HXB/BXH Rat Published Phenotypes

The HXB/BXH Phenotype data set was assembled by Michal Pravenec and Robert Williams in 2004. We thank Pierre Mormede for adding dat for a number of very useful traits.

The HXB/BXH recombinant inbred strains of rats were derived from a cross between the spontaneously hypertensive rat (SHR/OlaIpcv = H) and Brown Norway (BN.Lx/Cub or BN = B). The HXB strains were generated by Michal Pravenec at the Institute of Physiology, Czech Academy of Sciences. The BXH strains were generated by Vladimir Kren (see Pravenec et al. 1989, 2004) at a similar animal facility at the Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University. As of 2003, most of these strains have been inbred for 60 or more generations (F60).

Acknowledgments:

The HXB strains were generated by M Pravenec, V Kren and colleagues. For additional details please contact Dr. Michal Pravenec, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic. Phone: +(420)241062297; E-mail: pravenec@biomed.cas.cz

Jirout M, Krenova D, Kren V, Breen L, Pravenec M, Schork NJ, Printz MP (2003) A new framework marker-based linkage map and SDPs for the rat HXB/BXH strain set. expression differences in mice diverently selected for methamphetamine sensitivity. Mammalian Genome 14:537-546.

Pravenec M, Kren V (2004) Genetic analysis of complex cardiovascular traits in the spontaneously hypertensive rat. Experimental Physiology 90:273-276.