""" This module will contain functions to be used in computation of the data used to generate various kinds of heatmaps. """ from functools import reduce from typing import Any, Dict, Sequence from gn3.computations.slink import slink from gn3.db.traits import retrieve_trait_data, retrieve_trait_info from gn3.computations.correlations2 import compute_correlation def export_trait_data( trait_data: dict, strainlist: Sequence[str], dtype: str = "val", var_exists: bool = False, n_exists: bool = False): """ Export data according to `strainlist`. Mostly used in calculating correlations. DESCRIPTION: Migrated from https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L166-L211 PARAMETERS trait: (dict) The dictionary of key-value pairs representing a trait strainlist: (list) A list of strain names type: (str) ... verify what this is ... var_exists: (bool) A flag indicating existence of variance n_exists: (bool) A flag indicating existence of ndata """ def __export_all_types(tdata, strain): sample_data = [] if tdata[strain]["val"]: sample_data.append(tdata[strain]["val"]) if var_exists: if tdata[strain].var: sample_data.append(tdata[strain]["var"]) else: sample_data.append(None) if n_exists: if tdata[strain]["ndata"]: sample_data.append(tdata[strain]["ndata"]) else: sample_data.append(None) else: if var_exists and n_exists: sample_data += [None, None, None] elif var_exists or n_exists: sample_data += [None, None] else: sample_data.append(None) return tuple(sample_data) def __exporter(accumulator, strain): if tdata.has_key(strain): if dtype == "val": return accumulator + (tdata[strain]["val"], ) if dtype == "var": return accumulator + (tdata[strain]["var"], ) if dtype == "N": return tdata[strain]["ndata"] if dtype == "all": return accumulator + __export_all_types( accumulator, tdata, strain) else: raise KeyError("Type `%s` is incorrect" % dtype) else: if var_exists and n_exists: return accumulator + (None, None, None) if var_exists or n_exists: return accumulator + (None, None) return accumulator + (None,) return reduce(__exporter(strain), strainlist, tuple()) def trait_display_name(trait: Dict): """ Given a trait, return a name to use to display the trait on a heatmap. DESCRIPTION Migrated from https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L141-L157 """ if trait.get("db", None) and trait.get("trait_name", None): if trait["db"]["dataset_type"] == "Temp": desc = trait["description"] if desc.find("PCA") >= 0: return "%s::%s" % ( trait["db"]["displayname"], desc[desc.rindex(':')+1:].strip()) return "%s::%s" % ( trait["db"]["displayname"], desc[:desc.index('entered')].strip()) else: prefix = "%s::%s" % ( trait["db"]["dataset_name"], trait["trait_name"]) if trait["cellid"]: return "%s::%s" % (prefix, trait["cellid"]) return prefix return trait["description"] def cluster_traits(traits_data_list: Sequence[Dict]): """ Clusters the trait values. DESCRIPTION Attempts to replicate the clustering of the traits, as done at https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/heatmap/Heatmap.py#L138-L162 """ def __compute_corr(tdata_i, tdata_j): if tdata_j[0] < tdata_i[0]: corr, nOverlap = compute_correlation(tdata_i, tdata_j) if (1 - corr) < 0: return 0.0 return 1 - corr return 0.0 def __cluster(tdata_i): res2 = tuple( __compute_corr(tdata_i, tdata_j) for tdata_j in enumerate(traits)) return tuple(__cluster(tdata_i) for tdata_i in enumerate(traits_data_list)) def heatmap_data( fd, search_result, conn: Any, colorScheme=None, userPrivilege=None, userName=None): """ heatmap function DESCRIPTION This function is an attempt to reproduce the initialisation at https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/heatmap/Heatmap.py#L46-L64 and also the clustering and slink computations at https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/heatmap/Heatmap.py#L138-L165 with the help of the `gn3.computations.heatmap.cluster_traits` function. It does not try to actually draw the heatmap image. PARAMETERS: TODO: Elaborate on the parameters here... """ cluster_checked = fd.formdata.getvalue("clusterCheck", "") strainlist = [strain for strain in fd.strainlist if strain not in fd.parlist] genotype = fd.genotype def __retrieve_traitlist_and_datalist(threshold, fullname): trait = retrieve_trait_info(threshold, fullname, conn) return (trait, export_trait_data(retrieve_trait_data(trait), strainlist)) traits_details = [ __retrieve_traitlist_and_datalist(threshold, fullname) for fullname in search_result] traits_list = map(lambda x: x[0], traits_details) traits_data_list = map(lambda x: x[1], traits_details) return { "target_description_checked": fd.formdata.getvalue( "targetDescriptionCheck", ""), "cluster_checked": cluster_checked, "slink_data": ( slink(cluster_traits(traits_list, strainlist)) if cluster_checked else False) "sessionfile": fd.formdata.getvalue("session"), "genotype": genotype, "nLoci": sum(map(lambda x: len(x), genotype)) "strainlist": strainlist, "ppolar": fd.ppolar, "mpolar":fd.mpolar, "traits_list": traits_list "traits_data_list": traits_data_list }