<html> <head> <meta http-equiv=Content-Type content="text/html; charset=macintosh"> <meta name=ProgId content=PowerPoint.Slide> <meta name=Generator content="Microsoft Macintosh PowerPoint 10"> <link id=Main-File rel=Main-File href="WebQTLDemo.htm"> <title>PowerPoint Presentation - Complex trait analysis, develop-ment, and genomics</title> <link title="Presentation File" type="application/powerpoint" rel=alternate href=WebQTLDemo.ppt> <script> if ( ! top.PPTPRESENTATION ) { window.location.replace( "endshow.htm" ); } </script> <meta name=Description content=Jun-19-03> <link rel=Stylesheet href="master03_stylesheet.css"> <style media=print> <!--.sld {left:0px !important; width:6.0in !important; height:4.5in !important; font-size:76% !important;} --> </style> <script language=JavaScript src=script.js></script><script language=JavaScript><!-- gId="slide0022.htm" if ( !parent.base.g_done && (parent.base.msie < 0 ) ) { parent.base.g_done = 1; document.location.replace( parent.base.GetHrefObj(parent.base.g_currentSlide).m_slideHref); } if( !IsNts() ) Redirect( "PPTSld", gId ); var g_hasTrans = true, g_autoTrans = false, g_transSecs = 1; //--> </script><script for=window event=onload language=JavaScript><!-- if( !IsSldOrNts() ) return; if( MakeNotesVis() ) return; LoadSld( gId ); playList();MakeSldVis(1); //--> </script> </head> <body style='margin:0px;background-color:black' onclick="DocumentOnClick(event)" onresize="_RSW()" onkeypress="_KPH(event)"> <div id=SlideObj class=sld style='position:absolute;top:0px;left:0px; width:755px;height:566px;font-size:16px;background-color:#484848;clip:rect(0%, 101%, 101%, 0%); visibility:hidden'><img src="master03_background.gif" v:shapes="_x0000_s1026" style='position:absolute;top:0%;left:0%;width:100.0%;height:100.0%'> <div style='position:absolute;top:1.59%;left:3.97%;width:104.1%;height:13.78%; filter:DropShadow(Color=#000000, OffX=4, OffY=4)'> <div class=O style='mso-line-spacing:" 0 0";mso-margin-left-alt:16;mso-text-indent-alt: 16;position:absolute;top:1.28%;left:1.27%;width:98.72%;height:88.46%'><span style='position:absolute;top:0%;left:0%;width:100.0%'><span style='font-size: 233%;color:#E9EB5D'><i>Only one of these candidates is a functional </i></span></span><span style='position:absolute;top:46.37%;left:0%;width:85.69%'><span style='font-size:233%;color:#E9EB5D'><i>polymorphism</i></span></span></div> </div> <img border=0 src="slide0022_image092.gif" style='position:absolute;top:15.54%; left:2.64%;width:41.98%;height:84.45%'><img border=0 src="slide0022_image093.gif" style='position:absolute;top:31.44%;left:26.09%; width:27.15%;height:5.83%'> <div class=O style='position:absolute;top:28.09%;left:54.3%;width:50.06%; height:21.73%'> <div style='position:absolute;top:0%;left:0%;width:100.0%;height:25.2%'><span style='font-size:200%;color:#E9EB5D'><i>Hars2 = 0610006H08Rik<br> </i></span></div> <span style='position:absolute;top:24.39%;left:0%;width:94.7%'><span style='font-size:200%;color:#E9EB5D'><i>is a cis-QTL with a very </i></span></span><span style='position:absolute;top:49.59%;left:0%;width:84.39%'><span style='font-size:200%;color:#E9EB5D'><i>high likelihood ratio </i></span></span><span style='position:absolute;top:73.98%;left:0%;width:84.39%'><span style='font-size:200%;color:#E9EB5D'><i>statistic (LRS) score</i></span><span style='font-size:267%;color:#E9EB5D;mso-special-format:lastCR;display:none'><i><br> </i></span></span></div> </div> <div id=NotesObj style='display:none'> <table style='color:white' border=0 width="100%"> <tr> <td width=5 nowrap></td> <td width="100%"></td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Helvetica size=3>When you do this you will find that only the transcript 0610006H08Rik has a strong cis QTL. See the slide above. The LRS peaks above 35<span style="mso-spacerun: yes"> </span>(LOD of greater than 7.5). It turns out that this transcript is really Hars2, also known as histydl tRNA synthase 2.</font><br> </td> </tr> </table> </div> <script language=JavaScript><!-- function playList() { } //--> </script> </body> </html>