the immune system related to diabetes?", "What are the genomic variants associated with immune system components and diabetes?", "What is the role of the immune system in the metabolomics of diabetes and associated conditions?", "Can the landscape of QTL and GWAS hits be used to dissect the role of immune system in diabetes and complications?" ] }, { "level": "domainexpert", "domain": "aging", "query": [ "What is the significance of the length of telomeres?", "Which mouse genes have been associated with longevity?", "what genetic factor are associated with aging", "which genes are typically associated with early aging?", "How do I generate a linkage or association mapping study in mice to understand aging?", "is there a specific genetic variation that can cause someone to live longer? please make your answer accessible to a non-expert" ] }, { "level": "citizenscientist", "domain": "gn", "query": [ "What is the most cited environmental factor for the onset of asthma?", "How would one extract the DNA, from say, flora or fauna?","genetics", "what is bioinformatics", "Explain the process of finding a genetic marker followed by a quantitative trait loci.", "What about recombination in human centromeres?", "How does recombination work in human centromeres?", "What about recombination in the human genome?", "Create a how to guide for genetic sequencing", "What is the significance of the length of telomeres? ", "Once a sperm combines with an egg, what determines how traits are passed on to the resulting lifeform? ", "Why is genetic tracing matrilineal rather than patrilineal? ", "How does one tell the difference between X and Y DNA, with respect to DNA tracing and determining QTLs?", "what type of dataset is useful for qtl mapping analysis in genenetwork2?", "what are the bioinformatics tools for QTLs analysis?", "what are the statistical approaches for qtls analysis?", "Create a how-to guide for GWAS analysis?", "Create a how-to guide for genetic sequencing", "Create a how-to guide for genetic sequencing.", "What is the significance of the length of telomeres?", "Create a how-to guide for genetic sequencing", "Create a guide for genetic sequencing", "Define dyslipidemia.", "What is cytochrome?", "How does one tell the difference between X and Y DNA, with respect to DNA tracing and determining QTLs?", "how does environment influence fertilisation", "how does diet impact someone's height", "which animal has the same number of chromosomes as human", "what ensures brains work", "how do our brains maintain emotions", "what hormones do our brains release during stressful experiences?", "what is the use of corticosterone?" ] }, { "level": "citizenscientist", "domain": "diabetes", "query": [ "What are the genetic bases for the varying efficacy of diabetes treatments among individuals?", "Explain Protective Genetic Factors Against Diabetes in Elderly Populations", "Explain Effect of Lifestyle Modifications on Aging-Associated Diabetes Risk", "Explain The Role of Longevity Genes in Protecting Against Diabetes", "What are the types of diabetes", "How many types of diabetes exist?", "Is there a direct association between aging and susceptibility to having diabetes?", "How does genetics influence the emergency of diabetes?", "what genes are associated with diabetes?", "What causes diabetes?", "Does cycling reduce risk of diabetes?", "How can GeneNetwork assist in identifying genetic factors involved in diabetes?", "What specific tools within GeneNetwork are most useful for diabetes research, and how are they applied?", "What role does insulin play in the regulation of blood glucose levels?", "How does aging affect the risk of developing type 2 diabetes?", "Can lifestyle changes reverse type 2 diabetes?" ] }, { "level": "citizenscientist", "domain": "aging", "query": [ "List as many studies as you can that include rapamycin.", "Why is it so diffuclut to map gene loci that control aging in humans?", "What is apoptosis?", "which genes are involved in the aging process", "what causes the aging process", "which genes are involved in aging", "what genes are involved in the aging process", "Describe the genotypes related to Alzheimers and dementia which have commonalities with those for aging.", "Describe the genotypes related to Alzheimer's and dementia which have commonalities with those for aging.", "What genetic factors influence aging in humans?", "what genes are associated with aging?", "Which genes are associated with aging in human", "What is GeneNetwork and how does it relate to aging research?" ] } ]