from typing import Any, Dict, Union def retrieve_probeset_trait_dataset_name( threshold: int, name: str, connection: Any): query = ( "SELECT Id, Name, FullName, ShortName, DataScale " "FROM ProbeSetFreeze " "WHERE " "public > %(threshold)s " "AND " "(Name = %(name)s OR FullName = %(name)s OR ShortName = %(name)s)") with connection.cursor() as cursor: cursor.execute( query, { "threshold": threshold, "name": name }) return dict(zip( ["dataset_id", "dataset_name", "dataset_fullname", "dataset_shortname", "dataset_datascale"], cursor.fetchone)) def retrieve_publish_trait_dataset_name(threshold: int, name: str, connection: Any): query = ( "SELECT Id, Name, FullName, ShortName " "FROM PublishFreeze " "WHERE " "public > %(threshold)s " "AND " "(Name = %(name)s OR FullName = %(name)s OR ShortName = %(name)s)") with connection.cursor() as cursor: cursor.execute( query, { "threshold": threshold, "name": name }) return dict(zip( ["dataset_id", "dataset_name", "dataset_fullname", "dataset_shortname"], cursor.fetchone)) def retrieve_geno_trait_dataset_name(threshold: int, name: str, connection: Any): query = ( "SELECT Id, Name, FullName, ShortName " "FROM GenoFreeze " "WHERE " "public > %(threshold)s " "AND " "(Name = %(name)s OR FullName = %(name)s OR ShortName = %(name)s)") with connection.cursor() as cursor: cursor.execute( query, { "threshold": threshold, "name": name }) return dict(zip( ["dataset_id", "dataset_name", "dataset_fullname", "dataset_shortname"], cursor.fetchone)) def retrieve_temp_trait_dataset_name(threshold: int, name: str, connection: Any): query = ( "SELECT Id, Name, FullName, ShortName " "FROM TempFreeze " "WHERE " "public > %(threshold)s " "AND " "(Name = %(name)s OR FullName = %(name)s OR ShortName = %(name)s)") with connection.cursor() as cursor: cursor.execute( query, { "threshold": threshold, "name": name }) return dict(zip( ["dataset_id", "dataset_name", "dataset_fullname", "dataset_shortname"], cursor.fetchone)) def retrieve_dataset_name( trait_type: str, threshold: int, trait_name: str, dataset_name: str, conn: Any): """ Retrieve the name of a trait given the trait's name This is extracted from the `webqtlDataset.retrieveName` function as is implemented at https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlDataset.py#L140-L169 """ fn_map = { "ProbeSet": retrieve_probeset_trait_dataset_name, "Publish": retrieve_publish_trait_dataset_name, "Geno": retrieve_geno_trait_dataset_name, "Temp": retrieve_temp_trait_dataset_name} if trait_type == "Temp": return retrieve_temp_trait_dataset_name(threshold, trait_name, conn) return fn_map[trait_type](threshold, dataset_name, conn) def retrieve_geno_riset_fields(name, conn): """ Retrieve the RISet, and RISetID values for various Geno trait types. """ query = ( "SELECT InbredSet.Name, InbredSet.Id " "FROM InbredSet, GenoFreeze " "WHERE GenoFreeze.InbredSetId = InbredSet.Id " "AND GenoFreeze.Name = %(name)s") with conn.cursor() as cursor: cursor.execute(query, {"name": name}) return dict(zip(["riset", "risetid"], cursor.fetchone())) return {} def retrieve_publish_riset_fields(name, conn): """ Retrieve the RISet, and RISetID values for various Publish trait types. """ query = ( "SELECT InbredSet.Name, InbredSet.Id " "FROM InbredSet, PublishFreeze " "WHERE PublishFreeze.InbredSetId = InbredSet.Id " "AND PublishFreeze.Name = %(name)s") with conn.cursor() as cursor: cursor.execute(query, {"name": name}) return dict(zip(["riset", "risetid"], cursor.fetchone())) return {} def retrieve_probeset_riset_fields(name, conn): """ Retrieve the RISet, and RISetID values for various ProbeSet trait types. """ query = ( "SELECT InbredSet.Name, InbredSet.Id " "FROM InbredSet, ProbeSetFreeze, ProbeFreeze " "WHERE ProbeFreeze.InbredSetId = InbredSet.Id " "AND ProbeFreeze.Id = ProbeSetFreeze.ProbeFreezeId " "AND ProbeSetFreeze.Name = %(name)s") with conn.cursor() as cursor: cursor.execute(query, {"name": name}) return dict(zip(["riset", "risetid"], cursor.fetchone())) return {} def retrieve_temp_riset_fields(name, conn): query = ( "SELECT InbredSet.Name, InbredSet.Id " "FROM InbredSet, Temp " "WHERE Temp.InbredSetId = InbredSet.Id " "AND Temp.Name = %(name)s") with conn.cursor() as cursor: cursor.execute(query, {"name": name}) return dict(zip(["riset", "risetid"], cursor.fetchone())) return {} def retrieve_riset_fields(trait_type, trait_name, dataset_info, conn): """ Retrieve the RISet, and RISetID values for various trait types. """ riset_fns_map = { "Geno": retrieve_geno_riset_fields, "Publish": retrieve_publish_riset_fields, "ProbeSet": retrieve_probeset_riset_fields } if trait_type == "Temp": riset_info = retrieve_temp_riset_fields(trait_name, conn) else: riset_info = riset_fns_map[trait_type](dataset_info["dataset_name"], conn) return { **dataset_info, **riset_info, "riset": ( "BXD" if riset_info.get("riset") == "BXD300" else riset_info.get("riset", "")) } def retrieve_temp_trait_dataset(): return { "searchfield": ["name", "description"], "disfield": ["name", "description"], "type": "Temp", "dataset_id": 1, "fullname": "Temporary Storage", "shortname": "Temp" } def retrieve_geno_trait_dataset(): return { "searchfield": ["name","chr"], "disfield": ["name","chr","mb", "source2", "sequence"], "type": "Geno" } def retrieve_publish_trait_dataset(): return { "searchfield": [ "name", "post_publication_description", "abstract", "title", "authors"], "disfield": [ "name","pubmed_id", "pre_publication_description", "post_publication_description", "original_description", "pre_publication_abbreviation", "post_publication_abbreviation", "lab_code", "submitter", "owner", "authorized_users", "authors","title","abstract", "journal","volume","pages","month", "year","sequence", "units", "comments"], "type": "Publish" } def retrieve_probeset_trait_dataset(): return { "searchfield": [ "name", "description", "probe_target_description", "symbol", "alias", "genbankid", "unigeneid", "omim", "refseq_transcriptid", "probe_set_specificity", "probe_set_blat_score"], "disfield": [ "name", "symbol", "description", "probe_target_description", "chr", "mb", "alias", "geneid", "genbankid", "unigeneid", "omim", "refseq_transcriptid", "blatseq", "targetseq", "chipid", "comments", "strand_probe", "strand_gene", "probe_set_target_region", "proteinid", "probe_set_specificity", "probe_set_blat_score", "probe_set_blat_mb_start", "probe_set_blat_mb_end", "probe_set_strand", "probe_set_note_by_rw", "flag"], "type": "ProbeSet" } def retrieve_trait_dataset(trait_type, trait, threshold, conn): dataset_fns = { "Temp": retrieve_temp_trait_dataset, "Geno": retrieve_geno_trait_dataset, "Publish": retrieve_publish_trait_dataset, "ProbeSet": retrieve_probeset_trait_dataset } dataset_name_info = { "dataset_id": None, "dataset_name": trait["db"]["dataset_name"], **retrieve_dataset_name( trait_type, threshold, trait["trait_name"], trait["db"]["dataset_name"], conn) } riset = retrieve_riset_fields( trait_type, trait["trait_name"], dataset_name_info, conn) return { "display_name": dataset_name_info["dataset_name"], **dataset_name_info, **dataset_fns[trait_type](), **riset }