<html> <head> <meta http-equiv=Content-Type content="text/html; charset=macintosh"> <meta name=ProgId content=PowerPoint.Slide> <meta name=Generator content="Microsoft Macintosh PowerPoint 10"> <link id=Main-File rel=Main-File href="WebQTLDemo.htm"> <title>PowerPoint Presentation - Complex trait analysis, develop-ment, and genomics</title> <link title="Presentation File" type="application/powerpoint" rel=alternate href=WebQTLDemo.ppt> <script> if ( ! top.PPTPRESENTATION ) { window.location.replace( "endshow.htm" ); } </script> <meta name=Description content="Jun-19-03: The whole neighborhood is modulated!"> <link rel=Stylesheet href="master03_stylesheet.css"> <style media=print> <!--.sld {left:0px !important; width:6.0in !important; height:4.5in !important; font-size:76% !important;} --> </style> <script language=JavaScript src=script.js></script><script language=JavaScript><!-- gId="slide0020.htm" if ( !parent.base.g_done && (parent.base.msie < 0 ) ) { parent.base.g_done = 1; document.location.replace( parent.base.GetHrefObj(parent.base.g_currentSlide).m_slideHref); } if( !IsNts() ) Redirect( "PPTSld", gId ); var g_hasTrans = true, g_autoTrans = false, g_transSecs = 1; //--> </script><script for=window event=onload language=JavaScript><!-- if( !IsSldOrNts() ) return; if( MakeNotesVis() ) return; LoadSld( gId ); playList();MakeSldVis(1); //--> </script> </head> <body style='margin:0px;background-color:black' onclick="DocumentOnClick(event)" onresize="_RSW()" onkeypress="_KPH(event)"> <div id=SlideObj class=sld style='position:absolute;top:0px;left:0px; width:755px;height:566px;font-size:16px;background-color:#484848;clip:rect(0%, 101%, 101%, 0%); visibility:hidden'><img src="master03_background.gif" v:shapes="_x0000_s1026" style='position:absolute;top:0%;left:0%;width:100.0%;height:100.0%'> <div style='position:absolute;top:2.29%;left:4.1%;width:105.82%;height:9.01%; filter:DropShadow(Color=#000000, OffX=2, OffY=2)'> <div class=T style='mso-line-spacing:" 0 ";position:absolute;top:11.76%; left:1.25%;width:98.87%;height:82.35%'><span style='font-family:Verdana; font-size:73%'><i>The whole neighborhood is modulated!</i></span></div> </div> <img border=0 src="slide0020_image088.gif" style='position:absolute;top:13.07%; left:9.53%;width:80.79%;height:80.38%'></div> <div id=NotesObj style='display:none'> <table style='color:white' border=0 width="100%"> <tr> <td width=5 nowrap></td> <td width="100%"></td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>App has a suggestive QTL on Chr 2. What about the neighbors that we defined as having shared expression patterns. This figure shows that members of the immediate App neigborhood share a weak Chr 2 QTL.<span style="mso-spacerun: yes"> </span>That is what the blue oval in the background is meant to represent. But some transcripts, such as Ndr4 and Psen2 do not share this Chr 2 interval.</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>QUESTION: What kind of headway can we make in detemining what polymorphism or polymorphisms on Chr 2 near 130 Mb might contribute to the variance in the expression of all of these important transcripts?</font><br> </td> </tr> </table> </div> <script language=JavaScript><!-- function playList() { } //--> </script> </body> </html>