The DGRP is a community resource for association mapping of quantitative trait loci. The same strains can be evaluated for multiple complex traits, including ‘intermediate’ phenotypes such as whole genome transcript abundance and quantitative variation in the proteome and metabolome. This will facilitate a systems genetics approach for understanding the genetic architecture of complex traits in an economical genetic model organism. Interrogating a common resource population for genetic variation at multiple levels, traits, and environments will provide an unprecedented opportunity to quantify genetic correlations and pleiotropy among traits, as well as to quantify the magnitude and nature of genotype by environment interaction. A sample of 192 strains has the power to detect intermediate frequency variants with moderately small to large effects on complex traits.
The DGRP is a community resource of common Drosophila sequence polymorphisms (SNPs and indels) with a minor allele frequency (MAF) of 0.02 or greater. These variants will be valuable for high resolution QTL mapping as well as mapping alleles of major effect, molecular population genetic analyses, and allele specific transcription studies.
The DGRP can also be used to identify extreme lines for QTL mapping – the lines are already inbred and therefore can be used immediately to construct mapping populations. They can also be used as a base population for artificial selection experiments, in which lines can be derived with trait phenotypes that greatly exceed the range of the base population.
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