Stuart CXB Mouse Spleen Normative Affy M430 2.0 (Nov 2007) RMA data set modify this page

Accession number: GN153

This is a new and untested data set from John Stuart and colleagues, VA Medical Center, Memphis, TN.

Please contact Rob Williams (rwilliam@nb.utmem.edu) for access.

The recombinant inbred CXB (BALB/cBy x C57BL/6By) RI set have often been used to study the influence of non-H-2 chromosomal regions on the progression of collagen-induced arthritis (CIA). C57BL/6By mice are of intermediate susceptibility to CIA while BALB/cBy mice are resistant, but are highly susceptible to proteoglycan-induced arthritis. While antigen presentation is H-2 directed, the amount of disease that results is thought to be driven by regions outside of the MHC. CXB strains that are H-2b are predicted to show variation in the frequency and severity of disease relative to C57BL/6By, depending on which BALB/cBy chromosome regions are present. Nine of thirteen CXB strains are H-2b (2, 3, 5, 6, 7, 8, 10, 11 and 13) while one has a recombined H-2 region (CXB9). The four H-2d strains were crossed with C57Bl/6ByJ to generate F1 mice that could present collagen via the B allele at the H-2b locus, while possibly identifying BALB/cBy alleles that would have a dominant effect on disease progression. A number of disease and immunological parameters were collected. (text from Dana Marshall, Jan 2008)

Gene expression analysis was performed using samples from resting naive spleens from adult female adult mice. Information on these cases is provided below.

Index Tube ID RNA ID Strain Age Source Pool size
1R2440S1R2440SBALB/cByJ60UTHSCn/a
2R2435S1R2435SBALB/cByJ83JAXn/a
3R2394S1R2394SC57BL/6BYJ51JAXn/a
4R2395S1R2395SC57BL/6BYJ51JAXn/a
5R2410S1R2410SCXB155JAXn/a
6R2655S1R2655SCXB158JAXn/a
7R2392S1R2392SCXB253JAXn/a
8R2393S1R2393SCXB253JAXn/a
9R2430S1R2430SCXB341JAXn/a
10R2412S1R2412SCXB347JAXn/a
11R2432S1R2432SCXB447JAXn/a
12R2413S1R2413SCXB458JAXn/a
13R2441S1R2441SCXB567UTHSCn/a
14R2444S1R2444SCXB580UTHSCn/a
15R2437S1R2437SCXB647JAXn/a
16R2414S1R2414SCXB649JAXn/a
17R2416S1R2416SCXB758JAXn/a
18R2415S1R2415SCXB763JAXn/a
19R2418S1R2418SCXB841JAXn/a
20R2417S1R2417SCXB854JAXn/a
21R2420S1R2420SCXB953JAXn/a
22R2419S1R2419SCXB954JAXn/a
23R2422S1R2422SCXB1048JAXn/a
24R2421S1R2421SCXB1053JAXn/a
25R2423S1R2423SCXB1158JAXn/a
26R2424S1R2424SCXB1177JAXn/a
27R2425S1R2425SCXB1247JAXn/a
28R2442S1R2442SCXB1276UTHSCn/a
29R2427S1R2427SCXB1349JAXn/a
30R2426S1R2426SCXB1356JAXn/a