GeneNetwork Classification Scheme For Resources
The Type of a Dataset which can be a ProbeSet, Genotype, or Phenotype
The species in which this resource belongs
The Type of Set, Ie InbredSet/OutbredSet that a resource can belong to
Arabidopsis (Arabidopsis thaliana, araTha1)
Soybean (Glycine max, US DOE JGI-PGF v2 2021)
Tomato (Solanum lycopersicum, GCF_001406875.1)
Reference Populations (replicate average, SE, N)
Hybrid Rat Diversity Panel (Includes HXB/BXH)
Lymphoblastoid Cells: Gene Expression (CEPH, Williams)
Crosses and Heterogeneous Stock (individuals)
Brain, Aging: AD, Normal Gene Expression (Liang)
Brain, Aging: AD, Normal Gene Expression with Genotypes (Myers)
DO Hitzemann Striatum mRNA n=90 (Feb11, no mapping)
Liver: Normal Gene Expression with Genotypes (Merck)
Child Development: CANDLE Cohort with Genotypes (TUCI/UTHSC)
Brain, Aging: AD, HD, Normal Gene Expression (Harvard/Merck)
Brain, Development: Normal Gene Expression (Yale/Sestan)
Brain, Aging: Normal Gene Expression (UCI/Cotman)
Brain: Normal Gene Expression (NIH/Gibbs)
GTEx v3 All Tissues, RNA-Seq with Genotypes
Brain, Cognition, Human Connectome Project
GTEx v5 All Tissues, RNA-Seq with Genotypes
Retina: Normal Adult Gene Expression, RNA-Seq (TIGEM)
Aging Mouse Lifespan Studies (NIA UM-HET3)
GTEx v8 All Tissues, RNA-Seq without Genotypes
EBV, T cells Type 1 Diabetes: Gene Expression (Perkins, Morahan)
Medaka Inbred Kiyosu-Karlsruhe (MIKK) Panel
Optional user or project code or your initials
The reason why this resource was modified
Represents GeneRIF Entries entered from GeneNetwork
hippocampal CA1-3 expression signature
Expression signature for cells in globus pallidus and cerebellar Purkinje cells of adults (ABA). test
Expression patterns: mature cells, tissues
Expression signature for cells in globus pallidus and cerebellar Purkinje cells (ABA).
Expression signature for cells in globus pallidus and cerebellar Purkinje cells of adults (ABA).
Slight clarification. Entered other fields.
Associated with glioma.
Associated with glioma
high similarities on four locations on three different chromosomes
Validated strong cis-QTL in CNS using allele-specific expression (ASE) SNaPshot assay (Daniel Ciobanu and al., 2007). Possible 3' UTR variants.
putative 3' UTR variants
Validated strong cis-QTL in CNS using allele-specific expression (ASE) SNaPshot assay. Possible 3' UTR variants.
cis QTL present in hippocampus LXS, ILM2970706 (distal 3' UTR), 121.4 LRS, ISS increases the trait;
Individual probe analysis:probably true cisQTL
Merck, Rosetta, Schadt, Lusis target gene associated with obesity, diabetes and atherosclerosis.
Drug abuse and substance dependence gene list member. One of 172 genes with high expression in hippocampus and amygdala that contain clusters of SNPs associated with drug abuse in research volunteer samples that display nominal p < 0.05. C Johnson, T Drgon, George R Uhl and colleagues.
cis eQTL in BXD brain RNA-seq data with LRS of 33 and high D allele. No obvious trans target transcripts.
Strong cis eQTL in brain RNA-seq data (LRS of 29 high B allele). Highly expressed in almost all neurons (not just interneurons). Trans targets of CKB include striatin (STRN) and C1QL3 (CTRP13).
Interactions: mRNA, proteins, other molecules
Of interest to Lu Lu and colleagues (2015) due to modulation of expression of this gene in hippocampus following stress or ethanol (BXD Illumina Hippocampus data sets).
Possible retinal ganglion cell marker.
AC was here
Test
Represents GeneRIF Entries obtained from NCBI
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function.
DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury.
Prefrontal cortex-specific Dcc deletion induces schizophrenia-related behavioral phenotypes and fail to be rescued by olanzapine treatment.
Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease.
IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.
The SHH-GLI1 pathway is required in skin expansion and angiogenesis.
[Effect study of Sonic hedgehog overexpressed hair follicle stem cells in hair follicle regeneration].
Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration.
Developing a model to predict the early risk of hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL): a translational study.
Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in Rectal Nervous System Development of Fetal Rats with Anorectal Malformation.
Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling.
Mirror movements and callosal dysgenesis in a family with a DCC mutation: Neuropsychological and neuroimaging outcomes.
An imbalance of netrin-1 and DCC during nigral degeneration in experimental models and patients with Parkinson's disease.
Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity.
The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme?
Plasma Lipoprotein Lipase Is Associated with Risk of Future Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy.
Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Effect of the Interaction between Seaweed Intake and LPL Polymorphisms on Metabolic Syndrome in Middle-Aged Korean Adults.
Frameshift coding sequence variants in the LPL gene: identification of two novel events and exploration of the genotype-phenotype relationship for variants reported to date.
The East Asian-specific LPL p.Ala288Thr (c.862G > A) missense variant exerts a mild effect on protein function.
Interaction between APOE, APOA1, and LPL Gene Polymorphisms and Variability in Changes in Lipid and Blood Pressure following Orange Juice Intake: A Pilot Study.
Variants within the LPL gene confer susceptility to diabetic kidney disease and rapid decline in kidney function in Chinese patients with type 2 diabetes.
The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants.
The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing.
Clinical profile, genetic spectrum and therapy evaluation of 19 Chinese pediatric patients with lipoprotein lipase deficiency.
Low Expression of the NRP1 Gene Is Associated with Shorter Overall Survival in Patients with Sonic Hedgehog and Group 3 Medulloblastoma.
Activation of Sonic Hedgehog Signaling Pathway Regulates Human Trabecular Meshwork Cell Function.