From d0911a04958a04042da02a334ccc528dae79cc17 Mon Sep 17 00:00:00 2001
From: zsloan
Date: Fri, 27 Mar 2015 20:28:51 +0000
Subject: Removed everything from 'web' directory except genofiles and renamed
the directory to 'genotype_files'
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PowerPoint Presentation - Complex trait analysis, develop-ment, and
genomics
WebQTL link
to www.webqtl.org/search.html
1.Discovering shared expression patterns
2.Discovering upstream modulators (QTLs)
3.Discovering downstream targets
Part 3.Many investigators would like to
discover the set of downstream targets of a gene of interest.
In a genetic and
functional sense, that question can only be addressed effectively if there is
genetic variation in the particular gene.We know that Fos is an important transcription factor, but
unless it is polymorphic between C57BL/6J and DBA/2J, then it cannot generate
a genetic variance signal with which we can work. We can still study
covariance of Fos and hundreds of other transcripts (an interesting
exercise), but there are no genetic causes-and-effects.
