From 7c20150278dbcb18f088de1afe6ea8411d29827c Mon Sep 17 00:00:00 2001
From: Alexander Kabui
Date: Fri, 17 Dec 2021 02:17:04 +0300
Subject: to drop commit:test on penguin

---
 gn3/computations/correlations.py | 59 ++++++++++++++++++++++++++++++++--------
 1 file changed, 47 insertions(+), 12 deletions(-)

diff --git a/gn3/computations/correlations.py b/gn3/computations/correlations.py
index 24e9871..cc166fa 100644
--- a/gn3/computations/correlations.py
+++ b/gn3/computations/correlations.py
@@ -9,6 +9,7 @@ from typing import Optional
 from typing import Callable
 
 import scipy.stats
+import numpy as np
 import pingouin as pg
 
 
@@ -424,24 +425,58 @@ def fast_compute_tissue_correlation(primary_tissue_dict: dict,
         key=lambda trait_name: -abs(list(trait_name.values())[0]["tissue_corr"]))
 
 
-def _mp_calculate(x_val, dataset, n_jobs, chunk_size):
+def compute_correlation_2(corr_inputs):
+
+    (this_trait_samples, target_trait) = corr_inputs
+
+    trait_name = target_trait.get("trait_id")
+    target_trait_data = target_trait["trait_sample_data"]
+
+    try:
+        (x_vals, y_vals) = list(zip(*list(filter_shared_sample_keys(
+            this_trait_samples, target_trait_data))))
+
+        x_vals = np.array(x_vals, dtype=float)
+        y_vals = np.array(y_vals, dtype=float)
+
+        if len(x_vals) > 5:
+            # remove nan values
+            nans_values = np.logical_or(np.isnan(x_vals), np.isnan(y_vals))
+
+            (corr_coeff, p_val) = scipy.stats.pearsonr(
+                x_vals[~nans_values], y_vals[~nans_values])
+
+            # print(corr_coeff, p_val)
+            return{trait_name: {
+                "corr_coefficient": corr_coeff,
+                "p_value": p_val,
+                "num_overlap": len(x_vals)
+            }}
+
+    except ValueError:
+        return
+
+
+def mp_calculate(this_trait, dataset, n_jobs: int = -1, chunk_size: int = 500):
     """corr mp reimplementation
     credit:https://github.com/bukson/nancorrmp
-    """
 
-    def _compute_correlation_2(x_val, y_val, trait_name):
-    """function to compute correlation"""
-
-    return (trait_name, scipy.stats.pearsonr(x_val, y_val))
+    """
+    this_trait_samples = this_trait["trait_sample_data"]
 
-    arguments = ((x_val, y_val, trait_name) for (trait_name, y_val) in dataset)
+    arguments = [(this_trait_samples, target_trait)
+                 for target_trait in dataset]
 
     processes = n_jobs if n_jobs > 0 else None
 
-    worker_function = _compute_correlation_2
+    chunksize = len(arguments)//processes
+
+    worker_function = compute_correlation_2
 
-    with multiprocessing.pool(processes=processes) as pool:
-        results = list(pool.imap_unordered(
-            worker_function, arguments, chunksize=chunks))
+    with multiprocessing.Pool(processes=processes) as pool:
+        corr_results = list(pool.imap_unordered(
+            worker_function, arguments, chunksize=chunksize))
 
-    return results
+    return sorted(
+        corr_results,
+        key=lambda trait_name: -abs(list(trait_name.values())[0]["corr_coefficient"]))
-- 
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