<html> <head> <meta http-equiv=Content-Type content="text/html; charset=macintosh"> <meta name=ProgId content=PowerPoint.Slide> <meta name=Generator content="Microsoft Macintosh PowerPoint 10"> <link id=Main-File rel=Main-File href="WebQTLDemo.htm"> <title>PowerPoint Presentation - Complex trait analysis, develop-ment, and genomics</title> <link title="Presentation File" type="application/powerpoint" rel=alternate href=WebQTLDemo.ppt> <script> if ( ! top.PPTPRESENTATION ) { window.location.replace( "endshow.htm" ); } </script> <meta name=Description content="Jun-19-03: What�s downstream of Chr 2 near Hars2?"> <link rel=Stylesheet href="master03_stylesheet.css"> <style media=print> <!--.sld {left:0px !important; width:6.0in !important; height:4.5in !important; font-size:76% !important;} --> </style> <script language=JavaScript src=script.js></script><script language=JavaScript><!-- gId="slide0029.htm" if ( !parent.base.g_done && (parent.base.msie < 0 ) ) { parent.base.g_done = 1; document.location.replace( parent.base.GetHrefObj(parent.base.g_currentSlide).m_slideHref); } if( !IsNts() ) Redirect( "PPTSld", gId ); var g_hasTrans = true, g_autoTrans = false, g_transSecs = 1; //--> </script><script for=window event=onload language=JavaScript><!-- if( !IsSldOrNts() ) return; if( MakeNotesVis() ) return; LoadSld( gId ); playList();MakeSldVis(1); //--> </script> </head> <body style='margin:0px;background-color:black' onclick="DocumentOnClick(event)" onresize="_RSW()" onkeypress="_KPH(event)"> <div id=SlideObj class=sld style='position:absolute;top:0px;left:0px; width:755px;height:566px;font-size:16px;background-color:#484848;clip:rect(0%, 101%, 101%, 0%); visibility:hidden'><img src="master03_background.gif" v:shapes="_x0000_s1026" style='position:absolute;top:0%;left:0%;width:100.0%;height:100.0%'> <div style='position:absolute;top:-.35%;left:2.51%;width:96.95%;height:11.66%; filter:DropShadow(Color=#000000, OffX=2, OffY=2)'> <div class=T style='mso-line-spacing:" 0 ";position:absolute;top:16.66%; left:1.36%;width:98.77%;height:66.66%'><span style='font-size:82%'><i>What�s downstream of Chr 2 near Hars2?</i></span><span style='font-size:82%; mso-special-format:lastCR;display:none'><br> </span></div> </div> <img border=0 src="slide0029_image112.gif" style='position:absolute;top:9.54%; left:1.98%;width:83.04%;height:79.5%'> <div style='position:absolute;top:86.92%;left:2.51%;width:111.12%;height:11.66%; filter:DropShadow(Color=#000000, OffX=2, OffY=2)'> <div class=T style='mso-line-spacing:" 0 ";position:absolute;top:27.27%; left:1.19%;width:98.8%;height:51.51%'><span style='font-size:64%'><i>Notice many Chr 2 hits: Linkage disequilibrium limits specificity</i></span><span style='font-size:64%;mso-special-format:lastCR;display:none'><br> </span></div> </div> <img border=0 src="slide0029_image113.gif" style='position:absolute;top:27.03%; left:7.01%;width:22.38%;height:17.49%'> <div class=O style='position:absolute;top:24.73%;left:27.68%;width:16.82%; height:4.24%'><span style='font-size:150%;color:#FF0F0F'><b>Click here</b></span></div> <img border=0 src="slide0029_image114.gif" style='position:absolute;top:39.22%; left:48.21%;width:12.18%;height:5.47%'></div> <div id=NotesObj style='display:none'> <table style='color:white' border=0 width="100%"> <tr> <td width=5 nowrap></td> <td width="100%"></td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>The marker D2Mit423 correlates moderately well with a number of Chr 2 transcripts. This is due to linkage disequilibrium. These correlations are not due to a molecular interactions other than being close together on a chromosome.<span style="mso-spacerun: yes"> </span>But we have circled one transcript, actinin alpha 2, that has a moderately good correlation (0.59) with D2Mit423. If we map this gene we expect to find a suggestive QTL that peaks near D2Mit423</font><br> </td> </tr> </table> </div> <script language=JavaScript><!-- function playList() { } //--> </script> </body> </html>