The next set of slides
provide a very short interlude on QTL mapping. You will need to do some
independent reading on this topic if this is your first exposure to QTL
mapping. The recombinant inbred strains that we are using in WebQTL and in
this particular demo were generated about 25 years ago by Dr. Ben Taylor at
The Jackson Laboratory. He crossed a female C57BL/6J mouse with a male
DBA/2J mice. At the bottom of this slide we have schematized one chromosome
pair from three out of 80 BXD RI strains.The dashed vertical lines that lead to the final BXD RI
lines involve 20 full sib matings (about 6 years of breeding). Some lines
dieout during inbreeding. For
example, there is no extant BXD3 or BXD4 strain.