<html> <head> <meta name=ProgId content=PowerPoint.Slide> <meta name=Generator content="Microsoft Macintosh PowerPoint 10"> <title>PowerPoint Presentation - Complex trait analysis, develop-ment, and genomics</title> <link title="Presentation File" type="application/powerpoint" rel=alternate href=WebQTLDemo.ppt> <script> if ( ! top.PPTPRESENTATION ) { window.location.replace( "endshow.htm" ); } </script> <meta name=Description content="Jun-19-03: WebQTL link to www.webqtl.org/search.html"> <style media=print> <!--.sld {left:0px !important; width:6.0in !important; height:4.5in !important; font-size:76% !important;} --> </style> <script language=Javascript src=script.js></script> <script language=JavaScript> function font_size() { var min = window.innerWidth/20; if ( min > window.innerHeight/20 ) min = window.innerHeight/20; return min+"pt"; } var SoundEnabled = navigator.plugins && navigator.plugins["LiveAudio"]; function restore() { self.location.reload(); } function set_size() { document.SlideLayer.width = window.innerWidth; 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myheight = 0.06 * g_height; mywidth = 0.89 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script><span style='text-align:left'><span style='font-size:68%'><i>link to <br> </i></span></span></layer><script> mytop = 0.11 * g_height; myleft = 0.04 * g_width; myheight = 0.08 * g_height; mywidth = 0.89 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script><span style='text-align:left'><span style='font-size:86%'><i>www.webqtl.org/search.html</i></span><span style='font-size:68%;mso-special-format:lastCR;display:none'><i><br> </i></span></span></layer></div> </layer></div> </layer><script> mytop = 0.36 * g_height; myleft = 0.02 * g_width; myheight = 0.45 * g_height; mywidth = 0.73 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script> <div><script> mytop = 0 * g_height; 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left:-8.06%;font-family:Times;font-size:99%'>1.</span></span><span style='font-size:94%;color:#E9EB5D;mso-color-index:3'>Discovering shared expression </span></span></layer><script> mytop = 0.05 * g_height; myleft = 0.05 * g_width; myheight = 0.06 * g_height; mywidth = 0.55 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script><span style='text-align:left'><span style='font-size:94%;color:#E9EB5D;mso-color-index: 3'>patterns<br> </span></span></layer></div> </layer><script> mytop = 0.15 * g_height; myleft = 0 * g_width; myheight = 0.11 * g_height; mywidth = 0.6 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script> <div style='mso-line-spacing:" 0 ";mso-margin-left-alt:348;mso-text-indent-alt: 56'><script> mytop = 0 * g_height; myleft = 0.05 * g_width; myheight = 0.06 * g_height; mywidth = 0.55 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script><span style='text-align:left'><span style='font-size:94%;color:#E9EB5D;mso-color-index: 3'><span style='mso-special-format:numbullet;color:#FBFDB8;position:absolute; left:-9.09%;font-family:Times;font-size:99%'>2.</span></span><span style='font-size:94%;color:#E9EB5D;mso-color-index:3'>Discovering upstream </span></span></layer><script> mytop = 0.05 * g_height; myleft = 0.05 * g_width; myheight = 0.06 * g_height; mywidth = 0.55 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script><span style='text-align:left'><span style='font-size:94%;color:#E9EB5D;mso-color-index: 3'>modulators (QTLs)<br> </span></span></layer></div> </layer><script> mytop = 0.3 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.71 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script> <div style='mso-line-spacing:" 0 ";mso-margin-left-alt:348;mso-text-indent-alt: 56'><script> mytop = 0 * g_height; myleft = 0.05 * g_width; myheight = 0.06 * g_height; mywidth = 0.66 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script><span style='text-align:left'><span style='font-size:94%;color:#E9EB5D;mso-color-index: 3'><span style='mso-special-format:numbullet;color:#FBFDB8;position:absolute; left:-7.61%;font-family:Times;font-size:99%'>3.</span></span><span style='font-size:94%;color:#E9EB5D;mso-color-index:3'>Discovering downstream targets</span></span></layer></div> </layer></div> </layer></div> </layer><script> mytop = 0.17 * g_height; myleft = 0.74 * g_width; myheight = 0.64 * g_height; mywidth = 0.23 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script> <div><script language=JavaScript><!-- xx = 0.74 * g_width; yy = 0.17 * g_height; ht = 0.64 * g_height; wd = 0.23 * g_width; document.write( '<img border=0 src="slide0015_image023.gif" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' ); //--> </script></div> </layer><script> mytop = 0.75 * g_height; myleft = 0.74 * g_width; myheight = 0.14 * g_height; mywidth = 0.1 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script> <div style='text-align:left;font-family:Verdana;font-weight:normal;font-style: normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint: no;layout-flow:horizontal;color:black;mso-color-index:1;font-size:80%; mso-text-raise:0%'><script> mytop = 0 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.1 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script> <div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt: 17'><span style='font-family:"Arial Rounded MT Bold";font-size:233%;color:#6E6E6E'>RNA</span><span style='font-family:"Arial Rounded MT Bold";font-size:300%;color:#6E6E6E; display:none'><br> </span></div> </layer><script> mytop = 0.06 * g_height; myleft = 0 * g_width; myheight = 0.07 * g_height; mywidth = 0.08 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script> <div style='mso-line-spacing:" 0 0";mso-margin-left-alt:17;mso-text-indent-alt: 17'><span style='font-family:"Arial Rounded MT Bold";font-size:300%;color:#6E6E6E; mso-special-format:lastCR;display:none'><br> </span></div> </layer></div> </layer><script> mytop = 0.82 * g_height; myleft = 0.04 * g_width; myheight = 0.18 * g_height; mywidth = 0.96 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script> <div></div> </layer><script> mytop = 0.51 * g_height; myleft = 0.47 * g_width; myheight = 0.1 * g_height; mywidth = 0.26 * g_width; document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); </script> <div><script language=JavaScript><!-- xx = 0.47 * g_width; yy = 0.51 * g_height; ht = 0.1 * g_height; wd = 0.26 * g_width; document.write( '<img border=0 src="slide0015_image024.gif" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' ); //--> </script></div> </layer></div> </LAYER> <layer> <div id=NotesObj style='display:none'> <table style='color:white' border=0 width="100%"> <tr> <td width=5 nowrap></td> <td width="100%"></td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Helvetica size=3>Part 2: Mapping upstream modulators or QTLs. A quantitative trait locus is a chromosomal region that harbors one or a few polymorphic gene loci that influence a trait. We are going to be looking for QTLs that modulate the steady state expression level of App in the adult mouse forebrain.</font><br> </td> </tr> </table> </div> </layer> <script language=JavaScript><!-- //--> </script><script language=JavaScript><!-- function playList() { } //--> </script> </body> </html>