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  <td align=left colspan=1><font face=Helvetica size=3>Part 3.<span
  style="mso-spacerun: yes">&nbsp; </span>Many investigators would like to
  discover the set of downstream targets of a gene of interest.</font><br>
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  <td align=left colspan=1><font face=Helvetica size=3>In a genetic and
  functional sense, that question can only be addressed effectively if there is
  genetic variation in the particular gene.<span style="mso-spacerun:
  yes">&nbsp; </span>We know that Fos is an important transcription factor, but
  unless it is polymorphic between C57BL/6J and DBA/2J, then it cannot generate
  a genetic variance signal with which we can work. We can still study
  covariance of Fos and hundreds of other transcripts (an interesting
  exercise), but there are no genetic causes-and-effects.</font><br>
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