UCLA BHF2 Adipose (June05) mlratio

Accession number: GN165

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Summary:
This June 2005 data freeze provides estimate of mRNA expression in (adult?) brains of F2 intercross mice (C57BL/6J x C3H/HeJ) on ApoE null backgrouds, measured using Agilent microarray pairs. Data were generated at The Univesity of California Los Angeles (UCLA), by Jake Lusis and Thomas Drake. Data were processed using mlratio method developed by He and colleagues (2003 -- Paper with He and Schadt).

The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat "Western" diet from 8-24 weeks of age. These have been genotyped for QTL mapping, and various phenotypes measured.

Adipose from 295 F2 female and male mice (animals fed a high fat "Western" diet from 8-24 weeks of age.) derived from C57BL/6J and C3H/HeJ parental strains with both on ApoE null backgrounds. All samples were compared to a common pool created from equal portions of RNA from each of the samples. Keywords=Genetics of Gene Expression Keywords=C57BL/6J Keywords=C3H/HeJ

Contributors:
Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, Drake TA, Lusis AJ

Citation:
Yang X, Schadt EE, Wang S, Wang H et al. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res 2006 Aug;16(8):995-1004. PMID: 16825664
Chen Y, Zhu J, Lum PY, Yang X et al. Variations in DNA elucidate molecular networks that cause disease. Nature 2008 Mar 27;452(7186):429-35. PMID: 18344982