<html> <head> <meta http-equiv=Content-Type content="text/html; charset=macintosh"> <meta name=ProgId content=PowerPoint.Slide> <meta name=Generator content="Microsoft Macintosh PowerPoint 10"> <link id=Main-File rel=Main-File href="WebQTLDemo.htm"> <title>PowerPoint Presentation - Complex trait analysis, develop-ment, and genomics</title> <link title="Presentation File" type="application/powerpoint" rel=alternate href=WebQTLDemo.ppt> <script> if ( ! top.PPTPRESENTATION ) { window.location.replace( "endshow.htm" ); } </script> <meta name=Description content="Jun-19-03: Is there known biology to link Hars2 with App? "> <link rel=Stylesheet href="master03_stylesheet.css"> <style media=print> <!--.sld {left:0px !important; width:6.0in !important; height:4.5in !important; font-size:76% !important;} --> </style> <script language=JavaScript src=script.js></script><script language=JavaScript><!-- gId="slide0025.htm" if ( !parent.base.g_done && (parent.base.msie < 0 ) ) { parent.base.g_done = 1; document.location.replace( parent.base.GetHrefObj(parent.base.g_currentSlide).m_slideHref); } if( !IsNts() ) Redirect( "PPTSld", gId ); var g_hasTrans = true, g_autoTrans = false, g_transSecs = 1; //--> </script><script for=window event=onload language=JavaScript><!-- if( !IsSldOrNts() ) return; if( MakeNotesVis() ) return; LoadSld( gId ); playList();MakeSldVis(1); //--> </script> </head> <body style='margin:0px;background-color:black' onclick="DocumentOnClick(event)" onresize="_RSW()" onkeypress="_KPH(event)"> <div id=SlideObj class=sld style='position:absolute;top:0px;left:0px; width:755px;height:566px;font-size:16px;background-color:#484848;clip:rect(0%, 101%, 101%, 0%); visibility:hidden'><img src="master03_background.gif" v:shapes="_x0000_s1026" style='position:absolute;top:0%;left:0%;width:100.0%;height:100.0%'> <div style='position:absolute;top:-3.53%;left:2.11%;width:96.42%;height:18.55%; filter:DropShadow(Color=#000000, OffX=2, OffY=2)'> <div class=T style='mso-line-spacing:" 0 ";mso-margin-left-alt:232; mso-text-indent-alt:0;position:absolute;top:30.47%;left:.96%;width:97.39%; height:35.23%'><span style='font-size:68%'><i>Is there known biology to link Hars2 with App? </i></span></div> </div> <div style='position:absolute;top:82.15%;left:4.1%;width:96.42%;height:18.55%; filter:DropShadow(Color=#000000, OffX=2, OffY=2)'></div> <div class=O style='position:absolute;top:62.54%;left:5.16%;width:29.13%; height:12.36%'> <div style='position:absolute;top:0%;left:0%;width:100.0%;height:34.28%'><span style='font-size:150%;color:#E9EB5D;mso-color-index:3'><b>69 SNPs, 1 cSNP: <br> </b></span></div> <div style='position:absolute;top:32.85%;left:0%;width:96.81%;height:34.28%'><span style='font-size:150%;color:#E9EB5D;mso-color-index:3'><b>6 exons in NCBI, <br> </b></span></div> <div style='position:absolute;top:65.71%;left:0%;width:100.0%;height:34.28%'><span style='font-size:150%;color:#E9EB5D;mso-color-index:3'><b>2 exons in Celera</b></span></div> </div> <img border=0 src="slide0025_image105.gif" style='position:absolute;top:9.54%; left:3.31%;width:60.79%;height:42.57%'><img border=0 src="slide0025_image106.gif" style='position:absolute;top:28.62%;left:40.0%; width:55.76%;height:69.78%'> <div class=O style='position:absolute;top:14.13%;left:69.4%;width:23.84%; height:6.53%'><span style='font-family:"Gill Sans";font-size:250%;color:#E9EB5D'><i><span style="mso-spacerun: yes"> </span>Not obvious</i></span></div> </div> <div id=NotesObj style='display:none'> <table style='color:white' border=0 width="100%"> <tr> <td width=5 nowrap></td> <td width="100%"></td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Helvetica size=3>Hars2 is not a well characterized gene and their is no biology yet to support the hypothesis that Hars2 modulates gene expression, let alone App expression in specific. There are also serious database/assembly discrepancies between Celera and MGSCv3 regarding the genomic organization of this gene. But there appear to be approximately 69 SNPs in Hars2, one of which results in a substitution.</font><br> </td> </tr> </table> </div> <script language=JavaScript><!-- function playList() { } //--> </script> </body> </html>