<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN"> <HTML><HEAD><TITLE>NCSU Drosophila Whole Body (Jan11) RMA</TITLE> <META http-equiv=Content-Type content="text/html; charset=iso-8859-1"> <LINK REL="stylesheet" TYPE="text/css" HREF='/css/general.css'> <LINK REL="stylesheet" TYPE="text/css" HREF='/css/menu.css'> <link rel="stylesheet" media="all" type="text/css" href="/css/tabbed_pages.css" /> <SCRIPT SRC="/javascript/webqtl.js"></SCRIPT> <SCRIPT SRC="/javascript/dhtml.js"></SCRIPT> <script src="/javascript/tabbed_pages.js" type="text/javascript"></script> </HEAD> <BODY bottommargin="2" leftmargin="2" rightmargin="2" topmargin="2" text=#000000 bgColor=#ffffff > <TABLE cellSpacing=5 cellPadding=4 width="100%" border=0> <TBODY> <TR> <script language="JavaScript" src="/javascript/header.js"></script> </TR> <TR> <TD bgColor=#eeeeee class="solidBorder"> <Table width= "100%" cellSpacing=0 cellPadding=5> <TR> <!-- split from Here --> <!-- Body Start from Here --> <P class="title">NCSU Drosophila Whole Body (Jan11) RMA <BR>Accession number: <A HREF="/webqtl/main.py?FormID=sharinginfo&GN_AccessionId=297">GN297</A> <A HREF="/webqtl/main.py?FormID=editHtml"> <img src="/images/modify.gif" alt="modify this page" border= 0 valign="middle"></A></P> <blockquote> <p class="subtitle">Summary:</p> <p>Determining the genetic architecture of complex traits is challenging because phenotypic variation arises from interactions between multiple, environmentally sensitive alleles. We quantified genomewide transcript abundance and phenotypes for six ecologically relevant traits in D. melanogaster wild-derived inbred lines. We observed 10,096 genetically variable transcripts and high heritabilities for all organismal phenotypes. The transcriptome is highly genetically inter-correlated, forming 241 transcriptional modules. Modules are enriched for transcripts in common pathways, gene ontology categories, tissue-specific expression, and transcription factor binding sites. The high transcriptional connectivity allows us to infer genetic networks and the function of predicted genes based on annotations of other genes in the network. Regressions of organismal phenotypes on transcript abundance implicate several hundred candidate genes that form modules of biologically meaningful correlated transcripts affecting each phenotype. Overlapping transcripts in modules associated with different traits provides insight into the molecular basis of pleiotropy between complex traits.<br> <A HREF="http://www.nature.com/ng/journal/v41/n3/abs/ng.332.html" target="_blank">Full Article</A></p> <p class="subtitle">Animals and Tissue Used to Generate This Set of Data:</p> <p>The raw microarray data are deposited in the ArrayExpress database (<A HREF="http://www.ebi.ac.uk/arrayexpress/browse.html?keywords=E-MEXP-1594&expandefo=on">www.ebi.ac.uk/arrayexpress,</A>) under accession number E-MEXP-1594</p> </blockquote> </TR></TABLE> </TD> </TR> <TR> <TD align=center bgColor=#ddddff class="solidBorder"> <!--Start of footer--> <TABLE width="90%"> <script language='JavaScript' src='/javascript/footer.js'></script> <TR> <TD colspan=3 class="fs12"> <UL> </UL> </TD> </TR> </TABLE> <!--End of footer--> </TD> </TR> </TABLE> <!-- /Footer --> <!-- menu script itself. you should not modify this file --> <script language="JavaScript" src="/javascript/menu_new.js"></script> <!-- items structure. menu hierarchy and links are stored there --> <script language="JavaScript" src="/javascript/menu_items.js"></script> <!-- files with geometry and styles structures --> <script language="JavaScript" src="/javascript/menu_tpl.js"></script> <script language="JavaScript"> <!--// // Note where menu initialization block is located in HTML document. // Don't try to position menu locating menu initialization block in // some table cell or other HTML element. Always put it before </body> // each menu gets two parameters (see demo files) // 1. items structure // 2. geometry structure new menu (MENU_ITEMS, MENU_POS); // make sure files containing definitions for these variables are linked to the document // if you got some javascript error like "MENU_POS is not defined", then you've made syntax // error in menu_tpl.js file or that file isn't linked properly. // also take a look at stylesheets loaded in header in order to set styles //--> </script> </BODY> </HTML>