From e3b27c18f379e969c06f8e0b79daf8b762d4fc1d Mon Sep 17 00:00:00 2001 From: zsloan Date: Mon, 6 Nov 2017 22:05:28 +0000 Subject: Replaced Histogram and Bar Chart with Plotly version and added new Box Plot with Plotly GEMMA now has option to select genotypes Updated dataset select dropdowns to be ordered correctly Fixed dataset select dropdowns for correlations to not show confidential datasets Added Skewness and Kurtosis to Basic Statistics table Fixed Verify and RNA-seq buttons on trait page Temporarily hardcoded Reference page until we get it to link with database --- wqflask/base/data_set.py | 9 +- wqflask/base/webqtlConfig.py | 1 + wqflask/maintenance/gen_select_dataset.py | 2 +- wqflask/wqflask/correlation/show_corr_results.py | 3 + .../interval_analyst/IntervalAnalystPage.py | 405 ------------ wqflask/wqflask/marker_regression/gemma_mapping.py | 53 +- .../marker_regression/marker_regression_gn1.py | 28 +- wqflask/wqflask/show_trait/show_trait.py | 73 ++- .../new/javascript/dataset_menu_structure.json | 192 +++--- .../wqflask/static/new/javascript/show_trait.js | 251 +++++++- .../new/javascript/show_trait_mapping_tools.js | 2 + wqflask/wqflask/static/new/javascript/stats.js | 63 ++ .../static/new/js_external/plotly-latest.min.js | 80 +++ .../static/packages/bootstrap/css/bootstrap.css | 2 +- wqflask/wqflask/templates/base.html | 2 +- wqflask/wqflask/templates/reference.html | 699 ++++++++++++--------- wqflask/wqflask/templates/show_trait.html | 1 + .../templates/show_trait_mapping_tools.html | 24 + .../wqflask/templates/show_trait_statistics.html | 22 +- wqflask/wqflask/views.py | 5 +- 20 files changed, 1054 insertions(+), 863 deletions(-) delete mode 100644 wqflask/wqflask/interval_analyst/IntervalAnalystPage.py create mode 100644 wqflask/wqflask/static/new/js_external/plotly-latest.min.js diff --git a/wqflask/base/data_set.py b/wqflask/base/data_set.py index dbdbb51c..6649f8af 100644 --- a/wqflask/base/data_set.py +++ b/wqflask/base/data_set.py @@ -111,7 +111,7 @@ Publish or ProbeSet. E.g. new_type = "ProbeSet" self.datasets[short_dataset_name] = new_type # Set LOG_LEVEL_DEBUG=5 to see the following: - logger.debugf(5,"datasets",self.datasets) + logger.debugf(5, "datasets",self.datasets) def __call__(self, name): return self.datasets[name] @@ -426,13 +426,15 @@ def datasets(group_name, this_group = None): FROM PublishFreeze,InbredSet WHERE PublishFreeze.InbredSetId = InbredSet.Id and InbredSet.Name = '%s' - and PublishFreeze.public > %s) + and PublishFreeze.public > %s + and PublishFreeze.confidentiality < 1) UNION (SELECT '#GenoFreeze',GenoFreeze.FullName,GenoFreeze.Name FROM GenoFreeze, InbredSet WHERE GenoFreeze.InbredSetId = InbredSet.Id and InbredSet.Name = '%s' - and GenoFreeze.public > %s) + and GenoFreeze.public > %s + and GenoFreeze.confidentiality < 1) UNION (SELECT Tissue.Name, ProbeSetFreeze.FullName,ProbeSetFreeze.Name FROM ProbeSetFreeze, ProbeFreeze, InbredSet, Tissue @@ -441,6 +443,7 @@ def datasets(group_name, this_group = None): and ProbeFreeze.InbredSetId = InbredSet.Id and InbredSet.Name like %s and ProbeSetFreeze.public > %s + and ProbeSetFreeze.confidentiality < 1 ORDER BY Tissue.Name, ProbeSetFreeze.CreateTime desc, ProbeSetFreeze.AvgId) ''' % (group_name, webqtlConfig.PUBLICTHRESH, group_name, webqtlConfig.PUBLICTHRESH, diff --git a/wqflask/base/webqtlConfig.py b/wqflask/base/webqtlConfig.py index c3f1e76a..1ef2bc26 100644 --- a/wqflask/base/webqtlConfig.py +++ b/wqflask/base/webqtlConfig.py @@ -49,6 +49,7 @@ PUBMEDLINK_URL = "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= UCSC_POS = "http://genome.ucsc.edu/cgi-bin/hgTracks?clade=mammal&org=%s&db=%s&position=chr%s:%s-%s&pix=800&Submit=submit" UCSC_BLAT = 'http://genome.ucsc.edu/cgi-bin/hgBlat?org=%s&db=%s&type=0&sort=0&output=0&userSeq=%s' UTHSC_BLAT = 'http://ucscbrowser.genenetwork.org/cgi-bin/hgBlat?org=%s&db=%s&type=0&sort=0&output=0&userSeq=%s' +UTHSC_BLAT2 = 'http://ucscbrowserbeta.genenetwork.org/cgi-bin/hgBlat?org=%s&db=%s&type=0&sort=0&output=0&userSeq=%s' UCSC_GENOME = "http://genome.ucsc.edu/cgi-bin/hgTracks?db=%s&position=chr%s:%d-%d&hgt.customText=http://web2qtl.utmem.edu:88/snp/chr%s" ENSEMBLE_BLAT = 'http://www.ensembl.org/Mus_musculus/featureview?type=AffyProbe&id=%s' DBSNP = 'http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=%s' diff --git a/wqflask/maintenance/gen_select_dataset.py b/wqflask/maintenance/gen_select_dataset.py index a5fd86e2..6553f090 100644 --- a/wqflask/maintenance/gen_select_dataset.py +++ b/wqflask/maintenance/gen_select_dataset.py @@ -251,7 +251,7 @@ def build_datasets(species, group, type_name): ProbeSetFreeze.ProbeFreezeId = ProbeFreeze.Id and Tissue.Name = '%s' and ProbeFreeze.TissueId = Tissue.Id and ProbeFreeze.InbredSetId = InbredSet.Id and ProbeSetFreeze.confidentiality < 1 and ProbeSetFreeze.public > 0 order by - ProbeSetFreeze.CreateTime desc""" % (species, group, type_name)) + ProbeSetFreeze.OrderList asc""" % (species, group, type_name)) dataset_results = Cursor.fetchall() datasets = [] diff --git a/wqflask/wqflask/correlation/show_corr_results.py b/wqflask/wqflask/correlation/show_corr_results.py index 7957e643..24432ad0 100644 --- a/wqflask/wqflask/correlation/show_corr_results.py +++ b/wqflask/wqflask/correlation/show_corr_results.py @@ -58,6 +58,9 @@ from pprint import pformat as pf from flask import Flask, g +import utility.logger +logger = utility.logger.getLogger(__name__ ) + METHOD_SAMPLE_PEARSON = "1" METHOD_SAMPLE_RANK = "2" METHOD_LIT = "3" diff --git a/wqflask/wqflask/interval_analyst/IntervalAnalystPage.py b/wqflask/wqflask/interval_analyst/IntervalAnalystPage.py deleted file mode 100644 index c5cf9e7f..00000000 --- a/wqflask/wqflask/interval_analyst/IntervalAnalystPage.py +++ /dev/null @@ -1,405 +0,0 @@ -# Copyright (C) University of Tennessee Health Science Center, Memphis, TN. -# -# This program is free software: you can redistribute it and/or modify it -# under the terms of the GNU Affero General Public License -# as published by the Free Software Foundation, either version 3 of the -# License, or (at your option) any later version. -# -# This program is distributed in the hope that it will be useful, -# but WITHOUT ANY WARRANTY; without even the implied warranty of -# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. -# See the GNU Affero General Public License for more details. -# -# This program is available from Source Forge: at GeneNetwork Project -# (sourceforge.net/projects/genenetwork/). -# -# Contact Drs. Robert W. Williams and Xiaodong Zhou (2010) -# at rwilliams@uthsc.edu and xzhou15@uthsc.edu -# -# -# -# This module is used by GeneNetwork project (www.genenetwork.org) -# -# Created by GeneNetwork Core Team 2010/08/10 -# -# Last updated by GeneNetwork Core Team 2010/10/20 - -from mod_python import apache, util, Cookie -import os -import time -import pyXLWriter as xl - -from htmlgen import HTMLgen2 as HT - -import GeneUtil -from base.templatePage import templatePage -from utility import webqtlUtil -from base import webqtlConfig - - -class IntervalAnalystPage(templatePage): - filename = webqtlUtil.genRandStr("Itan_") - - _scriptfile = "main.py?FormID=intervalAnalyst" - - #A dictionary that lets us map the html form names "txStart_mm6" -> "Mb Start (mm8)" - #the first item is the short name (column headers) and the second item is the long name (dropdown list) - # [short name, long name, category] - columnNames = {"GeneSymbol" : ["Gene", "Gene Name", 'gene'], - "GeneDescription" : ["Description", "Gene Description", 'species'], - 'GeneNeighborsCount' : ["Neighbors", "Gene Neighbors", 'gene'], - 'GeneNeighborsRange' : ["Neighborhood", "Gene Neighborhood (Mb)", 'gene'], - 'GeneNeighborsDensity' : ["Gene Density", "Gene Density (Neighbors/Mb)", 'gene'], - "ProteinID" : ["Prot ID", "Protein ID", 'protein'], - "Chromosome" : ["Chr", "Chromosome", 'species'], - "TxStart" : ["Start", "Mb Start", 'species'], - "TxEnd" : ["End", "Mb End", 'species'], - "GeneLength" : ["Length", "Kb Length", 'species'], - "cdsStart" : ["CDS Start", "Mb CDS Start", 'species'], - "cdsEnd" : ["CDS End", "Mb CDS End", 'species'], - "exonCount" : ["Num Exons", "Exon Count", 'species'], - "exonStarts" : ["Exon Starts", "Exon Starts", 'species'], - "exonEnds" : ["Exon Ends", "Exon Ends", 'species'], - "Strand" : ["Strand", "Strand", 'species'], - "GeneID" : ["Gene ID", "Gene ID", 'species'], - "GenBankID" : ["GenBank", "GenBank ID", 'species'], - "UnigenID" : ["Unigen", "Unigen ID", 'species'], - "NM_ID" : ["NM ID", "NM ID", 'species'], - "kgID" : ["kg ID", "kg ID", 'species'], - "snpCount" : ["SNPs", "SNP Count", 'species'], - "snpDensity" : ["SNP Density", "SNP Density", 'species'], - "lrs" : ["LRS", "Likelihood Ratio Statistic", 'misc'], - "lod" : ["LOD", "Likelihood Odds Ratio", 'misc'], - "pearson" : ["Pearson", "Pearson Product Moment", 'misc'], - "literature" : ["Lit Corr", "Literature Correlation", 'misc'], - } - - ###Species Freeze - speciesFreeze = {'mouse':'mm9', 'rat':'rn3', 'human':'hg19'} - for key in speciesFreeze.keys(): - speciesFreeze[speciesFreeze[key]] = key - - def __init__(self, fd): - - templatePage.__init__(self, fd) - - fd.formdata['remote_ip'] = fd.remote_ip - if not self.openMysql(): - return - - self.species = fd.formdata.getvalue("species", "mouse") - try: - self.startMb = float(fd.formdata.getvalue("startMb")) - except: - self.startMb = 10 - try: - self.endMb = float(fd.formdata.getvalue("endMb")) - except: - self.endMb = self.startMb + 10 - - self.Chr = fd.formdata.getvalue("chromosome", "1") - self.xls = fd.formdata.getvalue("xls", "1") - try: - s1 = int(fd.formdata.getvalue("s1")) - s2 = int(fd.formdata.getvalue("s2")) - self.diffColDefault = self.diffCol = [s1, s2] - except: - self.diffColDefault = self.diffCol = [] - if self.species != 'mouse': - self.diffColDefault = [2, 3]#default is B6 and D2 for other species - - controlFrm, dispFields = self.genControlForm(fd) - geneTable, filename = self.genGeneTable(fd, dispFields) - - infoTD = HT.TD(width=400, valign= "top") - infoTD.append(HT.Paragraph("Interval Analyst : Chr %s" % self.Chr, Class="title"), - HT.Strong("Species : "), self.species.title(), HT.BR(), - HT.Strong("Database : "), "UCSC %s" % self.speciesFreeze[self.species], HT.BR(), - HT.Strong("Range : "), "%2.6f Mb - %2.6f Mb" % (self.startMb, self.endMb), HT.BR(), - ) - if filename: - infoTD.append(HT.BR(), HT.BR(), HT.Href(text="Download", url = "/tmp/" + filename, Class="normalsize") - , " output in MS excel format.") - - mainTable = HT.TableLite(HT.TR(infoTD, HT.TD(controlFrm, Class="doubleBorder", width=400), HT.TD(" ", width="")), cellpadding=10) - mainTable.append(HT.TR(HT.TD(geneTable, colspan=3))) - self.dict['body'] = HT.TD(mainTable) - self.dict['title'] = "Interval Analyst" - - def genGeneTable(self, fd, dispFields): - filename = "" - if self.xls: - #import pyXLWriter as xl - filename = "IntAn_Chr%s_%2.6f-%2.6f" % (self.Chr, self.startMb, self.endMb) - filename += ".xls" - - # Create a new Excel workbook - workbook = xl.Writer(os.path.join(webqtlConfig.TMPDIR, filename)) - worksheet = workbook.add_worksheet() - titleStyle = workbook.add_format(align = 'left', bold = 0, size=18, border = 1, border_color="gray") - headingStyle = workbook.add_format(align = 'center', bold = 1, size=13, fg_color = 0x1E, color="white", border = 1, border_color="gray") - - ##Write title Info - worksheet.write([0, 0], "GeneNetwork Interval Analyst Table", titleStyle) - worksheet.write([1, 0], "%s%s" % (webqtlConfig.PORTADDR, os.path.join(webqtlConfig.CGIDIR, self._scriptfile))) - # - worksheet.write([2, 0], "Date : %s" % time.strftime("%B %d, %Y", time.gmtime())) - worksheet.write([3, 0], "Time : %s GMT" % time.strftime("%H:%M ", time.gmtime())) - worksheet.write([4, 0], "Search by : %s" % fd.formdata['remote_ip']) - worksheet.write([5, 0], "view region : Chr %s %2.6f - %2.6f Mb" % (self.Chr, self.startMb, self.endMb)) - nTitleRow = 7 - - geneTable = HT.TableLite(Class="collap", cellpadding=5) - headerRow = HT.TR(HT.TD(" ", Class="fs13 fwb ffl b1 cw cbrb", width="1")) - if self.xls: - worksheet.write([nTitleRow, 0], "Index", headingStyle) - - for ncol, column in enumerate(dispFields): - if len(column) == 1: - headerRow.append(HT.TD(self.columnNames[column[0]][0], Class="fs13 fwb ffl b1 cw cbrb", NOWRAP=1,align="Center")) - if self.xls: - colTitle = self.columnNames[column[0]][0] - worksheet.write([nTitleRow, ncol+1], colTitle, headingStyle) - worksheet.set_column([ncol+1, ncol+1], 2*len(colTitle)) - else: - headerRow.append(HT.TD(self.columnNames[column[0]][0], HT.BR(), " (%s)" % self.speciesFreeze[column[1]], - Class="fs13 fwb ffl b1 cw cbrb", NOWRAP=1, align="Center")) - if self.xls: - colTitle = self.columnNames[column[0]][0] + " (%s)" % self.speciesFreeze[column[1]] - worksheet.write([nTitleRow, ncol+1], colTitle, headingStyle) - worksheet.set_column([ncol+1, ncol+1], 2*len(colTitle)) - #headerRow.append(HT.TD(self.columnNames[column[0]][0], HT.BR(), - # "(%s %s)" % (column[1].title(), self.speciesFreeze[column[1]]), - # Class="colorBlue", NOWRAP=1, align="Center")) - geneTable.append(headerRow) - - geneCol = GeneUtil.loadGenes(self.cursor, self.Chr, self.diffColDefault, self.startMb, self.endMb, species=self.species) - for gIndex, theGO in enumerate(geneCol): - geneRow = HT.TR(HT.TD(gIndex+1, Class="fs12 fwn b1", align="right")) - if self.xls: - nTitleRow += 1 - worksheet.write([nTitleRow, 0], gIndex + 1) - - for ncol, column in enumerate(dispFields): - if len(column) == 1 or column[1]== self.species: - keyValue = "" - fieldName = column[0] - curSpecies = self.species - curGO = theGO - if theGO.has_key(fieldName): - keyValue = theGO[fieldName] - else: - fieldName , othSpec = column - curSpecies = othSpec - subGO = '%sGene' % othSpec - keyValue = "" - curGO = theGO[subGO] - if theGO[subGO].has_key(fieldName): - keyValue = theGO[subGO][fieldName] - - if self.xls: - worksheet.write([nTitleRow, ncol+1], keyValue) - geneRow.append(self.formatTD(keyValue, fieldName, curSpecies, curGO)) - - geneTable.append(geneRow) - - if self.xls: - workbook.close() - return geneTable, filename - - def formatTD(self, keyValue, fieldName, Species, theGO): - if keyValue is None: - keyValue = "" - if keyValue != "": - if fieldName in ("exonStarts", "exonEnds"): - keyValue = string.replace(keyValue, ',', ' ') - return HT.TD(HT.Span(keyValue, Class="code", Id="green"), width=350, Class="fs12 fwn b1") - elif fieldName in ("GeneDescription"): - if keyValue == "---": - keyValue = "" - return HT.TD(keyValue, Class="fs12 fwn b1", width=300) - elif fieldName in ("GeneSymbol"): - webqtlLink = HT.Href("./%s?cmd=sch&gene=%s&alias=1&species=%s" % (webqtlConfig.SCRIPTFILE, keyValue, Species), - HT.Image("/images/webqtl_search.gif", border=0, valign="top"), target="_blank") - if theGO['GeneID']: - geneSymbolLink = HT.Href(webqtlConfig.NCBI_LOCUSID % theGO['GeneID'], keyValue, Class="normalsize", target="_blank") - else: - geneSymbolLink = keyValue - return HT.TD(webqtlLink, geneSymbolLink, Class="fs12 fwn b1",NOWRAP=1) - elif fieldName == 'UnigenID': - try: - gurl = HT.Href(webqtlConfig.UNIGEN_ID % tuple(string.split(keyValue,'.')[:2]), keyValue, Class="normalsize", target="_blank") - except: - gurl = keyValue - return HT.TD(gurl, Class="fs12 fwn b1",NOWRAP=1) - elif fieldName in ("exonCount", "Chromosome"): - return HT.TD(keyValue, Class="fs12 fwn b1",align="right") - elif fieldName in ("snpCount"): - if keyValue: - snpString = HT.Href(url="%s&chr=%s&start=%s&end=%s&geneName=%s&s1=%d&s2=%d" % (os.path.join(webqtlConfig.CGIDIR, 'main.py?FormID=snpBrowser'), - theGO["Chromosome"], theGO["TxStart"], theGO["TxEnd"], theGO["GeneSymbol"], self.diffColDefault[0], self.diffColDefault[1]), - text=theGO["snpCount"], target="_blank", Class="normalsize") - else: - snpString = keyValue - return HT.TD(snpString, Class="fs12 fwn b1",align="right") - elif fieldName in ("snpDensity", "GeneLength"): - if keyValue: keyValue = "%2.3f" % keyValue - else: keyValue = "" - return HT.TD(keyValue, Class="fs12 fwn b1",align="right") - elif fieldName in ("TxStart", "TxEnd"): - return HT.TD("%2.6f" % keyValue, Class="fs12 fwn b1",align="right") - else: - return HT.TD(keyValue, Class="fs12 fwn b1",NOWRAP=1) - else: - return HT.TD(keyValue, Class="fs12 fwn b1",NOWRAP=1,align="right") - - def genControlForm(self, fd): - ##desc GeneList - self.cursor.execute("Desc GeneList") - GeneListFields = self.cursor.fetchall() - GeneListFields = map(lambda X: X[0], GeneListFields) - - #group columns by category--used for creating the dropdown list of possible columns - categories = {} - for item in self.columnNames.keys(): - category = self.columnNames[item] - if category[-1] not in categories.keys(): - categories[category[-1]] = [item ] - else: - categories[category[-1]] = categories[category[-1]]+[item] - - ##List All Species in the Gene Table - speciesDict = {} - self.cursor.execute("select Species.Name, GeneList.SpeciesId from Species, GeneList where \ - GeneList.SpeciesId = Species.Id group by GeneList.SpeciesId order by Species.Id") - results = self.cursor.fetchall() - speciesField = categories.pop('species', []) - categoriesOrder = ['gene', 'protein'] - for item in results: - specName, specId = item - categoriesOrder.append(specName) - speciesDict[specName] = specId - AppliedField = [] - for item2 in speciesField: - if item2 in GeneListFields: - self.cursor.execute("select %s from GeneList where SpeciesId = %d and %s is not NULL limit 1 " % (item2, specId, item2)) - columnApply = self.cursor.fetchone() - if not columnApply: - continue - elif specName != 'mouse' and item2 in ('snpCount', 'snpDensity'): - continue - else: - pass - AppliedField.append(item2) - categories[specName] = AppliedField - - categoriesOrder += ['misc'] - - ############################################################ - ## Create the list of possible columns for the dropdown list - ############################################################ - allColumnsList = HT.Select(name="allColumns", Class="snpBrowserDropBox") - - for category in categoriesOrder: - allFields = categories[category] - if allFields: - geneOpt = HT.Optgroup(label=category.title()) - for item in allFields: - if category in self.speciesFreeze.keys(): - geneOpt.append(("%s (%s %s)" % (self.columnNames[item][1], category.title(), self.speciesFreeze[category]), - "%s__%s" % (item, self.speciesFreeze[category]))) - else: - geneOpt.append((self.columnNames[item][1], item)) - geneOpt.sort() - allColumnsList.append(geneOpt) - - ###################################### - ## Create the list of selected columns - ###################################### - - #cols contains the value of all the selected columns - submitCols = cols = fd.formdata.getvalue("columns", "default") - - if cols == "default": - if self.species=="mouse": #these are the same columns that are shown on intervalPage.py - cols = ['GeneSymbol', 'GeneDescription', 'Chromosome', 'TxStart', 'Strand', 'GeneLength', 'GeneID', 'NM_ID', 'snpCount', 'snpDensity'] - elif self.species=="rat": - cols = ['GeneSymbol', 'GeneDescription', 'Chromosome', 'TxStart', 'GeneLength', 'Strand', 'GeneID', 'UnigenID'] - else: - #should not happen - cols = [] - else: - if type(cols)==type(""): - cols = [cols] - - colsLst = [] - dispFields = [] - for column in cols: - if submitCols == "default" and column not in ('GeneSymbol') and (column in GeneListFields or column in speciesField): - colsLst.append(("%s (%s %s)" % (self.columnNames[column][1], self.species.title(), self.speciesFreeze[self.species]), - "%s__%s" % (column, self.speciesFreeze[self.species]))) - dispFields.append([column, self.species]) - else: - column2 = column.split("__") - if len(column2) == 1: - colsLst.append((self.columnNames[column2[0]][1], column)) - dispFields.append([column]) - else: - thisSpecies = self.speciesFreeze[column2[1]] - colsLst.append(("%s (%s %s)" % (self.columnNames[column2[0]][1], thisSpecies.title(), column2[1]), - column)) - dispFields.append((column2[0], thisSpecies)) - selectedColumnsList = HT.Select(name="columns", Class="snpBrowserSelectBox", multiple="true", data=colsLst, size=6) - - ########################## - ## Create the columns form - ########################## - columnsForm = HT.Form(name="columnsForm", submit=HT.Input(type='hidden'), cgi=os.path.join(webqtlConfig.CGIDIR, self._scriptfile), enctype="multipart/form-data") - columnsForm.append(HT.Input(type="hidden", name="fromdatabase", value= fd.formdata.getvalue("fromdatabase", "unknown"))) - columnsForm.append(HT.Input(type="hidden", name="species", value=self.species)) - if self.diffCol: - columnsForm.append(HT.Input(type="hidden", name="s1", value=self.diffCol[0])) - columnsForm.append(HT.Input(type="hidden", name="s2", value=self.diffCol[1])) - startBox = HT.Input(type="text", name="startMb", value=self.startMb, size=10) - endBox = HT.Input(type="text", name="endMb", value=self.endMb, size=10) - addButton = HT.Input(type="button", name="add", value="Add", Class="button", onClick="addToList(this.form.allColumns.options[this.form.allColumns.selectedIndex].text, this.form.allColumns.options[this.form.allColumns.selectedIndex].value, this.form.columns)") - removeButton = HT.Input(type="button", name="remove", value="Remove", Class="button", onClick="removeFromList(this.form.columns.selectedIndex, this.form.columns)") - upButton = HT.Input(type="button", name="up", value="Up", Class="button", onClick="swapOptions(this.form.columns.selectedIndex, this.form.columns.selectedIndex-1, this.form.columns)") - downButton = HT.Input(type="button", name="down", value="Down", Class="button", onClick="swapOptions(this.form.columns.selectedIndex, this.form.columns.selectedIndex+1, this.form.columns)") - clearButton = HT.Input(type="button", name="clear", value="Clear", Class="button", onClick="deleteAllElements(this.form.columns)") - submitButton = HT.Input(type="submit", value="Refresh", Class="button", onClick="selectAllElements(this.form.columns)") - - selectChrBox = HT.Select(name="chromosome") - self.cursor.execute(""" - Select - Chr_Length.Name, Length from Chr_Length, Species - where - Chr_Length.SpeciesId = Species.Id AND - Species.Name = '%s' - Order by - Chr_Length.OrderId - """ % self.species) - - results = self.cursor.fetchall() - for chrInfo in results: - selectChrBox.append((chrInfo[0], chrInfo[0])) - selectChrBox.selected.append(self.Chr) - - innerColumnsTable = HT.TableLite(border=0, Class="collap", cellpadding = 2) - innerColumnsTable.append(HT.TR(HT.TD(selectedColumnsList)), - HT.TR(HT.TD(clearButton, removeButton, upButton, downButton))) - columnsTable = HT.TableLite(border=0, cellpadding=2, cellspacing=0) - columnsTable.append(HT.TR(HT.TD(HT.Font("Chr: ", size=-1)), - HT.TD(selectChrBox, submitButton)), - HT.TR(HT.TD(HT.Font("View: ", size=-1)), - HT.TD(startBox, HT.Font("Mb to ", size=-1), endBox, HT.Font("Mb", size=-1))), - HT.TR(HT.TD(HT.Font("Show: ", size=-1)), - HT.TD(allColumnsList, addButton)), - HT.TR(HT.TD(""), - HT.TD(innerColumnsTable))) - columnsForm.append(columnsTable) - #columnsForm.append(HT.Input(type="hidden", name="sort", value=diffCol), - # HT.Input(type="hidden", name="identification", value=identification), - # HT.Input(type="hidden", name="traitInfo", value=traitInfo)) - - return columnsForm, dispFields diff --git a/wqflask/wqflask/marker_regression/gemma_mapping.py b/wqflask/wqflask/marker_regression/gemma_mapping.py index f23c390e..bfcf0ffb 100644 --- a/wqflask/wqflask/marker_regression/gemma_mapping.py +++ b/wqflask/wqflask/marker_regression/gemma_mapping.py @@ -3,7 +3,7 @@ import os, math, string, random, json from base import webqtlConfig from base.trait import GeneralTrait from base.data_set import create_dataset -from utility.tools import flat_files, GEMMA_COMMAND, GEMMA_WRAPPER_COMMAND +from utility.tools import flat_files, GEMMA_COMMAND, GEMMA_WRAPPER_COMMAND, TEMPDIR import utility.logger logger = utility.logger.getLogger(__name__ ) @@ -11,12 +11,15 @@ logger = utility.logger.getLogger(__name__ ) def run_gemma(this_dataset, samples, vals, covariates, method, use_loco): """Generates p-values for each marker using GEMMA""" - print("INSIDE GEMMA_MAPPING") + if this_dataset.group.genofile != None: + genofile_name = this_dataset.group.genofile[:-5] + else: + genofile_name = this_dataset.group.name - gen_pheno_txt_file(this_dataset, vals, method) + gen_pheno_txt_file(this_dataset, genofile_name, vals, method) - if not os.path.isfile("{}{}_output.assoc.txt".format(webqtlConfig.GENERATED_IMAGE_DIR, this_dataset.group.name)): - open("{}{}_output.assoc.txt".format(webqtlConfig.GENERATED_IMAGE_DIR, this_dataset.group.name), "w+") + if not os.path.isfile("{}{}_output.assoc.txt".format(webqtlConfig.GENERATED_IMAGE_DIR, genofile_name)): + open("{}{}_output.assoc.txt".format(webqtlConfig.GENERATED_IMAGE_DIR, genofile_name), "w+") this_chromosomes = this_dataset.species.chromosomes.chromosomes chr_list_string = "" @@ -24,7 +27,7 @@ def run_gemma(this_dataset, samples, vals, covariates, method, use_loco): if i < (len(this_chromosomes) - 1): chr_list_string += this_chromosomes[i+1].name + "," else: - chr_list_string += this_chromosomes[i+1].name + chr_list_string += this_chromosomes[i+1].name if covariates != "": gen_covariates_file(this_dataset, covariates) @@ -47,51 +50,51 @@ def run_gemma(this_dataset, samples, vals, covariates, method, use_loco): if use_loco == "True": k_output_filename = this_dataset.group.name + "_K_" + ''.join(random.choice(string.ascii_uppercase + string.digits) for _ in range(6)) generate_k_command = GEMMA_WRAPPER_COMMAND + ' --json --loco ' + chr_list_string + ' -- -g %s/%s_geno.txt -p %s/%s_pheno.txt -a %s/%s_snps.txt -gk -debug > /home/zas1024/tmp/gn2/%s.json' % (flat_files('genotype/bimbam'), - this_dataset.group.name, + genofile_name, flat_files('genotype/bimbam'), - this_dataset.group.name, + genofile_name, flat_files('genotype/bimbam'), - this_dataset.group.name, + genofile_name, k_output_filename) logger.debug("k_command:" + generate_k_command) os.system(generate_k_command) gemma_command = GEMMA_WRAPPER_COMMAND + ' --json --loco --input /home/zas1024/tmp/gn2/%s.json -- -g %s/%s_geno.txt -p %s/%s_pheno.txt' % (k_output_filename, flat_files('genotype/bimbam'), - this_dataset.group.name, + genofile_name, flat_files('genotype/bimbam'), - this_dataset.group.name) + genofile_name) gwa_output_filename = this_dataset.group.name + "_GWA_" + ''.join(random.choice(string.ascii_uppercase + string.digits) for _ in range(6)) if covariates != "": gemma_command += ' -c %s/%s_covariates.txt -a %s/%s_snps.txt -lmm 1 -maf 0.1 -debug > /home/zas1024/tmp/gn2/%s.json' % (flat_files('mapping'), this_dataset.group.name, flat_files('genotype/bimbam'), - this_dataset.group.name, + genofile_name, gwa_output_filename) else: gemma_command += ' -a %s/%s_snps.txt -lmm 1 -maf 0.1 -debug > /home/zas1024/tmp/gn2/%s.json' % (flat_files('genotype/bimbam'), - this_dataset.group.name, + genofile_name, gwa_output_filename) else: gemma_command = GEMMA_COMMAND + ' -g %s/%s_geno.txt -p %s/%s_pheno.txt -a %s/%s_snps.txt -k %s/%s.cXX.txt -lmm 1 -maf 0.1' % (flat_files('genotype/bimbam'), - this_dataset.group.name, + genofile_name, flat_files('genotype/bimbam'), - this_dataset.group.name, + genofile_name, flat_files('genotype/bimbam'), - this_dataset.group.name, + genofile_name, flat_files('genotype/bimbam'), - this_dataset.group.name) + genofile_name) if covariates != "": gemma_command += ' -c %s/%s_covariates.txt -outdir %s -debug -o %s_output' % (flat_files('mapping'), this_dataset.group.name, webqtlConfig.GENERATED_IMAGE_DIR, - this_dataset.group.name) + genofile_name) else: gemma_command += ' -outdir %s -debug -o %s_output' % (webqtlConfig.GENERATED_IMAGE_DIR, - this_dataset.group.name) + genofile_name) logger.debug("gemma_command:" + gemma_command) os.system(gemma_command) @@ -99,11 +102,11 @@ def run_gemma(this_dataset, samples, vals, covariates, method, use_loco): if use_loco == "True": marker_obs = parse_loco_output(this_dataset, gwa_output_filename) else: - marker_obs = parse_gemma_output(this_dataset) + marker_obs = parse_gemma_output(genofile_name) return marker_obs -def gen_pheno_txt_file(this_dataset, vals, method): +def gen_pheno_txt_file(this_dataset, genofile_name, vals, method): """Generates phenotype file for GEMMA""" if method == "gemma": @@ -122,7 +125,7 @@ def gen_pheno_txt_file(this_dataset, vals, method): outfile.write("0" + " " + line[1] + " " + line[2] + " " + line[3] + " " + line[4] + " " + str(this_val) + "\n") else: current_file_data = [] - with open("{}/{}_pheno.txt".format(flat_files('genotype/bimbam'), this_dataset.group.name), "w") as outfile: + with open("{}/{}_pheno.txt".format(flat_files('genotype/bimbam'), genofile_name), "w") as outfile: for value in vals: if value == "x": outfile.write("NA\n") @@ -160,14 +163,14 @@ def gen_covariates_file(this_dataset, covariates): outfile.write(str(this_covariate[i]) + "\t") outfile.write("\n") -def parse_gemma_output(this_dataset): +def parse_gemma_output(genofile_name): included_markers = [] p_values = [] marker_obs = [] previous_chr = 0 #with open("/home/zas1024/gene/wqflask/output/{}_output.assoc.txt".format(this_dataset.group.name)) as output_file: - with open("{}{}_output.assoc.txt".format(webqtlConfig.GENERATED_IMAGE_DIR, this_dataset.group.name)) as output_file: + with open("{}{}_output.assoc.txt".format(webqtlConfig.GENERATED_IMAGE_DIR, genofile_name)) as output_file: for line in output_file: if line.startswith("chr"): continue @@ -202,7 +205,7 @@ def parse_gemma_output(this_dataset): def parse_loco_output(this_dataset, gwa_output_filename): output_filelist = [] - with open("/home/zas1024/tmp/gn2/" + gwa_output_filename + ".json") as data_file: + with open("{}/gn2/".format(TEMPDIR) + gwa_output_filename + ".json") as data_file: data = json.load(data_file) files = data['files'] diff --git a/wqflask/wqflask/marker_regression/marker_regression_gn1.py b/wqflask/wqflask/marker_regression/marker_regression_gn1.py index 687cfeb5..a26d1426 100644 --- a/wqflask/wqflask/marker_regression/marker_regression_gn1.py +++ b/wqflask/wqflask/marker_regression/marker_regression_gn1.py @@ -1800,9 +1800,10 @@ class MarkerRegression(object): distScale = 10 else: distScale = 5 - for tickdists in range(distScale, int(ceil(distLen)), distScale): + for i, tickdists in enumerate(range(distScale, int(ceil(distLen)), distScale)): canvas.drawLine(startPosX + tickdists*plotXScale, yZero, startPosX + tickdists*plotXScale, yZero + 7, color=pid.black, width=1*zoom) - canvas.drawString(str(tickdists), startPosX+tickdists*plotXScale, yZero + 10*zoom, color=pid.black, font=MBLabelFont, angle=270) + if i % 2 == 0: + canvas.drawString(str(tickdists), startPosX+tickdists*plotXScale, yZero + 10*zoom, color=pid.black, font=MBLabelFont, angle=270) startPosX += (self.ChrLengthDistList[i]+self.GraphInterval)*plotXScale megabaseLabelFont = pid.Font(ttf="verdana", size=18*zoom*1.5, bold=0) @@ -2736,9 +2737,9 @@ class MarkerRegression(object): "Human Chr", "Mb Start (hg19)", "Literature Correlation", - "Gene Description", - "PolymiRTS Database" + HT.Href(url='http://compbio.uthsc.edu/miRSNP/', text='>>', target="_blank").__str__(), - "Gene Weaver Info Content" + HT.Href(url='http://geneweaver.org/', text='>>', target="_blank").__str__()] + "Gene Description"] + #"PolymiRTS Database" + HT.Href(url='http://compbio.uthsc.edu/miRSNP/', text='>>', target="_blank").__str__(), + #"Gene Weaver Info Content" + HT.Href(url='http://geneweaver.org/', text='>>', target="_blank").__str__()] # gene_tblobj_header = [[THCell(HT.TD('Index', HT.BR(), HT.BR(), align='left', width=50, Class=col_class), text="index", idx=0), # THCell(HT.TD('Symbol', HT.BR(), HT.BR(), align='left', width=100, Class=col_class), text="symbol", idx=1), @@ -2767,9 +2768,9 @@ class MarkerRegression(object): "Avg Expr", "Human Chr", "Mb Start (hg19)", - "Gene Description", - "PolymiRTS Database" + HT.Href(url='http://compbio.uthsc.edu/miRSNP/', text='>>', target="_blank").__str__(), - "Gene Weaver Info Content" + HT.Href(url='http://geneweaver.org/', text='>>', target="_blank").__str__()] + "Gene Description"] + #"PolymiRTS Database" + HT.Href(url='http://compbio.uthsc.edu/miRSNP/', text='>>', target="_blank").__str__(), + #"Gene Weaver Info Content" + HT.Href(url='http://geneweaver.org/', text='>>', target="_blank").__str__()] # gene_tblobj_header = [[THCell(HT.TD('Index', HT.BR(), HT.BR(), align='left', width=50, Class=col_class), text="index", idx=0), # THCell(HT.TD('Symbol', HT.BR(), HT.BR(), align='left', width=100, Class=col_class), text="symbol", idx=1), @@ -2945,9 +2946,9 @@ class MarkerRegression(object): humanChr, HT.Href(humanStartString, humanStartDisplay, target="_blank").__str__(), literatureCorrelationString, - geneDescription, - polymiRTS, - ""] + geneDescription] + #polymiRTS, + # this_row.append(TDCell(HT.TD(tableIterationsCnt, selectCheck, width=30, align='right', Class=className), tableIterationsCnt, tableIterationsCnt)) # this_row.append(TDCell(HT.TD(HT.Href(geneIdString, theGO["GeneSymbol"], target="_blank"), " ", probeSetSearch, align='right', Class=className), theGO["GeneSymbol"], theGO["GeneSymbol"])) @@ -2975,9 +2976,8 @@ class MarkerRegression(object): avgExpr, humanChr, HT.Href(humanStartString, humanStartDisplay, target="_blank").__str__(), - geneDescription, - polymiRTS, - ""] + geneDescription] + #polymiRTS, # this_row.append(TDCell(HT.TD(tableIterationsCnt, selectCheck, width=30, align='right', Class=className), tableIterationsCnt, tableIterationsCnt)) diff --git a/wqflask/wqflask/show_trait/show_trait.py b/wqflask/wqflask/show_trait/show_trait.py index 13ad4a8f..6de5cd5f 100644 --- a/wqflask/wqflask/show_trait/show_trait.py +++ b/wqflask/wqflask/show_trait/show_trait.py @@ -82,6 +82,59 @@ class ShowTrait(object): # this_trait.mysqlid) # heritability = self.cursor.fetchone() + #ZS: Get verify/rna-seq link URLs + try: + blatsequence = self.this_trait.blatseq + if not blatsequence: + #XZ, 06/03/2009: ProbeSet name is not unique among platforms. We should use ProbeSet Id instead. + query1 = """SELECT Probe.Sequence, Probe.Name + FROM Probe, ProbeSet, ProbeSetFreeze, ProbeSetXRef + WHERE ProbeSetXRef.ProbeSetFreezeId = ProbeSetFreeze.Id AND + ProbeSetXRef.ProbeSetId = ProbeSet.Id AND + ProbeSetFreeze.Name = '%s' AND + ProbeSet.Name = '%s' AND + Probe.ProbeSetId = ProbeSet.Id order by Probe.SerialOrder""" % (self.this_trait.dataset.name, self.this_trait.name) + seqs = g.db.execute(query1).fetchall() + if not seqs: + raise ValueError + else: + blatsequence = '' + for seqt in seqs: + if int(seqt[1][-1]) % 2 == 1: + blatsequence += string.strip(seqt[0]) + + #--------Hongqiang add this part in order to not only blat ProbeSet, but also blat Probe + blatsequence = '%3E' + self.this_trait.name + '%0A' + blatsequence + '%0A' + #XZ, 06/03/2009: ProbeSet name is not unique among platforms. We should use ProbeSet Id instead. + query2 = """SELECT Probe.Sequence, Probe.Name + FROM Probe, ProbeSet, ProbeSetFreeze, ProbeSetXRef + WHERE ProbeSetXRef.ProbeSetFreezeId = ProbeSetFreeze.Id AND + ProbeSetXRef.ProbeSetId = ProbeSet.Id AND + ProbeSetFreeze.Name = '%s' AND + ProbeSet.Name = '%s' AND + Probe.ProbeSetId = ProbeSet.Id order by Probe.SerialOrder""" % (self.this_trait.dataset.name, self.this_trait.name) + + seqs = g.db.execute(query2).fetchall() + for seqt in seqs: + if int(seqt[1][-1]) %2 == 1: + blatsequence += '%3EProbe_' + string.strip(seqt[1]) + '%0A' + string.strip(seqt[0]) + '%0A' + + if self.dataset.group.species == "rat": + self.UCSC_BLAT_URL = webqtlConfig.UCSC_BLAT % ('rat', 'rn3', blatsequence) + self.UTHSC_BLAT_URL = "" + elif self.dataset.group.species == "mouse": + self.UCSC_BLAT_URL = webqtlConfig.UTHSC_BLAT2 % ('mouse', 'mm10', blatsequence) + self.UTHSC_BLAT_URL = webqtlConfig.UTHSC_BLAT % ('mouse', 'mm10', blatsequence) + elif self.dataset.group.species == "human": + self.UCSC_BLAT_URL = webqtlConfig.UTHSC_BLAT2 % ('human', 'hg19', blatsequence) + self.UTHSC_BLAT_URL = "" + else: + self.UCSC_BLAT_URL = "" + self.UTHSC_BLAT_URL = "" + except: + self.UCSC_BLAT_URL = "" + self.UTHSC_BLAT_URL = "" + self.build_correlation_tools() #Get nearest marker for composite mapping @@ -142,7 +195,7 @@ class ShowTrait(object): self.get_mapping_methods() - self.trait_table_width = get_trait_table_width(self.sample_groups) + self.stats_table_width, self.trait_table_width = get_table_widths(self.sample_groups) trait_symbol = None if not self.temp_trait: @@ -302,13 +355,17 @@ def get_genofiles(this_dataset): jsondata = json.load(f) return jsondata['genofile'] -def get_trait_table_width(sample_groups): - table_width = 25 +def get_table_widths(sample_groups): + stats_table_width = 200 + if len(sample_groups) > 1: + stats_table_width = 450 + + trait_table_width = 25 if sample_groups[0].se_exists(): - table_width += 15 - if (table_width + len(sample_groups[0].attributes)*10) > 100: - table_width = 100 + trait_table_width += 15 + if (trait_table_width + len(sample_groups[0].attributes)*10) > 100: + trait_table_width = 100 else: - table_width += len(sample_groups[0].attributes)*10 + trait_table_width += len(sample_groups[0].attributes)*10 - return table_width + return stats_table_width, trait_table_width diff --git a/wqflask/wqflask/static/new/javascript/dataset_menu_structure.json b/wqflask/wqflask/static/new/javascript/dataset_menu_structure.json index f3712b5d..75767f47 100644 --- a/wqflask/wqflask/static/new/javascript/dataset_menu_structure.json +++ b/wqflask/wqflask/static/new/javascript/dataset_menu_structure.json @@ -116,15 +116,15 @@ "B30_K_1206_M", "Barley1 Leaf MAS 5.0 SCRI (Dec06)" ], - [ - "126", - "B30_K_1206_Rn", - "Barley1 Leaf gcRMAn SCRI (Dec06)" - ], [ "125", "B30_K_1206_R", "Barley1 Leaf gcRMA SCRI (Dec06)" + ], + [ + "126", + "B30_K_1206_Rn", + "Barley1 Leaf gcRMAn SCRI (Dec06)" ] ], "Phenotypes": [ @@ -1135,6 +1135,13 @@ "GTEXv5 Human Pancreas RefSeq (Sep15) RPKM log2" ] ], + "Phenotypes": [ + [ + "None", + "GTEx_v5Publish", + "GTEx_v5 Published Phenotypes" + ] + ], "Pituitary Gland mRNA": [ [ "758", @@ -1534,15 +1541,15 @@ "NCI_Agil_Mam_Tum_RMA_0409", "NCI Mammary LMT miRNA v2 (Apr09) RMA" ], - [ - "37", - "MA_M_0704_R", - "NCI Mammary mRNA M430 (July04) RMA" - ], [ "36", "MA_M_0704_M", "NCI Mammary mRNA M430 (July04) MAS5" + ], + [ + "37", + "MA_M_0704_R", + "NCI Mammary mRNA M430 (July04) RMA" ] ] }, @@ -1609,15 +1616,15 @@ ] ], "Liver mRNA": [ - [ - "39", - "LVF2_M_0704_R", - "(B6 x BTBR)F2-ob/ob Liver mRNA M430 (Jul04) RMA" - ], [ "38", "LVF2_M_0704_M", "(B6 x BTBR)F2-ob/ob Liver mRNA M430 (Jul04) MAS5" + ], + [ + "39", + "LVF2_M_0704_R", + "(B6 x BTBR)F2-ob/ob Liver mRNA M430 (Jul04) RMA" ] ], "Phenotypes": [ @@ -1639,16 +1646,16 @@ }, "B6D2F2": { "Brain mRNA": [ - [ - "77", - "BRF2_M_0805_R", - "OHSU/VA B6D2F2 Brain mRNA M430 (Aug05) RMA" - ], [ "76", "BRF2_M_0805_M", "OHSU/VA B6D2F2 Brain mRNA M430 (Aug05) MAS5" ], + [ + "77", + "BRF2_M_0805_R", + "OHSU/VA B6D2F2 Brain mRNA M430 (Aug05) RMA" + ], [ "78", "BRF2_M_0805_P", @@ -1659,15 +1666,15 @@ "BRF2_M_0304_P", "OHSU/VA B6D2F2 Brain mRNA M430A (Mar04) PDNN" ], - [ - "32", - "BRF2_M_0304_R", - "OHSU/VA B6D2F2 Brain mRNA M430A (Mar04) RMA" - ], [ "31", "BRF2_M_0304_M", "OHSU/VA B6D2F2 Brain mRNA M430A (Mar04) MAS5" + ], + [ + "32", + "BRF2_M_0304_R", + "OHSU/VA B6D2F2 Brain mRNA M430A (Mar04) RMA" ] ], "Genotypes": [ @@ -1745,16 +1752,16 @@ ] ], "Striatum mRNA": [ - [ - "84", - "SA_M2_0905_R", - "OHSU/VA B6D2F2 Striatum M430v2 (Sep05) RMA" - ], [ "83", "SA_M2_0905_M", "OHSU/VA B6D2F2 Striatum M430v2 (Sep05) MAS5" ], + [ + "84", + "SA_M2_0905_R", + "OHSU/VA B6D2F2 Striatum M430v2 (Sep05) RMA" + ], [ "85", "SA_M2_0905_P", @@ -2023,16 +2030,16 @@ "BR_U_0805_M", "UTHSC Brain mRNA U74Av2 (Aug05) MAS5" ], - [ - "82", - "BR_U_0805_R", - "UTHSC Brain mRNA U74Av2 (Aug05) RMA" - ], [ "81", "BR_U_0805_P", "UTHSC Brain mRNA U74Av2 (Aug05) PDNN" ], + [ + "82", + "BR_U_0805_R", + "UTHSC Brain mRNA U74Av2 (Aug05) RMA" + ], [ "42", "CB_M_0204_P", @@ -2099,16 +2106,16 @@ "Eye_M2_0908_R_ND", "Eye M430v2 WT Gpnmb (Sep08) RMA" ], - [ - "279", - "Eye_M2_0908_R_WT", - "Eye M430v2 WT Tyrp1 (Sep08) RMA" - ], [ "278", "Eye_M2_0908_R_MT", "Eye M430v2 Mutant Tyrp1 (Sep08) RMA" ], + [ + "279", + "Eye_M2_0908_R_WT", + "Eye M430v2 WT Tyrp1 (Sep08) RMA" + ], [ "382", "Eye_M2_0908_WTWT", @@ -2397,15 +2404,15 @@ "MA_M2_0806_P", "Mouse Kidney M430v2 Sex Balanced (Aug06) PDNN" ], - [ - "116", - "MA_M2_0706_P", - "Mouse Kidney M430v2 (Jul06) PDNN" - ], [ "115", "MA_M2_0706_R", "Mouse Kidney M430v2 (Jul06) RMA" + ], + [ + "116", + "MA_M2_0706_P", + "Mouse Kidney M430v2 (Jul06) PDNN" ] ], "Liver Metabolome": [ @@ -2621,16 +2628,16 @@ ] ], "Neocortex mRNA": [ - [ - "375", - "DevNeocortex_ILM6.2P14RInv_1111", - "BIDMC/UTHSC Dev Neocortex P14 ILMv6.2 (Nov11) RankInv" - ], [ "374", "DevNeocortex_ILM6.2P3RInv_1111", "BIDMC/UTHSC Dev Neocortex P3 ILMv6.2 (Nov11) RankInv" ], + [ + "375", + "DevNeocortex_ILM6.2P14RInv_1111", + "BIDMC/UTHSC Dev Neocortex P14 ILMv6.2 (Nov11) RankInv" + ], [ "284", "HQFNeoc_1210v2_RankInv", @@ -2666,7 +2673,7 @@ ], "Phenotypes": [ [ - "602", + "None", "BXDPublish", "BXD Published Phenotypes" ] @@ -2711,6 +2718,16 @@ ] ], "Retina mRNA": [ + [ + "709", + "DoDCMMRPRetMoGene2_0515", + "DoD Retina Normal Affy MoGene 2.0 ST (May15) RMA Gene Level" + ], + [ + "710", + "DoDCMMRPRetMoGene2Ex_0515", + "DoD Retina Normal Affy MoGene 2.0 ST (May15) RMA Exon Level" + ], [ "267", "Illum_Retina_BXD_RankInv0410", @@ -2722,14 +2739,19 @@ "HEI Retina Normal Illumina V6.2 (Apr10) RankInv" ], [ - "709", - "DoDCMMRPRetMoGene2_0515", - "DoD Retina Normal Affy MoGene 2.0 ST (May15) RMA Gene Level" + "785", + "DoDTATRCRetBLMoGene2_0316", + "DoD Retina After Blast Affy MoGene 2.0 ST (Mar16) RMA Gene Level" ], [ - "710", - "DoDCMMRPRetMoGene2Ex_0515", - "DoD Retina Normal Affy MoGene 2.0 ST (May15) RMA Exon Level" + "787", + "DoDRetBlastvsNormal_0416", + "DoD Retina Blast vs Normal Retina Affy MoGene 2.0 ST (Apr16) RMA Gene Level" + ], + [ + "786", + "DoDTATRCRetBLMoGene2E_0316", + "DoD Retina After Blast Affy MoGene 2.0 ST (Mar16) RMA Exon Level" ], [ "385", @@ -2861,16 +2883,16 @@ ] ], "Ventral Tegmental Area mRNA": [ - [ - "229", - "VCUEtOH_0609_R", - "VCU BXD VTA EtOH M430 2.0 (Jun09) RMA" - ], [ "228", "VCUSal_0609_R", "VCU BXD VTA Sal M430 2.0 (Jun09) RMA" ], + [ + "229", + "VCUEtOH_0609_R", + "VCU BXD VTA EtOH M430 2.0 (Jun09) RMA" + ], [ "230", "VCUEtvsSal_0609_R", @@ -3151,15 +3173,15 @@ ] ], "Hippocampus mRNA": [ - [ - "100", - "HC_M2CB_1205_R", - "Hippocampus Consortium M430v2 CXB (Dec05) RMA" - ], [ "99", "HC_M2CB_1205_P", "Hippocampus Consortium M430v2 CXB (Dec05) PDNN" + ], + [ + "100", + "HC_M2CB_1205_R", + "Hippocampus Consortium M430v2 CXB (Dec05) RMA" ] ], "Liver mRNA": [ @@ -3234,29 +3256,29 @@ ], "Hippocampus mRNA": [ [ - "213", - "Illum_LXS_Hipp_NOS_1008", - "Hippocampus Illumina NOS (Oct08) RankInv beta" - ], - [ - "219", - "Illum_LXS_Hipp_NON_1008", - "Hippocampus Illumina NON (Oct08) RankInv beta" + "211", + "Illum_LXS_Hipp_RSS_1008", + "Hippocampus Illumina RSS (Oct08) RankInv beta" ], [ "212", "Illum_LXS_Hipp_RSE_1008", "Hippocampus Illumina RSE (Oct08) RankInv beta" ], + [ + "213", + "Illum_LXS_Hipp_NOS_1008", + "Hippocampus Illumina NOS (Oct08) RankInv beta" + ], [ "214", "Illum_LXS_Hipp_NOE_1008", "Hippocampus Illumina NOE (Oct08) RankInv beta" ], [ - "211", - "Illum_LXS_Hipp_RSS_1008", - "Hippocampus Illumina RSS (Oct08) RankInv beta" + "219", + "Illum_LXS_Hipp_NON_1008", + "Hippocampus Illumina NON (Oct08) RankInv beta" ], [ "143", @@ -3348,15 +3370,15 @@ ] ], "Hippocampus mRNA": [ - [ - "273", - "UMUTAffyExon_0209_RMA_MDP", - "UMUTAffy Hippocampus Exon (Feb09) RMA MDP" - ], [ "272", "HC_M2_0606_MDP", "Hippocampus Consortium M430v2 (Jun06) RMA MDP" + ], + [ + "273", + "UMUTAffyExon_0209_RMA_MDP", + "UMUTAffy Hippocampus Exon (Feb09) RMA MDP" ] ], "Liver mRNA": [ @@ -4244,6 +4266,10 @@ ] ], "GTEx_v5": [ + [ + "Phenotypes", + "Phenotypes" + ], [ "Adipose tissue, subcutaneous mRNA", "Adipose tissue, subcutaneous mRNA" diff --git a/wqflask/wqflask/static/new/javascript/show_trait.js b/wqflask/wqflask/static/new/javascript/show_trait.js index f08965e9..099d8010 100644 --- a/wqflask/wqflask/static/new/javascript/show_trait.js +++ b/wqflask/wqflask/static/new/javascript/show_trait.js @@ -52,6 +52,14 @@ pretty: "Interquartile Range", url: "http://www.genenetwork.org/glossary.html#Interquartile", digits: 3 + }, { + vn: "skewness", + pretty: "Skewness", + digits: 3 + }, { + vn: "kurtosis", + pretty: "Kurtosis", + digits: 3 } ]; @@ -181,25 +189,81 @@ } return _results; }; + redraw_histogram = function() { var x; - return root.histogram.redraw((function() { - var _i, _len, _ref, _results; - _ref = _.values(root.selected_samples[root.histogram_group]); - _results = []; - for (_i = 0, _len = _ref.length; _i < _len; _i++) { - x = _ref[_i]; - _results.push(x.value); - } - return _results; - })()); + var _i, _len, _ref, data; + _ref = _.values(root.selected_samples[root.stats_group]); + var trait_vals = []; + for (_i = 0, _len = _ref.length; _i < _len; _i++) { + x = _ref[_i]; + trait_vals.push(x.value); + } + Plotly.restyle('histogram', 'x', [trait_vals]) }; + redraw_bar_chart = function() { - return root.bar_chart.redraw(root.selected_samples, root.bar_chart_group); + var x; + var _i, _len, _ref, data; + _ref = _.values(root.selected_samples[root.stats_group]); + names_and_values = [] + for (i = 0; i < _ref.length; i++){ + _ref[i]["name"] = Object.keys(root.selected_samples[root.stats_group])[i] + } + trait_vals = []; + trait_vars = []; + trait_samples = []; + + function sortFunction(a, b) { + if (a.value === b.value) { + return 0; + } + else { + return (a.value < b.value) ? -1 : 1; + } + } + + if (root.bar_sort == "value") { + _ref.sort(sortFunction) + } + + for (_i = 0, _len = _ref.length; _i < _len; _i++) { + x = _ref[_i]; + trait_samples.push(x.name) + trait_vals.push(x.value); + if (x["variance"] != undefined) { + trait_vars.push(x.variance); + } else{ + trait_vars.push(null) + } + } + + root.bar_data[0]['y'] = trait_vals + root.bar_data[0]['error_y'] = { + type: 'data', + array: trait_vars, + visible: true + } + root.bar_data[0]['x'] = trait_samples + Plotly.newPlot('bar_chart', root.bar_data, root.bar_layout); }; + + redraw_box_plot = function() { + var x; + var _i, _len, _ref, data; + _ref = _.values(root.selected_samples[root.stats_group]); + trait_vals = []; + for (_i = 0, _len = _ref.length; _i < _len; _i++) { + x = _ref[_i]; + trait_vals.push(x.value); + } + Plotly.restyle('box_plot', 'y', [trait_vals]) + } + redraw_prob_plot = function() { return root.redraw_prob_plot_impl(root.selected_samples, root.prob_plot_group); }; + make_table = function() { var header, key, row, row_line, table, the_id, the_rows, value, _i, _len, _ref, _ref1; header = "Statistic"; @@ -312,6 +376,8 @@ redraw_histogram(); console.log("redrawing bar chart"); redraw_bar_chart(); + console.log("redrawing box plot"); + redraw_box_plot(); console.log("redrawing probability plot"); return redraw_prob_plot(); }; @@ -526,29 +592,174 @@ $('#block_outliers').click(block_outliers); console.log("after registering block_outliers"); _.mixin(_.str.exports()); - root.histogram_group = 'samples_primary'; - root.histogram = new Histogram(sample_lists[0]); - $('.histogram_samples_group').val(root.histogram_group); + + get_sample_vals = function(sample_list) { + var sample; + return this.sample_vals = (function() { + var i, len, results; + results = []; + for (i = 0, len = sample_list.length; i < len; i++) { + sample = sample_list[i]; + if (sample.value !== null) { + results.push(sample.value); + } + } + return results; + })(); + }; + + get_sample_errors = function(sample_list) { + var sample; + return this.sample_vals = (function() { + var i, len, results; + results = []; + for (i = 0, len = sample_list.length; i < len; i++) { + sample = sample_list[i]; + if (sample.variance !== null) { + results.push(sample.variance); + } + } + return results; + })(); + }; + + get_sample_names = function(sample_list) { + var sample; + return this.sample_names = (function() { + var i, len, results; + results = []; + for (i = 0, len = sample_list.length; i < len; i++) { + sample = sample_list[i]; + if (sample.value !== null) { + results.push(sample.name); + } + } + return results; + })(); + }; + + root.stats_group = 'samples_primary'; + // Histogram + var hist_trace = { + x: get_sample_vals(sample_lists[0]), + type: 'histogram' + }; + var data = [hist_trace]; + var layout = { + bargap: 0.05, + title: "Sample Values", + xaxis: {title: "Value"}, + yaxis: {title: "Count"}, + margin: { + l: 50, + r: 30, + t: 100, + b: 60 + } + }; + Plotly.newPlot('histogram', data, layout) + + // Bar Chart + console.log("SAMPLE LISTS:", sample_lists) + var bar_trace = { + x: get_sample_names(sample_lists[0]), + y: get_sample_vals(sample_lists[0]), + error_y: { + type: 'data', + array: get_sample_errors(sample_lists[0]), + visible: true + }, + type: 'bar' + }; + root.bar_data = [bar_trace] + var layout = { + width: 1200, + height: 500, + margin: { + l: 50, + r: 30, + t: 30, + b: 80 + } + }; + root.bar_layout = layout + Plotly.newPlot('bar_chart', root.bar_data, layout) + + if (Object.keys(js_data.sample_group_types).length > 1) { + full_sample_lists = [sample_lists[0], sample_lists[1], sample_lists[0].concat(sample_lists[1])] + sample_group_list = [js_data.sample_group_types['samples_primary'], js_data.sample_group_types['samples_other'], js_data.sample_group_types['samples_all']] + } else { + full_sample_lists = [sample_lists[0]] + sample_group_list = [js_data.sample_group_types['samples_primary']] + } + + data = [] + for ( var i = 0; i < full_sample_lists.length; i ++ ) { + var box_trace = { + type: 'box', + y: get_sample_vals(full_sample_lists[i]), + name: sample_group_list[i], + boxpoints: 'all', + jitter: 0.5, + whiskerwidth: 0.2, + fillcolor: 'cls', + marker: { + size: 2 + }, + line: { + width: 1 + } + }; + data.push(box_trace) + }; + layout = { + title: 'Box Plot', + yaxis: { + autorange: true, + showgrid: true, + zeroline: true + }, + margin: { + l: 50, + r: 30, + t: 80, + b: 80 + } + }; + + Plotly.newPlot('box_plot', data, layout); + + $('.histogram_samples_group').val(root.stats_group); $('.histogram_samples_group').change(function() { - root.histogram_group = $(this).val(); + root.stats_group = $(this).val(); return redraw_histogram(); }); - root.bar_chart_group = 'samples_primary'; - root.bar_chart = new Bar_Chart(sample_lists); - $('.bar_chart_samples_group').val(root.bar_chart_group); + $('.bar_chart_samples_group').change(function() { - root.bar_chart_group = $(this).val(); + root.stats_group = $(this).val(); + return redraw_bar_chart(); + }); + root.bar_sort = "name" + $('.sort_by_name').click(function() { + root.bar_sort = "name" return redraw_bar_chart(); }); + $('.sort_by_value').click(function() { + root.bar_sort = "value" + return redraw_bar_chart(); + }); + root.prob_plot_group = 'samples_primary'; $('.prob_plot_samples_group').val(root.prob_plot_group); $('.prob_plot_samples_group').change(function() { root.prob_plot_group = $(this).val(); return redraw_prob_plot(); }); + make_table(); edit_data_change(); $('#edit_sample_lists').change(edit_data_change); + $('.edit_sample_value').change(edit_data_change); $('#block_by_index').click(edit_data_change); $('#exclude_group').click(edit_data_change); $('#block_outliers').click(edit_data_change); @@ -561,4 +772,4 @@ return this.toString().split(".")[1].length || 0; } -}).call(this); +}).call(this); \ No newline at end of file diff --git a/wqflask/wqflask/static/new/javascript/show_trait_mapping_tools.js b/wqflask/wqflask/static/new/javascript/show_trait_mapping_tools.js index e11aaf4a..2f1d836a 100644 --- a/wqflask/wqflask/static/new/javascript/show_trait_mapping_tools.js +++ b/wqflask/wqflask/static/new/javascript/show_trait_mapping_tools.js @@ -229,6 +229,7 @@ //$("#static_progress_bar_container").modal(); url = "/loading"; $('input[name=method]').val("gemma"); + $('input[name=genofile]').val($('#genofile_gemma').val()); $('input[name=maf]').val($('input[name=maf_gemma]').val()); form_data = $('#trait_data_form').serialize(); console.log("form_data is:", form_data); @@ -244,6 +245,7 @@ //$("#static_progress_bar_container").modal(); url = "/loading"; $('input[name=method]').val("gemma_bimbam"); + $('input[name=genofile]').val($('#genofile_gemma').val()); $('input[name=maf]').val($('input[name=maf_gemma]').val()); form_data = $('#trait_data_form').serialize(); console.log("form_data is:", form_data); diff --git a/wqflask/wqflask/static/new/javascript/stats.js b/wqflask/wqflask/static/new/javascript/stats.js index 203652f8..4f99982e 100644 --- a/wqflask/wqflask/static/new/javascript/stats.js +++ b/wqflask/wqflask/static/new/javascript/stats.js @@ -87,6 +87,69 @@ Stats = (function() { return Math.pow(2, iq); }; + Stats.prototype.skewness = function() { + var len = this.the_values.length, + delta = 0, + delta_n = 0, + term1 = 0, + N = 0, + mean = 0, + M2 = 0, + M3 = 0, + g; + + for ( var i = 0; i < len; i++ ) { + N += 1; + + delta = this.the_values[ i ] - mean; + delta_n = delta / N; + + term1 = delta * delta_n * (N-1); + + M3 += term1*delta_n*(N-2) - 3*delta_n*M2; + M2 += term1; + mean += delta_n; + } + // Calculate the population skewness: + g = Math.sqrt( N )*M3 / Math.pow( M2, 3/2 ); + + // Return the corrected sample skewness: + return Math.sqrt( N*(N-1))*g / (N-2); + }; + + Stats.prototype.kurtosis = function() { + var len = this.the_values.length, + delta = 0, + delta_n = 0, + delta_n2 = 0, + term1 = 0, + N = 0, + mean = 0, + M2 = 0, + M3 = 0, + M4 = 0, + g; + + for ( var i = 0; i < len; i++ ) { + N += 1; + + delta = 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i=0,a=0,o=0;o>>24-i&16777215,r=0!==a||o!==this.length-1?_[6-l.length]+l+r:l+r,i+=2,i>=26&&(i-=26,o--)}for(0!==a&&(r=a.toString(16)+r);r.length%e!=0;)r="0"+r;return 0!==this.negative&&(r="-"+r),r}if(t===(0|t)&&t>=2&&t<=36){var u=w[t],c=M[t];r="";var h=this.clone();for(h.negative=0;!h.isZero();){var f=h.modn(c).toString(t);h=h.idivn(c),r=h.isZero()?f+r:_[u-f.length]+f+r}for(this.isZero()&&(r="0"+r);r.length%e!=0;)r="0"+r;return 0!==this.negative&&(r="-"+r),r}n(!1,"Base should be between 2 and 36")},a.prototype.toNumber=function(){var t=this.words[0];return 2===this.length?t+=67108864*this.words[1]:3===this.length&&1===this.words[2]?t+=4503599627370496+67108864*this.words[1]:this.length>2&&n(!1,"Number can only safely store up to 53 bits"),0!==this.negative?-t:t},a.prototype.toJSON=function(){return this.toString(16)},a.prototype.toBuffer=function(t,e){return n(void 0!==x),this.toArrayLike(x,t,e)},a.prototype.toArray=function(t,e){return this.toArrayLike(Array,t,e)},a.prototype.toArrayLike=function(t,e,r){var i=this.byteLength(),a=r||Math.max(1,i);n(i<=a,"byte array longer than desired length"),n(a>0,"Requested array length <= 0"),this.strip();var o,s,l="le"===e,u=new t(a),c=this.clone();if(l){for(s=0;!c.isZero();s++)o=c.andln(255),c.iushrn(8),u[s]=o;for(;s=4096&&(r+=13,e>>>=13),e>=64&&(r+=7,e>>>=7),e>=8&&(r+=4,e>>>=4),e>=2&&(r+=2,e>>>=2),r+e},a.prototype._zeroBits=function(t){if(0===t)return 26;var e=t,r=0;return 0==(8191&e)&&(r+=13,e>>>=13),0==(127&e)&&(r+=7,e>>>=7),0==(15&e)&&(r+=4,e>>>=4),0==(3&e)&&(r+=2,e>>>=2),0==(1&e)&&r++,r},a.prototype.bitLength=function(){var t=this.words[this.length-1],e=this._countBits(t);return 26*(this.length-1)+e},a.prototype.zeroBits=function(){if(this.isZero())return 0;for(var t=0,e=0;et.length?this.clone().ior(t):t.clone().ior(this)},a.prototype.uor=function(t){return this.length>t.length?this.clone().iuor(t):t.clone().iuor(this)},a.prototype.iuand=function(t){var e;e=this.length>t.length?t:this;for(var r=0;rt.length?this.clone().iand(t):t.clone().iand(this)},a.prototype.uand=function(t){return this.length>t.length?this.clone().iuand(t):t.clone().iuand(this)},a.prototype.iuxor=function(t){var e,r;this.length>t.length?(e=this,r=t):(e=t,r=this);for(var n=0;nt.length?this.clone().ixor(t):t.clone().ixor(this)},a.prototype.uxor=function(t){return this.length>t.length?this.clone().iuxor(t):t.clone().iuxor(this)},a.prototype.inotn=function(t){n("number"==typeof t&&t>=0);var e=0|Math.ceil(t/26),r=t%26;this._expand(e),r>0&&e--;for(var i=0;i0&&(this.words[i]=~this.words[i]&67108863>>26-r),this.strip()},a.prototype.notn=function(t){return this.clone().inotn(t)},a.prototype.setn=function(t,e){n("number"==typeof t&&t>=0);var r=t/26|0,i=t%26;return this._expand(r+1),this.words[r]=e?this.words[r]|1<t.length?(r=this,n=t):(r=t,n=this);for(var i=0,a=0;a>>26;for(;0!==i&&a>>26;if(this.length=r.length,0!==i)this.words[this.length]=i,this.length++;else if(r!==this)for(;at.length?this.clone().iadd(t):t.clone().iadd(this)},a.prototype.isub=function(t){if(0!==t.negative){t.negative=0;var e=this.iadd(t);return t.negative=1,e._normSign()}if(0!==this.negative)return this.negative=0,this.iadd(t),this.negative=1,this._normSign();var r=this.cmp(t);if(0===r)return this.negative=0,this.length=1,this.words[0]=0,this;var n,i;r>0?(n=this,i=t):(n=t,i=this);for(var a=0,o=0;o>26,this.words[o]=67108863&e;for(;0!==a&&o>26,this.words[o]=67108863&e;if(0===a&&o>>13,d=0|o[1],p=8191&d,m=d>>>13,v=0|o[2],g=8191&v,y=v>>>13,b=0|o[3],x=8191&b,_=b>>>13,w=0|o[4],M=8191&w,k=w>>>13,A=0|o[5],T=8191&A,S=A>>>13,E=0|o[6],L=8191&E,C=E>>>13,I=0|o[7],z=8191&I,D=I>>>13,P=0|o[8],O=8191&P,R=P>>>13,F=0|o[9],j=8191&F,N=F>>>13,B=0|s[0],U=8191&B,V=B>>>13,H=0|s[1],q=8191&H,G=H>>>13,Y=0|s[2],W=8191&Y,X=Y>>>13,Z=0|s[3],J=8191&Z,K=Z>>>13,Q=0|s[4],$=8191&Q,tt=Q>>>13,et=0|s[5],rt=8191&et,nt=et>>>13,it=0|s[6],at=8191&it,ot=it>>>13,st=0|s[7],lt=8191&st,ut=st>>>13,ct=0|s[8],ht=8191&ct,ft=ct>>>13,dt=0|s[9],pt=8191&dt,mt=dt>>>13;r.negative=t.negative^e.negative,r.length=19,n=Math.imul(h,U),i=Math.imul(h,V),i=i+Math.imul(f,U)|0,a=Math.imul(f,V);var vt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(vt>>>26)|0,vt&=67108863,n=Math.imul(p,U),i=Math.imul(p,V),i=i+Math.imul(m,U)|0,a=Math.imul(m,V),n=n+Math.imul(h,q)|0,i=i+Math.imul(h,G)|0,i=i+Math.imul(f,q)|0,a=a+Math.imul(f,G)|0;var gt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(gt>>>26)|0,gt&=67108863,n=Math.imul(g,U),i=Math.imul(g,V),i=i+Math.imul(y,U)|0,a=Math.imul(y,V),n=n+Math.imul(p,q)|0,i=i+Math.imul(p,G)|0,i=i+Math.imul(m,q)|0,a=a+Math.imul(m,G)|0,n=n+Math.imul(h,W)|0,i=i+Math.imul(h,X)|0,i=i+Math.imul(f,W)|0,a=a+Math.imul(f,X)|0;var yt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(yt>>>26)|0,yt&=67108863,n=Math.imul(x,U),i=Math.imul(x,V),i=i+Math.imul(_,U)|0,a=Math.imul(_,V),n=n+Math.imul(g,q)|0,i=i+Math.imul(g,G)|0,i=i+Math.imul(y,q)|0,a=a+Math.imul(y,G)|0,n=n+Math.imul(p,W)|0,i=i+Math.imul(p,X)|0,i=i+Math.imul(m,W)|0,a=a+Math.imul(m,X)|0,n=n+Math.imul(h,J)|0,i=i+Math.imul(h,K)|0,i=i+Math.imul(f,J)|0,a=a+Math.imul(f,K)|0;var bt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(bt>>>26)|0,bt&=67108863,n=Math.imul(M,U),i=Math.imul(M,V),i=i+Math.imul(k,U)|0,a=Math.imul(k,V),n=n+Math.imul(x,q)|0,i=i+Math.imul(x,G)|0,i=i+Math.imul(_,q)|0,a=a+Math.imul(_,G)|0,n=n+Math.imul(g,W)|0,i=i+Math.imul(g,X)|0,i=i+Math.imul(y,W)|0,a=a+Math.imul(y,X)|0,n=n+Math.imul(p,J)|0,i=i+Math.imul(p,K)|0,i=i+Math.imul(m,J)|0,a=a+Math.imul(m,K)|0,n=n+Math.imul(h,$)|0,i=i+Math.imul(h,tt)|0,i=i+Math.imul(f,$)|0,a=a+Math.imul(f,tt)|0;var xt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(xt>>>26)|0,xt&=67108863,n=Math.imul(T,U),i=Math.imul(T,V),i=i+Math.imul(S,U)|0,a=Math.imul(S,V),n=n+Math.imul(M,q)|0,i=i+Math.imul(M,G)|0,i=i+Math.imul(k,q)|0,a=a+Math.imul(k,G)|0,n=n+Math.imul(x,W)|0,i=i+Math.imul(x,X)|0,i=i+Math.imul(_,W)|0,a=a+Math.imul(_,X)|0,n=n+Math.imul(g,J)|0,i=i+Math.imul(g,K)|0,i=i+Math.imul(y,J)|0,a=a+Math.imul(y,K)|0,n=n+Math.imul(p,$)|0,i=i+Math.imul(p,tt)|0,i=i+Math.imul(m,$)|0,a=a+Math.imul(m,tt)|0,n=n+Math.imul(h,rt)|0,i=i+Math.imul(h,nt)|0,i=i+Math.imul(f,rt)|0,a=a+Math.imul(f,nt)|0;var _t=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(_t>>>26)|0,_t&=67108863,n=Math.imul(L,U),i=Math.imul(L,V),i=i+Math.imul(C,U)|0,a=Math.imul(C,V),n=n+Math.imul(T,q)|0,i=i+Math.imul(T,G)|0,i=i+Math.imul(S,q)|0,a=a+Math.imul(S,G)|0,n=n+Math.imul(M,W)|0,i=i+Math.imul(M,X)|0,i=i+Math.imul(k,W)|0,a=a+Math.imul(k,X)|0,n=n+Math.imul(x,J)|0,i=i+Math.imul(x,K)|0,i=i+Math.imul(_,J)|0,a=a+Math.imul(_,K)|0,n=n+Math.imul(g,$)|0,i=i+Math.imul(g,tt)|0,i=i+Math.imul(y,$)|0,a=a+Math.imul(y,tt)|0,n=n+Math.imul(p,rt)|0,i=i+Math.imul(p,nt)|0,i=i+Math.imul(m,rt)|0,a=a+Math.imul(m,nt)|0,n=n+Math.imul(h,at)|0,i=i+Math.imul(h,ot)|0,i=i+Math.imul(f,at)|0,a=a+Math.imul(f,ot)|0;var wt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(wt>>>26)|0,wt&=67108863,n=Math.imul(z,U),i=Math.imul(z,V),i=i+Math.imul(D,U)|0,a=Math.imul(D,V),n=n+Math.imul(L,q)|0,i=i+Math.imul(L,G)|0,i=i+Math.imul(C,q)|0,a=a+Math.imul(C,G)|0,n=n+Math.imul(T,W)|0,i=i+Math.imul(T,X)|0,i=i+Math.imul(S,W)|0,a=a+Math.imul(S,X)|0,n=n+Math.imul(M,J)|0,i=i+Math.imul(M,K)|0,i=i+Math.imul(k,J)|0,a=a+Math.imul(k,K)|0,n=n+Math.imul(x,$)|0,i=i+Math.imul(x,tt)|0,i=i+Math.imul(_,$)|0,a=a+Math.imul(_,tt)|0,n=n+Math.imul(g,rt)|0,i=i+Math.imul(g,nt)|0,i=i+Math.imul(y,rt)|0,a=a+Math.imul(y,nt)|0,n=n+Math.imul(p,at)|0,i=i+Math.imul(p,ot)|0,i=i+Math.imul(m,at)|0,a=a+Math.imul(m,ot)|0,n=n+Math.imul(h,lt)|0,i=i+Math.imul(h,ut)|0,i=i+Math.imul(f,lt)|0,a=a+Math.imul(f,ut)|0;var Mt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(Mt>>>26)|0,Mt&=67108863,n=Math.imul(O,U),i=Math.imul(O,V),i=i+Math.imul(R,U)|0,a=Math.imul(R,V),n=n+Math.imul(z,q)|0,i=i+Math.imul(z,G)|0,i=i+Math.imul(D,q)|0,a=a+Math.imul(D,G)|0,n=n+Math.imul(L,W)|0,i=i+Math.imul(L,X)|0,i=i+Math.imul(C,W)|0,a=a+Math.imul(C,X)|0,n=n+Math.imul(T,J)|0,i=i+Math.imul(T,K)|0,i=i+Math.imul(S,J)|0,a=a+Math.imul(S,K)|0,n=n+Math.imul(M,$)|0,i=i+Math.imul(M,tt)|0,i=i+Math.imul(k,$)|0,a=a+Math.imul(k,tt)|0,n=n+Math.imul(x,rt)|0,i=i+Math.imul(x,nt)|0,i=i+Math.imul(_,rt)|0,a=a+Math.imul(_,nt)|0,n=n+Math.imul(g,at)|0,i=i+Math.imul(g,ot)|0,i=i+Math.imul(y,at)|0,a=a+Math.imul(y,ot)|0,n=n+Math.imul(p,lt)|0,i=i+Math.imul(p,ut)|0,i=i+Math.imul(m,lt)|0,a=a+Math.imul(m,ut)|0,n=n+Math.imul(h,ht)|0,i=i+Math.imul(h,ft)|0,i=i+Math.imul(f,ht)|0,a=a+Math.imul(f,ft)|0;var kt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(kt>>>26)|0,kt&=67108863,n=Math.imul(j,U),i=Math.imul(j,V),i=i+Math.imul(N,U)|0,a=Math.imul(N,V),n=n+Math.imul(O,q)|0,i=i+Math.imul(O,G)|0,i=i+Math.imul(R,q)|0,a=a+Math.imul(R,G)|0,n=n+Math.imul(z,W)|0,i=i+Math.imul(z,X)|0,i=i+Math.imul(D,W)|0,a=a+Math.imul(D,X)|0,n=n+Math.imul(L,J)|0,i=i+Math.imul(L,K)|0,i=i+Math.imul(C,J)|0,a=a+Math.imul(C,K)|0,n=n+Math.imul(T,$)|0,i=i+Math.imul(T,tt)|0,i=i+Math.imul(S,$)|0,a=a+Math.imul(S,tt)|0,n=n+Math.imul(M,rt)|0,i=i+Math.imul(M,nt)|0,i=i+Math.imul(k,rt)|0,a=a+Math.imul(k,nt)|0,n=n+Math.imul(x,at)|0,i=i+Math.imul(x,ot)|0,i=i+Math.imul(_,at)|0,a=a+Math.imul(_,ot)|0,n=n+Math.imul(g,lt)|0,i=i+Math.imul(g,ut)|0,i=i+Math.imul(y,lt)|0,a=a+Math.imul(y,ut)|0,n=n+Math.imul(p,ht)|0,i=i+Math.imul(p,ft)|0,i=i+Math.imul(m,ht)|0,a=a+Math.imul(m,ft)|0,n=n+Math.imul(h,pt)|0,i=i+Math.imul(h,mt)|0,i=i+Math.imul(f,pt)|0,a=a+Math.imul(f,mt)|0;var At=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(At>>>26)|0,At&=67108863,n=Math.imul(j,q),i=Math.imul(j,G),i=i+Math.imul(N,q)|0,a=Math.imul(N,G),n=n+Math.imul(O,W)|0,i=i+Math.imul(O,X)|0,i=i+Math.imul(R,W)|0,a=a+Math.imul(R,X)|0,n=n+Math.imul(z,J)|0,i=i+Math.imul(z,K)|0,i=i+Math.imul(D,J)|0,a=a+Math.imul(D,K)|0,n=n+Math.imul(L,$)|0,i=i+Math.imul(L,tt)|0,i=i+Math.imul(C,$)|0,a=a+Math.imul(C,tt)|0,n=n+Math.imul(T,rt)|0,i=i+Math.imul(T,nt)|0,i=i+Math.imul(S,rt)|0,a=a+Math.imul(S,nt)|0,n=n+Math.imul(M,at)|0,i=i+Math.imul(M,ot)|0,i=i+Math.imul(k,at)|0,a=a+Math.imul(k,ot)|0,n=n+Math.imul(x,lt)|0,i=i+Math.imul(x,ut)|0,i=i+Math.imul(_,lt)|0,a=a+Math.imul(_,ut)|0,n=n+Math.imul(g,ht)|0,i=i+Math.imul(g,ft)|0,i=i+Math.imul(y,ht)|0,a=a+Math.imul(y,ft)|0,n=n+Math.imul(p,pt)|0,i=i+Math.imul(p,mt)|0,i=i+Math.imul(m,pt)|0,a=a+Math.imul(m,mt)|0;var Tt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(Tt>>>26)|0,Tt&=67108863,n=Math.imul(j,W),i=Math.imul(j,X),i=i+Math.imul(N,W)|0,a=Math.imul(N,X),n=n+Math.imul(O,J)|0,i=i+Math.imul(O,K)|0,i=i+Math.imul(R,J)|0,a=a+Math.imul(R,K)|0,n=n+Math.imul(z,$)|0,i=i+Math.imul(z,tt)|0,i=i+Math.imul(D,$)|0,a=a+Math.imul(D,tt)|0,n=n+Math.imul(L,rt)|0,i=i+Math.imul(L,nt)|0,i=i+Math.imul(C,rt)|0,a=a+Math.imul(C,nt)|0,n=n+Math.imul(T,at)|0,i=i+Math.imul(T,ot)|0,i=i+Math.imul(S,at)|0,a=a+Math.imul(S,ot)|0,n=n+Math.imul(M,lt)|0,i=i+Math.imul(M,ut)|0,i=i+Math.imul(k,lt)|0,a=a+Math.imul(k,ut)|0,n=n+Math.imul(x,ht)|0,i=i+Math.imul(x,ft)|0,i=i+Math.imul(_,ht)|0,a=a+Math.imul(_,ft)|0,n=n+Math.imul(g,pt)|0,i=i+Math.imul(g,mt)|0,i=i+Math.imul(y,pt)|0,a=a+Math.imul(y,mt)|0;var St=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(St>>>26)|0,St&=67108863,n=Math.imul(j,J),i=Math.imul(j,K),i=i+Math.imul(N,J)|0,a=Math.imul(N,K),n=n+Math.imul(O,$)|0,i=i+Math.imul(O,tt)|0,i=i+Math.imul(R,$)|0,a=a+Math.imul(R,tt)|0,n=n+Math.imul(z,rt)|0,i=i+Math.imul(z,nt)|0,i=i+Math.imul(D,rt)|0,a=a+Math.imul(D,nt)|0,n=n+Math.imul(L,at)|0,i=i+Math.imul(L,ot)|0,i=i+Math.imul(C,at)|0,a=a+Math.imul(C,ot)|0,n=n+Math.imul(T,lt)|0,i=i+Math.imul(T,ut)|0,i=i+Math.imul(S,lt)|0,a=a+Math.imul(S,ut)|0,n=n+Math.imul(M,ht)|0,i=i+Math.imul(M,ft)|0,i=i+Math.imul(k,ht)|0,a=a+Math.imul(k,ft)|0,n=n+Math.imul(x,pt)|0,i=i+Math.imul(x,mt)|0,i=i+Math.imul(_,pt)|0,a=a+Math.imul(_,mt)|0;var Et=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(Et>>>26)|0,Et&=67108863,n=Math.imul(j,$),i=Math.imul(j,tt),i=i+Math.imul(N,$)|0,a=Math.imul(N,tt),n=n+Math.imul(O,rt)|0,i=i+Math.imul(O,nt)|0,i=i+Math.imul(R,rt)|0,a=a+Math.imul(R,nt)|0,n=n+Math.imul(z,at)|0,i=i+Math.imul(z,ot)|0,i=i+Math.imul(D,at)|0,a=a+Math.imul(D,ot)|0,n=n+Math.imul(L,lt)|0,i=i+Math.imul(L,ut)|0,i=i+Math.imul(C,lt)|0,a=a+Math.imul(C,ut)|0,n=n+Math.imul(T,ht)|0,i=i+Math.imul(T,ft)|0,i=i+Math.imul(S,ht)|0,a=a+Math.imul(S,ft)|0,n=n+Math.imul(M,pt)|0,i=i+Math.imul(M,mt)|0,i=i+Math.imul(k,pt)|0,a=a+Math.imul(k,mt)|0;var Lt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(Lt>>>26)|0,Lt&=67108863,n=Math.imul(j,rt),i=Math.imul(j,nt),i=i+Math.imul(N,rt)|0,a=Math.imul(N,nt),n=n+Math.imul(O,at)|0,i=i+Math.imul(O,ot)|0,i=i+Math.imul(R,at)|0,a=a+Math.imul(R,ot)|0,n=n+Math.imul(z,lt)|0,i=i+Math.imul(z,ut)|0,i=i+Math.imul(D,lt)|0,a=a+Math.imul(D,ut)|0,n=n+Math.imul(L,ht)|0, +i=i+Math.imul(L,ft)|0,i=i+Math.imul(C,ht)|0,a=a+Math.imul(C,ft)|0,n=n+Math.imul(T,pt)|0,i=i+Math.imul(T,mt)|0,i=i+Math.imul(S,pt)|0,a=a+Math.imul(S,mt)|0;var Ct=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(Ct>>>26)|0,Ct&=67108863,n=Math.imul(j,at),i=Math.imul(j,ot),i=i+Math.imul(N,at)|0,a=Math.imul(N,ot),n=n+Math.imul(O,lt)|0,i=i+Math.imul(O,ut)|0,i=i+Math.imul(R,lt)|0,a=a+Math.imul(R,ut)|0,n=n+Math.imul(z,ht)|0,i=i+Math.imul(z,ft)|0,i=i+Math.imul(D,ht)|0,a=a+Math.imul(D,ft)|0,n=n+Math.imul(L,pt)|0,i=i+Math.imul(L,mt)|0,i=i+Math.imul(C,pt)|0,a=a+Math.imul(C,mt)|0;var It=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(It>>>26)|0,It&=67108863,n=Math.imul(j,lt),i=Math.imul(j,ut),i=i+Math.imul(N,lt)|0,a=Math.imul(N,ut),n=n+Math.imul(O,ht)|0,i=i+Math.imul(O,ft)|0,i=i+Math.imul(R,ht)|0,a=a+Math.imul(R,ft)|0,n=n+Math.imul(z,pt)|0,i=i+Math.imul(z,mt)|0,i=i+Math.imul(D,pt)|0,a=a+Math.imul(D,mt)|0;var zt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(zt>>>26)|0,zt&=67108863,n=Math.imul(j,ht),i=Math.imul(j,ft),i=i+Math.imul(N,ht)|0,a=Math.imul(N,ft),n=n+Math.imul(O,pt)|0,i=i+Math.imul(O,mt)|0,i=i+Math.imul(R,pt)|0,a=a+Math.imul(R,mt)|0;var Dt=(u+n|0)+((8191&i)<<13)|0;u=(a+(i>>>13)|0)+(Dt>>>26)|0,Dt&=67108863,n=Math.imul(j,pt),i=Math.imul(j,mt),i=i+Math.imul(N,pt)|0,a=Math.imul(N,mt);var Pt=(u+n|0)+((8191&i)<<13)|0;return u=(a+(i>>>13)|0)+(Pt>>>26)|0,Pt&=67108863,l[0]=vt,l[1]=gt,l[2]=yt,l[3]=bt,l[4]=xt,l[5]=_t,l[6]=wt,l[7]=Mt,l[8]=kt,l[9]=At,l[10]=Tt,l[11]=St,l[12]=Et,l[13]=Lt,l[14]=Ct,l[15]=It,l[16]=zt,l[17]=Dt,l[18]=Pt,0!==u&&(l[19]=u,r.length++),r};Math.imul||(k=u),a.prototype.mulTo=function(t,e){var r=this.length+t.length;return 10===this.length&&10===t.length?k(this,t,e):r<63?u(this,t,e):r<1024?c(this,t,e):h(this,t,e)},f.prototype.makeRBT=function(t){for(var e=new Array(t),r=a.prototype._countBits(t)-1,n=0;n>=1;return n},f.prototype.permute=function(t,e,r,n,i,a){for(var o=0;o>>=1)i++;return 1<>>=13,r[2*o+1]=8191&a,a>>>=13;for(o=2*e;o>=26,e+=i/67108864|0,e+=a>>>26,this.words[r]=67108863&a}return 0!==e&&(this.words[r]=e,this.length++),this},a.prototype.muln=function(t){return this.clone().imuln(t)},a.prototype.sqr=function(){return this.mul(this)},a.prototype.isqr=function(){return this.imul(this.clone())},a.prototype.pow=function(t){var e=l(t);if(0===e.length)return new a(1);for(var r=this,n=0;n=0);var e,r=t%26,i=(t-r)/26,a=67108863>>>26-r<<26-r;if(0!==r){var o=0;for(e=0;e>>26-r}o&&(this.words[e]=o,this.length++)}if(0!==i){for(e=this.length-1;e>=0;e--)this.words[e+i]=this.words[e];for(e=0;e=0);var i;i=e?(e-e%26)/26:0;var a=t%26,o=Math.min((t-a)/26,this.length),s=67108863^67108863>>>a<o)for(this.length-=o,u=0;u=0&&(0!==c||u>=i);u--){var h=0|this.words[u];this.words[u]=c<<26-a|h>>>a,c=h&s}return l&&0!==c&&(l.words[l.length++]=c),0===this.length&&(this.words[0]=0,this.length=1),this.strip()},a.prototype.ishrn=function(t,e,r){return n(0===this.negative),this.iushrn(t,e,r)},a.prototype.shln=function(t){return this.clone().ishln(t)},a.prototype.ushln=function(t){return this.clone().iushln(t)},a.prototype.shrn=function(t){return this.clone().ishrn(t)},a.prototype.ushrn=function(t){return this.clone().iushrn(t)},a.prototype.testn=function(t){n("number"==typeof t&&t>=0);var e=t%26,r=(t-e)/26,i=1<=0);var e=t%26,r=(t-e)/26;if(n(0===this.negative,"imaskn works only with positive numbers"),this.length<=r)return this;if(0!==e&&r++,this.length=Math.min(r,this.length),0!==e){var i=67108863^67108863>>>e<=67108864;e++)this.words[e]-=67108864,e===this.length-1?this.words[e+1]=1:this.words[e+1]++;return this.length=Math.max(this.length,e+1),this},a.prototype.isubn=function(t){if(n("number"==typeof t),n(t<67108864),t<0)return this.iaddn(-t);if(0!==this.negative)return this.negative=0,this.iaddn(t),this.negative=1,this;if(this.words[0]-=t,1===this.length&&this.words[0]<0)this.words[0]=-this.words[0],this.negative=1;else for(var e=0;e>26)-(l/67108864|0),this.words[i+r]=67108863&o}for(;i>26,this.words[i+r]=67108863&o;if(0===s)return this.strip();for(n(-1===s),s=0,i=0;i>26,this.words[i]=67108863&o;return this.negative=1,this.strip()},a.prototype._wordDiv=function(t,e){var r=this.length-t.length,n=this.clone(),i=t,o=0|i.words[i.length-1];0!==(r=26-this._countBits(o))&&(i=i.ushln(r),n.iushln(r),o=0|i.words[i.length-1]);var s,l=n.length-i.length;if("mod"!==e){s=new a(null),s.length=l+1,s.words=new Array(s.length);for(var u=0;u=0;h--){var f=67108864*(0|n.words[i.length+h])+(0|n.words[i.length+h-1]);for(f=Math.min(f/o|0,67108863),n._ishlnsubmul(i,f,h);0!==n.negative;)f--,n.negative=0,n._ishlnsubmul(i,1,h),n.isZero()||(n.negative^=1);s&&(s.words[h]=f)}return s&&s.strip(),n.strip(),"div"!==e&&0!==r&&n.iushrn(r),{div:s||null,mod:n}},a.prototype.divmod=function(t,e,r){if(n(!t.isZero()),this.isZero())return{div:new a(0),mod:new a(0)};var i,o,s;return 0!==this.negative&&0===t.negative?(s=this.neg().divmod(t,e),"mod"!==e&&(i=s.div.neg()),"div"!==e&&(o=s.mod.neg(),r&&0!==o.negative&&o.iadd(t)),{div:i,mod:o}):0===this.negative&&0!==t.negative?(s=this.divmod(t.neg(),e),"mod"!==e&&(i=s.div.neg()),{div:i,mod:s.mod}):0!=(this.negative&t.negative)?(s=this.neg().divmod(t.neg(),e),"div"!==e&&(o=s.mod.neg(),r&&0!==o.negative&&o.isub(t)),{div:s.div,mod:o}):t.length>this.length||this.cmp(t)<0?{div:new a(0),mod:this}:1===t.length?"div"===e?{div:this.divn(t.words[0]),mod:null}:"mod"===e?{div:null,mod:new a(this.modn(t.words[0]))}:{div:this.divn(t.words[0]),mod:new a(this.modn(t.words[0]))}:this._wordDiv(t,e)},a.prototype.div=function(t){return this.divmod(t,"div",!1).div},a.prototype.mod=function(t){return this.divmod(t,"mod",!1).mod},a.prototype.umod=function(t){return this.divmod(t,"mod",!0).mod},a.prototype.divRound=function(t){var e=this.divmod(t);if(e.mod.isZero())return e.div;var r=0!==e.div.negative?e.mod.isub(t):e.mod,n=t.ushrn(1),i=t.andln(1),a=r.cmp(n);return a<0||1===i&&0===a?e.div:0!==e.div.negative?e.div.isubn(1):e.div.iaddn(1)},a.prototype.modn=function(t){n(t<=67108863);for(var e=(1<<26)%t,r=0,i=this.length-1;i>=0;i--)r=(e*r+(0|this.words[i]))%t;return r},a.prototype.idivn=function(t){n(t<=67108863);for(var e=0,r=this.length-1;r>=0;r--){var i=(0|this.words[r])+67108864*e;this.words[r]=i/t|0,e=i%t}return this.strip()},a.prototype.divn=function(t){return this.clone().idivn(t)},a.prototype.egcd=function(t){n(0===t.negative),n(!t.isZero());var e=this,r=t.clone();e=0!==e.negative?e.umod(t):e.clone();for(var i=new a(1),o=new a(0),s=new a(0),l=new a(1),u=0;e.isEven()&&r.isEven();)e.iushrn(1),r.iushrn(1),++u;for(var c=r.clone(),h=e.clone();!e.isZero();){for(var f=0,d=1;0==(e.words[0]&d)&&f<26;++f,d<<=1);if(f>0)for(e.iushrn(f);f-- >0;)(i.isOdd()||o.isOdd())&&(i.iadd(c),o.isub(h)),i.iushrn(1),o.iushrn(1);for(var p=0,m=1;0==(r.words[0]&m)&&p<26;++p,m<<=1);if(p>0)for(r.iushrn(p);p-- >0;)(s.isOdd()||l.isOdd())&&(s.iadd(c),l.isub(h)),s.iushrn(1),l.iushrn(1);e.cmp(r)>=0?(e.isub(r),i.isub(s),o.isub(l)):(r.isub(e),s.isub(i),l.isub(o))}return{a:s,b:l,gcd:r.iushln(u)}},a.prototype._invmp=function(t){n(0===t.negative),n(!t.isZero());var e=this,r=t.clone();e=0!==e.negative?e.umod(t):e.clone();for(var i=new a(1),o=new a(0),s=r.clone();e.cmpn(1)>0&&r.cmpn(1)>0;){for(var l=0,u=1;0==(e.words[0]&u)&&l<26;++l,u<<=1);if(l>0)for(e.iushrn(l);l-- >0;)i.isOdd()&&i.iadd(s),i.iushrn(1);for(var c=0,h=1;0==(r.words[0]&h)&&c<26;++c,h<<=1);if(c>0)for(r.iushrn(c);c-- >0;)o.isOdd()&&o.iadd(s),o.iushrn(1);e.cmp(r)>=0?(e.isub(r),i.isub(o)):(r.isub(e),o.isub(i))}var f;return f=0===e.cmpn(1)?i:o,f.cmpn(0)<0&&f.iadd(t),f},a.prototype.gcd=function(t){if(this.isZero())return t.abs();if(t.isZero())return this.abs();var e=this.clone(),r=t.clone();e.negative=0,r.negative=0;for(var n=0;e.isEven()&&r.isEven();n++)e.iushrn(1),r.iushrn(1);for(;;){for(;e.isEven();)e.iushrn(1);for(;r.isEven();)r.iushrn(1);var i=e.cmp(r);if(i<0){var a=e;e=r,r=a}else if(0===i||0===r.cmpn(1))break;e.isub(r)}return r.iushln(n)},a.prototype.invm=function(t){return this.egcd(t).a.umod(t)},a.prototype.isEven=function(){return 0==(1&this.words[0])},a.prototype.isOdd=function(){return 1==(1&this.words[0])},a.prototype.andln=function(t){return this.words[0]&t},a.prototype.bincn=function(t){n("number"==typeof t);var e=t%26,r=(t-e)/26,i=1<>>26,s&=67108863,this.words[o]=s}return 0!==a&&(this.words[o]=a,this.length++),this},a.prototype.isZero=function(){return 1===this.length&&0===this.words[0]},a.prototype.cmpn=function(t){var e=t<0;if(0!==this.negative&&!e)return-1;if(0===this.negative&&e)return 1;this.strip();var r;if(this.length>1)r=1;else{e&&(t=-t),n(t<=67108863,"Number is too big");var i=0|this.words[0];r=i===t?0:it.length)return 1;if(this.length=0;r--){var n=0|this.words[r],i=0|t.words[r];if(n!==i){ni&&(e=1);break}}return e},a.prototype.gtn=function(t){return 1===this.cmpn(t)},a.prototype.gt=function(t){return 1===this.cmp(t)},a.prototype.gten=function(t){return this.cmpn(t)>=0},a.prototype.gte=function(t){return this.cmp(t)>=0},a.prototype.ltn=function(t){return-1===this.cmpn(t)},a.prototype.lt=function(t){return-1===this.cmp(t)},a.prototype.lten=function(t){return this.cmpn(t)<=0},a.prototype.lte=function(t){return this.cmp(t)<=0},a.prototype.eqn=function(t){return 0===this.cmpn(t)},a.prototype.eq=function(t){return 0===this.cmp(t)},a.red=function(t){return new y(t)},a.prototype.toRed=function(t){return n(!this.red,"Already a number in reduction context"),n(0===this.negative,"red works only with positives"),t.convertTo(this)._forceRed(t)},a.prototype.fromRed=function(){return n(this.red,"fromRed works only with numbers in reduction context"),this.red.convertFrom(this)},a.prototype._forceRed=function(t){return this.red=t,this},a.prototype.forceRed=function(t){return n(!this.red,"Already a number in reduction context"),this._forceRed(t)},a.prototype.redAdd=function(t){return n(this.red,"redAdd works only with red numbers"),this.red.add(this,t)},a.prototype.redIAdd=function(t){return n(this.red,"redIAdd works only with red numbers"),this.red.iadd(this,t)},a.prototype.redSub=function(t){return n(this.red,"redSub works only with red numbers"),this.red.sub(this,t)},a.prototype.redISub=function(t){return n(this.red,"redISub works only with red numbers"),this.red.isub(this,t)},a.prototype.redShl=function(t){return n(this.red,"redShl works only with red numbers"),this.red.shl(this,t)},a.prototype.redMul=function(t){return n(this.red,"redMul works only with red numbers"),this.red._verify2(this,t),this.red.mul(this,t)},a.prototype.redIMul=function(t){return n(this.red,"redMul works only with red numbers"),this.red._verify2(this,t),this.red.imul(this,t)},a.prototype.redSqr=function(){return n(this.red,"redSqr works only with red numbers"),this.red._verify1(this),this.red.sqr(this)},a.prototype.redISqr=function(){return n(this.red,"redISqr works only with red numbers"),this.red._verify1(this),this.red.isqr(this)},a.prototype.redSqrt=function(){return n(this.red,"redSqrt works only with red numbers"),this.red._verify1(this),this.red.sqrt(this)},a.prototype.redInvm=function(){return n(this.red,"redInvm works only with red numbers"),this.red._verify1(this),this.red.invm(this)},a.prototype.redNeg=function(){return n(this.red,"redNeg works only with red numbers"),this.red._verify1(this),this.red.neg(this)},a.prototype.redPow=function(t){return n(this.red&&!t.red,"redPow(normalNum)"),this.red._verify1(this),this.red.pow(this,t)};var A={k256:null,p224:null,p192:null,p25519:null};d.prototype._tmp=function(){var t=new a(null);return t.words=new Array(Math.ceil(this.n/13)),t},d.prototype.ireduce=function(t){var 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a=i.geometry[0].length;if(5!==a)return!1;for(var o=0;o1&&console.time("creation"),b=this.tiles[y]=p(t,g,r,n,x,e===d.maxZoom),this.tileCoords.push({z:e,x:r,y:n}),m)){m>1&&(console.log("tile z%d-%d-%d (features: %d, points: %d, simplified: %d)",e,r,n,b.numFeatures,b.numPoints,b.numSimplified),console.timeEnd("creation"));var _="z"+e;this.stats[_]=(this.stats[_]||0)+1,this.total++}if(b.source=t,i){if(e===d.maxZoom||e===i)continue;var w=1<1&&console.time("clipping");var M,k,A,T,S,E,L=.5*d.buffer/d.extent,C=.5-L,I=.5+L,z=1+L;M=k=A=T=null,S=f(t,g,r-L,r+I,0,o,b.min[0],b.max[0]),E=f(t,g,r+C,r+z,0,o,b.min[0],b.max[0]),S&&(M=f(S,g,n-L,n+I,1,s,b.min[1],b.max[1]),k=f(S,g,n+C,n+z,1,s,b.min[1],b.max[1])),E&&(A=f(E,g,n-L,n+I,1,s,b.min[1],b.max[1]),T=f(E,g,n+C,n+z,1,s,b.min[1],b.max[1])),m>1&&console.timeEnd("clipping"),t.length&&(h.push(M||[],e+1,2*r,2*n),h.push(k||[],e+1,2*r,2*n+1),h.push(A||[],e+1,2*r+1,2*n),h.push(T||[],e+1,2*r+1,2*n+1))}else i&&(v=e)}return 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s={features:[],numPoints:0,numSimplified:0,numFeatures:0,source:null,x:r,y:n,z2:e,transformed:!1,min:[2,1],max:[-1,0]},l=0;ls.max[0]&&(s.max[0]=c[0]),c[1]>s.max[1]&&(s.max[1]=c[1])}return s}function i(t,e,r,n){var i,o,s,l,u=e.geometry,c=e.type,h=[],f=r*r;if(1===c)for(i=0;if)&&(d.push(l),t.numSimplified++),t.numPoints++;3===c&&a(d,s.outer),h.push(d)}else t.numPoints+=s.length;if(h.length){var p={geometry:h,type:c,tags:e.tags||null};null!==e.id&&(p.id=e.id),t.features.push(p)}}function a(t,e){o(t)<0===e&&t.reverse()}function o(t){for(var e,r,n=0,i=0,a=t.length,o=a-1;i0?(d[c]=-1,p[c]=0):(d[c]=0,p[c]=1)}}function s(t,e){var r=new i(t);return r.update(e),r}e.exports=s;var l=t("./lib/text.js"),u=t("./lib/lines.js"),c=t("./lib/background.js"),h=t("./lib/cube.js"),f=t("./lib/ticks.js"),d=new Float32Array([1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1]),p=i.prototype;p.update=function(t){function e(e,r,n){if(n in t){var i,a=t[n],o=this[n];(e?Array.isArray(a)&&Array.isArray(a[0]):Array.isArray(a))?this[n]=i=[r(a[0]),r(a[1]),r(a[2])]:this[n]=i=[r(a),r(a),r(a)];for(var s=0;s<3;++s)if(i[s]!==o[s])return!0}return!1}t=t||{};var r,n=e.bind(this,!1,Number),i=e.bind(this,!1,Boolean),a=e.bind(this,!1,String),o=e.bind(this,!0,function(t){if(Array.isArray(t)){if(3===t.length)return[+t[0],+t[1],+t[2],1];if(4===t.length)return[+t[0],+t[1],+t[2],+t[3]]}return[0,0,0,1]}),s=!1,c=!1;if("bounds"in t)for(var h=t.bounds,d=0;d<2;++d)for(var p=0;p<3;++p)h[d][p]!==this.bounds[d][p]&&(c=!0),this.bounds[d][p]=h[d][p];if("ticks"in t){r=t.ticks,s=!0,this.autoTicks=!1;for(var d=0;d<3;++d)this.tickSpacing[d]=0}else n("tickSpacing")&&(this.autoTicks=!0,c=!0);if(this._firstInit&&("ticks"in t||"tickSpacing"in t||(this.autoTicks=!0),c=!0,s=!0,this._firstInit=!1),c&&this.autoTicks&&(r=f.create(this.bounds,this.tickSpacing),s=!0),s){for(var d=0;d<3;++d)r[d].sort(function(t,e){return t.x-e.x});f.equal(r,this.ticks)?s=!1:this.ticks=r}i("tickEnable"),a("tickFont")&&(s=!0),n("tickSize"),n("tickAngle"),n("tickPad"),o("tickColor");var m=a("labels");a("labelFont")&&(m=!0),i("labelEnable"),n("labelSize"),n("labelPad"),o("labelColor"),i("lineEnable"),i("lineMirror"),n("lineWidth"),o("lineColor"),i("lineTickEnable"),i("lineTickMirror"),n("lineTickLength"),n("lineTickWidth"),o("lineTickColor"),i("gridEnable"),n("gridWidth"),o("gridColor"),i("zeroEnable"),o("zeroLineColor"),n("zeroLineWidth"),i("backgroundEnable"),o("backgroundColor"),this._text?this._text&&(m||s)&&this._text.update(this.bounds,this.labels,this.labelFont,this.ticks,this.tickFont):this._text=l(this.gl,this.bounds,this.labels,this.labelFont,this.ticks,this.tickFont),this._lines&&s&&(this._lines.dispose(),this._lines=null),this._lines||(this._lines=u(this.gl,this.bounds,this.ticks))};var m=[new a,new a,new a],v=[0,0,0],g={model:d,view:d,projection:d};p.isOpaque=function(){return!0},p.isTransparent=function(){return!1},p.drawTransparent=function(t){};var y=[0,0,0],b=[0,0,0],x=[0,0,0];p.draw=function(t){t=t||g;for(var e=this.gl,r=t.model||d,i=t.view||d,a=t.projection||d,s=this.bounds,l=h(r,i,a,s),u=l.cubeEdges,c=l.axis,f=i[12],p=i[13],_=i[14],w=i[15],M=this.pixelRatio*(a[3]*f+a[7]*p+a[11]*_+a[15]*w)/e.drawingBufferHeight,k=0;k<3;++k)this.lastCubeProps.cubeEdges[k]=u[k],this.lastCubeProps.axis[k]=c[k];for(var A=m,k=0;k<3;++k)o(m[k],k,this.bounds,u,c);for(var e=this.gl,T=v,k=0;k<3;++k)this.backgroundEnable[k]?T[k]=c[k]:T[k]=0;this._background.draw(r,i,a,s,T,this.backgroundColor),this._lines.bind(r,i,a,this);for(var k=0;k<3;++k){var S=[0,0,0];c[k]>0?S[k]=s[1][k]:S[k]=s[0][k];for(var E=0;E<2;++E){var L=(k+1+E)%3,C=(k+1+(1^E))%3;this.gridEnable[L]&&this._lines.drawGrid(L,C,this.bounds,S,this.gridColor[L],this.gridWidth[L]*this.pixelRatio)}for(var E=0;E<2;++E){var L=(k+1+E)%3,C=(k+1+(1^E))%3;this.zeroEnable[C]&&s[0][C]<=0&&s[1][C]>=0&&this._lines.drawZero(L,C,this.bounds,S,this.zeroLineColor[C],this.zeroLineWidth[C]*this.pixelRatio)}}for(var k=0;k<3;++k){this.lineEnable[k]&&this._lines.drawAxisLine(k,this.bounds,A[k].primalOffset,this.lineColor[k],this.lineWidth[k]*this.pixelRatio),this.lineMirror[k]&&this._lines.drawAxisLine(k,this.bounds,A[k].mirrorOffset,this.lineColor[k],this.lineWidth[k]*this.pixelRatio);for(var I=n(y,A[k].primalMinor),z=n(b,A[k].mirrorMinor),D=this.lineTickLength,E=0;E<3;++E){var P=M/r[5*E];I[E]*=D[E]*P,z[E]*=D[E]*P}this.lineTickEnable[k]&&this._lines.drawAxisTicks(k,A[k].primalOffset,I,this.lineTickColor[k],this.lineTickWidth[k]*this.pixelRatio),this.lineTickMirror[k]&&this._lines.drawAxisTicks(k,A[k].mirrorOffset,z,this.lineTickColor[k],this.lineTickWidth[k]*this.pixelRatio)}this._text.bind(r,i,a,this.pixelRatio);for(var k=0;k<3;++k){for(var O=A[k].primalMinor,R=n(x,A[k].primalOffset),E=0;E<3;++E)this.lineTickEnable[k]&&(R[E]+=M*O[E]*Math.max(this.lineTickLength[E],0)/r[5*E]);if(this.tickEnable[k]){for(var E=0;E<3;++E)R[E]+=M*O[E]*this.tickPad[E]/r[5*E];this._text.drawTicks(k,this.tickSize[k],this.tickAngle[k],R,this.tickColor[k])}if(this.labelEnable[k]){for(var E=0;E<3;++E)R[E]+=M*O[E]*this.labelPad[E]/r[5*E];R[k]+=.5*(s[0][k]+s[1][k]),this._text.drawLabel(k,this.labelSize[k],this.labelAngle[k],R,this.labelColor[k])}}},p.dispose=function(){this._text.dispose(),this._lines.dispose(),this._background.dispose(),this._lines=null,this._text=null,this._background=null,this.gl=null}},{"./lib/background.js":149,"./lib/cube.js":150,"./lib/lines.js":151,"./lib/text.js":153,"./lib/ticks.js":154}],149:[function(t,e,r){"use strict";function n(t,e,r,n){this.gl=t,this.buffer=e,this.vao=r,this.shader=n}function i(t){for(var e=[],r=[],i=0,l=0;l<3;++l)for(var 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l=this.gl;l.enable(l.POLYGON_OFFSET_FILL),l.polygonOffset(1,2),this.shader.bind(),this.shader.uniforms={model:t,view:e,projection:r,bounds:n,enable:i,colors:a},this.vao.bind(),this.vao.draw(this.gl.TRIANGLES,36),l.disable(l.POLYGON_OFFSET_FILL)}},l.dispose=function(){this.vao.dispose(),this.buffer.dispose(),this.shader.dispose()}},{"./shaders":152,"gl-buffer":156,"gl-vao":271}],150:[function(t,e,r){"use strict";function n(t,e,r){for(var n=0;n<4;++n){t[n]=r[12+n];for(var i=0;i<3;++i)t[n]+=e[i]*r[4*i+n]}}function i(t){for(var e=0;eS&&(_|=1<S&&(_|=1<f[m][1]&&(O=m));for(var R=-1,m=0;m<3;++m){var F=O^1<f[j][0]&&(j=F)}}var N=v;N[0]=N[1]=N[2]=0,N[o.log2(R^O)]=O&R,N[o.log2(O^j)]=O&j;var B=7^j;B===_||B===P?(B=7^R,N[o.log2(j^B)]=B&j):N[o.log2(R^B)]=B&R;for(var U=g,V=_,k=0;k<3;++k)U[k]=V&1< 0.0) {\n vec3 nPosition = mix(bounds[0], bounds[1], 0.5 * (position + 1.0));\n gl_Position = projection * view * model * vec4(nPosition, 1.0);\n } else {\n gl_Position = vec4(0,0,0,0);\n }\n colorChannel = abs(normal);\n}","precision mediump float;\n#define GLSLIFY 1\n\nuniform vec4 colors[3];\n\nvarying vec3 colorChannel;\n\nvoid main() {\n gl_FragColor = colorChannel.x * colors[0] + \n colorChannel.y * colors[1] +\n colorChannel.z * colors[2];\n}",null,[{name:"position",type:"vec3"},{name:"normal",type:"vec3"}])}},{"gl-shader":255}],153:[function(t,e,r){(function(r){"use strict";function n(t,e,r,n){this.gl=t,this.shader=e,this.buffer=r,this.vao=n,this.tickOffset=this.tickCount=this.labelOffset=this.labelCount=null}function i(t,e){try{return l(t,e)}catch(t){return console.warn("error vectorizing text:",t),{cells:[],positions:[]}}}function a(t,e,r,i,a,l){var c=o(t),h=s(t,[{buffer:c,size:3}]),f=u(t);f.attributes.position.location=0;var d=new n(t,f,c,h);return d.update(e,r,i,a,l),d}e.exports=a;var o=t("gl-buffer"),s=t("gl-vao"),l=t("vectorize-text"),u=t("./shaders").text,c=window||r.global||{},h=c.__TEXT_CACHE||{};c.__TEXT_CACHE={};var f=n.prototype,d=[0,0];f.bind=function(t,e,r,n){this.vao.bind(),this.shader.bind();var i=this.shader.uniforms;i.model=t,i.view=e,i.projection=r,i.pixelScale=n,d[0]=this.gl.drawingBufferWidth,d[1]=this.gl.drawingBufferHeight,this.shader.uniforms.resolution=d},f.update=function(t,e,r,n,a){function o(t,e,r,n){var a=h[r];a||(a=h[r]={});var o=a[e];o||(o=a[e]=i(e,{triangles:!0,font:r,textAlign:"center",textBaseline:"middle"}));for(var l=(n||12)/12,u=o.positions,c=o.cells,f=0,d=c.length;f=0;--m){var v=u[p[m]];s.push(l*v[0],-l*v[1],t)}}for(var s=(this.gl,[]),l=[0,0,0],u=[0,0,0],c=[0,0,0],f=[0,0,0],d=0;d<3;++d){c[d]=s.length/3|0,o(.5*(t[0][d]+t[1][d]),e[d],r),f[d]=(s.length/3|0)-c[d],l[d]=s.length/3|0;for(var p=0;p=0&&(i=r.length-n-1);var a=Math.pow(10,i),o=Math.round(t*e*a),s=o+"";if(s.indexOf("e")>=0)return s;var l=o/a,u=o%a;o<0?(l=0|-Math.ceil(l),u=0|-u):(l=0|Math.floor(l),u|=0);var c=""+l;if(o<0&&(c="-"+c),i){for(var 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l=t("typedarray-pool"),u=t("ndarray-ops"),c=t("ndarray"),h=["uint8","uint8_clamped","uint16","uint32","int8","int16","int32","float32"],f=n.prototype;f.bind=function(){this.gl.bindBuffer(this.type,this.handle)},f.unbind=function(){this.gl.bindBuffer(this.type,null)},f.dispose=function(){this.gl.deleteBuffer(this.handle)},f.update=function(t,e){if("number"!=typeof e&&(e=-1),this.bind(),"object"==typeof t&&void 0!==t.shape){var r=t.dtype;if(h.indexOf(r)<0&&(r="float32"),this.type===this.gl.ELEMENT_ARRAY_BUFFER){r=gl.getExtension("OES_element_index_uint")&&"uint16"!==r?"uint32":"uint16"}if(r===t.dtype&&o(t.shape,t.stride))0===t.offset&&t.data.length===t.shape[0]?this.length=i(this.gl,this.type,this.length,this.usage,t.data,e):this.length=i(this.gl,this.type,this.length,this.usage,t.data.subarray(t.offset,t.shape[0]),e);else{var 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n=t("./1.0/numbers");e.exports=function(t){return n[t]}},{"./1.0/numbers":157}],159:[function(t,e,r){"use strict";function n(t,e,r,n){this.plot=t,this.shader=e,this.bufferHi=r,this.bufferLo=n,this.bounds=[1/0,1/0,-1/0,-1/0],this.numPoints=0,this.color=[0,0,0,1]}function i(t,e){var r=a(t.gl,l.vertex,l.fragment),i=o(t.gl),s=o(t.gl),u=new n(t,r,i,s);return u.update(e),t.addObject(u),u}var a=t("gl-shader"),o=t("gl-buffer"),s=t("typedarray-pool"),l=t("./lib/shaders");e.exports=i;var 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c=this.bounds=[1/0,1/0,-1/0,-1/0],h=this.numPoints=i.length>>1;for(e=0;e0&&(T*=_),S<0?S*=w:S>0&&(S*=M),v[b++]=f*(r-p+T),v[b++]=d*(n-m+S),v[b++]=o*A[2]+(l+o)*A[4],v[b++]=o*A[3]+(l+o)*A[5]}}for(e=0;e=1},h.isTransparent=function(){return this.opacity<1},h.drawTransparent=h.draw=function(t){var e=this.gl,r=this.shader.uniforms;this.shader.bind();var n=r.view=t.view||c,i=r.projection=t.projection||c;r.model=t.model||c,r.clipBounds=this.clipBounds,r.opacity=this.opacity;var a=n[12],o=n[13],s=n[14],l=n[15],u=this.pixelRatio*(i[3]*a+i[7]*o+i[11]*s+i[15]*l)/e.drawingBufferHeight;this.vao.bind();for(var h=0;h<3;++h)e.lineWidth(this.lineWidth[h]),r.capSize=this.capSize[h]*u,this.lineCount[h]&&e.drawArrays(e.LINES,this.lineOffset[h],this.lineCount[h]);this.vao.unbind()};var f=function(){for(var t=new Array(3),e=0;e<3;++e){for(var r=[],n=1;n<=2;++n)for(var i=-1;i<=1;i+=2){var a=(n+e)%3,o=[0,0,0];o[a]=i,r.push(o)}t[e]=r}return t}();h.update=function(t){t=t||{},"lineWidth"in 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e=[].slice.call(arguments,1),r=[],n=0;n1&&f.drawBuffersWEBGL(y[h]);var g=r.getExtension("WEBGL_depth_texture");g?d?t.depth=s(r,u,c,g.UNSIGNED_INT_24_8_WEBGL,r.DEPTH_STENCIL,r.DEPTH_STENCIL_ATTACHMENT):p&&(t.depth=s(r,u,c,r.UNSIGNED_SHORT,r.DEPTH_COMPONENT,r.DEPTH_ATTACHMENT)):p&&d?t._depth_rb=l(r,u,c,r.DEPTH_STENCIL,r.DEPTH_STENCIL_ATTACHMENT):p?t._depth_rb=l(r,u,c,r.DEPTH_COMPONENT16,r.DEPTH_ATTACHMENT):d&&(t._depth_rb=l(r,u,c,r.STENCIL_INDEX,r.STENCIL_ATTACHMENT));var b=r.checkFramebufferStatus(r.FRAMEBUFFER);if(b!==r.FRAMEBUFFER_COMPLETE){t._destroyed=!0,r.bindFramebuffer(r.FRAMEBUFFER,null),r.deleteFramebuffer(t.handle),t.handle=null,t.depth&&(t.depth.dispose(),t.depth=null),t._depth_rb&&(r.deleteRenderbuffer(t._depth_rb),t._depth_rb=null);for(var v=0;vs||r<0||r>s)throw new Error("gl-fbo: Can't resize FBO, invalid dimensions");t._shape[0]=e,t._shape[1]=r;for(var l=n(a),u=0;uo||r<0||r>o)throw new Error("gl-fbo: Parameters are too large for FBO");n=n||{};var s=1;if("color"in n){if((s=Math.max(0|n.color,0))<0)throw new Error("gl-fbo: Must specify a nonnegative number of colors");if(s>1){if(!i)throw new Error("gl-fbo: Multiple draw buffer extension not supported");if(s>t.getParameter(i.MAX_COLOR_ATTACHMENTS_WEBGL))throw new Error("gl-fbo: Context does not support "+s+" draw buffers")}}var l=t.UNSIGNED_BYTE,u=t.getExtension("OES_texture_float");if(n.float&&s>0){if(!u)throw new Error("gl-fbo: Context does not support floating point textures");l=t.FLOAT}else n.preferFloat&&s>0&&u&&(l=t.FLOAT);var h=!0;"depth"in n&&(h=!!n.depth);var f=!1;return"stencil"in n&&(f=!!n.stencil),new c(t,e,r,l,s,h,f,i)}var d=t("gl-texture2d");e.exports=f;var p,m,v,g,y=null,b=c.prototype;Object.defineProperties(b,{shape:{get:function(){return this._destroyed?[0,0]:this._shapeVector},set:function(t){if(Array.isArray(t)||(t=[0|t,0|t]),2!==t.length)throw new Error("gl-fbo: Shape vector must be length 2");var e=0|t[0],r=0|t[1];return h(this,e,r),[e,r]},enumerable:!1},width:{get:function(){return this._destroyed?0:this._shape[0]},set:function(t){return t|=0,h(this,t,this._shape[1]),t},enumerable:!1},height:{get:function(){return this._destroyed?0:this._shape[1]},set:function(t){return t|=0,h(this,this._shape[0],t),t},enumerable:!1}}),b.bind=function(){if(!this._destroyed){var t=this.gl;t.bindFramebuffer(t.FRAMEBUFFER,this.handle),t.viewport(0,0,this._shape[0],this._shape[1])}},b.dispose=function(){if(!this._destroyed){this._destroyed=!0;var t=this.gl;t.deleteFramebuffer(this.handle),this.handle=null,this.depth&&(this.depth.dispose(),this.depth=null),this._depth_rb&&(t.deleteRenderbuffer(this._depth_rb),this._depth_rb=null);for(var e=0;e>8*d&255;this.pickOffset=r,i.bind();var p=i.uniforms;p.viewTransform=t,p.pickOffset=e,p.shape=this.shape;var m=i.attributes;return this.positionBuffer.bind(),m.position.pointer(),this.weightBuffer.bind(),m.weight.pointer(s.UNSIGNED_BYTE,!1),this.idBuffer.bind(),m.pickId.pointer(s.UNSIGNED_BYTE,!1),s.drawArrays(s.TRIANGLES,0,o),r+this.shape[0]*this.shape[1]}}}(),h.pick=function(t,e,r){var n=this.pickOffset,i=this.shape[0]*this.shape[1];if(r=n+i)return null;var a=r-n,o=this.xData,s=this.yData;return{object:this,pointId:a,dataCoord:[o[a%this.shape[0]],s[a/this.shape[0]|0]]}},h.update=function(t){t=t||{};var e=t.shape||[0,0],r=t.x||o(e[0]),n=t.y||o(e[1]),i=t.z||new Float32Array(e[0]*e[1]);this.xData=r,this.yData=n;var l=t.colorLevels||[0],u=t.colorValues||[0,0,0,1],c=l.length,h=this.bounds,d=h[0]=r[0],p=h[1]=n[0],m=h[2]=r[r.length-1],v=h[3]=n[n.length-1],g=1/(m-d),y=1/(v-p),b=e[0],x=e[1];this.shape=[b,x];var _=(b-1)*(x-1)*(f.length>>>1);this.numVertices=_;for(var w=s.mallocUint8(4*_),M=s.mallocFloat32(2*_),k=s.mallocUint8(2*_),A=s.mallocUint32(_),T=0,S=0;S2&&!this.usingDashes){var b=this.mitreShader;this.lineBufferLo.bind(),b.attributes.aLo.pointer(l.FLOAT,!1,48,0),this.lineBufferHi.bind(),b.bind();var x=b.uniforms;this.setProjectionUniforms(x,a),x.color=c,x.radius=s*u,b.attributes.aHi.pointer(l.FLOAT,!1,48,0),l.drawArrays(l.POINTS,0,i/3|0)}}}}(),f.drawPick=function(){var t=[0,0,0,0];return function(e){var r=this.vertCount,n=this.numPoints;if(this.pickOffset=e,!r)return e+n;var i=this.setProjectionModel(),a=this.plot,o=this.width,s=a.gl,l=a.pickPixelRatio,u=this.pickShader,c=this.pickBuffer;t[0]=255&e,t[1]=e>>>8&255,t[2]=e>>>16&255,t[3]=e>>>24,u.bind();var h=u.uniforms;this.setProjectionUniforms(h,i),h.width=o*l,h.pickOffset=t;var f=u.attributes;return this.lineBufferHi.bind(),f.aHi.pointer(s.FLOAT,!1,16,0),f.dHi.pointer(s.FLOAT,!1,16,8),this.lineBufferLo.bind(),f.aLo.pointer(s.FLOAT,!1,16,0),c.bind(),f.pick0.pointer(s.UNSIGNED_BYTE,!1,8,0),f.pick1.pointer(s.UNSIGNED_BYTE,!1,8,4),s.drawArrays(s.TRIANGLES,0,r),e+n}}(),f.pick=function(t,e,r){var n=this.pickOffset,i=this.numPoints;if(r=n+i)return null;var a=r-n,o=this.data;return{object:this,pointId:a,dataCoord:[o[2*a],o[2*a+1]]}},f.update=function(t){t=t||{};var e,r,n,a,o,s=this.plot.gl;this.color=(t.color||[0,0,1,1]).slice(),this.width=+(t.width||1),this.fill=(t.fill||[!1,!1,!1,!1]).slice(),this.fillColor=i(t.fillColor||[[0,0,0,1],[0,0,0,1],[0,0,0,1],[0,0,0,1]]);var h=t.dashes||[1],f=0;for(e=0;e1,this.dashPattern=l(s,u(d,[f,1,4],[1,0,0])),this.dashPattern.minFilter=s.NEAREST,this.dashPattern.magFilter=s.NEAREST,this.dashLength=f,c.free(d);var m=t.positions;this.data=m;var v=this.bounds;v[0]=v[1]=1/0,v[2]=v[3]=-1/0;var g=this.numPoints=m.length>>>1;if(0!==g){for(e=0;e1;){var A=--n;a=m[2*n],o=m[2*n+1];var T=A-1,S=m[2*T],E=m[2*T+1];if(!(isNaN(a)||isNaN(o)||isNaN(S)||isNaN(E))){k+=1,a=(a-v[0])/(v[2]-v[0]),o=(o-v[1])/(v[3]-v[1]),S=(S-v[0])/(v[2]-v[0]),E=(E-v[1])/(v[3]-v[1]);var L=S-a,C=E-o,I=A|1<<24,z=A-1,D=A,P=A-1|1<<24;y[--w]=-C,y[--w]=-L,y[--w]=o,y[--w]=a,_[--M]=I,_[--M]=z,y[--w]=C,y[--w]=L,y[--w]=E,y[--w]=S,_[--M]=D,_[--M]=P,y[--w]=-C,y[--w]=-L,y[--w]=E,y[--w]=S,_[--M]=D,_[--M]=P,y[--w]=C,y[--w]=L,y[--w]=E,y[--w]=S,_[--M]=D,_[--M]=P,y[--w]=-C,y[--w]=-L,y[--w]=o,y[--w]=a,_[--M]=I,_[--M]=z,y[--w]=C,y[--w]=L,y[--w]=o,y[--w]=a,_[--M]=I,_[--M]=z}}for(e=0;e FLOAT_MAX) {\n return vec4(127.0, 128.0, 0.0, 0.0) / 255.0;\n } else if(v < -FLOAT_MAX) {\n return vec4(255.0, 128.0, 0.0, 0.0) / 255.0;\n }\n\n highp vec4 c = vec4(0,0,0,0);\n\n //Compute exponent and mantissa\n highp float e = floor(log2(av));\n highp float m = av * pow(2.0, -e) - 1.0;\n \n //Unpack mantissa\n c[1] = floor(128.0 * m);\n m -= c[1] / 128.0;\n c[2] = floor(32768.0 * m);\n m -= c[2] / 32768.0;\n c[3] = floor(8388608.0 * m);\n \n //Unpack exponent\n highp float ebias = e + 127.0;\n c[0] = floor(ebias / 2.0);\n ebias -= c[0] * 2.0;\n c[1] += floor(ebias) * 128.0; \n\n //Unpack sign bit\n c[0] += 128.0 * step(0.0, -v);\n\n //Scale back to range\n return c / 255.0;\n}\n\n\n\nuniform float pickId;\nuniform vec3 clipBounds[2];\n\nvarying vec3 worldPosition;\nvarying float pixelArcLength;\nvarying vec4 fragColor;\n\nvoid main() {\n if(any(lessThan(worldPosition, clipBounds[0])) || any(greaterThan(worldPosition, clipBounds[1]))) {\n discard;\n }\n gl_FragColor = vec4(pickId/255.0, encode_float_1_0(pixelArcLength).xyz);\n}",null,a)}},{"gl-shader":255}],172:[function(t,e,r){"use strict";function n(t,e){for(var r=0,n=0;n<3;++n){var i=t[n]-e[n];r+=i*i}return Math.sqrt(r)}function i(t){ +for(var e=[[-1e6,-1e6,-1e6],[1e6,1e6,1e6]],r=0;r<3;++r)e[0][r]=Math.max(t[0][r],e[0][r]),e[1][r]=Math.min(t[1][r],e[1][r]);return e}function a(t,e,r,n){this.arcLength=t,this.position=e,this.index=r,this.dataCoordinate=n}function o(t,e,r,n,i,a){this.gl=t,this.shader=e,this.pickShader=r,this.buffer=n,this.vao=i,this.clipBounds=[[-1/0,-1/0,-1/0],[1/0,1/0,1/0]],this.points=[],this.arcLength=[],this.vertexCount=0,this.bounds=[[0,0,0],[0,0,0]],this.pickId=0,this.lineWidth=1,this.texture=a,this.dashScale=1,this.opacity=1,this.dirty=!0,this.pixelRatio=1}function s(t){var e=t.gl||t.scene&&t.scene.gl,r=m(e);r.attributes.position.location=0,r.attributes.nextPosition.location=1,r.attributes.arcLength.location=2,r.attributes.lineWidth.location=3,r.attributes.color.location=4;var n=v(e);n.attributes.position.location=0,n.attributes.nextPosition.location=1,n.attributes.arcLength.location=2,n.attributes.lineWidth.location=3,n.attributes.color.location=4;for(var i=l(e),a=u(e,[{buffer:i,size:3,offset:0,stride:48},{buffer:i,size:3,offset:12,stride:48},{buffer:i,size:1,offset:24,stride:48},{buffer:i,size:1,offset:28,stride:48},{buffer:i,size:4,offset:32,stride:48}]),s=d(new Array(1024),[256,1,4]),h=0;h<1024;++h)s.data[h]=255;var f=c(e,s);f.wrap=e.REPEAT;var p=new o(e,r,n,i,a,f);return p.update(t),p}e.exports=s;var l=t("gl-buffer"),u=t("gl-vao"),c=t("gl-texture2d"),h=t("glsl-read-float"),f=t("binary-search-bounds"),d=t("ndarray"),p=t("./lib/shaders"),m=p.createShader,v=p.createPickShader,g=[1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1],y=o.prototype;y.isTransparent=function(){return this.opacity<1},y.isOpaque=function(){return this.opacity>=1},y.pickSlots=1,y.setPickBase=function(t){this.pickId=t},y.drawTransparent=y.draw=function(t){var e=this.gl,r=this.shader,n=this.vao;r.bind(),r.uniforms={model:t.model||g,view:t.view||g,projection:t.projection||g,clipBounds:i(this.clipBounds),dashTexture:this.texture.bind(),dashScale:this.dashScale/this.arcLength[this.arcLength.length-1],opacity:this.opacity,screenShape:[e.drawingBufferWidth,e.drawingBufferHeight],pixelRatio:this.pixelRatio},n.bind(),n.draw(e.TRIANGLE_STRIP,this.vertexCount)},y.drawPick=function(t){var e=this.gl,r=this.pickShader,n=this.vao;r.bind(),r.uniforms={model:t.model||g,view:t.view||g,projection:t.projection||g,pickId:this.pickId,clipBounds:i(this.clipBounds),screenShape:[e.drawingBufferWidth,e.drawingBufferHeight],pixelRatio:this.pixelRatio},n.bind(),n.draw(e.TRIANGLE_STRIP,this.vertexCount)},y.update=function(t){var e,r;this.dirty=!0;var i=!!t.connectGaps;"dashScale"in t&&(this.dashScale=t.dashScale),"opacity"in t&&(this.opacity=+t.opacity);var a=t.position||t.positions;if(a){var o=t.color||t.colors||[0,0,0,1],s=t.lineWidth||1,l=[],u=[],c=[],h=0,p=0,m=[[1/0,1/0,1/0],[-1/0,-1/0,-1/0]],v=!1;t:for(e=1;e0){for(var b=0;b<24;++b)l.push(l[l.length-12]);p+=2,v=!0}continue t}m[0][r]=Math.min(m[0][r],g[r],y[r]),m[1][r]=Math.max(m[1][r],g[r],y[r])}var x,_;Array.isArray(o[0])?(x=o[e-1],_=o[e]):x=_=o,3===x.length&&(x=[x[0],x[1],x[2],1]),3===_.length&&(_=[_[0],_[1],_[2],1]);var w;w=Array.isArray(s)?s[e-1]:s;var M=h;if(h+=n(g,y),v){for(r=0;r<2;++r)l.push(g[0],g[1],g[2],y[0],y[1],y[2],M,w,x[0],x[1],x[2],x[3]);p+=2,v=!1}l.push(g[0],g[1],g[2],y[0],y[1],y[2],M,w,x[0],x[1],x[2],x[3],g[0],g[1],g[2],y[0],y[1],y[2],M,-w,x[0],x[1],x[2],x[3],y[0],y[1],y[2],g[0],g[1],g[2],h,-w,_[0],_[1],_[2],_[3],y[0],y[1],y[2],g[0],g[1],g[2],h,w,_[0],_[1],_[2],_[3]),p+=4}if(this.buffer.update(l),u.push(h),c.push(a[a.length-1].slice()),this.bounds=m,this.vertexCount=p,this.points=c,this.arcLength=u,"dashes"in t){var k=t.dashes,A=k.slice();for(A.unshift(0),e=1;e0?(n=2*Math.sqrt(r+1),t[3]=.25*n,t[0]=(e[6]-e[9])/n,t[1]=(e[8]-e[2])/n,t[2]=(e[1]-e[4])/n):e[0]>e[5]&e[0]>e[10]?(n=2*Math.sqrt(1+e[0]-e[5]-e[10]),t[3]=(e[6]-e[9])/n,t[0]=.25*n,t[1]=(e[1]+e[4])/n,t[2]=(e[8]+e[2])/n):e[5]>e[10]?(n=2*Math.sqrt(1+e[5]-e[0]-e[10]),t[3]=(e[8]-e[2])/n,t[0]=(e[1]+e[4])/n,t[1]=.25*n,t[2]=(e[6]+e[9])/n):(n=2*Math.sqrt(1+e[10]-e[0]-e[5]),t[3]=(e[1]-e[4])/n,t[0]=(e[8]+e[2])/n,t[1]=(e[6]+e[9])/n,t[2]=.25*n),t},i.fromRotationTranslationScale=function(t,e,r,n){var i=e[0],a=e[1],o=e[2],s=e[3],l=i+i,u=a+a,c=o+o,h=i*l,f=i*u,d=i*c,p=a*u,m=a*c,v=o*c,g=s*l,y=s*u,b=s*c,x=n[0],_=n[1],w=n[2];return t[0]=(1-(p+v))*x,t[1]=(f+b)*x,t[2]=(d-y)*x,t[3]=0,t[4]=(f-b)*_,t[5]=(1-(h+v))*_,t[6]=(m+g)*_,t[7]=0,t[8]=(d+y)*w,t[9]=(m-g)*w,t[10]=(1-(h+p))*w,t[11]=0,t[12]=r[0],t[13]=r[1],t[14]=r[2],t[15]=1,t},i.fromRotationTranslationScaleOrigin=function(t,e,r,n,i){var a=e[0],o=e[1],s=e[2],l=e[3],u=a+a,c=o+o,h=s+s,f=a*u,d=a*c,p=a*h,m=o*c,v=o*h,g=s*h,y=l*u,b=l*c,x=l*h,_=n[0],w=n[1],M=n[2],k=i[0],A=i[1],T=i[2];return t[0]=(1-(m+g))*_,t[1]=(d+x)*_,t[2]=(p-b)*_,t[3]=0,t[4]=(d-x)*w,t[5]=(1-(f+g))*w,t[6]=(v+y)*w,t[7]=0,t[8]=(p+b)*M,t[9]=(v-y)*M,t[10]=(1-(f+m))*M,t[11]=0,t[12]=r[0]+k-(t[0]*k+t[4]*A+t[8]*T),t[13]=r[1]+A-(t[1]*k+t[5]*A+t[9]*T),t[14]=r[2]+T-(t[2]*k+t[6]*A+t[10]*T),t[15]=1,t},i.fromQuat=function(t,e){var r=e[0],n=e[1],i=e[2],a=e[3],o=r+r,s=n+n,l=i+i,u=r*o,c=n*o,h=n*s,f=i*o,d=i*s,p=i*l,m=a*o,v=a*s,g=a*l;return t[0]=1-h-p,t[1]=c+g,t[2]=f-v,t[3]=0,t[4]=c-g,t[5]=1-u-p,t[6]=d+m,t[7]=0,t[8]=f+v,t[9]=d-m,t[10]=1-u-h,t[11]=0,t[12]=0,t[13]=0,t[14]=0,t[15]=1,t},i.frustum=function(t,e,r,n,i,a,o){var s=1/(r-e),l=1/(i-n),u=1/(a-o);return t[0]=2*a*s,t[1]=0,t[2]=0,t[3]=0,t[4]=0,t[5]=2*a*l,t[6]=0,t[7]=0,t[8]=(r+e)*s,t[9]=(i+n)*l,t[10]=(o+a)*u,t[11]=-1,t[12]=0,t[13]=0,t[14]=o*a*2*u,t[15]=0,t},i.perspective=function(t,e,r,n,i){var a=1/Math.tan(e/2),o=1/(n-i);return t[0]=a/r,t[1]=0,t[2]=0,t[3]=0,t[4]=0,t[5]=a,t[6]=0,t[7]=0,t[8]=0,t[9]=0,t[10]=(i+n)*o,t[11]=-1,t[12]=0,t[13]=0,t[14]=2*i*n*o,t[15]=0,t},i.perspectiveFromFieldOfView=function(t,e,r,n){var i=Math.tan(e.upDegrees*Math.PI/180),a=Math.tan(e.downDegrees*Math.PI/180),o=Math.tan(e.leftDegrees*Math.PI/180),s=Math.tan(e.rightDegrees*Math.PI/180),l=2/(o+s),u=2/(i+a);return t[0]=l,t[1]=0,t[2]=0,t[3]=0,t[4]=0,t[5]=u,t[6]=0,t[7]=0,t[8]=-(o-s)*l*.5,t[9]=(i-a)*u*.5,t[10]=n/(r-n),t[11]=-1,t[12]=0,t[13]=0,t[14]=n*r/(r-n),t[15]=0,t},i.ortho=function(t,e,r,n,i,a,o){var s=1/(e-r),l=1/(n-i),u=1/(a-o);return t[0]=-2*s,t[1]=0,t[2]=0,t[3]=0,t[4]=0,t[5]=-2*l,t[6]=0,t[7]=0,t[8]=0,t[9]=0,t[10]=2*u,t[11]=0,t[12]=(e+r)*s,t[13]=(i+n)*l,t[14]=(o+a)*u,t[15]=1,t},i.lookAt=function(t,e,r,a){var o,s,l,u,c,h,f,d,p,m,v=e[0],g=e[1],y=e[2],b=a[0],x=a[1],_=a[2],w=r[0],M=r[1],k=r[2];return 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denom;\n}\n\n\n\nfloat cookTorranceSpecular_1_1(\n vec3 lightDirection,\n vec3 viewDirection,\n vec3 surfaceNormal,\n float roughness,\n float fresnel) {\n\n float VdotN = max(dot(viewDirection, surfaceNormal), 0.0);\n float LdotN = max(dot(lightDirection, surfaceNormal), 0.0);\n\n //Half angle vector\n vec3 H = normalize(lightDirection + viewDirection);\n\n //Geometric term\n float NdotH = max(dot(surfaceNormal, H), 0.0);\n float VdotH = max(dot(viewDirection, H), 0.000001);\n float LdotH = max(dot(lightDirection, H), 0.000001);\n float G1 = (2.0 * NdotH * VdotN) / VdotH;\n float G2 = (2.0 * NdotH * LdotN) / LdotH;\n float G = min(1.0, min(G1, G2));\n \n //Distribution term\n float D = beckmannDistribution_2_0(NdotH, roughness);\n\n //Fresnel term\n float F = pow(1.0 - VdotN, fresnel);\n\n //Multiply terms and done\n return G * F * D / max(3.14159265 * VdotN, 0.000001);\n}\n\n\n\nuniform vec3 clipBounds[2];\nuniform float roughness\n , fresnel\n , kambient\n , kdiffuse\n , kspecular\n 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f=this.pointShader;f.bind(),f.uniforms=s,this.pointVAO.bind(),e.drawArrays(e.POINTS,0,this.pointCount),this.pointVAO.unbind()}if(this.contourEnable&&this.contourCount>0&&this.contourLineWidth>0){var f=this.contourShader;f.bind(),f.uniforms=s,this.contourVAO.bind(),e.drawArrays(e.LINES,0,this.contourCount),this.contourVAO.unbind()}},P.drawPick=function(t){t=t||{};for(var e=this.gl,r=t.model||D,n=t.view||D,i=t.projection||D,a=[[-1e6,-1e6,-1e6],[1e6,1e6,1e6]],o=0;o<3;++o)a[0][o]=Math.max(a[0][o],this.clipBounds[0][o]),a[1][o]=Math.min(a[1][o],this.clipBounds[1][o]);this._model=[].slice.call(r),this._view=[].slice.call(n),this._projection=[].slice.call(i),this._resolution=[e.drawingBufferWidth,e.drawingBufferHeight];var 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t=M.parentNode,e=1,r=1;t&&t!==document.body?(e=t.clientWidth,r=t.clientHeight):(e=window.innerWidth,r=window.innerHeight);var n=0|Math.ceil(e*G.pixelRatio),i=0|Math.ceil(r*G.pixelRatio);if(n!==M.width||i!==M.height){M.width=n,M.height=i;var a=M.style;a.position=a.position||"absolute",a.left="0px",a.top="0px",a.width=e+"px",a.height=r+"px",N=!0}}}function r(){for(var t=O.length,e=j.length,r=0;r0&&0===F[e-1];)F.pop(),j.pop().dispose()}function s(){if(G.contextLost)return!0;A.isContextLost()&&(G.contextLost=!0,G.mouseListener.enabled=!1,G.selection.object=null,G.oncontextloss&&G.oncontextloss())}function b(){if(!s()){A.colorMask(!0,!0,!0,!0),A.depthMask(!0),A.disable(A.BLEND),A.enable(A.DEPTH_TEST);for(var t=O.length,e=j.length,r=0;rS.distance)continue;for(var u=0;u>>1;for(r=0;r=e[0]&&a<=e[2]&&o>=e[1]&&o<=e[3]&&n++}return n}function a(t,e){var r=t.gl,i=s(r),a=s(r),l=o(r,u.pointVertex,u.pointFragment),c=o(r,u.pickVertex,u.pickFragment),h=new n(t,i,a,l,c);return h.update(e),t.addObject(h),h}var o=t("gl-shader"),s=t("gl-buffer"),l=t("typedarray-pool"),u=t("./lib/shader");e.exports=a;var c=n.prototype;c.dispose=function(){this.shader.dispose(),this.pickShader.dispose(),this.offsetBuffer.dispose(),this.pickBuffer.dispose(),this.plot.removeObject(this)},c.update=function(t){function e(e,r){return e in t?t[e]:r}var r;t=t||{},this.sizeMin=e("sizeMin",.5),this.sizeMax=e("sizeMax",20),this.color=e("color",[1,0,0,1]).slice(),this.areaRatio=e("areaRatio",1),this.borderColor=e("borderColor",[0,0,0,1]).slice(),this.blend=e("blend",!1);var n=t.positions.length>>>1,i=t.positions instanceof Float32Array,a=t.idToIndex instanceof Int32Array&&t.idToIndex.length>=n,o=t.positions,s=i?o:l.mallocFloat32(o.length),u=a?t.idToIndex:l.mallocInt32(n);if(i||s.set(o),!a)for(s.set(o),r=0;r>8&255,e[2]=r>>16&255,e[3]=r>>24&255,this.pickBuffer.bind(),a.attributes.pickId.pointer(o.UNSIGNED_BYTE),a.uniforms.pickOffset=e,this.pickOffset=r);var f=o.getParameter(o.BLEND),d=o.getParameter(o.DITHER);return f&&!this.blend&&o.disable(o.BLEND),d&&o.disable(o.DITHER),o.drawArrays(o.POINTS,0,this.pointCount),f&&!this.blend&&o.enable(o.BLEND),d&&o.enable(o.DITHER),r+this.pointCount}}(),c.draw=c.unifiedDraw,c.drawPick=c.unifiedDraw,c.pick=function(t,e,r){var n=this.pickOffset,i=this.pointCount;if(r=n+i)return null;var a=r-n,o=this.points;return{object:this,pointId:a,dataCoord:[o[2*a],o[2*a+1]]}}},{"./lib/shader":222,"gl-buffer":156,"gl-shader":223,"typedarray-pool":541}],231:[function(t,e,r){function n(t,e,r,n){var i,a,o,s,l,u=e[0],c=e[1],h=e[2],f=e[3],d=r[0],p=r[1],m=r[2],v=r[3];return a=u*d+c*p+h*m+f*v,a<0&&(a=-a,d=-d,p=-p,m=-m,v=-v),1-a>1e-6?(i=Math.acos(a),o=Math.sin(i),s=Math.sin((1-n)*i)/o,l=Math.sin(n*i)/o):(s=1-n,l=n),t[0]=s*u+l*d,t[1]=s*c+l*p,t[2]=s*h+l*m,t[3]=s*f+l*v,t}e.exports=n},{}],232:[function(t,e,r){"use strict";e.exports={vertex:"precision highp float;\n#define GLSLIFY 1\n\n\nvec4 computePosition_1_0(vec2 posHi, vec2 posLo, vec2 scHi, vec2 scLo, vec2 trHi, vec2 trLo) {\n return vec4((posHi + trHi) * scHi\n \t\t\t//FIXME: this thingy does not give noticeable precision gain, need test\n + (posLo + trLo) * scHi\n + (posHi + trHi) * scLo\n + (posLo + trLo) * scLo\n , 0, 1);\n}\n\n\nattribute vec2 positionHi, positionLo;\nattribute float size, border;\nattribute vec2 char, color;\n\n//this is 64-bit form of scale and translate\nuniform vec2 scaleHi, scaleLo, translateHi, translateLo;\nuniform float pixelRatio;\nuniform vec4 viewBox;\nuniform sampler2D palette;\n\nvarying vec4 charColor, borderColor;\nvarying vec2 charId;\nvarying vec2 pointCoord;\nvarying float pointSize;\nvarying float borderWidth;\n\n\nvoid main() {\n charColor = texture2D(palette, vec2(color.x / 255., 0));\n borderColor = texture2D(palette, vec2(color.y / 255., 0));\n\n gl_PointSize = size * pixelRatio;\n pointSize = size * pixelRatio;\n\n charId = char;\n borderWidth = border;\n\n gl_Position = computePosition_1_0(\n positionHi, positionLo,\n scaleHi, scaleLo,\n translateHi, translateLo);\n\n pointCoord = viewBox.xy + (viewBox.zw - viewBox.xy) * (gl_Position.xy * .5 + .5);\n}\n",fragment:"precision highp float;\n#define GLSLIFY 1\n\nuniform sampler2D chars;\nuniform vec2 charsShape;\nuniform float charsStep, pixelRatio, charOffset;\n\nvarying vec4 borderColor;\nvarying vec4 charColor;\nvarying vec2 charId;\nvarying vec2 pointCoord;\nvarying float pointSize;\nvarying float borderWidth;\n\nvoid main() {\n\tvec2 pointUV = (pointCoord - gl_FragCoord.xy + pointSize * .5) / pointSize;\n\tpointUV.x = 1. - pointUV.x;\n\tvec2 texCoord = ((charId + pointUV) * charsStep) / charsShape;\n\tfloat dist = texture2D(chars, texCoord).r;\n\n\t//max-distance alpha\n\tif (dist < 1e-2)\n\t\tdiscard;\n\n\tfloat gamma = .0045 * charsStep / pointSize;\n\n //null-border case\n \tif (borderWidth * borderColor.a == 0.) {\n\t\tfloat charAmt = smoothstep(.748 - gamma, .748 + gamma, dist);\n\t\tgl_FragColor = vec4(charColor.rgb, charAmt*charColor.a);\n\t\treturn;\n\t}\n\n\tfloat dif = 5. * pixelRatio * borderWidth / pointSize;\n\tfloat borderLevel = .748 - dif * .5;\n\tfloat charLevel = .748 + dif * .5;\n\n\tfloat borderAmt = smoothstep(borderLevel - gamma, borderLevel + gamma, dist);\n\tfloat charAmt = smoothstep(charLevel - gamma, charLevel + gamma, dist);\n\n\tvec4 color = borderColor;\n\tcolor.a *= borderAmt;\n\n\tgl_FragColor = mix(color, charColor, charAmt);\n}\n",pickVertex:"precision highp float;\n#define GLSLIFY 1\n\nattribute vec2 positionHi, positionLo;\nattribute vec4 id;\nattribute float size;\n\nuniform vec2 scaleHi, scaleLo, translateHi, translateLo;\nuniform vec4 pickOffset;\nuniform float pixelRatio;\n\nvarying vec4 fragColor;\n\n\nvec4 computePosition_1_0(vec2 posHi, vec2 posLo, vec2 scHi, vec2 scLo, vec2 trHi, vec2 trLo) {\n return vec4((posHi + trHi) * scHi\n \t\t\t//FIXME: this thingy does not give noticeable precision gain, need test\n + (posLo + trLo) * scHi\n + (posHi + trHi) * scLo\n + (posLo + trLo) * scLo\n , 0, 1);\n}\n\n\nvoid main() {\n vec4 fragId = id + pickOffset;\n\n fragId.y += floor(fragId.x / 256.0);\n fragId.x -= floor(fragId.x / 256.0) * 256.0;\n\n fragId.z += floor(fragId.y / 256.0);\n fragId.y -= floor(fragId.y / 256.0) * 256.0;\n\n fragId.w += floor(fragId.z / 256.0);\n fragId.z -= floor(fragId.z / 256.0) * 256.0;\n\n fragColor = fragId / 255.0;\n\n gl_PointSize = size * .25 * pixelRatio;\n\n gl_Position = computePosition_1_0(\n positionHi, positionLo,\n scaleHi, scaleLo,\n translateHi, translateLo);\n}\n",pickFragment:"precision lowp float;\n#define GLSLIFY 1\nvarying vec4 fragColor;\nvoid main() {\n gl_FragColor = fragColor;\n}\n"}},{}],233:[function(t,e,r){arguments[4][84][0].apply(r,arguments)},{dup:84}],234:[function(t,e,r){arguments[4][212][0].apply(r,arguments)},{"./lib/GLError":235,"./lib/create-attributes":236,"./lib/create-uniforms":237,"./lib/reflect":238,"./lib/runtime-reflect":239,"./lib/shader-cache":240,dup:212}],235:[function(t,e,r){arguments[4][213][0].apply(r,arguments)},{dup:213}],236:[function(t,e,r){arguments[4][214][0].apply(r,arguments)},{"./GLError":235,dup:214}],237:[function(t,e,r){arguments[4][215][0].apply(r,arguments)},{"./GLError":235,"./reflect":238,dup:215}],238:[function(t,e,r){arguments[4][216][0].apply(r,arguments)},{dup:216}],239:[function(t,e,r){arguments[4][217][0].apply(r,arguments)},{dup:217}],240:[function(t,e,r){arguments[4][218][0].apply(r,arguments)},{"./GLError":235,dup:218,"gl-format-compiler-error":165,"weakmap-shim":562}],241:[function(t,e,r){"use strict";function n(t,e,r,n,a){a<=4*f?i(0,a-1,t,e,r,n):h(0,a-1,t,e,r,n)}function i(t,e,r,n,i,a){for(var o=t+1;o<=e;++o){for(var s=r[o],l=n[2*o],u=n[2*o+1],c=i[o],h=a[o],f=o;f>t;){var d=r[f-1],p=n[2*(f-1)];if((d-s||l-p)>=0)break;r[f]=d,n[2*f]=p,n[2*f+1]=n[2*f-1],i[f]=i[f-1],a[f]=a[f-1],f-=1}r[f]=s,n[2*f]=l,n[2*f+1]=u,i[f]=c,a[f]=h}}function a(t,e,r,n,i,a){var o=r[t],s=n[2*t],l=n[2*t+1],u=i[t],c=a[t];r[t]=r[e],n[2*t]=n[2*e],n[2*t+1]=n[2*e+1],i[t]=i[e],a[t]=a[e],r[e]=o,n[2*e]=s,n[2*e+1]=l,i[e]=u,a[e]=c}function o(t,e,r,n,i,a){r[t]=r[e],n[2*t]=n[2*e],n[2*t+1]=n[2*e+1],i[t]=i[e],a[t]=a[e]}function s(t,e,r,n,i,a,o){var s=n[t],l=i[2*t],u=i[2*t+1],c=a[t],h=o[t];n[t]=n[e],i[2*t]=i[2*e],i[2*t+1]=i[2*e+1],a[t]=a[e],o[t]=o[e],n[e]=n[r],i[2*e]=i[2*r],i[2*e+1]=i[2*r+1],a[e]=a[r],o[e]=o[r],n[r]=s,i[2*r]=l,i[2*r+1]=u,a[r]=c,o[r]=h}function l(t,e,r,n,i,a,o,s,l,u,c){s[t]=s[e],l[2*t]=l[2*e],l[2*t+1]=l[2*e+1],u[t]=u[e],c[t]=c[e],s[e]=r,l[2*e]=n,l[2*e+1]=i,u[e]=a,c[e]=o}function u(t,e,r,n,i){return(r[t]-r[e]||n[2*e]-n[2*t]||i[t]-i[e])<0}function c(t,e,r,n,i,a,o,s){return(e-a[t]||o[2*t]-r||i-s[t])<0}function h(t,e,r,n,d,p){var m=(e-t+1)/6|0,v=t+m,g=e-m,y=t+e>>1,b=y-m,x=y+m,_=v,w=b,M=y,k=x,A=g,T=t+1,S=e-1,E=0;u(_,w,r,n,d,p)&&(E=_,_=w,w=E),u(k,A,r,n,d,p)&&(E=k,k=A,A=E),u(_,M,r,n,d,p)&&(E=_,_=M,M=E),u(w,M,r,n,d,p)&&(E=w,w=M,M=E),u(_,k,r,n,d,p)&&(E=_,_=k,k=E),u(M,k,r,n,d,p)&&(E=M,M=k,k=E),u(w,A,r,n,d,p)&&(E=w,w=A,A=E),u(w,M,r,n,d,p)&&(E=w,w=M,M=E),u(k,A,r,n,d,p)&&(E=k,k=A,A=E);var L=r[w],C=n[2*w],I=n[2*w+1],z=d[w],D=p[w],P=r[k],O=n[2*k],R=n[2*k+1],F=d[k],j=p[k],N=_,B=M,U=A,V=v,H=y,q=g,G=r[N],Y=r[B],W=r[U];r[V]=G,r[H]=Y,r[q]=W;for(var X=0;X<2;++X){var Z=n[2*N+X],J=n[2*B+X],K=n[2*U+X];n[2*V+X]=Z,n[2*H+X]=J,n[2*q+X]=K}var Q=d[N],$=d[B],tt=d[U];d[V]=Q,d[H]=$,d[q]=tt;var et=p[N],rt=p[B],nt=p[U];p[V]=et,p[H]=rt,p[q]=nt,o(b,t,r,n,d,p),o(x,e,r,n,d,p);for(var it=T;it<=S;++it)if(c(it,L,C,I,z,r,n,d))it!==T&&a(it,T,r,n,d,p),++T;else if(!c(it,P,O,R,F,r,n,d))for(;;){if(c(S,P,O,R,F,r,n,d)){c(S,L,C,I,z,r,n,d)?(s(it,T,S,r,n,d,p),++T,--S):(a(it,S,r,n,d,p),--S);break}if(--S=Math.max(.9*d,32)){var b=u+s>>>1;l(v,g,h,f,b,c+1),f=b}l(v,g,h,f,y,c+1),f=y}}}var u=t.length>>>1;if(u<1)return[];for(var c=1/0,h=1/0,f=-1/0,d=-1/0,p=0;p=0;--_){t[2*_]=(t[2*_]-c)*g,t[2*_+1]=(t[2*_+1]-h)*y;var A=x[_];A!==M&&(w.push(new i(b*Math.pow(.5,A),_+1,k-(_+1))),k=_+1,M=A)}return w.push(new i(b*Math.pow(.5,A+1),0,k)),o.free(x),w}var o=t("typedarray-pool"),s=t("./lib/sort");e.exports=a},{"./lib/sort":241,"typedarray-pool":541}],243:[function(t,e,r){"use strict";function n(t,e,r,n,i,a,o,s){this.plot=t,this.shader=e,this.pickShader=r,this.positionBuffer=n,this.sizeBuffer=i,this.colorBuffer=a,this.idBuffer=o,this.charBuffer=s,this.pointCount=0,this.pickOffset=0,this.points=null,this.scales=[],this.xCoords=[],this.charCanvas=document.createElement("canvas"),this.charTexture=m(this.plot.gl,this.charCanvas),this.charStep=400,this.charFit=.255,this.snapThreshold=1e4,this.paletteTexture=m(this.plot.gl,[256,1])}function i(){var t=this.plot,e=t.viewBox,r=t.dataBox,n=t.pixelRatio,i=r[2]-r[0],a=r[3]-r[1],u=2/i,c=2/a,h=-r[0]-.5*i,f=-r[1]-.5*a;_[0]=u,w[0]=u-_[0],_[1]=c,w[1]=c-_[1],M[0]=h,k[0]=h-M[0],M[1]=f,k[1]=f-M[1];var d=e[2]-e[0],p=e[3]-e[1];o=Math.min(i/d,a/p),A[0]=2*n/d,A[1]=2*n/p,s=r[0],l=r[2]}function a(t,e){var r=t.gl,i=u(r,f.vertex,f.fragment),a=u(r,f.pickVertex,f.pickFragment),o=c(r),s=c(r),l=c(r),h=c(r),d=c(r),p=new n(t,i,a,o,s,l,h,d);return p.update(e),t.addObject(p),p}e.exports=a;var o,s,l,u=t("gl-shader"),c=t("gl-buffer"),h=t("typedarray-pool"),f=t("./lib/shaders"),d=t("snap-points-2d"),p=t("font-atlas-sdf"),m=t("gl-texture2d"),v=t("color-id"),g=t("ndarray"),y=t("clamp"),b=t("binary-search-bounds"),x=n.prototype,_=new Float32Array([0,0]),w=new Float32Array([0,0]),M=new Float32Array([0,0]),k=new Float32Array([0,0]),A=[0,0],T=[0,0,0,0];x.drawPick=function(t){var e=void 0!==t,r=this.plot,n=this.pointCount,a=n>this.snapThreshold;if(!n)return t;i.call(this);var u=r.gl,c=e?this.pickShader:this.shader,h=u.isEnabled(u.BLEND);if(c.bind(),e){this.pickOffset=t;for(var f=0;f<4;++f)T[f]=t>>8*f&255;c.uniforms.pickOffset=T,this.idBuffer.bind(),c.attributes.id.pointer(u.UNSIGNED_BYTE,!1)}else u.blendFuncSeparate(u.SRC_ALPHA,u.ONE_MINUS_SRC_ALPHA,u.ONE,u.ONE_MINUS_SRC_ALPHA),u.blendColor(0,0,0,1),h||u.enable(u.BLEND),this.colorBuffer.bind(),c.attributes.color.pointer(u.UNSIGNED_BYTE,!1),this.charBuffer.bind(),c.attributes.char.pointer(u.UNSIGNED_BYTE,!1),c.uniforms.chars=this.charTexture.bind(0),c.uniforms.charsShape=[this.charCanvas.width,this.charCanvas.height],c.uniforms.charsStep=this.charStep,c.uniforms.palette=this.paletteTexture.bind(1);this.sizeBuffer.bind(),c.attributes.size.pointer(u.FLOAT,!1,8,0),e||c.attributes.border.pointer(u.FLOAT,!1,8,4),this.positionBuffer.bind(),c.attributes.positionHi.pointer(u.FLOAT,!1,16,0),c.attributes.positionLo.pointer(u.FLOAT,!1,16,8),c.uniforms.pixelRatio=r.pixelRatio,c.uniforms.scaleHi=_,c.uniforms.scaleLo=w,c.uniforms.translateHi=M,c.uniforms.translateLo=k,c.uniforms.viewBox=r.viewBox;var d=this.scales;if(a)for(var p=d.length-1;p>=0;p--){var m=d[p];if(!(m.pixelSize&&m.pixelSize<1.25*o&&p>1)){var v=m.offset,g=m.count+v,y=b.ge(this.xCoords,s,v,g-1),x=b.lt(this.xCoords,l,y,g-1)+1;x>y&&u.drawArrays(u.POINTS,y,x-y)}}else u.drawArrays(u.POINTS,0,n);if(e)return t+n;h?u.blendFunc(u.ONE,u.ONE_MINUS_SRC_ALPHA):u.disable(u.BLEND)},x.draw=x.drawPick,x.pick=function(t,e,r){var n=this.pickOffset,i=this.pointCount;if(r=n+i)return null;var a=r-n,o=this.points;return{object:this,pointId:a,dataCoord:[o[2*a],o[2*a+1]]}},x.update=function(t){t=t||{};var e=t.positions||[],r=t.colors||[],n=t.glyphs||[],i=t.sizes||[],a=t.borderWidths||[],o=t.borderColors||[],s=this.plot.gl,l=this.pointCount,u=l>this.snapThreshold;if(null!=t.positions){this.points=e,l=this.points.length/2,u=l>this.snapThreshold;var c=h.mallocFloat32(2*l),f=h.mallocFloat64(2*l),m=h.mallocUint32(l),b=h.mallocFloat32(4*l);f.set(this.points),u&&(this.i2idx&&h.free(this.i2idx),this.i2idx=h.mallocInt32(l),this.scales=d(f,this.i2idx,c)),this.pointCount=l;for(var x=0;xF&&(F=i[x]);var j=this.charStep;this.charStep=y(Math.ceil(4*F),128,768);var N=Object.keys(O),B=this.charStep,U=Math.floor(B/2),V=s.getParameter(s.MAX_TEXTURE_SIZE),H=V/B*(V/B),q=Math.min(V,B*N.length),G=Math.min(V,B*Math.ceil(B*N.length/V)),Y=Math.floor(q/B);N.length>H&&console.warn("gl-scatter2d-fancy: number of characters is more than maximum texture size. Try reducing it."),this.chars&&this.chars+""==N+""&&this.charStep==j||(this.charCanvas=p({canvas:this.charCanvas,family:"sans-serif",size:U,shape:[q,G],step:[B,B],chars:N,align:!0,fit:this.charFit}),this.chars=N);for(var x=0;x>>1,n=u.mallocInt32(r),i=u.mallocFloat32(r),a=u.mallocFloat64(2*r);if(a.set(this.points),this.snapPoints)this.scales=l(a,n,i,this.bounds);else{this.bounds=f(a,2),h(a,2,this.bounds);for(var o=0;o>8&255,y[2]=t>>16&255,y[3]=t>>24&255,n.uniforms.pickOffset=y,s.bind(),n.attributes.pickId.pointer(h.UNSIGNED_BYTE)):(n.uniforms.useWeight=1,this.weightBuffer.bind(),n.attributes.weight.pointer());var I=!0;if(this.snapPoints)for(var z=i.length-1;z>=0;z--){var D=i[z];if(!(D.pixelSize1)){var P=this.getVisibleRange(D),O=P[0],R=P[1];R>O&&h.drawArrays(h.POINTS,O,R-O),!e&&I&&(I=!1,n.uniforms.useWeight=0)}}else h.drawArrays(h.POINTS,0,this.pointCount);return t+this.pointCount},d.getVisibleRange=function(t){var e=this.plot.dataBox,r=this.bounds,n=this.pixelSize,i=this.size,a=this.plot.pixelRatio,o=r[2]-r[0];r[3],r[1];if(!t)for(var t,l=this.scales.length-1;l>=0&&(t=this.scales[l],t.pixelSize1);l--);var u=this.xCoords,c=(e[0]-r[0]-n*i*a)/o,h=(e[2]-r[0]+n*i*a)/o,f=t.offset,d=t.count+f,p=s.ge(u,c,f,d-1);return[p,s.lt(u,h,p,d-1)+1]},d.drawPick=d.draw,d.pick=function(t,e,r){var n=r-this.pickOffset;return n<0||n>=this.pointCount?null:{object:this,pointId:n,dataCoord:[this.points[2*n],this.points[2*n+1]]}}},{"./lib/shader":244,"array-bounds":44,"array-normalize":45,"binary-search-bounds":245,"gl-buffer":156,"gl-shader":255,"snap-points-2d":247,"typedarray-pool":541}],249:[function(t,e,r){"use strict";function n(t,e){var r=a[e];if(r||(r=a[e]={}),t in r)return r[t];for(var n=i(t,{textAlign:"center",textBaseline:"middle",lineHeight:1,font:e}),o=i(t,{triangles:!0,textAlign:"center",textBaseline:"middle",lineHeight:1,font:e}),s=[[1/0,1/0],[-1/0,-1/0]],l=0;lMath.abs(R[1])){var F=O;O=R,R=F,F=D,D=P,P=F;var j=I;I=z,z=j}O[0]<0&&(D[I]=-1),R[1]>0&&(P[z]=-1);for(var N=0,B=0,C=0;C<4;++C)N+=Math.pow(p[4*I+C],2),B+=Math.pow(p[4*z+C],2);D[I]/=Math.sqrt(N),P[z]/=Math.sqrt(B),d.axes[0]=D,d.axes[1]=P,d.fragClipBounds[0]=u(E,b[0],_,-1e8),d.fragClipBounds[1]=u(E,b[1],_,1e8),e.vao.draw(f.TRIANGLES,e.vertexCount),e.lineWidth>0&&(f.lineWidth(e.lineWidth),e.vao.draw(f.LINES,e.lineVertexCount,e.vertexCount))}}function f(t,e,r,n,i,a){var o=r.gl;if(r.vao.bind(),i===r.opacity<1||a){t.bind();var s=t.uniforms;s.model=n.model||x,s.view=n.view||x,s.projection=n.projection||x,w[0]=2/o.drawingBufferWidth,w[1]=2/o.drawingBufferHeight,s.screenSize=w,s.highlightId=r.highlightId,s.highlightScale=r.highlightScale,s.fragClipBounds=z,s.clipBounds=r.axes.bounds,s.opacity=r.opacity,s.pickGroup=r.pickId/255,s.pixelRatio=r.pixelRatio,r.vao.draw(o.TRIANGLES,r.vertexCount),r.lineWidth>0&&(o.lineWidth(r.lineWidth),r.vao.draw(o.LINES,r.lineVertexCount,r.vertexCount))}h(e,r,n,i,a),r.vao.unbind()}function d(t){var e=t.gl,r=y.createPerspective(e),n=y.createOrtho(e),i=y.createProject(e),a=y.createPickPerspective(e),s=y.createPickOrtho(e),l=y.createPickProject(e),u=p(e),c=p(e),h=p(e),f=p(e),d=m(e,[{buffer:u,size:3,type:e.FLOAT},{buffer:c,size:4,type:e.FLOAT},{buffer:h,size:2,type:e.FLOAT},{buffer:f,size:4,type:e.UNSIGNED_BYTE,normalized:!0}]),v=new o(e,r,n,i,u,c,h,f,d,a,s,l);return v.update(t),v}var p=t("gl-buffer"),m=t("gl-vao"),v=t("typedarray-pool"),g=t("gl-mat4/multiply"),y=t("./lib/shaders"),b=t("./lib/glyphs"),x=[1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1];e.exports=d;var _=o.prototype;_.pickSlots=1,_.setPickBase=function(t){this.pickId=t},_.isTransparent=function(){if(this.opacity<1)return!0;for(var t=0;t<3;++t)if(this.axesProject[t]&&this.projectOpacity[t]<1)return!0;return!1},_.isOpaque=function(){if(this.opacity>=1)return!0;for(var t=0;t<3;++t)if(this.axesProject[t]&&this.projectOpacity[t]>=1)return!0;return!1};var w=[0,0],M=[0,0,0],k=[0,0,0],A=[0,0,0,1],T=[0,0,0,1],S=x.slice(),E=[0,0,0],L=[[0,0,0],[0,0,0]],C=[-1e8,-1e8,-1e8],I=[1e8,1e8,1e8],z=[C,I];_.draw=function(t){f(this.useOrtho?this.orthoShader:this.shader,this.projectShader,this,t,!1,!1)},_.drawTransparent=function(t){f(this.useOrtho?this.orthoShader:this.shader,this.projectShader,this,t,!0,!1)},_.drawPick=function(t){f(this.useOrtho?this.pickOrthoShader:this.pickPerspectiveShader,this.pickProjectShader,this,t,!1,!0)},_.pick=function(t){if(!t)return null;if(t.id!==this.pickId)return null;var e=t.value[2]+(t.value[1]<<8)+(t.value[0]<<16);if(e>=this.pointCount||e<0)return null;var r=this.points[e],n=this._selectResult;n.index=e;for(var i=0;i<3;++i)n.position[i]=n.dataCoordinate[i]=r[i];return n},_.highlight=function(t){if(t){var e=t.index,r=255&e,n=e>>8&255,i=e>>16&255;this.highlightId=[r/255,n/255,i/255,0]}else this.highlightId=[1,1,1,1]},_.update=function(t){if(t=t||{},"perspective"in t&&(this.useOrtho=!t.perspective),"orthographic"in t&&(this.useOrtho=!!t.orthographic),"lineWidth"in t&&(this.lineWidth=t.lineWidth),"project"in t)if(Array.isArray(t.project))this.axesProject=t.project;else{var e=!!t.project;this.axesProject=[e,e,e]}if("projectScale"in t)if(Array.isArray(t.projectScale))this.projectScale=t.projectScale.slice();else{var r=+t.projectScale;this.projectScale=[r,r,r]}if("projectOpacity"in t)if(Array.isArray(t.projectOpacity))this.projectOpacity=t.projectOpacity.slice();else{var r=+t.projectOpacity;this.projectOpacity=[r,r,r]}"opacity"in t&&(this.opacity=t.opacity),this.dirty=!0;var n=t.position;if(n){var i=t.font||"normal",a=t.alignment||[0,0],o=[1/0,1/0,1/0],s=[-1/0,-1/0,-1/0],l=t.glyph,u=t.color,c=t.size,h=t.angle,f=t.lineColor,d=0,p=0,m=0,g=n.length;t:for(var y=0;y0&&(I[0]=-a[0]*(1+A[0][0]));for(var H=M.cells,q=M.positions,_=0;_0){var g=r*c;o.drawBox(h-g,f-g,d+g,f+g,a),o.drawBox(h-g,p-g,d+g,p+g,a),o.drawBox(h-g,f-g,h+g,p+g,a),o.drawBox(d-g,f-g,d+g,p+g,a)}}}},l.update=function(t){t=t||{},this.innerFill=!!t.innerFill,this.outerFill=!!t.outerFill,this.innerColor=(t.innerColor||[0,0,0,.5]).slice(),this.outerColor=(t.outerColor||[0,0,0,.5]).slice(),this.borderColor=(t.borderColor||[0,0,0,1]).slice(),this.borderWidth=t.borderWidth||0,this.selectBox=(t.selectBox||this.selectBox).slice()},l.dispose=function(){this.boxBuffer.dispose(),this.boxShader.dispose(),this.plot.removeOverlay(this)}},{"./lib/shaders":252,"gl-buffer":156,"gl-shader":255}],254:[function(t,e,r){"use strict";function n(t,e,r,n,i){this.coord=[t,e],this.id=r,this.value=n,this.distance=i}function i(t,e,r){this.gl=t,this.fbo=e,this.buffer=r,this._readTimeout=null;var n=this;this._readCallback=function(){n.gl&&(e.bind(),t.readPixels(0,0,e.shape[0],e.shape[1],t.RGBA,t.UNSIGNED_BYTE,n.buffer),n._readTimeout=null)}}function a(t,e){return new i(t,o(t,e),s.mallocUint8(e[0]*e[1]*4))}e.exports=a;var o=t("gl-fbo"),s=t("typedarray-pool"),l=t("ndarray"),u=t("bit-twiddle").nextPow2,c=t("cwise/lib/wrapper")({args:["array",{offset:[0,0,1],array:0},{offset:[0,0,2],array:0},{offset:[0,0,3],array:0},"scalar","scalar","index"],pre:{body:"{this_closestD2=1e8,this_closestX=-1,this_closestY=-1}",args:[],thisVars:["this_closestD2","this_closestX","this_closestY"],localVars:[]},body:{body:"{if(_inline_46_arg0_<255||_inline_46_arg1_<255||_inline_46_arg2_<255||_inline_46_arg3_<255){var _inline_46_l=_inline_46_arg4_-_inline_46_arg6_[0],_inline_46_a=_inline_46_arg5_-_inline_46_arg6_[1],_inline_46_f=_inline_46_l*_inline_46_l+_inline_46_a*_inline_46_a;_inline_46_fthis.buffer.length){s.free(this.buffer);for(var n=this.buffer=s.mallocUint8(u(r*e*4)),i=0;i=0){for(var k=0|M.type.charAt(M.type.length-1),A=new Array(k),T=0;T=0;)S+=1;_[w]=S}var E=new Array(r.length);a(),d._relink=a,d.types={uniforms:l(r),attributes:l(n)},d.attributes=s(p,d,b,_),Object.defineProperty(d,"uniforms",o(p,d,r,E))},e.exports=a},{"./lib/GLError":256,"./lib/create-attributes":257,"./lib/create-uniforms":258,"./lib/reflect":259,"./lib/runtime-reflect":260,"./lib/shader-cache":261}],256:[function(t,e,r){arguments[4][213][0].apply(r,arguments)},{dup:213}],257:[function(t,e,r){arguments[4][214][0].apply(r,arguments)},{"./GLError":256,dup:214}],258:[function(t,e,r){arguments[4][215][0].apply(r,arguments)},{"./GLError":256,"./reflect":259,dup:215}],259:[function(t,e,r){arguments[4][216][0].apply(r,arguments)},{dup:216}],260:[function(t,e,r){arguments[4][217][0].apply(r,arguments)},{dup:217}],261:[function(t,e,r){arguments[4][218][0].apply(r,arguments)},{"./GLError":256,dup:218,"gl-format-compiler-error":165,"weakmap-shim":562}],262:[function(t,e,r){"use strict";function n(t){this.plot=t,this.enable=[!0,!0,!1,!1],this.width=[1,1,1,1],this.color=[[0,0,0,1],[0,0,0,1],[0,0,0,1],[0,0,0,1]],this.center=[1/0,1/0]}function i(t,e){var r=new n(t);return r.update(e),t.addOverlay(r),r}e.exports=i;var a=n.prototype;a.update=function(t){t=t||{},this.enable=(t.enable||[!0,!0,!1,!1]).slice(),this.width=(t.width||[1,1,1,1]).slice(),this.color=(t.color||[[0,0,0,1],[0,0,0,1],[0,0,0,1],[0,0,0,1]]).map(function(t){return t.slice()}),this.center=(t.center||[1/0,1/0]).slice(),this.plot.setOverlayDirty()},a.draw=function(){var t=this.enable,e=this.width,r=this.color,n=this.center,i=this.plot,a=i.line,o=i.dataBox,s=i.viewBox;if(a.bind(),o[0]<=n[0]&&n[0]<=o[2]&&o[1]<=n[1]&&n[1]<=o[3]){var l=s[0]+(n[0]-o[0])/(o[2]-o[0])*(s[2]-s[0]),u=s[1]+(n[1]-o[1])/(o[3]-o[1])*(s[3]-s[1]);t[0]&&a.drawLine(l,u,s[0],u,e[0],r[0]),t[1]&&a.drawLine(l,u,l,s[1],e[1],r[1]),t[2]&&a.drawLine(l,u,s[2],u,e[2],r[2]),t[3]&&a.drawLine(l,u,l,s[3],e[3],r[3])}},a.dispose=function(){this.plot.removeOverlay(this)}},{}],263:[function(t,e,r){"use strict";var n=t("gl-shader");e.exports=function(t){return n(t,"precision mediump float;\n#define GLSLIFY 1\n\nattribute vec3 position, color;\nattribute float weight;\n\nuniform mat4 model, view, projection;\nuniform vec3 coordinates[3];\nuniform vec4 colors[3];\nuniform vec2 screenShape;\nuniform float lineWidth;\n\nvarying vec4 fragColor;\n\nvoid main() {\n vec3 vertexPosition = mix(coordinates[0],\n mix(coordinates[2], coordinates[1], 0.5 * (position + 1.0)), abs(position));\n\n vec4 clipPos = projection * view * model * vec4(vertexPosition, 1.0);\n vec2 clipOffset = (projection * view * model * vec4(color, 0.0)).xy;\n vec2 delta = weight * clipOffset * screenShape;\n vec2 lineOffset = normalize(vec2(delta.y, -delta.x)) / screenShape;\n\n gl_Position = vec4(clipPos.xy + clipPos.w * 0.5 * lineWidth * lineOffset, clipPos.z, clipPos.w);\n fragColor = color.x * colors[0] + color.y * colors[1] + color.z * colors[2];\n}\n","precision mediump float;\n#define GLSLIFY 1\n\nvarying vec4 fragColor;\n\nvoid main() {\n gl_FragColor = fragColor;\n}",null,[{name:"position",type:"vec3"},{name:"color",type:"vec3"},{name:"weight",type:"float"}])}},{"gl-shader":255}],264:[function(t,e,r){"use strict";function n(t,e,r,n){this.gl=t,this.buffer=e,this.vao=r,this.shader=n,this.pixelRatio=1,this.bounds=[[-1e3,-1e3,-1e3],[1e3,1e3,1e3]],this.position=[0,0,0],this.lineWidth=[2,2,2],this.colors=[[0,0,0,1],[0,0,0,1],[0,0,0,1]],this.enabled=[!0,!0,!0],this.drawSides=[!0,!0,!0],this.axes=null}function i(t,e){function r(t,e,r,n,a,o){var s=[t,e,r,0,0,0,1];s[n+3]=1,s[n]=a,i.push.apply(i,s),s[6]=-1,i.push.apply(i,s),s[n]=o,i.push.apply(i,s),i.push.apply(i,s),s[6]=1,i.push.apply(i,s),s[n]=a,i.push.apply(i,s)}var i=[];r(0,0,0,0,0,1),r(0,0,0,1,0,1),r(0,0,0,2,0,1),r(1,0,0,1,-1,1),r(1,0,0,2,-1,1),r(0,1,0,0,-1,1),r(0,1,0,2,-1,1),r(0,0,1,0,-1,1),r(0,0,1,1,-1,1);var l=a(t,i),u=o(t,[{type:t.FLOAT,buffer:l,size:3,offset:0,stride:28},{type:t.FLOAT,buffer:l,size:3,offset:12,stride:28},{type:t.FLOAT,buffer:l,size:1,offset:24,stride:28}]),c=s(t);c.attributes.position.location=0,c.attributes.color.location=1,c.attributes.weight.location=2;var h=new n(t,l,u,c);return h.update(e),h}var a=t("gl-buffer"),o=t("gl-vao"),s=t("./shaders/index");e.exports=i;var l=[1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1],u=n.prototype,c=[0,0,0],h=[0,0,0],f=[0,0];u.isTransparent=function(){return!1},u.drawTransparent=function(t){},u.draw=function(t){var e=this.gl,r=this.vao,n=this.shader;r.bind(),n.bind();var i,a=t.model||l,o=t.view||l,s=t.projection||l;this.axes&&(i=this.axes.lastCubeProps.axis);for(var u=c,d=h,p=0;p<3;++p)i&&i[p]<0?(u[p]=this.bounds[0][p],d[p]=this.bounds[1][p]):(u[p]=this.bounds[1][p],d[p]=this.bounds[0][p]);f[0]=e.drawingBufferWidth,f[1]=e.drawingBufferHeight,n.uniforms.model=a,n.uniforms.view=o,n.uniforms.projection=s,n.uniforms.coordinates=[this.position,u,d],n.uniforms.colors=this.colors,n.uniforms.screenShape=f;for(var p=0;p<3;++p)n.uniforms.lineWidth=this.lineWidth[p]*this.pixelRatio,this.enabled[p]&&(r.draw(e.TRIANGLES,6,6*p),this.drawSides[p]&&r.draw(e.TRIANGLES,12,18+12*p));r.unbind()},u.update=function(t){t&&("bounds"in t&&(this.bounds=t.bounds),"position"in t&&(this.position=t.position),"lineWidth"in t&&(this.lineWidth=t.lineWidth),"colors"in t&&(this.colors=t.colors),"enabled"in t&&(this.enabled=t.enabled),"drawSides"in t&&(this.drawSides=t.drawSides))},u.dispose=function(){this.vao.dispose(),this.buffer.dispose(),this.shader.dispose()}},{"./shaders/index":263,"gl-buffer":156,"gl-vao":271}],265:[function(t,e,r){var n=t("gl-shader"),i="precision mediump float;\n#define GLSLIFY 1\n\nattribute vec4 uv;\nattribute vec3 f;\nattribute vec3 normal;\n\nuniform mat4 model, view, projection, inverseModel;\nuniform vec3 lightPosition, eyePosition;\nuniform sampler2D colormap;\n\nvarying float value, kill;\nvarying vec3 worldCoordinate;\nvarying vec2 planeCoordinate;\nvarying vec3 lightDirection, eyeDirection, surfaceNormal;\nvarying vec4 vColor;\n\nvoid main() {\n worldCoordinate = vec3(uv.zw, f.x);\n vec4 worldPosition = model * vec4(worldCoordinate, 1.0);\n vec4 clipPosition = projection * view * worldPosition;\n gl_Position = clipPosition;\n kill = f.y;\n value = f.z;\n planeCoordinate = uv.xy;\n\n vColor = texture2D(colormap, vec2(value, value));\n\n //Lighting geometry parameters\n vec4 cameraCoordinate = view * worldPosition;\n cameraCoordinate.xyz /= cameraCoordinate.w;\n lightDirection = lightPosition - cameraCoordinate.xyz;\n eyeDirection = eyePosition - cameraCoordinate.xyz;\n surfaceNormal = normalize((vec4(normal,0) * inverseModel).xyz);\n}\n",a="precision mediump float;\n#define GLSLIFY 1\n\nfloat beckmannDistribution_2_0(float x, float roughness) {\n float NdotH = max(x, 0.0001);\n float cos2Alpha = NdotH * NdotH;\n float tan2Alpha = (cos2Alpha - 1.0) / cos2Alpha;\n float roughness2 = roughness * roughness;\n float denom = 3.141592653589793 * roughness2 * cos2Alpha * cos2Alpha;\n return exp(tan2Alpha / roughness2) / denom;\n}\n\n\n\nfloat beckmannSpecular_1_1(\n vec3 lightDirection,\n vec3 viewDirection,\n vec3 surfaceNormal,\n float roughness) {\n return beckmannDistribution_2_0(dot(surfaceNormal, normalize(lightDirection + viewDirection)), roughness);\n}\n\n\n\nuniform vec3 lowerBound, upperBound;\nuniform float contourTint;\nuniform vec4 contourColor;\nuniform sampler2D colormap;\nuniform vec3 clipBounds[2];\nuniform float roughness, fresnel, kambient, kdiffuse, kspecular, opacity;\nuniform float vertexColor;\n\nvarying float value, kill;\nvarying vec3 worldCoordinate;\nvarying vec3 lightDirection, eyeDirection, surfaceNormal;\nvarying vec4 vColor;\n\nvoid main() {\n if (kill > 0.0 ||\n any(lessThan(worldCoordinate, clipBounds[0])) || any(greaterThan(worldCoordinate, clipBounds[1]))) {\n discard;\n }\n\n vec3 N = normalize(surfaceNormal);\n vec3 V = normalize(eyeDirection);\n vec3 L = normalize(lightDirection);\n\n if(gl_FrontFacing) {\n N = -N;\n }\n\n float specular = max(beckmannSpecular_1_1(L, V, N, roughness), 0.);\n float diffuse = min(kambient + kdiffuse * max(dot(N, L), 0.0), 1.0);\n\n //decide how to interpolate color \u2014 in vertex or in fragment\n vec4 surfaceColor = step(vertexColor, .5) * texture2D(colormap, vec2(value, value)) + step(.5, vertexColor) * vColor;\n\n vec4 litColor = surfaceColor.a * vec4(diffuse * surfaceColor.rgb + kspecular * vec3(1,1,1) * specular, 1.0);\n\n gl_FragColor = mix(litColor, contourColor, contourTint) * opacity;\n}\n",o="precision mediump float;\n#define GLSLIFY 1\n\nattribute vec4 uv;\nattribute float f;\n\nuniform mat3 permutation;\nuniform mat4 model, view, projection;\nuniform float height, zOffset;\nuniform sampler2D colormap;\n\nvarying float value, kill;\nvarying vec3 worldCoordinate;\nvarying vec2 planeCoordinate;\nvarying vec3 lightDirection, eyeDirection, surfaceNormal;\nvarying vec4 vColor;\n\nvoid main() {\n vec3 dataCoordinate = permutation * vec3(uv.xy, height);\n vec4 worldPosition = model * vec4(dataCoordinate, 1.0);\n\n vec4 clipPosition = projection * view * worldPosition;\n clipPosition.z = clipPosition.z + zOffset;\n\n gl_Position = clipPosition;\n value = f;\n kill = -1.0;\n worldCoordinate = dataCoordinate;\n planeCoordinate = uv.zw;\n\n vColor = texture2D(colormap, vec2(value, value));\n\n //Don't do lighting for contours\n surfaceNormal = vec3(1,0,0);\n eyeDirection = vec3(0,1,0);\n lightDirection = vec3(0,0,1);\n}\n",s="precision mediump float;\n#define GLSLIFY 1\n\nuniform vec2 shape;\nuniform vec3 clipBounds[2];\nuniform float pickId;\n\nvarying float value, kill;\nvarying vec3 worldCoordinate;\nvarying vec2 planeCoordinate;\nvarying vec3 surfaceNormal;\n\nvec2 splitFloat(float v) {\n float vh = 255.0 * v;\n float upper = floor(vh);\n float lower = fract(vh);\n return vec2(upper / 255.0, floor(lower * 16.0) / 16.0);\n}\n\nvoid main() {\n if(kill > 0.0 ||\n any(lessThan(worldCoordinate, clipBounds[0])) || any(greaterThan(worldCoordinate, clipBounds[1]))) {\n discard;\n }\n vec2 ux = splitFloat(planeCoordinate.x / shape.x);\n vec2 uy = splitFloat(planeCoordinate.y / shape.y);\n gl_FragColor = vec4(pickId, ux.x, uy.x, ux.y + (uy.y/16.0));\n}\n";r.createShader=function(t){var e=n(t,i,a,null,[{name:"uv",type:"vec4"},{name:"f",type:"vec3"},{name:"normal",type:"vec3"}]);return e.attributes.uv.location=0,e.attributes.f.location=1,e.attributes.normal.location=2,e},r.createPickShader=function(t){var e=n(t,i,s,null,[{name:"uv",type:"vec4"},{name:"f",type:"vec3"},{name:"normal",type:"vec3"}]);return e.attributes.uv.location=0,e.attributes.f.location=1,e.attributes.normal.location=2,e},r.createContourShader=function(t){var e=n(t,o,a,null,[{name:"uv",type:"vec4"},{name:"f",type:"float"}]);return e.attributes.uv.location=0,e.attributes.f.location=1,e},r.createPickContourShader=function(t){var e=n(t,o,s,null,[{name:"uv",type:"vec4"},{name:"f",type:"float"}]);return e.attributes.uv.location=0,e.attributes.f.location=1,e}},{"gl-shader":255}],266:[function(t,e,r){"use strict";function n(t,e,r,n,i){this.position=t,this.index=e,this.uv=r,this.level=n,this.dataCoordinate=i}function i(t){var e=x([y({colormap:t,nshades:R,format:"rgba"}).map(function(t){return[t[0],t[1],t[2],255*t[3]]})]);return b.divseq(e,255),e}function a(t,e,r,i,a,o,s,l,u,c,h,f,d,p){this.gl=t,this.shape=e,this.bounds=r,this.intensityBounds=[],this._shader=i,this._pickShader=a,this._coordinateBuffer=o,this._vao=s,this._colorMap=l,this._contourShader=u,this._contourPickShader=c,this._contourBuffer=h,this._contourVAO=f,this._contourOffsets=[[],[],[]],this._contourCounts=[[],[],[]],this._vertexCount=0,this._pickResult=new n([0,0,0],[0,0],[0,0],[0,0,0],[0,0,0]),this._dynamicBuffer=d,this._dynamicVAO=p,this._dynamicOffsets=[0,0,0],this._dynamicCounts=[0,0,0],this.contourWidth=[1,1,1],this.contourLevels=[[1],[1],[1]],this.contourTint=[0,0,0],this.contourColor=[[.5,.5,.5,1],[.5,.5,.5,1],[.5,.5,.5,1]],this.showContour=!0,this.showSurface=!0,this.enableHighlight=[!0,!0,!0],this.highlightColor=[[0,0,0,1],[0,0,0,1],[0,0,0,1]],this.highlightTint=[1,1,1],this.highlightLevel=[-1,-1,-1],this.enableDynamic=[!0,!0,!0],this.dynamicLevel=[NaN,NaN,NaN],this.dynamicColor=[[0,0,0,1],[0,0,0,1],[0,0,0,1]],this.dynamicTint=[1,1,1],this.dynamicWidth=[1,1,1],this.axesBounds=[[1/0,1/0,1/0],[-1/0,-1/0,-1/0]],this.surfaceProject=[!1,!1,!1],this.contourProject=[[!1,!1,!1],[!1,!1,!1],[!1,!1,!1]],this.colorBounds=[!1,!1],this._field=[_(g.mallocFloat(1024),[0,0]),_(g.mallocFloat(1024),[0,0]),_(g.mallocFloat(1024),[0,0])],this.pickId=1,this.clipBounds=[[-1/0,-1/0,-1/0],[1/0,1/0,1/0]],this.snapToData=!1,this.opacity=1,this.lightPosition=[10,1e4,0],this.ambientLight=.8,this.diffuseLight=.8,this.specularLight=2,this.roughness=.5,this.fresnel=1.5,this.vertexColor=0,this.dirty=!0}function o(t,e){var r,n,i,a=e.axes&&e.axes.lastCubeProps.axis||j,o=e.showSurface,s=e.showContour;for(r=0;r<3;++r)for(o=o||e.surfaceProject[r],n=0;n<3;++n)s=s||e.contourProject[r][n];for(r=0;r<3;++r){var l=N.projections[r];for(n=0;n<16;++n)l[n]=0;for(n=0;n<4;++n)l[5*n]=1;l[5*r]=0,l[12+r]=e.axesBounds[+(a[r]>0)][r],M(l,t.model,l);var u=N.clipBounds[r];for(i=0;i<2;++i)for(n=0;n<3;++n)u[i][n]=t.clipBounds[i][n];u[0][r]=-1e8,u[1][r]=1e8}return N.showSurface=o,N.showContour=s,N}function s(t,e){t=t||{};var r=this.gl;r.disable(r.CULL_FACE),this._colorMap.bind(0);var n=B;n.model=t.model||D,n.view=t.view||D,n.projection=t.projection||D,n.lowerBound=[this.bounds[0][0],this.bounds[0][1],this.colorBounds[0]||this.bounds[0][2]],n.upperBound=[this.bounds[1][0],this.bounds[1][1],this.colorBounds[1]||this.bounds[1][2]],n.contourColor=this.contourColor[0],n.inverseModel=k(n.inverseModel,n.model);for(var i=0;i<2;++i)for(var a=n.clipBounds[i],s=0;s<3;++s)a[s]=Math.min(Math.max(this.clipBounds[i][s],-1e8),1e8);n.kambient=this.ambientLight,n.kdiffuse=this.diffuseLight,n.kspecular=this.specularLight,n.roughness=this.roughness,n.fresnel=this.fresnel,n.opacity=this.opacity,n.height=0,n.permutation=V,n.vertexColor=this.vertexColor;var l=U;for(M(l,n.view,n.model),M(l,n.projection,l),k(l,l),i=0;i<3;++i)n.eyePosition[i]=l[12+i]/l[15];var u=l[15];for(i=0;i<3;++i)u+=this.lightPosition[i]*l[4*i+3];for(i=0;i<3;++i){var c=l[12+i];for(s=0;s<3;++s)c+=l[4*s+i]*this.lightPosition[s];n.lightPosition[i]=c/u}var h=o(n,this);if(h.showSurface&&e===this.opacity<1){for(this._shader.bind(),this._shader.uniforms=n,this._vao.bind(),this.showSurface&&this._vertexCount&&this._vao.draw(r.TRIANGLES,this._vertexCount),i=0;i<3;++i)this.surfaceProject[i]&&this.vertexCount&&(this._shader.uniforms.model=h.projections[i],this._shader.uniforms.clipBounds=h.clipBounds[i],this._vao.draw(r.TRIANGLES,this._vertexCount));this._vao.unbind()}if(h.showContour&&!e){var f=this._contourShader;n.kambient=1,n.kdiffuse=0,n.kspecular=0,n.opacity=1,f.bind(),f.uniforms=n;var d=this._contourVAO;for(d.bind(),i=0;i<3;++i)for(f.uniforms.permutation=O[i],r.lineWidth(this.contourWidth[i]),s=0;s=1)return!0;for(var t=0;t<3;++t)if(this._contourCounts[t].length>0||this._dynamicCounts[t]>0)return!0;return!1},F.pickSlots=1,F.setPickBase=function(t){this.pickId=t};var j=[0,0,0],N={showSurface:!1,showContour:!1,projections:[D.slice(),D.slice(),D.slice()],clipBounds:[[[0,0,0],[0,0,0]],[[0,0,0],[0,0,0]],[[0,0,0],[0,0,0]]]},B={model:D,view:D,projection:D,inverseModel:D.slice(),lowerBound:[0,0,0],upperBound:[0,0,0],colorMap:0,clipBounds:[[0,0,0],[0,0,0]],height:0,contourTint:0,contourColor:[0,0,0,1],permutation:[1,0,0,0,1,0,0,0,1],zOffset:-1e-4,kambient:1,kdiffuse:1,kspecular:1,lightPosition:[1e3,1e3,1e3],eyePosition:[0,0,0],roughness:1,fresnel:1,opacity:1,vertexColor:0},U=D.slice(),V=[1,0,0,0,1,0,0,0,1];F.draw=function(t){return s.call(this,t,!1)},F.drawTransparent=function(t){return s.call(this,t,!0)};var H={model:D,view:D,projection:D,inverseModel:D,clipBounds:[[0,0,0],[0,0,0]],height:0,shape:[0,0],pickId:0,lowerBound:[0,0,0],upperBound:[0,0,0],zOffset:0,permutation:[1,0,0,0,1,0,0,0,1],lightPosition:[0,0,0],eyePosition:[0,0,0]};F.drawPick=function(t){t=t||{};var e=this.gl;e.disable(e.CULL_FACE);var r=H;r.model=t.model||D,r.view=t.view||D,r.projection=t.projection||D,r.shape=this._field[2].shape,r.pickId=this.pickId/255,r.lowerBound=this.bounds[0],r.upperBound=this.bounds[1],r.permutation=V;for(var n=0;n<2;++n)for(var i=r.clipBounds[n],a=0;a<3;++a)i[a]=Math.min(Math.max(this.clipBounds[n][a],-1e8),1e8);var s=o(r,this);if(s.showSurface){for(this._pickShader.bind(),this._pickShader.uniforms=r,this._vao.bind(),this._vao.draw(e.TRIANGLES,this._vertexCount),n=0;n<3;++n)this.surfaceProject[n]&&(this._pickShader.uniforms.model=s.projections[n],this._pickShader.uniforms.clipBounds=s.clipBounds[n],this._vao.draw(e.TRIANGLES,this._vertexCount));this._vao.unbind()}if(s.showContour){var l=this._contourPickShader;l.bind(),l.uniforms=r;var u=this._contourVAO;for(u.bind(),a=0;a<3;++a)for(e.lineWidth(this.contourWidth[a]),l.uniforms.permutation=O[a],n=0;n>4)/16)/255,i=Math.floor(n),a=n-i,o=e[1]*(t.value[1]+(15&t.value[2])/16)/255,s=Math.floor(o),l=o-s;i+=1,s+=1;var u=r.position;u[0]=u[1]=u[2]=0;for(var c=0;c<2;++c)for(var h=c?a:1-a,f=0;f<2;++f)for(var d=f?l:1-l,p=i+c,m=s+f,v=h*d,g=0;g<3;++g)u[g]+=this._field[g].get(p,m)*v;for(var y=this._pickResult.level,b=0;b<3;++b)if(y[b]=A.le(this.contourLevels[b],u[b]),y[b]<0)this.contourLevels[b].length>0&&(y[b]=0);else if(y[b]Math.abs(_-u[b])&&(y[b]+=1)}for(r.index[0]=a<.5?i:i+1,r.index[1]=l<.5?s:s+1,r.uv[0]=n/e[0],r.uv[1]=o/e[1],g=0;g<3;++g)r.dataCoordinate[g]=this._field[g].get(r.index[0],r.index[1]);return r},F.update=function(t){t=t||{},this.dirty=!0,"contourWidth"in t&&(this.contourWidth=u(t.contourWidth,Number)),"showContour"in t&&(this.showContour=u(t.showContour,Boolean)),"showSurface"in t&&(this.showSurface=!!t.showSurface),"contourTint"in t&&(this.contourTint=u(t.contourTint,Boolean)),"contourColor"in t&&(this.contourColor=h(t.contourColor)),"contourProject"in t&&(this.contourProject=u(t.contourProject,function(t){return u(t,Boolean)})),"surfaceProject"in t&&(this.surfaceProject=t.surfaceProject),"dynamicColor"in t&&(this.dynamicColor=h(t.dynamicColor)),"dynamicTint"in t&&(this.dynamicTint=u(t.dynamicTint,Number)),"dynamicWidth"in t&&(this.dynamicWidth=u(t.dynamicWidth,Number)),"opacity"in t&&(this.opacity=t.opacity),"colorBounds"in t&&(this.colorBounds=t.colorBounds),"vertexColor"in t&&(this.vertexColor=t.vertexColor?1:0);var e=t.field||t.coords&&t.coords[2]||null,r=!1;if(e||(e=this._field[2].shape[0]||this._field[2].shape[2]?this._field[2].lo(1,1).hi(this._field[2].shape[0]-2,this._field[2].shape[1]-2):this._field[2].hi(0,0)),"field"in t||"coords"in t){var n=(e.shape[0]+2)*(e.shape[1]+2);n>this._field[2].data.length&&(g.freeFloat(this._field[2].data),this._field[2].data=g.mallocFloat(d.nextPow2(n))),this._field[2]=_(this._field[2].data,[e.shape[0]+2,e.shape[1]+2]),l(this._field[2],e),this.shape=e.shape.slice();for(var a=this.shape,o=0;o<2;++o)this._field[2].size>this._field[o].data.length&&(g.freeFloat(this._field[o].data),this._field[o].data=g.mallocFloat(this._field[2].size)),this._field[o]=_(this._field[o].data,[a[0]+2,a[1]+2]);if(t.coords){var s=t.coords;if(!Array.isArray(s)||3!==s.length)throw new Error("gl-surface: invalid coordinates for x/y");for(o=0;o<2;++o){var c=s[o];for(y=0;y<2;++y)if(c.shape[y]!==a[y])throw new Error("gl-surface: coords have incorrect shape");l(this._field[o],c)}}else if(t.ticks){var f=t.ticks;if(!Array.isArray(f)||2!==f.length)throw new Error("gl-surface: invalid ticks");for(o=0;o<2;++o){var p=f[o];if((Array.isArray(p)||p.length)&&(p=_(p)),p.shape[0]!==a[o])throw new Error("gl-surface: invalid tick length");var m=_(p.data,a);m.stride[o]=p.stride[0],m.stride[1^o]=0,l(this._field[o],m)}}else{for(o=0;o<2;++o){var v=[0,0];v[o]=1,this._field[o]=_(this._field[o].data,[a[0]+2,a[1]+2],v,0)}this._field[0].set(0,0,0);for(var y=0;y0){for(var xt=0;xt<5;++xt)tt.pop();H-=1}continue t}tt.push(it[0],it[1],st[0],st[1],it[2]),H+=1}}nt.push(H)}this._contourOffsets[et]=rt,this._contourCounts[et]=nt}var _t=g.mallocFloat(tt.length);for(o=0;oi||r<0||r>i)throw new Error("gl-texture2d: Invalid texture size");return t._shape=[e,r],t.bind(),n.texImage2D(n.TEXTURE_2D,0,t.format,e,r,0,t.format,t.type,null),t._mipLevels=[0],t}function o(t,e,r,n,i,a){this.gl=t,this.handle=e,this.format=i,this.type=a,this._shape=[r,n],this._mipLevels=[0],this._magFilter=t.NEAREST,this._minFilter=t.NEAREST,this._wrapS=t.CLAMP_TO_EDGE,this._wrapT=t.CLAMP_TO_EDGE,this._anisoSamples=1;var o=this,s=[this._wrapS,this._wrapT];Object.defineProperties(s,[{get:function(){return o._wrapS},set:function(t){return o.wrapS=t}},{get:function(){return o._wrapT},set:function(t){return o.wrapT=t}}]),this._wrapVector=s;var l=[this._shape[0],this._shape[1]];Object.defineProperties(l,[{get:function(){return o._shape[0]},set:function(t){return o.width=t}},{get:function(){return o._shape[1]},set:function(t){return o.height=t}}]),this._shapeVector=l}function s(t,e){return 3===t.length?1===e[2]&&e[1]===t[0]*t[2]&&e[0]===t[2]:1===e[0]&&e[1]===t[0]}function l(t,e,r,n,i,a,o,l){var u=l.dtype,c=l.shape.slice();if(c.length<2||c.length>3)throw new Error("gl-texture2d: Invalid ndarray, must be 2d or 3d");var h=0,f=0,d=s(c,l.stride.slice());"float32"===u?h=t.FLOAT:"float64"===u?(h=t.FLOAT,d=!1,u="float32"):"uint8"===u?h=t.UNSIGNED_BYTE:(h=t.UNSIGNED_BYTE,d=!1,u="uint8");if(2===c.length)f=t.LUMINANCE,c=[c[0],c[1],1],l=p(l.data,c,[l.stride[0],l.stride[1],1],l.offset);else{if(3!==c.length)throw new Error("gl-texture2d: Invalid shape for texture");if(1===c[2])f=t.ALPHA;else if(2===c[2])f=t.LUMINANCE_ALPHA;else if(3===c[2])f=t.RGB;else{if(4!==c[2])throw new Error("gl-texture2d: Invalid shape for pixel coords");f=t.RGBA}c[2]}if(f!==t.LUMINANCE&&f!==t.ALPHA||i!==t.LUMINANCE&&i!==t.ALPHA||(f=i),f!==i)throw new Error("gl-texture2d: Incompatible texture format for setPixels");var g=l.size,y=o.indexOf(n)<0;if(y&&o.push(n),h===a&&d)0===l.offset&&l.data.length===g?y?t.texImage2D(t.TEXTURE_2D,n,i,c[0],c[1],0,i,a,l.data):t.texSubImage2D(t.TEXTURE_2D,n,e,r,c[0],c[1],i,a,l.data):y?t.texImage2D(t.TEXTURE_2D,n,i,c[0],c[1],0,i,a,l.data.subarray(l.offset,l.offset+g)):t.texSubImage2D(t.TEXTURE_2D,n,e,r,c[0],c[1],i,a,l.data.subarray(l.offset,l.offset+g));else{var b;b=a===t.FLOAT?v.mallocFloat32(g):v.mallocUint8(g);var _=p(b,c,[c[2],c[2]*c[0],1]);h===t.FLOAT&&a===t.UNSIGNED_BYTE?x(_,l):m.assign(_,l),y?t.texImage2D(t.TEXTURE_2D,n,i,c[0],c[1],0,i,a,b.subarray(0,g)):t.texSubImage2D(t.TEXTURE_2D,n,e,r,c[0],c[1],i,a,b.subarray(0,g)),a===t.FLOAT?v.freeFloat32(b):v.freeUint8(b)}}function u(t){var e=t.createTexture();return t.bindTexture(t.TEXTURE_2D,e),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_MIN_FILTER,t.NEAREST),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_MAG_FILTER,t.NEAREST),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_WRAP_S,t.CLAMP_TO_EDGE),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_WRAP_T,t.CLAMP_TO_EDGE),e}function c(t,e,r,n,i){var a=t.getParameter(t.MAX_TEXTURE_SIZE);if(e<0||e>a||r<0||r>a)throw new Error("gl-texture2d: Invalid texture shape");if(i===t.FLOAT&&!t.getExtension("OES_texture_float"))throw new Error("gl-texture2d: Floating point textures not supported on this platform");var s=u(t);return t.texImage2D(t.TEXTURE_2D,0,n,e,r,0,n,i,null),new o(t,s,e,r,n,i)}function h(t,e,r,n,i,a){var s=u(t);return t.texImage2D(t.TEXTURE_2D,0,i,i,a,e),new o(t,s,r,n,i,a)}function f(t,e){var r=e.dtype,n=e.shape.slice(),i=t.getParameter(t.MAX_TEXTURE_SIZE);if(n[0]<0||n[0]>i||n[1]<0||n[1]>i)throw new Error("gl-texture2d: Invalid texture size");var a=s(n,e.stride.slice()),l=0;"float32"===r?l=t.FLOAT:"float64"===r?(l=t.FLOAT,a=!1,r="float32"):"uint8"===r?l=t.UNSIGNED_BYTE:(l=t.UNSIGNED_BYTE,a=!1,r="uint8");var c=0;if(2===n.length)c=t.LUMINANCE,n=[n[0],n[1],1],e=p(e.data,n,[e.stride[0],e.stride[1],1],e.offset);else{if(3!==n.length)throw new Error("gl-texture2d: Invalid shape for texture");if(1===n[2])c=t.ALPHA;else if(2===n[2])c=t.LUMINANCE_ALPHA;else if(3===n[2])c=t.RGB;else{if(4!==n[2])throw new Error("gl-texture2d: Invalid shape for pixel coords");c=t.RGBA}}l!==t.FLOAT||t.getExtension("OES_texture_float")||(l=t.UNSIGNED_BYTE,a=!1);var h,f,d=e.size;if(a)h=0===e.offset&&e.data.length===d?e.data:e.data.subarray(e.offset,e.offset+d);else{var g=[n[2],n[2]*n[0],1];f=v.malloc(d,r);var y=p(f,n,g,0);"float32"!==r&&"float64"!==r||l!==t.UNSIGNED_BYTE?m.assign(y,e):x(y,e),h=f.subarray(0,d)}var b=u(t);return t.texImage2D(t.TEXTURE_2D,0,c,n[0],n[1],0,c,l,h),a||v.free(f),new o(t,b,n[0],n[1],c,l)}function d(t){if(arguments.length<=1)throw new Error("gl-texture2d: Missing arguments for texture2d constructor");if(g||n(t),"number"==typeof arguments[1])return c(t,arguments[1],arguments[2],arguments[3]||t.RGBA,arguments[4]||t.UNSIGNED_BYTE);if(Array.isArray(arguments[1]))return c(t,0|arguments[1][0],0|arguments[1][1],arguments[2]||t.RGBA,arguments[3]||t.UNSIGNED_BYTE);if("object"==typeof arguments[1]){var e=arguments[1],r=i(e)?e:e.raw;if(r)return h(t,r,0|e.width,0|e.height,arguments[2]||t.RGBA,arguments[3]||t.UNSIGNED_BYTE);if(e.shape&&e.data&&e.stride)return f(t,e)}throw new Error("gl-texture2d: Invalid arguments for texture2d constructor")}var p=t("ndarray"),m=t("ndarray-ops"),v=t("typedarray-pool");e.exports=d;var g=null,y=null,b=null,x=function(t,e){m.muls(t,e,255)},_=o.prototype;Object.defineProperties(_,{minFilter:{get:function(){return this._minFilter},set:function(t){this.bind();var e=this.gl;if(this.type===e.FLOAT&&g.indexOf(t)>=0&&(e.getExtension("OES_texture_float_linear")||(t=e.NEAREST)),y.indexOf(t)<0)throw new 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This is either when fading in\n // the line in case of an offset line (v_linewidth.t) or when fading out\n // (v_linewidth.s)\n float blur = u_blur * v_gamma_scale;\n float alpha = clamp(min(dist - (v_linewidth.t - blur), v_linewidth.s - dist) / blur, 0.0, 1.0);\n\n float sdfdist_a = texture2D(u_image, v_tex_a).a;\n float sdfdist_b = texture2D(u_image, v_tex_b).a;\n float sdfdist = mix(sdfdist_a, sdfdist_b, u_mix);\n alpha *= smoothstep(0.5 - u_sdfgamma, 0.5 + u_sdfgamma, sdfdist);\n\n gl_FragColor = u_color * (alpha * u_opacity);\n\n#ifdef OVERDRAW_INSPECTOR\n gl_FragColor = vec4(1.0);\n#endif\n}\n",vertexSource:"#ifdef GL_ES\nprecision highp float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\n// floor(127 / 2) == 63.0\n// the maximum allowed miter limit is 2.0 at the moment. the extrude normal is\n// stored in a byte (-128..127). we scale regular normals up to length 63, but\n// there are also \"special\" normals that have a bigger length (of up to 126 in\n// this case).\n// #define scale 63.0\n#define scale 0.015873016\n\n// We scale the distance before adding it to the buffers so that we can store\n// long distances for long segments. Use this value to unscale the distance.\n#define LINE_DISTANCE_SCALE 2.0\n\nattribute vec2 a_pos;\nattribute vec4 a_data;\n\nuniform mat4 u_matrix;\nuniform mediump float u_ratio;\nuniform mediump float u_linewidth;\nuniform mediump float u_gapwidth;\nuniform mediump float u_antialiasing;\nuniform vec2 u_patternscale_a;\nuniform float u_tex_y_a;\nuniform vec2 u_patternscale_b;\nuniform float u_tex_y_b;\nuniform float u_extra;\nuniform mat2 u_antialiasingmatrix;\nuniform mediump float u_offset;\n\nvarying vec2 v_normal;\nvarying vec2 v_linewidth;\nvarying vec2 v_tex_a;\nvarying vec2 v_tex_b;\nvarying float v_gamma_scale;\n\nvoid main() {\n vec2 a_extrude = a_data.xy - 128.0;\n float a_direction = mod(a_data.z, 4.0) - 1.0;\n float a_linesofar = (floor(a_data.z / 4.0) + a_data.w * 64.0) * LINE_DISTANCE_SCALE;\n\n // We store the texture normals in the most insignificant bit\n // transform y so that 0 => -1 and 1 => 1\n // In the texture normal, x is 0 if the normal points straight up/down and 1 if it's a round cap\n // y is 1 if the normal points up, and -1 if it points down\n mediump vec2 normal = mod(a_pos, 2.0);\n normal.y = sign(normal.y - 0.5);\n v_normal = normal;\n\n float inset = u_gapwidth + (u_gapwidth > 0.0 ? u_antialiasing : 0.0);\n float outset = u_gapwidth + u_linewidth * (u_gapwidth > 0.0 ? 2.0 : 1.0) + u_antialiasing;\n\n // Scale the extrusion vector down to a normal and then up by the line width\n // of this vertex.\n mediump vec2 dist = outset * a_extrude * scale;\n\n // Calculate the offset when drawing a line that is to the side of the actual line.\n // We do this by creating a vector that points towards the extrude, but rotate\n // it when we're drawing round end points (a_direction = -1 or 1) since their\n // extrude vector points in another direction.\n mediump float u = 0.5 * a_direction;\n mediump float t = 1.0 - abs(u);\n mediump vec2 offset = u_offset * a_extrude * scale * normal.y * mat2(t, -u, u, t);\n\n // Remove the texture normal bit of the position before scaling it with the\n // model/view matrix.\n gl_Position = u_matrix * vec4(floor(a_pos * 0.5) + (offset + dist) / u_ratio, 0.0, 1.0);\n\n v_tex_a = vec2(a_linesofar * u_patternscale_a.x, normal.y * u_patternscale_a.y + u_tex_y_a);\n v_tex_b = vec2(a_linesofar * u_patternscale_b.x, normal.y * u_patternscale_b.y + u_tex_y_b);\n\n // position of y on the screen\n float y = gl_Position.y / gl_Position.w;\n\n // how much features are squished in the y direction by the tilt\n float squish_scale = length(a_extrude) / length(u_antialiasingmatrix * a_extrude);\n\n // how much features are squished in all directions by the perspectiveness\n float perspective_scale = 1.0 / (1.0 - min(y * u_extra, 0.9));\n\n v_linewidth = vec2(outset, inset);\n v_gamma_scale = perspective_scale * squish_scale;\n}\n"},outline:{fragmentSource:"#ifdef GL_ES\nprecision mediump float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\n#pragma mapbox: define lowp vec4 outline_color\n#pragma mapbox: define lowp float opacity\n\nvarying vec2 v_pos;\n\nvoid main() {\n #pragma mapbox: initialize lowp vec4 outline_color\n #pragma mapbox: initialize lowp float opacity\n\n float dist = length(v_pos - gl_FragCoord.xy);\n float alpha = smoothstep(1.0, 0.0, dist);\n gl_FragColor = outline_color * (alpha * opacity);\n\n#ifdef OVERDRAW_INSPECTOR\n gl_FragColor = vec4(1.0);\n#endif\n}\n",vertexSource:"#ifdef GL_ES\nprecision highp float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nattribute vec2 a_pos;\n\nuniform mat4 u_matrix;\nuniform vec2 u_world;\n\nvarying vec2 v_pos;\n\n#pragma mapbox: define lowp vec4 outline_color\n#pragma mapbox: define lowp float opacity\n\nvoid main() {\n #pragma mapbox: initialize lowp vec4 outline_color\n #pragma mapbox: initialize lowp float opacity\n\n gl_Position = u_matrix * vec4(a_pos, 0, 1);\n v_pos = (gl_Position.xy / gl_Position.w + 1.0) / 2.0 * u_world;\n}\n"},outlinepattern:{fragmentSource:"#ifdef GL_ES\nprecision mediump float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nuniform float u_opacity;\nuniform vec2 u_pattern_tl_a;\nuniform vec2 u_pattern_br_a;\nuniform vec2 u_pattern_tl_b;\nuniform vec2 u_pattern_br_b;\nuniform float u_mix;\n\nuniform sampler2D u_image;\n\nvarying vec2 v_pos_a;\nvarying vec2 v_pos_b;\nvarying vec2 v_pos;\n\nvoid main() {\n vec2 imagecoord = mod(v_pos_a, 1.0);\n vec2 pos = mix(u_pattern_tl_a, u_pattern_br_a, imagecoord);\n vec4 color1 = texture2D(u_image, pos);\n\n vec2 imagecoord_b = mod(v_pos_b, 1.0);\n vec2 pos2 = mix(u_pattern_tl_b, u_pattern_br_b, imagecoord_b);\n vec4 color2 = texture2D(u_image, pos2);\n\n // find distance to outline for alpha interpolation\n\n float dist = length(v_pos - gl_FragCoord.xy);\n float alpha = smoothstep(1.0, 0.0, dist);\n \n\n gl_FragColor = mix(color1, color2, u_mix) * alpha * u_opacity;\n\n#ifdef OVERDRAW_INSPECTOR\n gl_FragColor = vec4(1.0);\n#endif\n}\n",vertexSource:"#ifdef GL_ES\nprecision highp float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nuniform vec2 u_pattern_size_a;\nuniform vec2 u_pattern_size_b;\nuniform vec2 u_pixel_coord_upper;\nuniform vec2 u_pixel_coord_lower;\nuniform float u_scale_a;\nuniform float u_scale_b;\nuniform float u_tile_units_to_pixels;\n\nattribute vec2 a_pos;\n\nuniform mat4 u_matrix;\nuniform vec2 u_world;\n\nvarying vec2 v_pos_a;\nvarying vec2 v_pos_b;\nvarying vec2 v_pos;\n\nvoid main() {\n gl_Position = u_matrix * vec4(a_pos, 0, 1);\n vec2 scaled_size_a = u_scale_a * u_pattern_size_a;\n vec2 scaled_size_b = u_scale_b * u_pattern_size_b;\n\n // the correct offset needs to be calculated.\n //\n // The offset depends on how many pixels are between the world origin and\n // the edge of the tile:\n // vec2 offset = mod(pixel_coord, size)\n //\n // At high zoom levels there are a ton of pixels between the world origin\n // and the edge of the tile. The glsl spec only guarantees 16 bits of\n // precision for highp floats. We need more than that.\n //\n // The pixel_coord is passed in as two 16 bit values:\n // pixel_coord_upper = floor(pixel_coord / 2^16)\n // pixel_coord_lower = mod(pixel_coord, 2^16)\n //\n // The offset is calculated in a series of steps that should preserve this precision:\n vec2 offset_a = mod(mod(mod(u_pixel_coord_upper, scaled_size_a) * 256.0, scaled_size_a) * 256.0 + u_pixel_coord_lower, scaled_size_a);\n vec2 offset_b = mod(mod(mod(u_pixel_coord_upper, scaled_size_b) * 256.0, scaled_size_b) * 256.0 + u_pixel_coord_lower, scaled_size_b);\n\n v_pos_a = (u_tile_units_to_pixels * a_pos + offset_a) / scaled_size_a;\n v_pos_b = (u_tile_units_to_pixels * a_pos + offset_b) / scaled_size_b;\n\n v_pos = (gl_Position.xy / gl_Position.w + 1.0) / 2.0 * u_world;\n}\n"},pattern:{fragmentSource:"#ifdef GL_ES\nprecision mediump float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nuniform float u_opacity;\nuniform vec2 u_pattern_tl_a;\nuniform vec2 u_pattern_br_a;\nuniform vec2 u_pattern_tl_b;\nuniform vec2 u_pattern_br_b;\nuniform float u_mix;\n\nuniform sampler2D u_image;\n\nvarying vec2 v_pos_a;\nvarying vec2 v_pos_b;\n\nvoid main() {\n\n vec2 imagecoord = mod(v_pos_a, 1.0);\n vec2 pos = mix(u_pattern_tl_a, u_pattern_br_a, imagecoord);\n vec4 color1 = texture2D(u_image, pos);\n\n vec2 imagecoord_b = mod(v_pos_b, 1.0);\n vec2 pos2 = mix(u_pattern_tl_b, u_pattern_br_b, imagecoord_b);\n vec4 color2 = texture2D(u_image, pos2);\n\n gl_FragColor = mix(color1, color2, u_mix) * u_opacity;\n\n#ifdef OVERDRAW_INSPECTOR\n gl_FragColor = vec4(1.0);\n#endif\n}\n",vertexSource:"#ifdef GL_ES\nprecision highp float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nuniform mat4 u_matrix;\nuniform vec2 u_pattern_size_a;\nuniform vec2 u_pattern_size_b;\nuniform vec2 u_pixel_coord_upper;\nuniform vec2 u_pixel_coord_lower;\nuniform float u_scale_a;\nuniform float u_scale_b;\nuniform float u_tile_units_to_pixels;\n\nattribute vec2 a_pos;\n\nvarying vec2 v_pos_a;\nvarying vec2 v_pos_b;\n\nvoid main() {\n gl_Position = u_matrix * vec4(a_pos, 0, 1);\n vec2 scaled_size_a = u_scale_a * u_pattern_size_a;\n vec2 scaled_size_b = u_scale_b * u_pattern_size_b;\n\n // the correct offset needs to be calculated.\n //\n // The offset depends on how many pixels are between the world origin and\n // the edge of the tile:\n // vec2 offset = mod(pixel_coord, size)\n //\n // At high zoom levels there are a ton of pixels between the world origin\n // and the edge of the tile. The glsl spec only guarantees 16 bits of\n // precision for highp floats. We need more than that.\n //\n // The pixel_coord is passed in as two 16 bit values:\n // pixel_coord_upper = floor(pixel_coord / 2^16)\n // pixel_coord_lower = mod(pixel_coord, 2^16)\n //\n // The offset is calculated in a series of steps that should preserve this precision:\n vec2 offset_a = mod(mod(mod(u_pixel_coord_upper, scaled_size_a) * 256.0, scaled_size_a) * 256.0 + u_pixel_coord_lower, scaled_size_a);\n vec2 offset_b = mod(mod(mod(u_pixel_coord_upper, scaled_size_b) * 256.0, scaled_size_b) * 256.0 + u_pixel_coord_lower, scaled_size_b);\n\n v_pos_a = (u_tile_units_to_pixels * a_pos + offset_a) / scaled_size_a;\n v_pos_b = (u_tile_units_to_pixels * a_pos + offset_b) / scaled_size_b;\n}\n"},raster:{fragmentSource:"#ifdef GL_ES\nprecision mediump float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nuniform float u_opacity0;\nuniform float u_opacity1;\nuniform sampler2D u_image0;\nuniform sampler2D u_image1;\nvarying vec2 v_pos0;\nvarying vec2 v_pos1;\n\nuniform float u_brightness_low;\nuniform float u_brightness_high;\n\nuniform float u_saturation_factor;\nuniform float u_contrast_factor;\nuniform vec3 u_spin_weights;\n\nvoid main() {\n\n // read and cross-fade colors from the main and parent tiles\n vec4 color0 = texture2D(u_image0, v_pos0);\n vec4 color1 = texture2D(u_image1, v_pos1);\n vec4 color = color0 * u_opacity0 + color1 * u_opacity1;\n vec3 rgb = color.rgb;\n\n // spin\n rgb = vec3(\n dot(rgb, u_spin_weights.xyz),\n dot(rgb, u_spin_weights.zxy),\n dot(rgb, u_spin_weights.yzx));\n\n // saturation\n float average = (color.r + color.g + color.b) / 3.0;\n rgb += (average - rgb) * u_saturation_factor;\n\n // contrast\n rgb = (rgb - 0.5) * u_contrast_factor + 0.5;\n\n // brightness\n vec3 u_high_vec = vec3(u_brightness_low, u_brightness_low, u_brightness_low);\n vec3 u_low_vec = vec3(u_brightness_high, u_brightness_high, u_brightness_high);\n\n gl_FragColor = vec4(mix(u_high_vec, u_low_vec, rgb), color.a);\n\n#ifdef OVERDRAW_INSPECTOR\n gl_FragColor = vec4(1.0);\n#endif\n}\n",vertexSource:"#ifdef GL_ES\nprecision highp float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nuniform mat4 u_matrix;\nuniform vec2 u_tl_parent;\nuniform float u_scale_parent;\nuniform float u_buffer_scale;\n\nattribute vec2 a_pos;\nattribute vec2 a_texture_pos;\n\nvarying vec2 v_pos0;\nvarying vec2 v_pos1;\n\nvoid main() {\n gl_Position = u_matrix * vec4(a_pos, 0, 1);\n v_pos0 = (((a_texture_pos / 32767.0) - 0.5) / u_buffer_scale ) + 0.5;\n v_pos1 = (v_pos0 * u_scale_parent) + u_tl_parent;\n}\n"},icon:{fragmentSource:"#ifdef GL_ES\nprecision mediump float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nuniform sampler2D u_texture;\nuniform sampler2D u_fadetexture;\nuniform lowp float u_opacity;\n\nvarying vec2 v_tex;\nvarying vec2 v_fade_tex;\n\nvoid main() {\n lowp float alpha = texture2D(u_fadetexture, v_fade_tex).a * u_opacity;\n gl_FragColor = texture2D(u_texture, v_tex) * alpha;\n\n#ifdef OVERDRAW_INSPECTOR\n gl_FragColor = vec4(1.0);\n#endif\n}\n",vertexSource:"#ifdef GL_ES\nprecision highp float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nattribute vec2 a_pos;\nattribute vec2 a_offset;\nattribute vec2 a_texture_pos;\nattribute vec4 a_data;\n\n\n// matrix is for the vertex position.\nuniform mat4 u_matrix;\n\nuniform mediump float u_zoom;\nuniform bool u_rotate_with_map;\nuniform vec2 u_extrude_scale;\n\nuniform vec2 u_texsize;\n\nvarying vec2 v_tex;\nvarying vec2 v_fade_tex;\n\nvoid main() {\n vec2 a_tex = a_texture_pos.xy;\n mediump float a_labelminzoom = a_data[0];\n mediump vec2 a_zoom = a_data.pq;\n mediump float a_minzoom = a_zoom[0];\n mediump float a_maxzoom = a_zoom[1];\n\n // u_zoom is the current zoom level adjusted for the change in font size\n mediump float z = 2.0 - step(a_minzoom, u_zoom) - (1.0 - step(a_maxzoom, u_zoom));\n\n vec2 extrude = u_extrude_scale * (a_offset / 64.0);\n if (u_rotate_with_map) {\n gl_Position = u_matrix * vec4(a_pos + extrude, 0, 1);\n gl_Position.z += z * gl_Position.w;\n } else {\n gl_Position = u_matrix * vec4(a_pos, 0, 1) + vec4(extrude, 0, 0);\n }\n\n v_tex = a_tex / u_texsize;\n v_fade_tex = vec2(a_labelminzoom / 255.0, 0.0);\n}\n"},sdf:{fragmentSource:"#ifdef GL_ES\nprecision mediump float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nuniform sampler2D u_texture;\nuniform sampler2D u_fadetexture;\nuniform lowp vec4 u_color;\nuniform lowp float u_opacity;\nuniform lowp float u_buffer;\nuniform lowp float u_gamma;\n\nvarying vec2 v_tex;\nvarying vec2 v_fade_tex;\nvarying float v_gamma_scale;\n\nvoid main() {\n lowp float dist = texture2D(u_texture, v_tex).a;\n lowp float fade_alpha = texture2D(u_fadetexture, v_fade_tex).a;\n lowp float gamma = u_gamma * v_gamma_scale;\n lowp float alpha = smoothstep(u_buffer - gamma, u_buffer + gamma, dist) * fade_alpha;\n\n gl_FragColor = u_color * (alpha * u_opacity);\n\n#ifdef OVERDRAW_INSPECTOR\n gl_FragColor = vec4(1.0);\n#endif\n}\n",vertexSource:"#ifdef GL_ES\nprecision highp float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nconst float PI = 3.141592653589793;\n\nattribute vec2 a_pos;\nattribute vec2 a_offset;\nattribute vec2 a_texture_pos;\nattribute vec4 a_data;\n\n\n// matrix is for the vertex position.\nuniform mat4 u_matrix;\n\nuniform mediump float u_zoom;\nuniform bool u_rotate_with_map;\nuniform bool u_pitch_with_map;\nuniform mediump float u_pitch;\nuniform mediump float u_bearing;\nuniform mediump float u_aspect_ratio;\nuniform vec2 u_extrude_scale;\n\nuniform vec2 u_texsize;\n\nvarying vec2 v_tex;\nvarying vec2 v_fade_tex;\nvarying float v_gamma_scale;\n\nvoid main() {\n vec2 a_tex = a_texture_pos.xy;\n mediump float a_labelminzoom = a_data[0];\n mediump vec2 a_zoom = a_data.pq;\n mediump float a_minzoom = a_zoom[0];\n mediump float a_maxzoom = a_zoom[1];\n\n // u_zoom is the current zoom level adjusted for the change in font size\n mediump float z = 2.0 - step(a_minzoom, u_zoom) - (1.0 - step(a_maxzoom, u_zoom));\n\n // pitch-alignment: map\n // rotation-alignment: map | viewport\n if (u_pitch_with_map) {\n lowp float angle = u_rotate_with_map ? (a_data[1] / 256.0 * 2.0 * PI) : u_bearing;\n lowp float asin = sin(angle);\n lowp float acos = cos(angle);\n mat2 RotationMatrix = mat2(acos, asin, -1.0 * asin, acos);\n vec2 offset = RotationMatrix * a_offset;\n vec2 extrude = u_extrude_scale * (offset / 64.0);\n gl_Position = u_matrix * vec4(a_pos + extrude, 0, 1);\n gl_Position.z += z * gl_Position.w;\n // pitch-alignment: viewport\n // rotation-alignment: map\n } else if (u_rotate_with_map) {\n // foreshortening factor to apply on pitched maps\n // as a label goes from horizontal <=> vertical in angle\n // it goes from 0% foreshortening to up to around 70% foreshortening\n lowp float pitchfactor = 1.0 - cos(u_pitch * sin(u_pitch * 0.75));\n\n lowp float lineangle = a_data[1] / 256.0 * 2.0 * PI;\n\n // use the lineangle to position points a,b along the line\n // project the points and calculate the label angle in projected space\n // this calculation allows labels to be rendered unskewed on pitched maps\n vec4 a = u_matrix * vec4(a_pos, 0, 1);\n vec4 b = u_matrix * vec4(a_pos + vec2(cos(lineangle),sin(lineangle)), 0, 1);\n lowp float angle = atan((b[1]/b[3] - a[1]/a[3])/u_aspect_ratio, b[0]/b[3] - a[0]/a[3]);\n lowp float asin = sin(angle);\n lowp float acos = cos(angle);\n mat2 RotationMatrix = mat2(acos, -1.0 * asin, asin, acos);\n\n vec2 offset = RotationMatrix * (vec2((1.0-pitchfactor)+(pitchfactor*cos(angle*2.0)), 1.0) * a_offset);\n vec2 extrude = u_extrude_scale * (offset / 64.0);\n gl_Position = u_matrix * vec4(a_pos, 0, 1) + vec4(extrude, 0, 0);\n gl_Position.z += z * gl_Position.w;\n // pitch-alignment: viewport\n // rotation-alignment: viewport\n } else {\n vec2 extrude = u_extrude_scale * (a_offset / 64.0);\n gl_Position = u_matrix * vec4(a_pos, 0, 1) + vec4(extrude, 0, 0);\n }\n\n v_gamma_scale = (gl_Position.w - 0.5);\n\n v_tex = a_tex / u_texsize;\n v_fade_tex = vec2(a_labelminzoom / 255.0, 0.0);\n}\n"},collisionbox:{fragmentSource:"#ifdef GL_ES\nprecision mediump float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nuniform float u_zoom;\nuniform float u_maxzoom;\n\nvarying float v_max_zoom;\nvarying float v_placement_zoom;\n\nvoid main() {\n\n float alpha = 0.5;\n\n gl_FragColor = vec4(0.0, 1.0, 0.0, 1.0) * alpha;\n\n if (v_placement_zoom > u_zoom) {\n gl_FragColor = vec4(1.0, 0.0, 0.0, 1.0) * alpha;\n }\n\n if (u_zoom >= v_max_zoom) {\n gl_FragColor = vec4(0.0, 0.0, 0.0, 1.0) * alpha * 0.25;\n }\n\n if (v_placement_zoom >= u_maxzoom) {\n gl_FragColor = vec4(0.0, 0.0, 1.0, 1.0) * alpha * 0.2;\n }\n}\n",vertexSource:"#ifdef GL_ES\nprecision highp float;\n#else\n#define lowp\n#define mediump\n#define highp\n#endif\n\nattribute vec2 a_pos;\nattribute vec2 a_extrude;\nattribute vec2 a_data;\n\nuniform mat4 u_matrix;\nuniform float u_scale;\n\nvarying float v_max_zoom;\nvarying float v_placement_zoom;\n\nvoid main() {\n gl_Position = u_matrix * vec4(a_pos + a_extrude / u_scale, 0.0, 1.0);\n\n v_max_zoom = a_data.x;\n v_placement_zoom = 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i=t("../util/util");e.exports=n,n.MAX_VERTEX_ARRAY_LENGTH=Math.pow(2,16)-1,n.prototype.hasCapacityFor=function(t){return this.layoutVertexArray.length+t<=n.MAX_VERTEX_ARRAY_LENGTH},n.prototype.isEmpty=function(){return 0===this.layoutVertexArray.length},n.prototype.trim=function(){this.layoutVertexArray.trim(),this.elementArray&&this.elementArray.trim(),this.elementArray2&&this.elementArray2.trim();for(var t in this.paintVertexArrays)this.paintVertexArrays[t].trim()},n.prototype.serialize=function(){return{layoutVertexArray:this.layoutVertexArray.serialize(),elementArray:this.elementArray&&this.elementArray.serialize(),elementArray2:this.elementArray2&&this.elementArray2.serialize(),paintVertexArrays:i.mapObject(this.paintVertexArrays,function(t){return t.serialize()})}},n.prototype.getTransferables=function(t){t.push(this.layoutVertexArray.arrayBuffer),this.elementArray&&t.push(this.elementArray.arrayBuffer),this.elementArray2&&t.push(this.elementArray2.arrayBuffer);for(var e in this.paintVertexArrays)t.push(this.paintVertexArrays[e].arrayBuffer)}},{"../util/util":442}],329:[function(t,e,r){"use strict";function n(t){if(this.zoom=t.zoom,this.overscaling=t.overscaling,this.layer=t.layer,this.childLayers=t.childLayers,this.type=this.layer.type,this.features=[],this.id=this.layer.id,this.index=t.index,this.sourceLayer=this.layer.sourceLayer,this.sourceLayerIndex=t.sourceLayerIndex,this.minZoom=this.layer.minzoom,this.maxZoom=this.layer.maxzoom,this.paintAttributes=i(this),t.arrays){var e=this.programInterfaces;this.bufferGroups=c.mapObject(t.arrays,function(r,n){var i=e[n],a=t.paintVertexArrayTypes[n];return r.map(function(t){return new u(t,{layoutVertexArrayType:i.layoutVertexArrayType.serialize(),elementArrayType:i.elementArrayType&&i.elementArrayType.serialize(),elementArrayType2:i.elementArrayType2&&i.elementArrayType2.serialize(),paintVertexArrayTypes:a})})})}}function i(t){var e={};for(var r in t.programInterfaces){for(var 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t.getPaintValue("circle-color",e,r)},multiplier:255,paintProperty:"circle-color"},{name:"a_radius",components:1,type:"Uint16",isLayerConstant:!1,getValue:function(t,e,r){return[t.getPaintValue("circle-radius",e,r)]},multiplier:10,paintProperty:"circle-radius"},{name:"a_blur",components:1,type:"Uint16",isLayerConstant:!1,getValue:function(t,e,r){return[t.getPaintValue("circle-blur",e,r)]},multiplier:10,paintProperty:"circle-blur"},{name:"a_opacity",components:1,type:"Uint16",isLayerConstant:!1,getValue:function(t,e,r){return[t.getPaintValue("circle-opacity",e,r)]},multiplier:255,paintProperty:"circle-opacity"}]}},n.prototype.addFeature=function(t){for(var e={zoom:this.zoom},r=o(t),n=this.prepareArrayGroup("circle",0),i=n.layoutVertexArray.length,a=0;a=s||c<0||c>=s)){var h=this.prepareArrayGroup("circle",4),f=h.layoutVertexArray,d=this.addCircleVertex(f,u,c,-1,-1);this.addCircleVertex(f,u,c,1,-1),this.addCircleVertex(f,u,c,1,1),this.addCircleVertex(f,u,c,-1,1),h.elementArray.emplaceBack(d,d+1,d+2),h.elementArray.emplaceBack(d,d+3,d+2)}}this.populatePaintArrays("circle",e,t.properties,n,i)}},{"../../util/util":442,"../bucket":329,"../load_geometry":337}],331:[function(t,e,r){"use strict";function n(){i.apply(this,arguments)}var i=t("../bucket"),a=t("../../util/util"),o=t("../load_geometry"),s=t("earcut"),l=t("../../util/classify_rings");e.exports=n,n.prototype=a.inherit(i,{}),n.prototype.programInterfaces={fill:{layoutVertexArrayType:new i.VertexArrayType([{name:"a_pos",components:2,type:"Int16"}]),elementArrayType:new i.ElementArrayType(1),elementArrayType2:new i.ElementArrayType(2),paintAttributes:[{name:"a_color",components:4,type:"Uint8",getValue:function(t,e,r){return t.getPaintValue("fill-color",e,r)},multiplier:255,paintProperty:"fill-color"},{name:"a_outline_color",components:4,type:"Uint8",getValue:function(t,e,r){return t.getPaintValue("fill-outline-color",e,r)},multiplier:255,paintProperty:"fill-outline-color"},{name:"a_opacity",components:1,type:"Uint8",getValue:function(t,e,r){return[t.getPaintValue("fill-opacity",e,r)]},multiplier:255,paintProperty:"fill-opacity"}]}},n.prototype.addFeature=function(t){for(var e=o(t),r=l(e,500),n=this.prepareArrayGroup("fill",0),i=n.layoutVertexArray.length,a=0;a0&&a.push(i.length/2);for(var c=0;c=1&&n.elementArray2.emplaceBack(f-1,f),i.push(h.x),i.push(h.y)}}for(var d=s(i,a),p=0;p>6)},n.prototype.programInterfaces={line:{layoutVertexArrayType:new i.VertexArrayType([{name:"a_pos",components:2,type:"Int16"},{name:"a_data",components:4,type:"Uint8"}]),elementArrayType:new i.ElementArrayType}},n.prototype.addFeature=function(t){for(var e=o(t,15),r=0;r2&&t[a-1].equals(t[a-2]);)a--;if(!(t.length<2)){"bevel"===e&&(n=1.05);var o=s/(512*this.overscaling)*15,u=t[0],c=t[a-1],h=u.equals(c);if(this.prepareArrayGroup("line",10*a),2!==a||!h){this.distance=0;var f,d,p,m,v,g,y,b=r,x=h?"butt":r,_=!0;this.e1=this.e2=this.e3=-1,h&&(f=t[a-2],v=u.sub(f)._unit()._perp());for(var w=0;w0){var S=f.dist(d);if(S>2*o){var E=f.sub(f.sub(d)._mult(o/S)._round());this.distance+=E.dist(d),this.addCurrentVertex(E,this.distance,m.mult(1),0,0,!1),d=E}}var L=d&&p,C=L?e:p?b:x;if(L&&"round"===C&&(An&&(C="bevel"),"bevel"===C&&(A>2&&(C="flipbevel"),A100)M=v.clone();else{var I=m.x*v.y-m.y*v.x>0?-1:1,z=A*m.add(v).mag()/m.sub(v).mag();M._perp()._mult(z*I)}this.addCurrentVertex(f,this.distance,M,0,0,!1),this.addCurrentVertex(f,this.distance,M.mult(-1),0,0,!1)}else if("bevel"===C||"fakeround"===C){var D=m.x*v.y-m.y*v.x>0,P=-Math.sqrt(A*A-1);if(D?(y=0,g=P):(g=0,y=P),_||this.addCurrentVertex(f,this.distance,m,g,y,!1),"fakeround"===C){for(var O,R=Math.floor(8*(.5-(k-.5))),F=0;F=0;j--)O=m.mult((j+1)/(R+1))._add(v)._unit(),this.addPieSliceVertex(f,this.distance,O,D)}p&&this.addCurrentVertex(f,this.distance,v,-g,-y,!1)}else"butt"===C?(_||this.addCurrentVertex(f,this.distance,m,0,0,!1),p&&this.addCurrentVertex(f,this.distance,v,0,0,!1)):"square"===C?(_||(this.addCurrentVertex(f,this.distance,m,1,1,!1),this.e1=this.e2=-1),p&&this.addCurrentVertex(f,this.distance,v,-1,-1,!1)):"round"===C&&(_||(this.addCurrentVertex(f,this.distance,m,0,0,!1),this.addCurrentVertex(f,this.distance,m,1,1,!0),this.e1=this.e2=-1),p&&(this.addCurrentVertex(f,this.distance,v,-1,-1,!0),this.addCurrentVertex(f,this.distance,v,0,0,!1)));if(T&&w2*o){var B=f.add(p.sub(f)._mult(o/N)._round());this.distance+=B.dist(f),this.addCurrentVertex(B,this.distance,v.mult(1),0,0,!1),f=B}}_=!1}}}},n.prototype.addCurrentVertex=function(t,e,r,n,i,a){var o,s=a?1:0,l=this.arrayGroups.line[this.arrayGroups.line.length-1],c=l.layoutVertexArray,h=l.elementArray;o=r.clone(),n&&o._sub(r.perp()._mult(n)),this.e3=this.addLineVertex(c,t,o,s,0,n,e),this.e1>=0&&this.e2>=0&&h.emplaceBack(this.e1,this.e2,this.e3),this.e1=this.e2,this.e2=this.e3,o=r.mult(-1),i&&o._sub(r.perp()._mult(i)),this.e3=this.addLineVertex(c,t,o,s,1,-i,e),this.e1>=0&&this.e2>=0&&h.emplaceBack(this.e1,this.e2,this.e3),this.e1=this.e2,this.e2=this.e3,e>u/2&&(this.distance=0,this.addCurrentVertex(t,this.distance,r,n,i,a))},n.prototype.addPieSliceVertex=function(t,e,r,n){var i=n?1:0;r=r.mult(n?-1:1);var a=this.arrayGroups.line[this.arrayGroups.line.length-1],o=a.layoutVertexArray,s=a.elementArray;this.e3=this.addLineVertex(o,t,r,0,i,0,e),this.e1>=0&&this.e2>=0&&s.emplaceBack(this.e1,this.e2,this.e3),n?this.e2=this.e3:this.e1=this.e3}},{"../../util/util":442,"../bucket":329,"../load_geometry":337}],333:[function(t,e,r){"use strict";function n(t){o.apply(this,arguments),this.showCollisionBoxes=t.showCollisionBoxes,this.overscaling=t.overscaling,this.collisionBoxArray=t.collisionBoxArray,this.symbolQuadsArray=t.symbolQuadsArray,this.symbolInstancesArray=t.symbolInstancesArray,this.sdfIcons=t.sdfIcons,this.iconsNeedLinear=t.iconsNeedLinear,this.adjustedTextSize=t.adjustedTextSize,this.adjustedIconSize=t.adjustedIconSize,this.fontstack=t.fontstack}function i(t,e,r,n,i,a,o,s,l,u,c){return t.emplaceBack(e,r,Math.round(64*n),Math.round(64*i),a/4,o/4,10*(u||0),c,10*(s||0),10*Math.min(l||25,25))}var a=t("point-geometry"),o=t("../bucket"),s=t("../../symbol/anchor"),l=t("../../symbol/get_anchors"),u=t("../../util/token"),c=t("../../symbol/quads"),h=t("../../symbol/shaping"),f=t("../../symbol/resolve_text"),d=t("../../symbol/mergelines"),p=t("../../symbol/clip_line"),m=t("../../util/util"),v=t("../load_geometry"),g=t("../../symbol/collision_feature"),y=h.shapeText,b=h.shapeIcon,x=c.getGlyphQuads,_=c.getIconQuads,w=o.EXTENT;e.exports=n,n.MAX_QUADS=65535,n.prototype=m.inherit(o,{}),n.prototype.serialize=function(){var t=o.prototype.serialize.apply(this);return t.sdfIcons=this.sdfIcons,t.iconsNeedLinear=this.iconsNeedLinear,t.adjustedTextSize=this.adjustedTextSize,t.adjustedIconSize=this.adjustedIconSize,t.fontstack=this.fontstack,t};var M=new o.VertexArrayType([{name:"a_pos",components:2,type:"Int16"},{name:"a_offset",components:2,type:"Int16"},{name:"a_texture_pos",components:2,type:"Uint16"},{name:"a_data",components:4,type:"Uint8"}]),k=new o.ElementArrayType;n.prototype.addCollisionBoxVertex=function(t,e,r,n,i){return t.emplaceBack(e.x,e.y,Math.round(r.x),Math.round(r.y),10*n,10*i)},n.prototype.programInterfaces={glyph:{layoutVertexArrayType:M,elementArrayType:k},icon:{layoutVertexArrayType:M,elementArrayType:k},collisionBox:{layoutVertexArrayType:new o.VertexArrayType([{name:"a_pos",components:2,type:"Int16"},{name:"a_extrude",components:2,type:"Int16"},{name:"a_data",components:2,type:"Uint8"}])}},n.prototype.populateArrays=function(t,e,r){var n={lastIntegerZoom:1/0,lastIntegerZoomTime:0,lastZoom:0};this.adjustedTextMaxSize=this.layer.getLayoutValue("text-size",{zoom:18,zoomHistory:n}),this.adjustedTextSize=this.layer.getLayoutValue("text-size",{zoom:this.zoom+1,zoomHistory:n}),this.adjustedIconMaxSize=this.layer.getLayoutValue("icon-size",{zoom:18,zoomHistory:n}),this.adjustedIconSize=this.layer.getLayoutValue("icon-size",{zoom:this.zoom+1,zoomHistory:n});var i=512*this.overscaling;this.tilePixelRatio=w/i,this.compareText={},this.iconsNeedLinear=!1,this.symbolInstancesStartIndex=this.symbolInstancesArray.length;var a=this.layer.layout,o=this.features,s=this.textFeatures,l=.5,c=.5;switch(a["text-anchor"]){case"right":case"top-right":case"bottom-right":l=1;break;case"left":case"top-left":case"bottom-left":l=0}switch(a["text-anchor"]){case"bottom":case"bottom-right":case"bottom-left":c=1;break;case"top":case"top-right":case"top-left":c=0}for(var h="right"===a["text-justify"]?1:"left"===a["text-justify"]?0:.5,f=24*a["text-line-height"],p="line"!==a["symbol-placement"]?24*a["text-max-width"]:0,g=24*a["text-letter-spacing"],x=[24*a["text-offset"][0],24*a["text-offset"][1]],_=this.fontstack=a["text-font"].join(","),M=[],k=0;kw||L.y<0||L.y>w);if(!d||C){var I=C||x;this.addSymbolInstance(L,T,e,r,this.layer,I,this.symbolInstancesArray.length,this.collisionBoxArray,n.index,this.sourceLayerIndex,this.index,u,m,y,h,v,b,{zoom:this.zoom},n.properties)}}}}},n.prototype.anchorIsTooClose=function(t,e,r){var n=this.compareText;if(t in n){for(var i=n[t],a=i.length-1;a>=0;a--)if(r.dist(i[a])3*Math.PI/2))){var v=p.tl,g=p.tr,y=p.bl,b=p.br,x=p.tex,_=p.anchorPoint,w=Math.max(h+Math.log(p.minScale)/Math.LN2,f),M=Math.min(h+Math.log(p.maxScale)/Math.LN2,25);if(!(M<=w)){w===f&&(w=0);var k=Math.round(p.glyphAngle/(2*Math.PI)*256),A=i(c,_.x,_.y,v.x,v.y,x.x,x.y,w,M,f,k);i(c,_.x,_.y,g.x,g.y,x.x+x.w,x.y,w,M,f,k),i(c,_.x,_.y,y.x,y.y,x.x,x.y+x.h,w,M,f,k),i(c,_.x,_.y,b.x,b.y,x.x+x.w,x.y+x.h,w,M,f,k),u.emplaceBack(A,A+1,A+2),u.emplaceBack(A+1,A+2,A+3)}}}},n.prototype.updateIcons=function(t){this.recalculateStyleLayers();var e=this.layer.layout["icon-image"];if(e)for(var r=0;rn.MAX_QUADS&&m.warnOnce("Too many symbols being rendered in a tile. See https://github.com/mapbox/mapbox-gl-js/issues/2907"),A>n.MAX_QUADS&&m.warnOnce("Too many glyphs being rendered in a tile. See https://github.com/mapbox/mapbox-gl-js/issues/2907"),this.symbolInstancesArray.emplaceBack(D,P,O,R,k,A,T,S,t.x,t.y,s)},n.prototype.addSymbolQuad=function(t){return this.symbolQuadsArray.emplaceBack(t.anchorPoint.x,t.anchorPoint.y,t.tl.x,t.tl.y,t.tr.x,t.tr.y,t.bl.x,t.bl.y,t.br.x,t.br.y,t.tex.h,t.tex.w,t.tex.x,t.tex.y,t.anchorAngle,t.glyphAngle,t.maxScale,t.minScale)}},{"../../symbol/anchor":391,"../../symbol/clip_line":393,"../../symbol/collision_feature":395,"../../symbol/get_anchors":397,"../../symbol/mergelines":400,"../../symbol/quads":401,"../../symbol/resolve_text":402,"../../symbol/shaping":403,"../../util/token":441,"../../util/util":442,"../bucket":329,"../load_geometry":337,"point-geometry":484}],334:[function(t,e,r){"use strict";function n(t,e,r){this.arrayBuffer=t.arrayBuffer,this.length=t.length,this.attributes=e.members,this.itemSize=e.bytesPerElement,this.type=r,this.arrayType=e}e.exports=n,n.prototype.bind=function(t){var e=t[this.type];this.buffer?t.bindBuffer(e,this.buffer):(this.buffer=t.createBuffer(),t.bindBuffer(e,this.buffer),t.bufferData(e,this.arrayBuffer,t.STATIC_DRAW),this.arrayBuffer=null)};var i={Int8:"BYTE",Uint8:"UNSIGNED_BYTE",Int16:"SHORT",Uint16:"UNSIGNED_SHORT"};n.prototype.setVertexAttribPointers=function(t,e){for(var r=0;r0?t["line-gap-width"]+2*t["line-width"]:t["line-width"]}function s(t,e,r,n,i){if(!e[0]&&!e[1])return t;e=u.convert(e),"viewport"===r&&e._rotate(-n);for(var a=[],o=0;or.max||f.yr.max)&&i.warnOnce("Geometry exceeds allowed extent, reduce your vector tile buffer size")}return l}},{"../util/util":442,"./bucket":329,assert:47}],338:[function(t,e,r){"use strict";function n(t,e,r){this.column=t,this.row=e,this.zoom=r}e.exports=n,n.prototype={clone:function(){return new n(this.column,this.row,this.zoom)},zoomTo:function(t){return this.clone()._zoomTo(t)},sub:function(t){return this.clone()._sub(t)},_zoomTo:function(t){var e=Math.pow(2,t-this.zoom);return this.column*=e,this.row*=e,this.zoom=t,this},_sub:function(t){return t=t.zoomTo(this.zoom),this.column-=t.column,this.row-=t.row,this}}},{}],339:[function(t,e,r){"use strict";function n(t,e){if(isNaN(t)||isNaN(e))throw new Error("Invalid LngLat object: ("+t+", "+e+")");if(this.lng=+t,this.lat=+e,this.lat>90||this.lat<-90)throw new Error("Invalid LngLat latitude value: must be between -90 and 90")}e.exports=n +;var i=t("../util/util").wrap;n.prototype.wrap=function(){return new n(i(this.lng,-180,180),this.lat)},n.prototype.toArray=function(){return[this.lng,this.lat]},n.prototype.toString=function(){return"LngLat("+this.lng+", "+this.lat+")"},n.convert=function(t){return t instanceof n?t:Array.isArray(t)?new n(t[0],t[1]):t}},{"../util/util":442}],340:[function(t,e,r){"use strict";function n(t,e){t&&(e?this.extend(t).extend(e):4===t.length?this.extend([t[0],t[1]]).extend([t[2],t[3]]):this.extend(t[0]).extend(t[1]))}e.exports=n;var i=t("./lng_lat");n.prototype={extend:function(t){var e,r,a=this._sw,o=this._ne;if(t instanceof i)e=t,r=t;else{if(!(t instanceof n))return t?this.extend(i.convert(t)||n.convert(t)):this;if(e=t._sw,r=t._ne,!e||!r)return this}return a||o?(a.lng=Math.min(e.lng,a.lng),a.lat=Math.min(e.lat,a.lat),o.lng=Math.max(r.lng,o.lng),o.lat=Math.max(r.lat,o.lat)):(this._sw=new i(e.lng,e.lat),this._ne=new i(r.lng,r.lat)),this},getCenter:function(){return new i((this._sw.lng+this._ne.lng)/2,(this._sw.lat+this._ne.lat)/2)},getSouthWest:function(){return this._sw},getNorthEast:function(){return this._ne},getNorthWest:function(){return new i(this.getWest(),this.getNorth())},getSouthEast:function(){return new i(this.getEast(),this.getSouth())},getWest:function(){return this._sw.lng},getSouth:function(){return this._sw.lat},getEast:function(){return this._ne.lng},getNorth:function(){return this._ne.lat},toArray:function(){return[this._sw.toArray(),this._ne.toArray()]},toString:function(){return"LngLatBounds("+this._sw.toString()+", "+this._ne.toString()+")"}},n.convert=function(t){return!t||t instanceof n?t:new n(t)}},{"./lng_lat":339}],341:[function(t,e,r){"use strict";function n(t,e){this.tileSize=512,this._minZoom=t||0,this._maxZoom=e||22,this.latRange=[-85.05113,85.05113],this.width=0,this.height=0,this._center=new i(0,0),this.zoom=0,this.angle=0,this._altitude=1.5,this._pitch=0,this._unmodified=!0}var i=t("./lng_lat"),a=t("point-geometry"),o=t("./coordinate"),s=t("../util/util").wrap,l=t("../util/interpolate"),u=t("../source/tile_coord"),c=t("../data/bucket").EXTENT,h=t("gl-matrix"),f=h.vec4,d=h.mat4,p=h.mat2;e.exports=n,n.prototype={get minZoom(){return this._minZoom},set minZoom(t){this._minZoom!==t&&(this._minZoom=t,this.zoom=Math.max(this.zoom,t))},get maxZoom(){return this._maxZoom},set maxZoom(t){this._maxZoom!==t&&(this._maxZoom=t,this.zoom=Math.min(this.zoom,t))},get worldSize(){return this.tileSize*this.scale},get centerPoint(){return this.size._div(2)},get size(){return new a(this.width,this.height)},get bearing(){return-this.angle/Math.PI*180},set bearing(t){var e=-s(t,-180,180)*Math.PI/180;this.angle!==e&&(this._unmodified=!1,this.angle=e,this._calcMatrices(),this.rotationMatrix=p.create(),p.rotate(this.rotationMatrix,this.rotationMatrix,this.angle))},get pitch(){return this._pitch/Math.PI*180},set pitch(t){var e=Math.min(60,t)/180*Math.PI;this._pitch!==e&&(this._unmodified=!1,this._pitch=e,this._calcMatrices())},get altitude(){return this._altitude},set altitude(t){var e=Math.max(.75,t);this._altitude!==e&&(this._unmodified=!1,this._altitude=e,this._calcMatrices())},get zoom(){return this._zoom},set zoom(t){var e=Math.min(Math.max(t,this.minZoom),this.maxZoom);this._zoom!==e&&(this._unmodified=!1,this._zoom=e,this.scale=this.zoomScale(e),this.tileZoom=Math.floor(e),this.zoomFraction=e-this.tileZoom,this._calcMatrices(),this._constrain())},get center(){return this._center},set center(t){t.lat===this._center.lat&&t.lng===this._center.lng||(this._unmodified=!1,this._center=t,this._calcMatrices(),this._constrain())},coveringZoomLevel:function(t){return(t.roundZoom?Math.round:Math.floor)(this.zoom+this.scaleZoom(this.tileSize/t.tileSize))},coveringTiles:function(t){var e=this.coveringZoomLevel(t),r=e;if(et.maxzoom&&(e=t.maxzoom);var n=this,i=n.locationCoordinate(n.center)._zoomTo(e),o=new a(i.column-.5,i.row-.5);return u.cover(e,[n.pointCoordinate(new a(0,0))._zoomTo(e),n.pointCoordinate(new a(n.width,0))._zoomTo(e),n.pointCoordinate(new a(n.width,n.height))._zoomTo(e),n.pointCoordinate(new a(0,n.height))._zoomTo(e)],t.reparseOverscaled?r:e).sort(function(t,e){return o.dist(t)-o.dist(e)})},resize:function(t,e){this.width=t,this.height=e,this.pixelsToGLUnits=[2/t,-2/e],this._calcMatrices(),this._constrain()},get unmodified(){return this._unmodified},zoomScale:function(t){return Math.pow(2,t)},scaleZoom:function(t){return Math.log(t)/Math.LN2},project:function(t,e){return new a(this.lngX(t.lng,e),this.latY(t.lat,e))},unproject:function(t,e){return new i(this.xLng(t.x,e),this.yLat(t.y,e))},get x(){return this.lngX(this.center.lng)},get y(){return this.latY(this.center.lat)},get point(){return new a(this.x,this.y)},lngX:function(t,e){return(180+t)*(e||this.worldSize)/360},latY:function(t,e){return(180-180/Math.PI*Math.log(Math.tan(Math.PI/4+t*Math.PI/360)))*(e||this.worldSize)/360},xLng:function(t,e){return 360*t/(e||this.worldSize)-180},yLat:function(t,e){var r=180-360*t/(e||this.worldSize);return 360/Math.PI*Math.atan(Math.exp(r*Math.PI/180))-90},panBy:function(t){var e=this.centerPoint._add(t);this.center=this.pointLocation(e)},setLocationAtPoint:function(t,e){var r=this.locationCoordinate(t),n=this.pointCoordinate(e),i=this.pointCoordinate(this.centerPoint),a=n._sub(r);this._unmodified=!1,this.center=this.coordinateLocation(i._sub(a))},locationPoint:function(t){return this.coordinatePoint(this.locationCoordinate(t))},pointLocation:function(t){return this.coordinateLocation(this.pointCoordinate(t))},locationCoordinate:function(t){var e=this.zoomScale(this.tileZoom)/this.worldSize,r=i.convert(t);return new o(this.lngX(r.lng)*e,this.latY(r.lat)*e,this.tileZoom)},coordinateLocation:function(t){var e=this.zoomScale(t.zoom);return new i(this.xLng(t.column,e),this.yLat(t.row,e))},pointCoordinate:function(t){var e=[t.x,t.y,0,1],r=[t.x,t.y,1,1];f.transformMat4(e,e,this.pixelMatrixInverse),f.transformMat4(r,r,this.pixelMatrixInverse);var n=e[3],i=r[3],a=e[0]/n,s=r[0]/i,u=e[1]/n,c=r[1]/i,h=e[2]/n,d=r[2]/i,p=h===d?0:(0-h)/(d-h),m=this.worldSize/this.zoomScale(this.tileZoom);return new o(l(a,s,p)/m,l(u,c,p)/m,this.tileZoom)},coordinatePoint:function(t){var e=this.worldSize/this.zoomScale(t.zoom),r=[t.column*e,t.row*e,0,1];return f.transformMat4(r,r,this.pixelMatrix),new a(r[0]/r[3],r[1]/r[3])},calculatePosMatrix:function(t,e){void 0===e&&(e=1/0),t instanceof u&&(t=t.toCoordinate(e));var r=Math.min(t.zoom,e),n=this.worldSize/Math.pow(2,r),i=new Float64Array(16);return d.identity(i),d.translate(i,i,[t.column*n,t.row*n,0]),d.scale(i,i,[n/c,n/c,1]),d.multiply(i,this.projMatrix,i),new Float32Array(i)},_constrain:function(){if(this.center&&this.width&&this.height&&!this._constraining){this._constraining=!0;var t,e,r,n,i,o,s,l,u=this.size,c=this._unmodified;this.latRange&&(t=this.latY(this.latRange[1]),e=this.latY(this.latRange[0]),i=e-te&&(l=e-d)}if(this.lngRange){var p=this.x,m=u.x/2;p-mn&&(s=n-m)}void 0===s&&void 0===l||(this.center=this.unproject(new a(void 0!==s?s:this.x,void 0!==l?l:this.y))),this._unmodified=c,this._constraining=!1}},_calcMatrices:function(){if(this.height){var t=Math.atan(.5/this.altitude),e=Math.sin(t)*this.altitude/Math.sin(Math.PI/2-this._pitch-t),r=Math.cos(Math.PI/2-this._pitch)*e+this.altitude,n=new Float64Array(16);if(d.perspective(n,2*Math.atan(this.height/2/this.altitude),this.width/this.height,.1,r),d.translate(n,n,[0,0,-this.altitude]),d.scale(n,n,[1,-1,1/this.height]),d.rotateX(n,n,this._pitch),d.rotateZ(n,n,this.angle),d.translate(n,n,[-this.x,-this.y,0]),this.projMatrix=n,n=d.create(),d.scale(n,n,[this.width/2,-this.height/2,1]),d.translate(n,n,[1,-1,0]),this.pixelMatrix=d.multiply(new Float64Array(16),n,this.projMatrix),!(n=d.invert(new Float64Array(16),this.pixelMatrix)))throw new Error("failed to invert matrix");this.pixelMatrixInverse=n}}}},{"../data/bucket":329,"../source/tile_coord":369,"../util/interpolate":436,"../util/util":442,"./coordinate":338,"./lng_lat":339,"gl-matrix":193,"point-geometry":484}],342:[function(t,e,r){"use strict";var n={" 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a,o,s,l,u,c,h,f,d=[];for(a=0,o=t.length;a>16,_>>16),s.uniform2f(n.u_pixel_coord_lower,65535&x,65535&_)}s.uniformMatrix4fv(n.u_matrix,!1,t.transform.calculatePosMatrix(g)),s.drawArrays(s.TRIANGLE_STRIP,0,t.tileExtentBuffer.length)}s.stencilMask(0),s.stencilFunc(s.EQUAL,128,128)}var i=t("../source/pixels_to_tile_units"),a=t("./create_uniform_pragmas"),o=512;e.exports=n},{"../source/pixels_to_tile_units":363,"./create_uniform_pragmas":344}],346:[function(t,e,r){"use strict";function n(t,e,r,n){if(!t.isOpaquePass){var a=t.gl;t.setDepthSublayer(0),t.depthMask(!1),a.disable(a.STENCIL_TEST);for(var o=0;o>16,f>>16),o.uniform2f(a.u_pixel_coord_lower,65535&h,65535&f),o.activeTexture(o.TEXTURE0),i.spriteAtlas.bind(o,!0)}}var s=t("../source/pixels_to_tile_units");e.exports=n},{"../source/pixels_to_tile_units":363}],350:[function(t,e,r){"use strict";var n=t("../util/browser"),i=t("gl-matrix").mat2,a=t("../source/pixels_to_tile_units");e.exports=function(t,e,r,o){if(!t.isOpaquePass){t.setDepthSublayer(0),t.depthMask(!1);var s=t.gl;if(s.enable(s.STENCIL_TEST),!(r.paint["line-width"]<=0)){var l=1/n.devicePixelRatio,u=r.paint["line-blur"]+l,c=r.paint["line-color"],h=t.transform,f=i.create();i.scale(f,f,[1,Math.cos(h._pitch)]),i.rotate(f,f,t.transform.angle);var d,p,m,v,g,y=Math.sqrt(h.height*h.height/4*(1+h.altitude*h.altitude)),b=h.height/2*Math.tan(h._pitch),x=(y+b)/y-1,_=r.paint["line-dasharray"],w=r.paint["line-pattern"];if(_)d=t.useProgram("linesdfpattern"),s.uniform1f(d.u_linewidth,r.paint["line-width"]/2),s.uniform1f(d.u_gapwidth,r.paint["line-gap-width"]/2),s.uniform1f(d.u_antialiasing,l/2),s.uniform1f(d.u_blur,u),s.uniform4fv(d.u_color,c),s.uniform1f(d.u_opacity,r.paint["line-opacity"]),p=t.lineAtlas.getDash(_.from,"round"===r.layout["line-cap"]),m=t.lineAtlas.getDash(_.to,"round"===r.layout["line-cap"]),s.uniform1i(d.u_image,0),s.activeTexture(s.TEXTURE0),t.lineAtlas.bind(s),s.uniform1f(d.u_tex_y_a,p.y),s.uniform1f(d.u_tex_y_b,m.y),s.uniform1f(d.u_mix,_.t),s.uniform1f(d.u_extra,x),s.uniform1f(d.u_offset,-r.paint["line-offset"]),s.uniformMatrix2fv(d.u_antialiasingmatrix,!1,f);else if(w){if(v=t.spriteAtlas.getPosition(w.from,!0),g=t.spriteAtlas.getPosition(w.to,!0),!v||!g)return;d=t.useProgram("linepattern"),s.uniform1i(d.u_image,0),s.activeTexture(s.TEXTURE0),t.spriteAtlas.bind(s,!0),s.uniform1f(d.u_linewidth,r.paint["line-width"]/2),s.uniform1f(d.u_gapwidth,r.paint["line-gap-width"]/2),s.uniform1f(d.u_antialiasing,l/2),s.uniform1f(d.u_blur,u),s.uniform2fv(d.u_pattern_tl_a,v.tl),s.uniform2fv(d.u_pattern_br_a,v.br),s.uniform2fv(d.u_pattern_tl_b,g.tl),s.uniform2fv(d.u_pattern_br_b,g.br),s.uniform1f(d.u_fade,w.t),s.uniform1f(d.u_opacity,r.paint["line-opacity"]),s.uniform1f(d.u_extra,x),s.uniform1f(d.u_offset,-r.paint["line-offset"]),s.uniformMatrix2fv(d.u_antialiasingmatrix,!1,f)}else d=t.useProgram("line"),s.uniform1f(d.u_linewidth,r.paint["line-width"]/2),s.uniform1f(d.u_gapwidth,r.paint["line-gap-width"]/2),s.uniform1f(d.u_antialiasing,l/2),s.uniform1f(d.u_blur,u),s.uniform1f(d.u_extra,x),s.uniform1f(d.u_offset,-r.paint["line-offset"]),s.uniformMatrix2fv(d.u_antialiasingmatrix,!1,f),s.uniform4fv(d.u_color,c),s.uniform1f(d.u_opacity,r.paint["line-opacity"]);for(var M=0;M0?1/(1-t):1+t}function s(t){return t>0?1-1/(1.001-t):-t}function l(t,e,r,n){var i=[1,0],a=r.paint["raster-fade-duration"];if(t.source&&a>0){var o=(new Date).getTime(),s=(o-t.timeAdded)/a,l=e?(o-e.timeAdded)/a:-1,c=n.coveringZoomLevel(t.source),h=!!e&&Math.abs(e.coord.z-c)>Math.abs(t.coord.z-c);!e||h?(i[0]=u.clamp(s,0,1),i[1]=1-i[0]):(i[0]=u.clamp(1-l,0,1),i[1]=1-i[0])}var f=r.paint["raster-opacity"];return i[0]*=f,i[1]*=f,i}var u=t("../util/util"),c=t("../util/struct_array");e.exports=n,n.RasterBoundsArray=new c({members:[{name:"a_pos",type:"Int16",components:2},{name:"a_texture_pos",type:"Int16",components:2}]})},{"../util/struct_array":440,"../util/util":442}],352:[function(t,e,r){"use strict";function n(t,e,r,n){if(!t.isOpaquePass){var a=!(r.layout["text-allow-overlap"]||r.layout["icon-allow-overlap"]||r.layout["text-ignore-placement"]||r.layout["icon-ignore-placement"]),o=t.gl;a?o.disable(o.STENCIL_TEST):o.enable(o.STENCIL_TEST),t.setDepthSublayer(0),t.depthMask(!1),o.disable(o.DEPTH_TEST),i(t,e,r,n,!1,r.paint["icon-translate"],r.paint["icon-translate-anchor"],r.layout["icon-rotation-alignment"],r.layout["icon-rotation-alignment"],r.layout["icon-size"],r.paint["icon-halo-width"],r.paint["icon-halo-color"],r.paint["icon-halo-blur"],r.paint["icon-opacity"],r.paint["icon-color"]), +i(t,e,r,n,!0,r.paint["text-translate"],r.paint["text-translate-anchor"],r.layout["text-rotation-alignment"],r.layout["text-pitch-alignment"],r.layout["text-size"],r.paint["text-halo-width"],r.paint["text-halo-color"],r.paint["text-halo-blur"],r.paint["text-opacity"],r.paint["text-color"]),o.enable(o.DEPTH_TEST),e.map.showCollisionBoxes&&s(t,e,r,n)}}function i(t,e,r,n,i,o,s,l,u,c,h,f,d,p,m){for(var v=0;vthis.previousZoom;r--)this.changeTimes[r]=e,this.changeOpacities[r]=this.opacities[r];for(r=0;r<256;r++){var n=e-this.changeTimes[r],i=n/this.fadeDuration*255;this.opacities[r]=r<=t?this.changeOpacities[r]+i:this.changeOpacities[r]-i}this.changed=!0,this.previousZoom=t},n.prototype.bind=function(t){this.texture?(t.bindTexture(t.TEXTURE_2D,this.texture),this.changed&&(t.texSubImage2D(t.TEXTURE_2D,0,0,0,256,1,t.ALPHA,t.UNSIGNED_BYTE,this.array),this.changed=!1)):(this.texture=t.createTexture(),t.bindTexture(t.TEXTURE_2D,this.texture),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_WRAP_S,t.CLAMP_TO_EDGE),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_WRAP_T,t.CLAMP_TO_EDGE),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_MIN_FILTER,t.NEAREST),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_MAG_FILTER,t.NEAREST),t.texImage2D(t.TEXTURE_2D,0,t.ALPHA,256,1,0,t.ALPHA,t.UNSIGNED_BYTE,this.array))}},{}],354:[function(t,e,r){"use strict";function n(t,e){this.width=t,this.height=e,this.nextRow=0,this.bytes=4,this.data=new Uint8Array(this.width*this.height*this.bytes),this.positions={}}var i=t("../util/util");e.exports=n,n.prototype.setSprite=function(t){this.sprite=t},n.prototype.getDash=function(t,e){var r=t.join(",")+e;return this.positions[r]||(this.positions[r]=this.addDash(t,e)),this.positions[r]},n.prototype.addDash=function(t,e){var r=e?7:0,n=2*r+1;if(this.nextRow+n>this.height)return i.warnOnce("LineAtlas out of space"),null;for(var a=0,o=0;o0?e.pop():null},n.prototype.lineWidth=function(t){this.gl.lineWidth(c.clamp(t,this.lineWidthRange[0],this.lineWidthRange[1]))},n.prototype.showOverdrawInspector=function(t){if(t||this._showOverdrawInspector){this._showOverdrawInspector=t;var e=this.gl;if(t){e.blendFunc(e.CONSTANT_COLOR,e.ONE);e.blendColor(1/8,1/8,1/8,0),e.clearColor(0,0,0,1),e.clear(e.COLOR_BUFFER_BIT)}else e.blendFunc(e.ONE,e.ONE_MINUS_SRC_ALPHA)}}},{"../data/bucket":329,"../data/buffer":334,"../source/pixels_to_tile_units":363,"../source/source_cache":367,"../util/browser":426,"../util/struct_array":440,"../util/util":442,"./create_uniform_pragmas":344,"./draw_background":345,"./draw_circle":346,"./draw_debug":348,"./draw_fill":349,"./draw_line":350,"./draw_raster":351,"./draw_symbol":352,"./frame_history":353,"./painter/use_program":356,"./vertex_array_object":357,"gl-matrix":193}],356:[function(t,e,r){"use strict";function n(t,e){return t.replace(/#pragma mapbox: ([\w]+) ([\w]+) ([\w]+) ([\w]+)/g,function(t,r,n,i,a){return e[r][a].replace(/{type}/g,i).replace(/{precision}/g,n)})}var i=t("assert"),a=t("../../util/util"),o=t("mapbox-gl-shaders"),s=o.util;e.exports._createProgram=function(t,e,r,l){for(var u=this.gl,c=u.createProgram(),h=o[t],f="#define MAPBOX_GL_JS;\n",d=0;dthis.maxzoom?Math.pow(2,t.coord.z-this.maxzoom):1,n={type:this.type,uid:t.uid,coord:t.coord,zoom:t.coord.z,maxZoom:this.maxzoom,tileSize:this.tileSize,source:this.id,overscaling:r,angle:this.map.transform.angle,pitch:this.map.transform.pitch,showCollisionBoxes:this.map.showCollisionBoxes};t.workerID=this.dispatcher.send("load tile",n,function(r,n){if(t.unloadVectorData(this.map.painter),!t.aborted)return r?e(r):(t.loadVectorData(n,this.map.style),t.redoWhenDone&&(t.redoWhenDone=!1,t.redoPlacement(this)),e(null))}.bind(this),this.workerID)},abortTile:function(t){t.aborted=!0},unloadTile:function(t){t.unloadVectorData(this.map.painter),this.dispatcher.send("remove tile",{uid:t.uid,source:this.id},function(){},t.workerID)},serialize:function(){return{type:this.type,data:this._data}}})},{"../data/bucket":329,"../util/evented":434,"../util/util":442,"resolve-url":501}],359:[function(t,e,r){"use strict";function n(t,e,r){r&&(this.loadGeoJSON=r),h.call(this,t,e)}var i=t("../util/util"),a=t("../util/ajax"),o=t("geojson-rewind"),s=t("./geojson_wrapper"),l=t("vt-pbf"),u=t("supercluster"),c=t("geojson-vt"),h=t("./vector_tile_worker_source");e.exports=n,n.prototype=i.inherit(h,{_geoJSONIndexes:{},loadVectorData:function(t,e){var r=t.source,n=t.coord;if(!this._geoJSONIndexes[r])return e(null,null);var i=this._geoJSONIndexes[r].getTile(Math.min(n.z,t.maxZoom),n.x,n.y);if(!i)return e(null,null);var a=new s(i.features);a.name="_geojsonTileLayer";var o=l({layers:{_geojsonTileLayer:a}});0===o.byteOffset&&o.byteLength===o.buffer.byteLength||(o=new Uint8Array(o)),e(null,{tile:a,rawTileData:o.buffer})},loadData:function(t,e){var r=function(r,n){return r?e(r):"object"!=typeof n?e(new Error("Input data is not a valid GeoJSON object.")):(o(n,!0),void this._indexData(n,t,function(r,n){if(r)return e(r);this._geoJSONIndexes[t.source]=n,e(null)}.bind(this)))}.bind(this);this.loadGeoJSON(t,r)},loadGeoJSON:function(t,e){if(t.url)a.getJSON(t.url,e);else{if("string"!=typeof t.data)return e(new Error("Input data is not a valid GeoJSON object."));try{return e(null,JSON.parse(t.data))}catch(t){return e(new Error("Input data is not a valid GeoJSON object."))}}},_indexData:function(t,e,r){try{e.cluster?r(null,u(e.superclusterOptions).load(t.features)):r(null,c(t,e.geojsonVtOptions))}catch(t){return r(t)}}})},{"../util/ajax":425,"../util/util":442,"./geojson_wrapper":360,"./vector_tile_worker_source":371,"geojson-rewind":138,"geojson-vt":142,supercluster:529,"vt-pbf":556}],360:[function(t,e,r){"use strict";function n(t){this.features=t,this.length=t.length,this.extent=s}function i(t){if(this.type=t.type,1===t.type){this.rawGeometry=[];for(var e=0;ee)){var o=Math.pow(2,Math.min(a.coord.z,this.maxzoom)-Math.min(t.z,this.maxzoom));if(Math.floor(a.coord.x/o)===t.x&&Math.floor(a.coord.y/o)===t.y)for(r[i]=!0,n=!0;a&&a.coord.z-1>t.z;){var s=a.coord.parent(this.maxzoom).id;a=this._tiles[s],a&&a.isRenderable()&&(delete r[i],r[s]=!0)}}}return n},findLoadedParent:function(t,e,r){for(var n=t.z-1;n>=e;n--){t=t.parent(this.maxzoom);var i=this._tiles[t.id];if(i&&i.isRenderable())return r[t.id]=!0,i;if(this._cache.has(t.id))return this.addTile(t),r[t.id]=!0,this._tiles[t.id]}},updateCacheSize:function(t){var e=Math.ceil(t.width/t.tileSize)+1,r=Math.ceil(t.height/t.tileSize)+1,n=e*r;this._cache.setMaxSize(Math.floor(5*n))},update:function(t,e){if(this._sourceLoaded){var r,i,a;this.updateCacheSize(t);var o=(this.roundZoom?Math.round:Math.floor)(this.getZoom(t)),s=Math.max(o-n.maxOverzooming,this.minzoom),l=Math.max(o+n.maxUnderzooming,this.minzoom),c={},h=(new Date).getTime();this._coveredTiles={};var d=this.used?t.coveringTiles(this._source):[];for(r=0;rh-(e||0)&&(this.findLoadedChildren(i,l,c)&&(c[g]=!0),this.findLoadedParent(i,s,p))}var y;for(y in p)c[y]||(this._coveredTiles[y]=!0);for(y in p)c[y]=!0;var b=f.keysDifference(this._tiles,c);for(r=0;rthis.maxzoom?Math.pow(2,n-this.maxzoom):1;e=new s(r,this.tileSize*i,this.maxzoom),this.loadTile(e,this._tileLoaded.bind(this,e))}return e.uses++,this._tiles[t.id]=e,this.fire("tile.add",{tile:e}),this._source.fire("tile.add",{tile:e}),e},removeTile:function(t){var e=this._tiles[t];e&&(e.uses--,delete this._tiles[t],this.fire("tile.remove",{tile:e}),this._source.fire("tile.remove",{tile:e}),e.uses>0||(e.isRenderable()?this._cache.add(e.coord.wrapped().id,e):(e.aborted=!0,this.abortTile(e),this.unloadTile(e))))},clearTiles:function(){for(var t in this._tiles)this.removeTile(t);this._cache.reset()},tilesIn:function(t){for(var e={},r=this.getIds(),n=1/0,a=1/0,o=-1/0,s=-1/0,l=t[0].zoom,c=0;c=0&&g[1].y>=0){for(var y=[],b=0;b=0&&t%1==0),l(!isNaN(e)&&e>=0&&e%1==0),l(!isNaN(r)&&r>=0&&r%1==0),isNaN(n)&&(n=0),this.z=+t,this.x=+e,this.y=+r,this.w=+n,(n*=2)<0&&(n=-1*n-1);var i=1<0;a--)n=1<e.row){var r=t;t=e,e=r}return{x0:t.column,y0:t.row,x1:e.column,y1:e.row,dx:e.column-t.column,dy:e.row-t.row}}function o(t,e,r,n,i){var a=Math.max(r,Math.floor(e.y0)),o=Math.min(n,Math.ceil(e.y1));if(t.x0===e.x0&&t.y0===e.y0?t.x0+e.dy/t.dy*t.dx0,h=e.dx<0,f=a;fc.dy&&(l=u,u=c,c=l),u.dy>h.dy&&(l=u,u=h,h=l),c.dy>h.dy&&(l=c,c=h,h=l),u.dy&&o(h,u,n,i,s),c.dy&&o(h,c,n,i,s)}var l=t("assert"),u=t("whoots-js"),c=t("../geo/coordinate");e.exports=n,n.prototype.toString=function(){return this.z+"/"+this.x+"/"+this.y},n.prototype.toCoordinate=function(t){var e=Math.min(this.z,t),r=Math.pow(2,e),n=this.y,i=this.x+r*this.w;return new c(i,n,e)},n.fromID=function(t){var e=t%32,r=1<t?new n(this.z-1,this.x,this.y,this.w):new n(this.z-1,Math.floor(this.x/2),Math.floor(this.y/2),this.w)},n.prototype.wrapped=function(){return new n(this.z,this.x,this.y,0)},n.prototype.children=function(t){if(this.z>=t)return[new n(this.z+1,this.x,this.y,this.w)];var e=this.z+1,r=2*this.x,i=2*this.y;return[new n(e,r,i,this.w),new n(e,r+1,i,this.w),new n(e,r,i+1,this.w),new n(e,r+1,i+1,this.w)]},n.cover=function(t,e,r){function i(t,e,i){var s,l,u;if(i>=0&&i<=a)for(s=t;sthis.maxzoom?Math.pow(2,t.coord.z-this.maxzoom):1,i={url:s(t.coord.url(this.tiles,this.maxzoom,this.scheme),this.url),uid:t.uid,coord:t.coord,zoom:t.coord.z,tileSize:this.tileSize*n,source:this.id,overscaling:n,angle:this.map.transform.angle,pitch:this.map.transform.pitch,showCollisionBoxes:this.map.showCollisionBoxes};t.workerID?"loading"===t.state?t.reloadCallback=e:(i.rawTileData=t.rawTileData,this.dispatcher.send("reload tile",i,r.bind(this),t.workerID)):t.workerID=this.dispatcher.send("load tile",i,r.bind(this))},abortTile:function(t){this.dispatcher.send("abort tile",{uid:t.uid,source:this.id},null,t.workerID)},unloadTile:function(t){t.unloadVectorData(this.map.painter),this.dispatcher.send("remove tile",{uid:t.uid,source:this.id},null,t.workerID)}})},{"../util/evented":434,"../util/mapbox":439,"../util/util":442,"./load_tilejson":362}],371:[function(t,e,r){"use strict";function n(t,e,r){this.actor=t,this.styleLayers=e,r&&(this.loadVectorData=r),this.loading={},this.loaded={}}var i=t("../util/ajax"),a=t("vector-tile"),o=t("pbf"),s=t("./worker_tile");e.exports=n,n.prototype={loadTile:function(t,e){function r(t,r){return delete this.loading[n][i],t?e(t):r?(a.data=r.tile,a.parse(a.data,this.styleLayers.getLayerFamilies(),this.actor,r.rawTileData,e),this.loaded[n]=this.loaded[n]||{},void(this.loaded[n][i]=a)):e(null,null)}var n=t.source,i=t.uid;this.loading[n]||(this.loading[n]={});var a=this.loading[n][i]=new s(t);a.abort=this.loadVectorData(t,r.bind(this))},reloadTile:function(t,e){var r=this.loaded[t.source],n=t.uid;if(r&&r[n]){var i=r[n];i.parse(i.data,this.styleLayers.getLayerFamilies(),this.actor,t.rawTileData,e)}},abortTile:function(t){var e=this.loading[t.source],r=t.uid;e&&e[r]&&e[r].abort&&(e[r].abort(),delete e[r])},removeTile:function(t){var e=this.loaded[t.source],r=t.uid;e&&e[r]&&delete e[r]},loadVectorData:function(t,e){function r(t,r){if(t)return e(t);var n=new a.VectorTile(new o(new Uint8Array(r)));e(t,{tile:n,rawTileData:r})}var n=i.getArrayBuffer(t.url,r.bind(this));return function(){n.abort()}},redoPlacement:function(t,e){var r=this.loaded[t.source],n=this.loading[t.source],i=t.uid;if(r&&r[i]){var a=r[i],o=a.redoPlacement(t.angle,t.pitch,t.showCollisionBoxes);o.result&&e(null,o.result,o.transferables)}else n&&n[i]&&(n[i].angle=t.angle)}}},{"../util/ajax":425,"./worker_tile":374,pbf:478,"vector-tile":550}],372:[function(t,e,r){"use strict";function n(t,e){this.id=t,this.urls=e.urls,this.coordinates=e.coordinates,u.getVideo(e.urls,function(t,r){if(t)return this.fire("error",{error:t});this.video=r,this.video.loop=!0;var n;this.video.addEventListener("playing",function(){n=this.map.style.animationLoop.set(1/0),this.map._rerender()}.bind(this)),this.video.addEventListener("pause",function(){this.map.style.animationLoop.cancel(n)}.bind(this)),this.map&&(this.video.play(),this.setCoordinates(e.coordinates)),this.fire("load")}.bind(this))}var i=t("../util/util"),a=t("./tile_coord"),o=t("../geo/lng_lat"),s=t("point-geometry"),l=t("../util/evented"),u=t("../util/ajax"),c=t("../data/bucket").EXTENT,h=t("../render/draw_raster").RasterBoundsArray,f=t("../data/buffer"),d=t("../render/vertex_array_object");e.exports=n,n.prototype=i.inherit(l,{minzoom:0,maxzoom:22,tileSize:512,roundZoom:!0,getVideo:function(){return this.video},onAdd:function(t){this.map||(this.map=t,this.video&&(this.video.play(),this.setCoordinates(this.coordinates)))},setCoordinates:function(t){this.coordinates=t;var e=this.map,r=t.map(function(t){return e.transform.locationCoordinate(o.convert(t)).zoomTo(0)}),n=this.centerCoord=i.getCoordinatesCenter(r);return n.column=Math.round(n.column),n.row=Math.round(n.row),this.minzoom=this.maxzoom=n.zoom,this._coord=new a(n.zoom,n.column,n.row),this._tileCoords=r.map(function(t){var e=t.zoomTo(n.zoom);return new s(Math.round((e.column-n.column)*c),Math.round((e.row-n.row)*c))}),this.fire("change"),this},_setTile:function(t){this._prepared=!1,this.tile=t;var e=new h;e.emplaceBack(this._tileCoords[0].x,this._tileCoords[0].y,0,0),e.emplaceBack(this._tileCoords[1].x,this._tileCoords[1].y,32767,0),e.emplaceBack(this._tileCoords[3].x,this._tileCoords[3].y,0,32767),e.emplaceBack(this._tileCoords[2].x,this._tileCoords[2].y,32767,32767),this.tile.buckets={},this.tile.boundsBuffer=new f(e.serialize(),h.serialize(),f.BufferType.VERTEX),this.tile.boundsVAO=new d,this.tile.state="loaded"},prepare:function(){if(!(this.video.readyState<2)&&this.tile){var t=this.map.painter.gl;this._prepared?(t.bindTexture(t.TEXTURE_2D,this.tile.texture),t.texSubImage2D(t.TEXTURE_2D,0,0,0,t.RGBA,t.UNSIGNED_BYTE,this.video)):(this._prepared=!0,this.tile.texture=t.createTexture(),t.bindTexture(t.TEXTURE_2D,this.tile.texture),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_WRAP_S,t.CLAMP_TO_EDGE),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_WRAP_T,t.CLAMP_TO_EDGE),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_MIN_FILTER,t.LINEAR),t.texParameteri(t.TEXTURE_2D,t.TEXTURE_MAG_FILTER,t.LINEAR),t.texImage2D(t.TEXTURE_2D,0,t.RGBA,t.RGBA,t.UNSIGNED_BYTE,this.video)),this._currentTime=this.video.currentTime}},loadTile:function(t,e){this._coord&&this._coord.toString()===t.coord.toString()?(this._setTile(t),e(null)):(t.state="errored",e(null))},serialize:function(){return{type:"video",urls:this.urls,coordinates:this.coordinates}}})},{"../data/bucket":329,"../data/buffer":334,"../geo/lng_lat":339,"../render/draw_raster":351,"../render/vertex_array_object":357,"../util/ajax":425,"../util/evented":434,"../util/util":442,"./tile_coord":369,"point-geometry":484}],373:[function(t,e,r){"use strict";function n(t){this.self=t,this.actor=new a(t,this);var e={getLayers:function(){return this.layers}.bind(this),getLayerFamilies:function(){return this.layerFamilies}.bind(this)};this.workerSources={vector:new l(this.actor,e),geojson:new u(this.actor,e)},this.self.registerWorkerSource=function(t,r){if(this.workerSources[t])throw new Error('Worker source with name "'+t+'" already registered.');this.workerSources[t]=new r(this.actor,e)}.bind(this)}function i(t){var e={};for(var r in t){var n=t[r],i=n.ref||n.id,a=t[i];a.layout&&"none"===a.layout.visibility||(e[i]=e[i]||[],r===i?e[i].unshift(n):e[i].push(n))}return e}var a=t("../util/actor"),o=t("../style/style_layer"),s=t("../util/util"),l=t("./vector_tile_worker_source"),u=t("./geojson_worker_source");e.exports=function(t){return new n(t)},s.extend(n.prototype,{"set layers":function(t){function e(t){var e=o.create(t,t.ref&&r.layers[t.ref]);e.updatePaintTransitions({},{transition:!1}),r.layers[e.id]=e}this.layers={};for(var r=this,n=[],a=0;a=0;e--)b(E,P[e]);x()}}function b(t,e){if(e.populateArrays(A,j,F),"symbol"!==e.type)for(var r=0;r=w.maxzoom||w.layout&&"none"===w.layout.visibility||t.layers&&!t.layers[w.sourceLayer]||(k=c.create({layer:w,index:I++,childLayers:e[z],zoom:this.zoom,overscaling:this.overscaling,showCollisionBoxes:this.showCollisionBoxes,collisionBoxArray:this.collisionBoxArray,symbolQuadsArray:this.symbolQuadsArray,symbolInstancesArray:this.symbolInstancesArray,sourceLayerIndex:S.encode(w.sourceLayer||"_geojsonTileLayer")}),k.createFilter(),L[w.id]=k,t.layers&&(M=w.sourceLayer,C[M]=C[M]||{},C[M][w.id]=k)));if(t.layers)for(M in C)1===w.version&&d.warnOnce('Vector tile source "'+this.source+'" layer "'+M+'" does not use vector tile spec v2 and therefore may have some rendering errors.'),(w=t.layers[M])&&g(w,C[M]);else g(t,L);var D=[],P=this.symbolBuckets=[],O=[];T.bucketLayerIDs={};for(var R in L)k=L[R],0!==k.features.length&&(T.bucketLayerIDs[k.index]=k.childLayers.map(s),D.push(k),"symbol"===k.type?P.push(k):O.push(k));var F={},j={},N=0;if(P.length>0){for(_=P.length-1;_>=0;_--)P[_].updateIcons(F),P[_].updateFont(j);for(var B in j)j[B]=Object.keys(j[B]).map(Number);F=Object.keys(F),r.send("get glyphs",{uid:this.uid,stacks:j},function(t,e){j=e,y(t)}),F.length?r.send("get icons",{icons:F},function(t,e){F=e,y(t)}):y()}for(_=O.length-1;_>=0;_--)b(this,O[_]);if(0===P.length)return x()},n.prototype.redoPlacement=function(t,e,r){if("done"!==this.status)return this.redoPlacementAfterDone=!0,this.angle=t,{};for(var n=new u(t,e,this.collisionBoxArray),s=this.symbolBuckets,l=s.length-1;l>=0;l--)s[l].placeFeatures(n,r);var c=n.serialize(),h=s.filter(i);return{result:{buckets:h.map(a),collisionTile:c.data},transferables:o(h).concat(c.transferables)}}},{"../data/bucket":329,"../data/feature_index":336,"../symbol/collision_box":394,"../symbol/collision_tile":396,"../symbol/symbol_instances":405,"../symbol/symbol_quads":406,"../util/dictionary_coder":432,"../util/util":442}],375:[function(t,e,r){"use strict";function n(){this.n=0,this.times=[]}e.exports=n,n.prototype.stopped=function(){return this.times=this.times.filter(function(t){return t.time>=(new Date).getTime()}),!this.times.length},n.prototype.set=function(t){return this.times.push({id:this.n,time:t+(new Date).getTime()}),this.n++},n.prototype.cancel=function(t){this.times=this.times.filter(function(e){return e.id!==t})}},{}],376:[function(t,e,r){"use strict";function n(t){this.base=t,this.retina=s.devicePixelRatio>1;var e=this.retina?"@2x":"";o.getJSON(l(t,e,".json"),function(t,e){if(t)return void this.fire("error",{error:t});this.data=e,this.img&&this.fire("load")}.bind(this)),o.getImage(l(t,e,".png"),function(t,e){if(t)return void this.fire("error",{error:t});for(var r=e.getData(),n=e.data=new Uint8Array(r.length),i=0;i1!==this.retina){var t=new n(this.base);t.on("load",function(){this.img=t.img,this.data=t.data,this.retina=t.retina}.bind(this))}},i.prototype={x:0,y:0,width:0,height:0,pixelRatio:1,sdf:!1},n.prototype.getSpritePosition=function(t){if(!this.loaded())return new i;var e=this.data&&this.data[t];return e&&this.img?e:new i}},{"../util/ajax":425,"../util/browser":426,"../util/evented":434,"../util/mapbox":439}],377:[function(t,e,r){"use strict";var n=t("csscolorparser").parseCSSColor,i=t("../util/util"),a=t("./style_function"),o={};e.exports=function t(e){if(a.isFunctionDefinition(e))return i.extend({},e,{stops:e.stops.map(function(e){return[e[0],t(e[1])]})});if("string"==typeof e){if(!o[e]){var r=n(e);if(!r)throw new Error("Invalid color "+e);o[e]=[r[0]/255*r[3],r[1]/255*r[3],r[2]/255*r[3],r[3]]}return o[e]}throw new Error("Invalid color "+e)}},{"../util/util":442,"./style_function":380,csscolorparser:108}],378:[function(t,e,r){"use strict";function n(t,e,r){this.animationLoop=e||new m,this.dispatcher=new p(r||1,this),this.spriteAtlas=new l(1024,1024),this.lineAtlas=new u(256,512),this._layers={},this._order=[],this._groups=[],this.sources={},this.zoomHistory={},c.bindAll(["_forwardSourceEvent","_forwardTileEvent","_forwardLayerEvent","_redoPlacement"],this),this._resetUpdates();var n=function(t,e){if(t)return void this.fire("error",{error:t});if(!v.emitErrors(this,v(e))){this._loaded=!0,this.stylesheet=e,this.updateClasses();var r=e.sources;for(var n in r)this.addSource(n,r[n]);e.sprite&&(this.sprite=new o(e.sprite),this.sprite.on("load",this.fire.bind(this,"change"))),this.glyphSource=new s(e.glyphs),this._resolve(),this.fire("load")}}.bind(this);"string"==typeof t?h.getJSON(f(t),n):d.frame(n.bind(this,null,t)),this.on("source.load",function(t){var e=t.source;if(e&&e.vectorLayerIds)for(var r in this._layers){var n=this._layers[r];n.source===e.id&&this._validateLayer(n)}})}var i=t("../util/evented"),a=t("./style_layer"),o=t("./image_sprite"),s=t("../symbol/glyph_source"),l=t("../symbol/sprite_atlas"),u=t("../render/line_atlas"),c=t("../util/util"),h=t("../util/ajax"),f=t("../util/mapbox").normalizeStyleURL,d=t("../util/browser"),p=t("../util/dispatcher"),m=t("./animation_loop"),v=t("./validate_style"),g=t("../source/source"),y=t("../source/query_features"),b=t("../source/source_cache"),x=t("./style_spec"),_=t("./style_function");e.exports=n,n.prototype=c.inherit(i,{_loaded:!1,_validateLayer:function(t){var e=this.sources[t.source];t.sourceLayer&&e&&e.vectorLayerIds&&-1===e.vectorLayerIds.indexOf(t.sourceLayer)&&this.fire("error",{error:new Error('Source layer "'+t.sourceLayer+'" does not exist on source "'+e.id+'" as specified by style layer "'+t.id+'"')})},loaded:function(){if(!this._loaded)return!1;if(Object.keys(this._updates.sources).length)return!1;for(var t in this.sources)if(!this.sources[t].loaded())return!1;return!(this.sprite&&!this.sprite.loaded())},_resolve:function(){var t,e;this._layers={},this._order=this.stylesheet.layers.map(function(t){return t.id});for(var r=0;rMath.floor(t)&&(e.lastIntegerZoom=Math.floor(t+1),e.lastIntegerZoomTime=Date.now()),e.lastZoom=t},_checkLoaded:function(){if(!this._loaded)throw new Error("Style is not done loading")},update:function(t,e){if(!this._updates.changed)return this;if(this._updates.allLayers)this._groupLayers(),this._updateWorkerLayers();else{var r=Object.keys(this._updates.layers);r.length&&this._updateWorkerLayers(r)}var n,i=Object.keys(this._updates.sources);for(n=0;n=0&&this._handleErrors(v.source,"sources."+t,e)?this:(e=new b(t,e,this.dispatcher),this.sources[t]=e,e.style=this,e.on("load",this._forwardSourceEvent).on("error",this._forwardSourceEvent).on("change",this._forwardSourceEvent).on("tile.add",this._forwardTileEvent).on("tile.load",this._forwardTileEvent).on("tile.error",this._forwardTileEvent).on("tile.remove",this._forwardTileEvent).on("tile.stats",this._forwardTileEvent),this._updates.events.push(["source.add",{source:e}]),this._updates.changed=!0,this)},removeSource:function(t){if(this._checkLoaded(),void 0===this.sources[t])throw new Error("There is no source with this ID");var e=this.sources[t];return delete this.sources[t],delete this._updates.sources[t],e.off("load",this._forwardSourceEvent).off("error",this._forwardSourceEvent).off("change",this._forwardSourceEvent).off("tile.add",this._forwardTileEvent).off("tile.load",this._forwardTileEvent).off("tile.error",this._forwardTileEvent).off("tile.remove",this._forwardTileEvent).off("tile.stats",this._forwardTileEvent),this._updates.events.push(["source.remove",{source:e}]),this._updates.changed=!0,this},getSource:function(t){return this.sources[t]&&this.sources[t].getSource()},addLayer:function(t,e){if(this._checkLoaded(),!(t instanceof a)){if(this._handleErrors(v.layer,"layers."+t.id,t,!1,{arrayIndex:-1}))return this;var r=t.ref&&this.getLayer(t.ref);t=a.create(t,r)}return this._validateLayer(t),t.on("error",this._forwardLayerEvent),this._layers[t.id]=t,this._order.splice(e?this._order.indexOf(e):1/0,0,t.id),this._updates.allLayers=!0,t.source&&(this._updates.sources[t.source]=!0),this._updates.events.push(["layer.add",{layer:t}]),this.updateClasses(t.id)},removeLayer:function(t){this._checkLoaded();var e=this._layers[t];if(void 0===e)throw new Error("There is no layer with this ID");for(var r in this._layers)this._layers[r].ref===t&&this.removeLayer(r);return e.off("error",this._forwardLayerEvent),delete this._layers[t],delete this._updates.layers[t],delete this._updates.paintProps[t],this._order.splice(this._order.indexOf(t),1),this._updates.allLayers=!0,this._updates.events.push(["layer.remove",{layer:e}]),this._updates.changed=!0,this},getLayer:function(t){return this._layers[t]},getReferentLayer:function(t){var e=this.getLayer(t);return e.ref&&(e=this.getLayer(e.ref)),e},setLayerZoomRange:function(t,e,r){this._checkLoaded();var n=this.getReferentLayer(t);return n.minzoom===e&&n.maxzoom===r?this:(null!=e&&(n.minzoom=e),null!=r&&(n.maxzoom=r),this._updateLayer(n))},setFilter:function(t,e){this._checkLoaded();var r=this.getReferentLayer(t);return null!==e&&this._handleErrors(v.filter,"layers."+r.id+".filter",e)?this:c.deepEqual(r.filter,e)?this:(r.filter=c.clone(e),this._updateLayer(r))},getFilter:function(t){return this.getReferentLayer(t).filter},setLayoutProperty:function(t,e,r){this._checkLoaded();var n=this.getReferentLayer(t);return c.deepEqual(n.getLayoutProperty(e),r)?this:(n.setLayoutProperty(e,r),this._updateLayer(n))},getLayoutProperty:function(t,e){return this.getReferentLayer(t).getLayoutProperty(e)},setPaintProperty:function(t,e,r,n){this._checkLoaded();var i=this.getLayer(t);if(c.deepEqual(i.getPaintProperty(e,n),r))return this;var a=i.isPaintValueFeatureConstant(e);return i.setPaintProperty(e,r,n),!(r&&_.isFunctionDefinition(r)&&"$zoom"!==r.property&&void 0!==r.property)&&a||(this._updates.layers[t]=!0,i.source&&(this._updates.sources[i.source]=!0)),this.updateClasses(t,e)},getPaintProperty:function(t,e,r){return this.getLayer(t).getPaintProperty(e,r)},updateClasses:function(t,e){if(this._updates.changed=!0,t){var r=this._updates.paintProps;r[t]||(r[t]={}),r[t][e||"all"]=!0}else this._updates.allPaintProps=!0;return this},serialize:function(){return c.filterObject({version:this.stylesheet.version,name:this.stylesheet.name,metadata:this.stylesheet.metadata,center:this.stylesheet.center,zoom:this.stylesheet.zoom,bearing:this.stylesheet.bearing,pitch:this.stylesheet.pitch,sprite:this.stylesheet.sprite,glyphs:this.stylesheet.glyphs,transition:this.stylesheet.transition,sources:c.mapObject(this.sources,function(t){return t.serialize()}),layers:this._order.map(function(t){return this._layers[t].serialize()},this)},function(t){return void 0!==t})},_updateLayer:function(t){return this._updates.layers[t.id]=!0,t.source&&(this._updates.sources[t.source]=!0),this._updates.changed=!0,this},_flattenRenderedFeatures:function(t){for(var e=[],r=this._order.length-1;r>=0;r--)for(var n=this._order[r],i=0;is.lastIntegerZoom?(n=u+(1-u)*c,h*=2,i=t({zoom:o-1},r),a=t({zoom:o},r)):(n=1-(1-c)*u,a=t({zoom:o},r),i=t({zoom:o+1},r),h/=2),void 0===i||void 0===a?void 0:{from:i,fromScale:h,to:a,toScale:1,t:n}}}var a=t("./style_function"),o=t("./parse_color"),s=t("../util/util");e.exports=n},{"../util/util":442,"./parse_color":377,"./style_function":380}],380:[function(t,e,r){"use strict";var n=t("mapbox-gl-function");r.interpolated=function(t){var e=n.interpolated(t),r=function(t,r){return e(t&&t.zoom,r||{})};return r.isFeatureConstant=e.isFeatureConstant,r.isZoomConstant=e.isZoomConstant,r},r["piecewise-constant"]=function(t){var e=n["piecewise-constant"](t),r=function(t,r){return e(t&&t.zoom,r||{})};return r.isFeatureConstant=e.isFeatureConstant,r.isZoomConstant=e.isZoomConstant,r},r.isFunctionDefinition=n.isFunctionDefinition},{"mapbox-gl-function":302}],381:[function(t,e,r){"use strict";function n(t,e){this.set(t,e)}function i(t){return t.value}var a=t("../util/util"),o=t("./style_transition"),s=t("./style_declaration"),l=t("./style_spec"),u=t("./validate_style"),c=t("./parse_color"),h=t("../util/evented");e.exports=n;n.create=function(e,r){return new({background:t("./style_layer/background_style_layer"),circle:t("./style_layer/circle_style_layer"),fill:t("./style_layer/fill_style_layer"),line:t("./style_layer/line_style_layer"),raster:t("./style_layer/raster_style_layer"),symbol:t("./style_layer/symbol_style_layer")}[(r||e).type])(e,r)},n.prototype=a.inherit(h,{set:function(t,e){this.id=t.id,this.ref=t.ref,this.metadata=t.metadata,this.type=(e||t).type,this.source=(e||t).source,this.sourceLayer=(e||t)["source-layer"],this.minzoom=(e||t).minzoom,this.maxzoom=(e||t).maxzoom,this.filter=(e||t).filter,this.paint={},this.layout={},this._paintSpecifications=l["paint_"+this.type],this._layoutSpecifications=l["layout_"+this.type],this._paintTransitions={},this._paintTransitionOptions={},this._paintDeclarations={},this._layoutDeclarations={},this._layoutFunctions={};var r,n;for(var i in t){var a=i.match(/^paint(?:\.(.*))?$/);if(a){var o=a[1]||"";for(r in t[i])this.setPaintProperty(r,t[i][r],o)}}if(this.ref)this._layoutDeclarations=e._layoutDeclarations;else for(n in t.layout)this.setLayoutProperty(n,t.layout[n]);for(r in this._paintSpecifications)this.paint[r]=this.getPaintValue(r);for(n in this._layoutSpecifications)this._updateLayoutValue(n)},setLayoutProperty:function(t,e){if(null==e)delete this._layoutDeclarations[t];else{var r="layers."+this.id+".layout."+t;if(this._handleErrors(u.layoutProperty,r,t,e))return;this._layoutDeclarations[t]=new s(this._layoutSpecifications[t],e)}this._updateLayoutValue(t)},getLayoutProperty:function(t){return this._layoutDeclarations[t]&&this._layoutDeclarations[t].value},getLayoutValue:function(t,e,r){var n=this._layoutSpecifications[t],i=this._layoutDeclarations[t];return i?i.calculate(e,r):n.default},setPaintProperty:function(t,e,r){var n="layers."+this.id+(r?'["paint.'+r+'"].':".paint.")+t;if(a.endsWith(t,"-transition"))if(this._paintTransitionOptions[r||""]||(this._paintTransitionOptions[r||""]={}),null===e||void 0===e)delete this._paintTransitionOptions[r||""][t];else{if(this._handleErrors(u.paintProperty,n,t,e))return;this._paintTransitionOptions[r||""][t]=e}else if(this._paintDeclarations[r||""]||(this._paintDeclarations[r||""]={}),null===e||void 0===e)delete this._paintDeclarations[r||""][t];else{if(this._handleErrors(u.paintProperty,n,t,e))return;this._paintDeclarations[r||""][t]=new s(this._paintSpecifications[t],e)}},getPaintProperty:function(t,e){return e=e||"",a.endsWith(t,"-transition")?this._paintTransitionOptions[e]&&this._paintTransitionOptions[e][t]:this._paintDeclarations[e]&&this._paintDeclarations[e][t]&&this._paintDeclarations[e][t].value},getPaintValue:function(t,e,r){var n=this._paintSpecifications[t],i=this._paintTransitions[t];return i?i.calculate(e,r):"color"===n.type&&n.default?c(n.default):n.default},getPaintValueStopZoomLevels:function(t){var e=this._paintTransitions[t];return e?e.declaration.stopZoomLevels:[]},getPaintInterpolationT:function(t,e){return this._paintTransitions[t].declaration.calculateInterpolationT({zoom:e})},isPaintValueFeatureConstant:function(t){var e=this._paintTransitions[t];return!e||e.declaration.isFeatureConstant},isLayoutValueFeatureConstant:function(t){var e=this._layoutDeclarations[t];return!e||e.isFeatureConstant},isPaintValueZoomConstant:function(t){var e=this._paintTransitions[t];return!e||e.declaration.isZoomConstant},isHidden:function(t){return!!(this.minzoom&&t=this.maxzoom)||("none"===this.layout.visibility||0===this.paint[this.type+"-opacity"]))},updatePaintTransitions:function(t,e,r,n){for(var i=a.extend({},this._paintDeclarations[""]),o=0;o-r/2;){if(--o<0)return!1;s-=t[o].dist(a),a=t[o]}s+=t[o].dist(t[o+1]),o++;for(var l=[],u=0;sn;)u-=l.shift().angleDelta;if(u>i)return!1;o++,s+=h.dist(f)}return!0}e.exports=n},{}],393:[function(t,e,r){"use strict";function n(t,e,r,n,a){for(var o=[],s=0;s=n&&f.x>=n||(h.x>=n?h=new i(n,h.y+(f.y-h.y)*((n-h.x)/(f.x-h.x)))._round():f.x>=n&&(f=new i(n,h.y+(f.y-h.y)*((n-h.x)/(f.x-h.x)))._round()),h.y>=a&&f.y>=a||(h.y>=a?h=new i(h.x+(f.x-h.x)*((a-h.y)/(f.y-h.y)),a)._round():f.y>=a&&(f=new i(h.x+(f.x-h.x)*((a-h.y)/(f.y-h.y)),a)._round()),l&&h.equals(l[l.length-1])||(l=[h],o.push(l)),l.push(f)))))}return o}var i=t("point-geometry");e.exports=n},{"point-geometry":484}],394:[function(t,e,r){"use strict";var n=t("../util/struct_array"),i=t("../util/util"),a=t("point-geometry"),o=e.exports=new n({members:[{type:"Int16",name:"anchorPointX"},{type:"Int16",name:"anchorPointY"},{type:"Int16",name:"x1"},{type:"Int16",name:"y1"},{type:"Int16",name:"x2"},{type:"Int16",name:"y2"},{type:"Float32",name:"maxScale"},{type:"Uint32",name:"featureIndex"},{type:"Uint16",name:"sourceLayerIndex"},{type:"Uint16",name:"bucketIndex"},{type:"Int16",name:"bbox0"},{type:"Int16",name:"bbox1"},{type:"Int16",name:"bbox2"},{type:"Int16",name:"bbox3"},{type:"Float32",name:"placementScale"}]});i.extendAll(o.prototype.StructType.prototype,{get anchorPoint(){return new a(this.anchorPointX,this.anchorPointY)}})},{"../util/struct_array":440,"../util/util":442,"point-geometry":484}],395:[function(t,e,r){"use strict";function n(t,e,r,n,i,a,o,s,l,u,c){var h=o.top*s-l,f=o.bottom*s+l,d=o.left*s-l,p=o.right*s+l;if(this.boxStartIndex=t.length,u){var m=f-h,v=p-d;if(m>0)if(m=Math.max(10*s,m),c){var g=e[r.segment+1].sub(e[r.segment])._unit()._mult(v),y=[r.sub(g),r.add(g)];this._addLineCollisionBoxes(t,y,r,0,v,m,n,i,a)}else this._addLineCollisionBoxes(t,e,r,r.segment,v,m,n,i,a)}else t.emplaceBack(r.x,r.y,d,h,p,f,1/0,n,i,a,0,0,0,0,0);this.boxEndIndex=t.length}e.exports=n,n.prototype._addLineCollisionBoxes=function(t,e,r,n,i,a,o,s,l){var u=a/2,c=Math.floor(i/u),h=-a/2,f=this.boxes,d=r,p=n+1,m=h;do{if(--p<0)return f;m-=e[p].dist(d),d=e[p]}while(m>-i/2);for(var v=e[p].dist(e[p+1]),g=0;g=e.length)return f;v=e[p].dist(e[p+1])}var b=y-m,x=e[p],_=e[p+1],w=_.sub(x)._unit()._mult(b)._add(x)._round(),M=Math.max(Math.abs(y-h)-u/2,0),k=i/2/M;t.emplaceBack(w.x,w.y,-a/2,-a/2,a/2,a/2,k,o,s,l,0,0,0,0,0)}return f}},{}],396:[function(t,e,r){"use strict";function n(t,e,r){if("object"==typeof t){var n=t;r=e,t=n.angle,e=n.pitch,this.grid=new o(n.grid),this.ignoredGrid=new o(n.ignoredGrid)}else this.grid=new o(a,12,6),this.ignoredGrid=new o(a,12,0);this.angle=t,this.pitch=e;var i=Math.sin(t),s=Math.cos(t);if(this.rotationMatrix=[s,-i,i,s],this.reverseRotationMatrix=[s,i,-i,s],this.yStretch=1/Math.cos(e/180*Math.PI),this.yStretch=Math.pow(this.yStretch,1.3),this.collisionBoxArray=r,0===r.length){r.emplaceBack();r.emplaceBack(0,0,0,-32767,0,32767,32767,0,0,0,0,0,0,0,0,0),r.emplaceBack(a,0,0,-32767,0,32767,32767,0,0,0,0,0,0,0,0,0),r.emplaceBack(0,0,-32767,0,32767,0,32767,0,0,0,0,0,0,0,0,0),r.emplaceBack(0,a,-32767,0,32767,0,32767,0,0,0,0,0,0,0,0,0)}this.tempCollisionBox=r.get(0),this.edges=[r.get(1),r.get(2),r.get(3),r.get(4)]}var i=t("point-geometry"),a=t("../data/bucket").EXTENT,o=t("grid-index");e.exports=n,n.prototype.serialize=function(){var t={angle:this.angle,pitch:this.pitch,grid:this.grid.toArrayBuffer(),ignoredGrid:this.ignoredGrid.toArrayBuffer()};return{data:t,transferables:[t.grid,t.ignoredGrid]}},n.prototype.minScale=.25,n.prototype.maxScale=2,n.prototype.placeCollisionFeature=function(t,e,r){for(var n=this.collisionBoxArray,a=this.minScale,o=this.rotationMatrix,s=this.yStretch,l=t.boxStartIndex;l=this.maxScale)return a}if(r){var _;if(this.angle){var w=this.reverseRotationMatrix,M=new i(u.x1,u.y1).matMult(w),k=new i(u.x2,u.y1).matMult(w),A=new i(u.x1,u.y2).matMult(w),T=new i(u.x2,u.y2).matMult(w);_=this.tempCollisionBox,_.anchorPointX=u.anchorPoint.x,_.anchorPointY=u.anchorPoint.y,_.x1=Math.min(M.x,k.x,A.x,T.x),_.y1=Math.min(M.y,k.x,A.x,T.x),_.x2=Math.max(M.x,k.x,A.x,T.x),_.y2=Math.max(M.y,k.x,A.x,T.x),_.maxScale=u.maxScale}else _=u;for(var S=0;S=this.maxScale)return a}}}return a},n.prototype.queryRenderedSymbols=function(t,e,r,n,a){var o={},s=[],l=this.collisionBoxArray,u=this.rotationMatrix,c=new i(t,e)._matMult(u),h=this.tempCollisionBox;h.anchorX=c.x,h.anchorY=c.y,h.x1=0,h.y1=0,h.x2=r-t,h.y2=n-e,h.maxScale=a,a=h.maxScale;for(var f=[c.x+h.x1/a,c.y+h.y1/a*this.yStretch,c.x+h.x2/a,c.y+h.y2/a*this.yStretch],d=this.grid.query(f[0],f[1],f[2],f[3]),p=this.ignoredGrid.query(f[0],f[1],f[2],f[3]),m=0;m=a&&(o[y][b]=!0,s.push(d[v]))}}return s},n.prototype.getPlacementScale=function(t,e,r,n,i){var a=e.x-n.x,o=e.y-n.y,s=(i.x1-r.x2)/a,l=(i.x2-r.x1)/a,u=(i.y1-r.y2)*this.yStretch/o,c=(i.y2-r.y1)*this.yStretch/o;(isNaN(s)||isNaN(l))&&(s=l=1),(isNaN(u)||isNaN(c))&&(u=c=1);var h=Math.min(Math.max(s,l),Math.max(u,c)),f=i.maxScale,d=r.maxScale;return h>f&&(h=f),h>d&&(h=d),h>t&&h>=i.placementScale&&(t=h),t},n.prototype.insertCollisionFeature=function(t,e,r){for(var n=r?this.ignoredGrid:this.grid,i=this.collisionBoxArray,a=t.boxStartIndex;a=0&&A=0&&T=0&&g+d<=p){var S=new o(A,T,M,b)._round();n&&!s(t,S,u,n,l)||y.push(S)}}v+=w}return h||y.length||c||(y=i(t,v/2,r,n,l,u,c,!0,f)),y}var a=t("../util/interpolate"),o=t("../symbol/anchor"),s=t("./check_max_angle");e.exports=n},{"../symbol/anchor":391,"../util/interpolate":436,"./check_max_angle":392}],398:[function(t,e,r){"use strict";function n(){this.width=o,this.height=o,this.bin=new i(this.width,this.height),this.index={},this.ids={},this.data=new Uint8Array(this.width*this.height)}var i=t("shelf-pack"),a=t("../util/util"),o=128;e.exports=n,n.prototype.getGlyphs=function(){var t,e,r,n={};for(var i in this.ids)t=i.split("#"),e=t[0],r=t[1],n[e]||(n[e]=[]),n[e].push(r);return n},n.prototype.getRects=function(){var t,e,r,n={};for(var i in this.ids)t=i.split("#"),e=t[0],r=t[1],n[e]||(n[e]={}),n[e][r]=this.index[i];return n},n.prototype.addGlyph=function(t,e,r,n){if(!r)return null;var i=e+"#"+r.id;if(this.index[i])return this.ids[i].indexOf(t)<0&&this.ids[i].push(t),this.index[i];if(!r.bitmap)return null;var o=r.width+2*n,s=r.height+2*n,l=o+2,u=s+2;l+=4-l%4,u+=4-u%4;var c=this.bin.packOne(l,u);if(c||(this.resize(),c=this.bin.packOne(l,u)),!c)return a.warnOnce("glyph bitmap overflow"),null;this.index[i]=c,this.ids[i]=[t];for(var h=this.data,f=r.bitmap,d=0;d=2048||e>=2048)){this.texture&&(this.gl&&this.gl.deleteTexture(this.texture),this.texture=null),this.width*=4,this.height*=4,this.bin.resize(this.width,this.height);for(var r=new ArrayBuffer(this.width*this.height),n=0;n65535)return r("glyphs > 65535 not supported");void 0===this.loading[t]&&(this.loading[t]={});var n=this.loading[t];if(n[e])n[e].push(r);else{n[e]=[r];var i=256*e+"-"+(256*e+255),o=a(t,i,this.url);s(o,function(t,r){for(var i=!t&&new l(new c(new Uint8Array(r))),a=0;an&&null!==c){var x=g[c+1].x;v=Math.max(x,v);for(var _=c+1;_<=y;_++)g[_].y+=r,g[_].x-=x;if(o){var w=c;h[g[c].codePoint]&&w--,s(g,e,p,w,o)}p=c+1,c=null,d+=x,m++}f[b.codePoint]&&(c=y)}var M=g[g.length-1],k=M.x+e[M.codePoint].advance;v=Math.max(v,k);var A=(m+1)*r;s(g,e,p,g.length-1,o),l(g,o,i,a,v,r,m,u),t.top+=-a*A,t.bottom=t.top+A,t.left+=-i*v,t.right=t.left+v}function s(t,e,r,n,i){for(var a=e[t[n].codePoint].advance,o=(t[n].x+a)*i,s=r;s<=n;s++)t[s].x-=o} +function l(t,e,r,n,i,a,o,s){for(var l=(e-r)*i+s[0],u=(-n*(o+1)+.5)*a+s[1],c=0;c1?2:1,this.canvas&&(this.canvas.width=this.width*this.pixelRatio,this.canvas.height=this.height*this.pixelRatio)),this.sprite=t},n.prototype.addIcons=function(t,e){for(var r=0;r1||(w?(clearTimeout(w),w=null,g("dblclick",e)):w=setTimeout(d,300))}function c(t){y("touchmove",t)}function h(t){y("touchend",t)}function f(t){y("touchcancel",t)}function d(){w=null}function p(t){n.mousePos(b,t).equals(_)&&g("click",t)}function m(t){g("dblclick",t),t.preventDefault()}function v(t){x=t,t.preventDefault()}function g(e,r){var i=n.mousePos(b,r);return t.fire(e,{lngLat:t.unproject(i),point:i,originalEvent:r})}function y(e,r){var a=n.touchPos(b,r),o=a.reduce(function(t,e,r,n){return t.add(e.div(n.length))},new i(0,0));return t.fire(e,{lngLat:t.unproject(o),point:o,lngLats:a.map(function(e){return t.unproject(e)},this),points:a,originalEvent:r})}var b=t.getCanvasContainer(),x=null,_=null,w=null;for(var M in a)t[M]=new a[M](t,e),e.interactive&&e[M]&&t[M].enable();b.addEventListener("mouseout",r,!1),b.addEventListener("mousedown",o,!1),b.addEventListener("mouseup",s,!1),b.addEventListener("mousemove",l,!1),b.addEventListener("touchstart",u,!1),b.addEventListener("touchend",h,!1),b.addEventListener("touchmove",c,!1),b.addEventListener("touchcancel",f,!1),b.addEventListener("click",p,!1),b.addEventListener("dblclick",m,!1),b.addEventListener("contextmenu",v,!1)}},{"../util/dom":428,"./handler/box_zoom":413,"./handler/dblclick_zoom":414,"./handler/drag_pan":415,"./handler/drag_rotate":416,"./handler/keyboard":417,"./handler/scroll_zoom":418,"./handler/touch_zoom_rotate":419,"point-geometry":484}],408:[function(t,e,r){"use strict";var n=t("../util/util"),i=t("../util/interpolate"),a=t("../util/browser"),o=t("../geo/lng_lat"),s=t("../geo/lng_lat_bounds"),l=t("point-geometry"),u=e.exports=function(){};n.extend(u.prototype,{getCenter:function(){return this.transform.center},setCenter:function(t,e){return this.jumpTo({center:t},e),this},panBy:function(t,e,r){return this.panTo(this.transform.center,n.extend({offset:l.convert(t).mult(-1)},e),r),this},panTo:function(t,e,r){return this.easeTo(n.extend({center:t},e),r)},getZoom:function(){return this.transform.zoom},setZoom:function(t,e){return this.jumpTo({zoom:t},e),this},zoomTo:function(t,e,r){return this.easeTo(n.extend({zoom:t},e),r)},zoomIn:function(t,e){return this.zoomTo(this.getZoom()+1,t,e),this},zoomOut:function(t,e){return this.zoomTo(this.getZoom()-1,t,e),this},getBearing:function(){return this.transform.bearing},setBearing:function(t,e){return this.jumpTo({bearing:t},e),this},rotateTo:function(t,e,r){return this.easeTo(n.extend({bearing:t},e),r)},resetNorth:function(t,e){return this.rotateTo(0,n.extend({duration:1e3},t),e),this},snapToNorth:function(t,e){return Math.abs(this.getBearing())180&&(c.center.lng>0&&m.lng<0?m.lng+=360:c.center.lng<0&&m.lng>0&&(m.lng-=360));var b=c.zoomScale(v-f),x=c.point,_="center"in t?c.project(m).sub(h.div(b)):x,w=c.worldSize,M=t.curve,k=Math.max(c.width,c.height),A=k/b,T=_.sub(x).mag();if("minZoom"in t){var S=n.clamp(Math.min(t.minZoom,f,v),c.minZoom,c.maxZoom),E=k/c.zoomScale(S-f);M=Math.sqrt(E/T*2)}var L=M*M,C=r(0),I=function(t){return s(C)/s(C+M*t)},z=function(t){return k*((s(C)*u(C+M*t)-a(C))/L)/T},D=(r(1)-C)/M;if(Math.abs(T)<1e-6){if(Math.abs(k-A)<1e-6)return this.easeTo(t);var P=A=0)return!1;return!0}),e.join(" | ")},n.prototype=o.inherit(i,{options:{position:"bottom-right"},onAdd:function(t){var e=this._container=a.create("div","mapboxgl-ctrl-attrib",t.getContainer());return this._update(),t.on("source.load",this._update.bind(this)),t.on("source.change",this._update.bind(this)),t.on("source.remove",this._update.bind(this)),t.on("moveend",this._updateEditLink.bind(this)),e},_update:function(){this._map.style&&(this._container.innerHTML=n.createAttributionString(this._map.style.sources)),this._editLink=this._container.getElementsByClassName("mapbox-improve-map")[0],this._updateEditLink()},_updateEditLink:function(){if(this._editLink){var t=this._map.getCenter();this._editLink.href="https://www.mapbox.com/map-feedback/#/"+t.lng+"/"+t.lat+"/"+Math.round(this._map.getZoom()+1)}}})},{"../../util/dom":428,"../../util/util":442,"./control":410}],410:[function(t,e,r){"use strict";function n(){}var i=t("../../util/util"),a=t("../../util/evented");e.exports=n,n.prototype={addTo:function(t){this._map=t;var e=this._container=this.onAdd(t);if(this.options&&this.options.position){var r=this.options.position,n=t._controlCorners[r];e.className+=" mapboxgl-ctrl",-1!==r.indexOf("bottom")?n.insertBefore(e,n.firstChild):n.appendChild(e)}return this},remove:function(){return this._container.parentNode.removeChild(this._container),this.onRemove&&this.onRemove(this._map),this._map=null,this}},i.extend(n.prototype,a)},{"../../util/evented":434,"../../util/util":442}],411:[function(t,e,r){"use strict";function n(t){s.setOptions(this,t)}var i=t("./control"),a=t("../../util/browser"),o=t("../../util/dom"),s=t("../../util/util");e.exports=n;var l={enableHighAccuracy:!1,timeout:6e3};n.prototype=s.inherit(i,{options:{position:"top-right"},onAdd:function(t){var e=this._container=o.create("div","mapboxgl-ctrl-group",t.getContainer());return a.supportsGeolocation?(this._container.addEventListener("contextmenu",this._onContextMenu.bind(this)),this._geolocateButton=o.create("button","mapboxgl-ctrl-icon mapboxgl-ctrl-geolocate",this._container),this._geolocateButton.type="button",this._geolocateButton.addEventListener("click",this._onClickGeolocate.bind(this)),e):e},_onContextMenu:function(t){t.preventDefault()},_onClickGeolocate:function(){navigator.geolocation.getCurrentPosition(this._success.bind(this),this._error.bind(this),l),this._timeoutId=setTimeout(this._finish.bind(this),1e4)},_success:function(t){this._map.jumpTo({center:[t.coords.longitude,t.coords.latitude],zoom:17,bearing:0,pitch:0}),this.fire("geolocate",t),this._finish()},_error:function(t){this.fire("error",t),this._finish()},_finish:function(){this._timeoutId&&clearTimeout(this._timeoutId),this._timeoutId=void 0}})},{"../../util/browser":426,"../../util/dom":428,"../../util/util":442,"./control":410}],412:[function(t,e,r){"use strict";function n(t){s.setOptions(this,t)}function i(t){return new MouseEvent(t.type,{button:2,buttons:2,bubbles:!0,cancelable:!0,detail:t.detail,view:t.view,screenX:t.screenX,screenY:t.screenY,clientX:t.clientX,clientY:t.clientY,movementX:t.movementX,movementY:t.movementY,ctrlKey:t.ctrlKey,shiftKey:t.shiftKey,altKey:t.altKey,metaKey:t.metaKey})}var a=t("./control"),o=t("../../util/dom"),s=t("../../util/util");e.exports=n,n.prototype=s.inherit(a,{options:{position:"top-right"},onAdd:function(t){var e="mapboxgl-ctrl",r=this._container=o.create("div",e+"-group",t.getContainer());return this._container.addEventListener("contextmenu",this._onContextMenu.bind(this)),this._zoomInButton=this._createButton(e+"-icon "+e+"-zoom-in",t.zoomIn.bind(t)),this._zoomOutButton=this._createButton(e+"-icon "+e+"-zoom-out",t.zoomOut.bind(t)),this._compass=this._createButton(e+"-icon "+e+"-compass",t.resetNorth.bind(t)),this._compassArrow=o.create("div","arrow",this._compass),this._compass.addEventListener("mousedown",this._onCompassDown.bind(this)),this._onCompassMove=this._onCompassMove.bind(this),this._onCompassUp=this._onCompassUp.bind(this),t.on("rotate",this._rotateCompassArrow.bind(this)),this._rotateCompassArrow(),this._el=t.getCanvasContainer(),r},_onContextMenu:function(t){t.preventDefault()},_onCompassDown:function(t){0===t.button&&(o.disableDrag(),document.addEventListener("mousemove",this._onCompassMove),document.addEventListener("mouseup",this._onCompassUp),this._el.dispatchEvent(i(t)),t.stopPropagation())},_onCompassMove:function(t){0===t.button&&(this._el.dispatchEvent(i(t)),t.stopPropagation())},_onCompassUp:function(t){0===t.button&&(document.removeEventListener("mousemove",this._onCompassMove),document.removeEventListener("mouseup",this._onCompassUp),o.enableDrag(),this._el.dispatchEvent(i(t)),t.stopPropagation())},_createButton:function(t,e){var r=o.create("button",t,this._container);return r.type="button",r.addEventListener("click",function(){e()}),r},_rotateCompassArrow:function(){var t="rotate("+this._map.transform.angle*(180/Math.PI)+"deg)";this._compassArrow.style.transform=t}})},{"../../util/dom":428,"../../util/util":442,"./control":410}],413:[function(t,e,r){"use strict";function n(t){this._map=t,this._el=t.getCanvasContainer(),this._container=t.getContainer(),o.bindHandlers(this)}var i=t("../../util/dom"),a=t("../../geo/lng_lat_bounds"),o=t("../../util/util");e.exports=n,n.prototype={_enabled:!1,_active:!1,isEnabled:function(){return this._enabled},isActive:function(){return this._active},enable:function(){this.isEnabled()||(this._el.addEventListener("mousedown",this._onMouseDown,!1),this._enabled=!0)},disable:function(){this.isEnabled()&&(this._el.removeEventListener("mousedown",this._onMouseDown),this._enabled=!1)},_onMouseDown:function(t){t.shiftKey&&0===t.button&&(document.addEventListener("mousemove",this._onMouseMove,!1),document.addEventListener("keydown",this._onKeyDown,!1),document.addEventListener("mouseup",this._onMouseUp,!1),i.disableDrag(),this._startPos=i.mousePos(this._el,t),this._active=!0)},_onMouseMove:function(t){var e=this._startPos,r=i.mousePos(this._el,t);this._box||(this._box=i.create("div","mapboxgl-boxzoom",this._container),this._container.classList.add("mapboxgl-crosshair"),this._fireEvent("boxzoomstart",t));var n=Math.min(e.x,r.x),a=Math.max(e.x,r.x),o=Math.min(e.y,r.y),s=Math.max(e.y,r.y);i.setTransform(this._box,"translate("+n+"px,"+o+"px)"),this._box.style.width=a-n+"px",this._box.style.height=s-o+"px"},_onMouseUp:function(t){if(0===t.button){var e=this._startPos,r=i.mousePos(this._el,t),n=new a(this._map.unproject(e),this._map.unproject(r));this._finish(),e.x===r.x&&e.y===r.y?this._fireEvent("boxzoomcancel",t):this._map.fitBounds(n,{linear:!0}).fire("boxzoomend",{originalEvent:t,boxZoomBounds:n})}},_onKeyDown:function(t){27===t.keyCode&&(this._finish(),this._fireEvent("boxzoomcancel",t))},_finish:function(){this._active=!1,document.removeEventListener("mousemove",this._onMouseMove,!1),document.removeEventListener("keydown",this._onKeyDown,!1),document.removeEventListener("mouseup",this._onMouseUp,!1),this._container.classList.remove("mapboxgl-crosshair"),this._box&&(this._box.parentNode.removeChild(this._box),this._box=null),i.enableDrag()},_fireEvent:function(t,e){return this._map.fire(t,{originalEvent:e})}}},{"../../geo/lng_lat_bounds":340,"../../util/dom":428,"../../util/util":442}],414:[function(t,e,r){"use strict";function n(t){this._map=t,this._onDblClick=this._onDblClick.bind(this)}e.exports=n,n.prototype={_enabled:!1,isEnabled:function(){return this._enabled},enable:function(){this.isEnabled()||(this._map.on("dblclick",this._onDblClick),this._enabled=!0)},disable:function(){this.isEnabled()&&(this._map.off("dblclick",this._onDblClick),this._enabled=!1)},_onDblClick:function(t){this._map.zoomTo(this._map.getZoom()+(t.originalEvent.shiftKey?-1:1),{around:t.lngLat},t)}}},{}],415:[function(t,e,r){"use strict";function n(t){this._map=t,this._el=t.getCanvasContainer(),a.bindHandlers(this)}var i=t("../../util/dom"),a=t("../../util/util");e.exports=n;var o=a.bezier(0,0,.3,1);n.prototype={_enabled:!1,_active:!1,isEnabled:function(){return this._enabled},isActive:function(){return this._active},enable:function(){this.isEnabled()||(this._el.addEventListener("mousedown",this._onDown),this._el.addEventListener("touchstart",this._onDown),this._enabled=!0)},disable:function(){this.isEnabled()&&(this._el.removeEventListener("mousedown",this._onDown),this._el.removeEventListener("touchstart",this._onDown),this._enabled=!1)},_onDown:function(t){this._ignoreEvent(t)||this.isActive()||(t.touches?(document.addEventListener("touchmove",this._onMove),document.addEventListener("touchend",this._onTouchEnd)):(document.addEventListener("mousemove",this._onMove),document.addEventListener("mouseup",this._onMouseUp)),this._active=!1,this._startPos=this._pos=i.mousePos(this._el,t),this._inertia=[[Date.now(),this._pos]])},_onMove:function(t){if(!this._ignoreEvent(t)){this.isActive()||(this._active=!0,this._fireEvent("dragstart",t),this._fireEvent("movestart",t));var e=i.mousePos(this._el,t),r=this._map;r.stop(),this._drainInertiaBuffer(),this._inertia.push([Date.now(),e]),r.transform.setLocationAtPoint(r.transform.pointLocation(this._pos),e),this._fireEvent("drag",t),this._fireEvent("move",t),this._pos=e,t.preventDefault()}},_onUp:function(t){if(this.isActive()){this._active=!1,this._fireEvent("dragend",t),this._drainInertiaBuffer();var e=function(){this._fireEvent("moveend",t)}.bind(this),r=this._inertia;if(r.length<2)return void e();var n=r[r.length-1],i=r[0],a=n[1].sub(i[1]),s=(n[0]-i[0])/1e3;if(0===s||n[1].equals(i[1]))return void e();var l=a.mult(.3/s),u=l.mag();u>1400&&(u=1400,l._unit()._mult(u));var c=u/750,h=l.mult(-c/2);this._map.panBy(h,{duration:1e3*c,easing:o,noMoveStart:!0},{originalEvent:t})}},_onMouseUp:function(t){this._ignoreEvent(t)||(this._onUp(t),document.removeEventListener("mousemove",this._onMove),document.removeEventListener("mouseup",this._onMouseUp))},_onTouchEnd:function(t){this._ignoreEvent(t)||(this._onUp(t),document.removeEventListener("touchmove",this._onMove),document.removeEventListener("touchend",this._onTouchEnd))},_fireEvent:function(t,e){return this._map.fire(t,{originalEvent:e})},_ignoreEvent:function(t){var e=this._map;if(e.boxZoom&&e.boxZoom.isActive())return!0;if(e.dragRotate&&e.dragRotate.isActive())return!0;if(t.touches)return t.touches.length>1;if(t.ctrlKey)return!0;return"mousemove"===t.type?!1&t.buttons:0!==t.button},_drainInertiaBuffer:function(){for(var t=this._inertia,e=Date.now();t.length>0&&e-t[0][0]>160;)t.shift()}}},{"../../util/dom":428,"../../util/util":442}],416:[function(t,e,r){"use strict";function n(t,e){this._map=t,this._el=t.getCanvasContainer(),this._bearingSnap=e.bearingSnap,o.bindHandlers(this)}var i=t("../../util/dom"),a=t("point-geometry"),o=t("../../util/util");e.exports=n;var s=o.bezier(0,0,.25,1);n.prototype={_enabled:!1,_active:!1,isEnabled:function(){return this._enabled},isActive:function(){return this._active},enable:function(){this.isEnabled()||(this._el.addEventListener("mousedown",this._onDown),this._enabled=!0)},disable:function(){this.isEnabled()&&(this._el.removeEventListener("mousedown",this._onDown),this._enabled=!1)},_onDown:function(t){if(!this._ignoreEvent(t)&&!this.isActive()){document.addEventListener("mousemove",this._onMove),document.addEventListener("mouseup",this._onUp),this._active=!1,this._inertia=[[Date.now(),this._map.getBearing()]],this._startPos=this._pos=i.mousePos(this._el,t),this._center=this._map.transform.centerPoint;var e=this._startPos.sub(this._center);e.mag()<200&&(this._center=this._startPos.add(new a(-200,0)._rotate(e.angle()))),t.preventDefault()}},_onMove:function(t){if(!this._ignoreEvent(t)){this.isActive()||(this._active=!0,this._fireEvent("rotatestart",t),this._fireEvent("movestart",t));var e=this._map;e.stop();var r=this._pos,n=i.mousePos(this._el,t),a=this._center,o=r.sub(a).angleWith(n.sub(a))/Math.PI*180,s=e.getBearing()-o,l=this._inertia,u=l[l.length-1];this._drainInertiaBuffer(),l.push([Date.now(),e._normalizeBearing(s,u[1])]),e.transform.bearing=s,this._fireEvent("rotate",t),this._fireEvent("move",t),this._pos=n}},_onUp:function(t){if(!this._ignoreEvent(t)&&(document.removeEventListener("mousemove",this._onMove),document.removeEventListener("mouseup",this._onUp),this.isActive())){this._active=!1,this._fireEvent("rotateend",t),this._drainInertiaBuffer();var e=this._map,r=e.getBearing(),n=this._inertia,i=function(){Math.abs(r)180&&(d=180);var p=d/180;u+=h*d*(p/2),Math.abs(e._normalizeBearing(u,0))1;var r=t.ctrlKey?1:2,n=t.ctrlKey?0:2;return"mousemove"===t.type?t.buttons&0===r:t.button!==n},_drainInertiaBuffer:function(){for(var t=this._inertia,e=Date.now();t.length>0&&e-t[0][0]>160;)t.shift()}}},{"../../util/dom":428,"../../util/util":442,"point-geometry":484}],417:[function(t,e,r){"use strict";function n(t){this._map=t,this._el=t.getCanvasContainer(),this._onKeyDown=this._onKeyDown.bind(this)}e.exports=n;n.prototype={_enabled:!1,isEnabled:function(){return this._enabled},enable:function(){this.isEnabled()||(this._el.addEventListener("keydown",this._onKeyDown,!1),this._enabled=!0)},disable:function(){this.isEnabled()&&(this._el.removeEventListener("keydown",this._onKeyDown),this._enabled=!1)},_onKeyDown:function(t){if(!(t.altKey||t.ctrlKey||t.metaKey)){var e=this._map,r={originalEvent:t};if(!e.isEasing())switch(t.keyCode){case 61:case 107:case 171:case 187:e.zoomTo(Math.round(e.getZoom())+(t.shiftKey?2:1),r);break;case 189:case 109:case 173:e.zoomTo(Math.round(e.getZoom())-(t.shiftKey?2:1),r);break;case 37:t.shiftKey?e.easeTo({bearing:e.getBearing()-2},r):(t.preventDefault(),e.panBy([-80,0],r));break;case 39:t.shiftKey?e.easeTo({bearing:e.getBearing()+2},r):(t.preventDefault(),e.panBy([80,0],r));break;case 38:t.shiftKey?e.easeTo({pitch:e.getPitch()+5},r):(t.preventDefault(),e.panBy([0,-80],r));break;case 40:t.shiftKey?e.easeTo({pitch:Math.max(e.getPitch()-5,0)},r):(t.preventDefault(),e.panBy([0,80],r))}}}}},{}],418:[function(t,e,r){"use strict";function n(t){this._map=t,this._el=t.getCanvasContainer(),o.bindHandlers(this)}var i=t("../../util/dom"),a=t("../../util/browser"),o=t("../../util/util");e.exports=n;var s="undefined"!=typeof navigator?navigator.userAgent.toLowerCase():"",l=-1!==s.indexOf("firefox"),u=-1!==s.indexOf("safari")&&-1===s.indexOf("chrom");n.prototype={_enabled:!1,isEnabled:function(){return this._enabled},enable:function(){this.isEnabled()||(this._el.addEventListener("wheel",this._onWheel,!1),this._el.addEventListener("mousewheel",this._onWheel,!1),this._enabled=!0)},disable:function(){this.isEnabled()&&(this._el.removeEventListener("wheel",this._onWheel),this._el.removeEventListener("mousewheel",this._onWheel),this._enabled=!1)},_onWheel:function(t){var e;"wheel"===t.type?(e=t.deltaY,l&&t.deltaMode===window.WheelEvent.DOM_DELTA_PIXEL&&(e/=a.devicePixelRatio),t.deltaMode===window.WheelEvent.DOM_DELTA_LINE&&(e*=40)):"mousewheel"===t.type&&(e=-t.wheelDeltaY,u&&(e/=3));var r=a.now(),n=r-(this._time||0);this._pos=i.mousePos(this._el,t),this._time=r,0!==e&&e%4.000244140625==0?(this._type="wheel",e=Math.floor(e/4)):0!==e&&Math.abs(e)<4?this._type="trackpad":n>400?(this._type=null,this._lastValue=e,this._timeout=setTimeout(this._onTimeout,40)):this._type||(this._type=Math.abs(n*e)<200?"trackpad":"wheel",this._timeout&&(clearTimeout(this._timeout),this._timeout=null,e+=this._lastValue)),t.shiftKey&&e&&(e/=4),this._type&&this._zoom(-e,t),t.preventDefault()},_onTimeout:function(){this._type="wheel",this._zoom(-this._lastValue)},_zoom:function(t,e){if(0!==t){var r=this._map,n=2/(1+Math.exp(-Math.abs(t/100)));t<0&&0!==n&&(n=1/n);var i=r.ease?r.ease.to:r.transform.scale,a=r.transform.scaleZoom(i*n);r.zoomTo(a,{duration:0,around:r.unproject(this._pos),delayEndEvents:200},{originalEvent:e})}}}},{"../../util/browser":426,"../../util/dom":428,"../../util/util":442}],419:[function(t,e,r){"use strict";function n(t){this._map=t,this._el=t.getCanvasContainer(),a.bindHandlers(this)}var i=t("../../util/dom"),a=t("../../util/util");e.exports=n;var o=a.bezier(0,0,.15,1);n.prototype={_enabled:!1,isEnabled:function(){return this._enabled},enable:function(){this.isEnabled()||(this._el.addEventListener("touchstart",this._onStart,!1),this._enabled=!0)},disable:function(){this.isEnabled()&&(this._el.removeEventListener("touchstart",this._onStart),this._enabled=!1)},disableRotation:function(){this._rotationDisabled=!0},enableRotation:function(){this._rotationDisabled=!1},_onStart:function(t){if(2===t.touches.length){var e=i.mousePos(this._el,t.touches[0]),r=i.mousePos(this._el,t.touches[1]);this._startVec=e.sub(r),this._startScale=this._map.transform.scale,this._startBearing=this._map.transform.bearing,this._gestureIntent=void 0,this._inertia=[], +document.addEventListener("touchmove",this._onMove,!1),document.addEventListener("touchend",this._onEnd,!1)}},_onMove:function(t){if(2===t.touches.length){var e=i.mousePos(this._el,t.touches[0]),r=i.mousePos(this._el,t.touches[1]),n=e.add(r).div(2),a=e.sub(r),o=a.mag()/this._startVec.mag(),s=this._rotationDisabled?0:180*a.angleWith(this._startVec)/Math.PI,l=this._map;if(this._gestureIntent){var u={duration:0,around:l.unproject(n)};"rotate"===this._gestureIntent&&(u.bearing=this._startBearing+s),"zoom"!==this._gestureIntent&&"rotate"!==this._gestureIntent||(u.zoom=l.transform.scaleZoom(this._startScale*o)),l.stop(),this._drainInertiaBuffer(),this._inertia.push([Date.now(),o,n]),l.easeTo(u,{originalEvent:t})}else{var c=Math.abs(1-o)>.15;Math.abs(s)>4?this._gestureIntent="rotate":c&&(this._gestureIntent="zoom"),this._gestureIntent&&(this._startVec=a,this._startScale=l.transform.scale,this._startBearing=l.transform.bearing)}t.preventDefault()}},_onEnd:function(t){document.removeEventListener("touchmove",this._onMove),document.removeEventListener("touchend",this._onEnd),this._drainInertiaBuffer();var e=this._inertia,r=this._map;if(e.length<2)return void r.snapToNorth({},{originalEvent:t});var n=e[e.length-1],i=e[0],a=r.transform.scaleZoom(this._startScale*n[1]),s=r.transform.scaleZoom(this._startScale*i[1]),l=a-s,u=(n[0]-i[0])/1e3,c=n[2];if(0===u||a===s)return void r.snapToNorth({},{originalEvent:t});var h=.15*l/u;Math.abs(h)>2.5&&(h=h>0?2.5:-2.5);var f=1e3*Math.abs(h/(12*.15)),d=a+h*f/2e3;d<0&&(d=0),r.easeTo({zoom:d,duration:f,easing:o,around:r.unproject(c)},{originalEvent:t})},_drainInertiaBuffer:function(){for(var t=this._inertia,e=Date.now();t.length>2&&e-t[0][0]>160;)t.shift()}}},{"../../util/dom":428,"../../util/util":442}],420:[function(t,e,r){"use strict";function n(){i.bindAll(["_onHashChange","_updateHash"],this)}e.exports=n;var i=t("../util/util");n.prototype={addTo:function(t){return this._map=t,window.addEventListener("hashchange",this._onHashChange,!1),this._map.on("moveend",this._updateHash),this},remove:function(){return window.removeEventListener("hashchange",this._onHashChange,!1),this._map.off("moveend",this._updateHash),delete this._map,this},_onHashChange:function(){var t=location.hash.replace("#","").split("/");return t.length>=3&&(this._map.jumpTo({center:[+t[2],+t[1]],zoom:+t[0],bearing:+(t[3]||0)}),!0)},_updateHash:function(){var t=this._map.getCenter(),e=this._map.getZoom(),r=this._map.getBearing(),n=Math.max(0,Math.ceil(Math.log(e)/Math.LN2)),i="#"+Math.round(100*e)/100+"/"+t.lat.toFixed(n)+"/"+t.lng.toFixed(n)+(r?"/"+Math.round(10*r)/10:"");window.history.replaceState("","",i)}}},{"../util/util":442}],421:[function(t,e,r){"use strict";function n(t){t.parentNode&&t.parentNode.removeChild(t)}var i=t("../util/canvas"),a=t("../util/util"),o=t("../util/browser"),s=t("../util/browser").window,l=t("../util/evented"),u=t("../util/dom"),c=t("../style/style"),h=t("../style/animation_loop"),f=t("../render/painter"),d=t("../geo/transform"),p=t("./hash"),m=t("./bind_handlers"),v=t("./camera"),g=t("../geo/lng_lat"),y=t("../geo/lng_lat_bounds"),b=t("point-geometry"),x=t("./control/attribution"),_={center:[0,0],zoom:0,bearing:0,pitch:0,minZoom:0,maxZoom:20,interactive:!0,scrollZoom:!0,boxZoom:!0,dragRotate:!0,dragPan:!0,keyboard:!0,doubleClickZoom:!0,touchZoomRotate:!0,bearingSnap:7,hash:!1,attributionControl:!0,failIfMajorPerformanceCaveat:!1,preserveDrawingBuffer:!1,trackResize:!0,workerCount:Math.max(o.hardwareConcurrency-1,1)},w=e.exports=function(t){if(t=a.extend({},_,t),t.workerCount<1)throw new Error("workerCount must an integer greater than or equal to 1.");this._interactive=t.interactive,this._failIfMajorPerformanceCaveat=t.failIfMajorPerformanceCaveat,this._preserveDrawingBuffer=t.preserveDrawingBuffer,this._trackResize=t.trackResize,this._workerCount=t.workerCount,this._bearingSnap=t.bearingSnap,"string"==typeof t.container?this._container=document.getElementById(t.container):this._container=t.container,this.animationLoop=new h,this.transform=new d(t.minZoom,t.maxZoom),t.maxBounds&&this.setMaxBounds(t.maxBounds),a.bindAll(["_forwardStyleEvent","_forwardSourceEvent","_forwardLayerEvent","_forwardTileEvent","_onStyleLoad","_onStyleChange","_onSourceAdd","_onSourceRemove","_onSourceUpdate","_onWindowOnline","_onWindowResize","_update","_render"],this),this._setupContainer(),this._setupPainter(),this.on("move",this._update.bind(this,!1)),this.on("zoom",this._update.bind(this,!0)),this.on("moveend",function(){this.animationLoop.set(300),this._rerender()}.bind(this)),void 0!==s&&(s.addEventListener("online",this._onWindowOnline,!1),s.addEventListener("resize",this._onWindowResize,!1)),m(this,t),this._hash=t.hash&&(new p).addTo(this),this._hash&&this._hash._onHashChange()||this.jumpTo({center:t.center,zoom:t.zoom,bearing:t.bearing,pitch:t.pitch}),this.stacks={},this._classes=[],this.resize(),t.classes&&this.setClasses(t.classes),t.style&&this.setStyle(t.style),t.attributionControl&&this.addControl(new x(t.attributionControl));var e=this.fire.bind(this,"error");this.on("style.error",e),this.on("source.error",e),this.on("tile.error",e),this.on("layer.error",e)};a.extend(w.prototype,l),a.extend(w.prototype,v.prototype),a.extend(w.prototype,{addControl:function(t){return t.addTo(this),this},addClass:function(t,e){return this._classes.indexOf(t)>=0||""===t?this:(this._classes.push(t),this._classOptions=e,this.style&&this.style.updateClasses(),this._update(!0))},removeClass:function(t,e){var r=this._classes.indexOf(t);return r<0||""===t?this:(this._classes.splice(r,1),this._classOptions=e,this.style&&this.style.updateClasses(),this._update(!0))},setClasses:function(t,e){for(var r={},n=0;n=0},getClasses:function(){return this._classes},resize:function(){var t=0,e=0;return this._container&&(t=this._container.offsetWidth||400,e=this._container.offsetHeight||300),this._canvas.resize(t,e),this.transform.resize(t,e),this.painter.resize(t,e),this.fire("movestart").fire("move").fire("resize").fire("moveend")},getBounds:function(){var t=new y(this.transform.pointLocation(new b(0,0)),this.transform.pointLocation(this.transform.size));return(this.transform.angle||this.transform.pitch)&&(t.extend(this.transform.pointLocation(new b(this.transform.size.x,0))),t.extend(this.transform.pointLocation(new b(0,this.transform.size.y)))),t},setMaxBounds:function(t){if(t){var e=y.convert(t);this.transform.lngRange=[e.getWest(),e.getEast()],this.transform.latRange=[e.getSouth(),e.getNorth()],this.transform._constrain(),this._update()}else null!==t&&void 0!==t||(this.transform.lngRange=[],this.transform.latRange=[],this._update());return this},setMinZoom:function(t){if((t=null===t||void 0===t?0:t)>=0&&t<=this.transform.maxZoom)return this.transform.minZoom=t,this._update(),this.getZoom()=this.transform.minZoom&&t<=20)return this.transform.maxZoom=t,this._update(),this.getZoom()>t&&this.setZoom(t),this;throw new Error("maxZoom must be between the current minZoom and 20, inclusive")},project:function(t){return this.transform.locationPoint(g.convert(t))},unproject:function(t){return this.transform.pointLocation(b.convert(t))},queryRenderedFeatures:function(){var t,e={};return 2===arguments.length?(t=arguments[0],e=arguments[1]):1===arguments.length&&function(t){return t instanceof b||Array.isArray(t)}(arguments[0])?t=arguments[0]:1===arguments.length&&(e=arguments[0]),this.style.queryRenderedFeatures(this._makeQueryGeometry(t),e,this.transform.zoom,this.transform.angle)},_makeQueryGeometry:function(t){void 0===t&&(t=[b.convert([0,0]),b.convert([this.transform.width,this.transform.height])]);var e;if(t instanceof b||"number"==typeof t[0])e=[b.convert(t)];else{var r=[b.convert(t[0]),b.convert(t[1])];e=[r[0],new b(r[1].x,r[0].y),r[1],new b(r[0].x,r[1].y),r[0]]}return e=e.map(function(t){return this.transform.pointCoordinate(t)}.bind(this))},querySourceFeatures:function(t,e){return this.style.querySourceFeatures(t,e)},setStyle:function(t){return this.style&&(this.style.off("load",this._onStyleLoad).off("error",this._forwardStyleEvent).off("change",this._onStyleChange).off("source.add",this._onSourceAdd).off("source.remove",this._onSourceRemove).off("source.load",this._onSourceUpdate).off("source.error",this._forwardSourceEvent).off("source.change",this._onSourceUpdate).off("layer.add",this._forwardLayerEvent).off("layer.remove",this._forwardLayerEvent).off("layer.error",this._forwardLayerEvent).off("tile.add",this._forwardTileEvent).off("tile.remove",this._forwardTileEvent).off("tile.load",this._update).off("tile.error",this._forwardTileEvent).off("tile.stats",this._forwardTileEvent)._remove(),this.off("rotate",this.style._redoPlacement),this.off("pitch",this.style._redoPlacement)),t?(this.style=t instanceof c?t:new c(t,this.animationLoop,this._workerCount),this.style.on("load",this._onStyleLoad).on("error",this._forwardStyleEvent).on("change",this._onStyleChange).on("source.add",this._onSourceAdd).on("source.remove",this._onSourceRemove).on("source.load",this._onSourceUpdate).on("source.error",this._forwardSourceEvent).on("source.change",this._onSourceUpdate).on("layer.add",this._forwardLayerEvent).on("layer.remove",this._forwardLayerEvent).on("layer.error",this._forwardLayerEvent).on("tile.add",this._forwardTileEvent).on("tile.remove",this._forwardTileEvent).on("tile.load",this._update).on("tile.error",this._forwardTileEvent).on("tile.stats",this._forwardTileEvent),this.on("rotate",this.style._redoPlacement),this.on("pitch",this.style._redoPlacement),this):(this.style=null,this)},getStyle:function(){if(this.style)return this.style.serialize()},addSource:function(t,e){return this.style.addSource(t,e),this._update(!0),this},addSourceType:function(t,e,r){return this.style.addSourceType(t,e,r)},removeSource:function(t){return this.style.removeSource(t),this._update(!0),this},getSource:function(t){return this.style.getSource(t)},addLayer:function(t,e){return this.style.addLayer(t,e),this._update(!0),this},removeLayer:function(t){return this.style.removeLayer(t),this._update(!0),this},getLayer:function(t){return this.style.getLayer(t)},setFilter:function(t,e){return this.style.setFilter(t,e),this._update(!0),this},setLayerZoomRange:function(t,e,r){return this.style.setLayerZoomRange(t,e,r),this._update(!0),this},getFilter:function(t){return this.style.getFilter(t)},setPaintProperty:function(t,e,r,n){return this.style.setPaintProperty(t,e,r,n),this._update(!0),this},getPaintProperty:function(t,e,r){return this.style.getPaintProperty(t,e,r)},setLayoutProperty:function(t,e,r){return this.style.setLayoutProperty(t,e,r),this._update(!0),this},getLayoutProperty:function(t,e){return this.style.getLayoutProperty(t,e)},getContainer:function(){return this._container},getCanvasContainer:function(){return this._canvasContainer},getCanvas:function(){return this._canvas.getElement()},_setupContainer:function(){var t=this._container;t.classList.add("mapboxgl-map");var e=this._canvasContainer=u.create("div","mapboxgl-canvas-container",t);this._interactive&&e.classList.add("mapboxgl-interactive"),this._canvas=new i(this,e);var r=this._controlContainer=u.create("div","mapboxgl-control-container",t),n=this._controlCorners={};["top-left","top-right","bottom-left","bottom-right"].forEach(function(t){n[t]=u.create("div","mapboxgl-ctrl-"+t,r)})},_setupPainter:function(){var t=this._canvas.getWebGLContext({failIfMajorPerformanceCaveat:this._failIfMajorPerformanceCaveat,preserveDrawingBuffer:this._preserveDrawingBuffer});if(!t)return void this.fire("error",{error:new Error("Failed to initialize WebGL")});this.painter=new f(t,this.transform)},_contextLost:function(t){t.preventDefault(),this._frameId&&o.cancelFrame(this._frameId),this.fire("webglcontextlost",{originalEvent:t})},_contextRestored:function(t){this._setupPainter(),this.resize(),this._update(),this.fire("webglcontextrestored",{originalEvent:t})},loaded:function(){return!this._styleDirty&&!this._sourcesDirty&&!(!this.style||!this.style.loaded())},_update:function(t){return this.style?(this._styleDirty=this._styleDirty||t,this._sourcesDirty=!0,this._rerender(),this):this},_render:function(){try{this.style&&this._styleDirty&&(this._styleDirty=!1,this.style.update(this._classes,this._classOptions),this._classOptions=null,this.style._recalculate(this.transform.zoom)),this.style&&this._sourcesDirty&&(this._sourcesDirty=!1,this.style._updateSources(this.transform)),this.painter.render(this.style,{debug:this.showTileBoundaries,showOverdrawInspector:this._showOverdrawInspector,vertices:this.vertices,rotating:this.rotating,zooming:this.zooming}),this.fire("render"),this.loaded()&&!this._loaded&&(this._loaded=!0,this.fire("load")),this._frameId=null,this.animationLoop.stopped()||(this._styleDirty=!0),(this._sourcesDirty||this._repaint||this._styleDirty)&&this._rerender()}catch(t){this.fire("error",{error:t})}return this},remove:function(){this._hash&&this._hash.remove(),o.cancelFrame(this._frameId),this.setStyle(null),void 0!==s&&s.removeEventListener("resize",this._onWindowResize,!1);var t=this.painter.gl.getExtension("WEBGL_lose_context");t&&t.loseContext(),n(this._canvasContainer),n(this._controlContainer),this._container.classList.remove("mapboxgl-map")},_rerender:function(){this.style&&!this._frameId&&(this._frameId=o.frame(this._render))},_forwardStyleEvent:function(t){this.fire("style."+t.type,a.extend({style:t.target},t))},_forwardSourceEvent:function(t){this.fire(t.type,a.extend({style:t.target},t))},_forwardLayerEvent:function(t){this.fire(t.type,a.extend({style:t.target},t))},_forwardTileEvent:function(t){this.fire(t.type,a.extend({style:t.target},t))},_onStyleLoad:function(t){this.transform.unmodified&&this.jumpTo(this.style.stylesheet),this.style.update(this._classes,{transition:!1}),this._forwardStyleEvent(t)},_onStyleChange:function(t){this._update(!0),this._forwardStyleEvent(t)},_onSourceAdd:function(t){var e=t.source;e.onAdd&&e.onAdd(this),this._forwardSourceEvent(t)},_onSourceRemove:function(t){var e=t.source;e.onRemove&&e.onRemove(this),this._forwardSourceEvent(t)},_onSourceUpdate:function(t){this._update(),this._forwardSourceEvent(t)},_onWindowOnline:function(){this._update()},_onWindowResize:function(){this._trackResize&&this.stop().resize()._update()}}),a.extendAll(w.prototype,{_showTileBoundaries:!1,get showTileBoundaries(){return this._showTileBoundaries},set showTileBoundaries(t){this._showTileBoundaries!==t&&(this._showTileBoundaries=t,this._update())},_showCollisionBoxes:!1,get showCollisionBoxes(){return this._showCollisionBoxes},set showCollisionBoxes(t){this._showCollisionBoxes!==t&&(this._showCollisionBoxes=t,this.style._redoPlacement())},_showOverdrawInspector:!1,get showOverdrawInspector(){return this._showOverdrawInspector},set showOverdrawInspector(t){this._showOverdrawInspector!==t&&(this._showOverdrawInspector=t,this._update())},_repaint:!1,get repaint(){return this._repaint},set repaint(t){this._repaint=t,this._update()},_vertices:!1,get vertices(){return this._vertices},set vertices(t){this._vertices=t,this._update()}})},{"../geo/lng_lat":339,"../geo/lng_lat_bounds":340,"../geo/transform":341,"../render/painter":355,"../style/animation_loop":375,"../style/style":378,"../util/browser":426,"../util/canvas":427,"../util/dom":428,"../util/evented":434,"../util/util":442,"./bind_handlers":407,"./camera":408,"./control/attribution":409,"./hash":420,"point-geometry":484}],422:[function(t,e,r){"use strict";function n(t,e){t||(t=i.create("div")),t.classList.add("mapboxgl-marker"),this._el=t,this._offset=o.convert(e&&e.offset||[0,0]),this._update=this._update.bind(this)}e.exports=n;var i=t("../util/dom"),a=t("../geo/lng_lat"),o=t("point-geometry");n.prototype={addTo:function(t){return this.remove(),this._map=t,t.getCanvasContainer().appendChild(this._el),t.on("move",this._update),this._update(),this},remove:function(){this._map&&(this._map.off("move",this._update),this._map=null);var t=this._el.parentNode;return t&&t.removeChild(this._el),this},getLngLat:function(){return this._lngLat},setLngLat:function(t){return this._lngLat=a.convert(t),this._update(),this},getElement:function(){return this._el},_update:function(){if(this._map){var t=this._map.project(this._lngLat)._add(this._offset);i.setTransform(this._el,"translate("+t.x+"px,"+t.y+"px)")}}}},{"../geo/lng_lat":339,"../util/dom":428,"point-geometry":484}],423:[function(t,e,r){"use strict";function n(t){i.setOptions(this,t),i.bindAll(["_update","_onClickClose"],this)}e.exports=n;var i=t("../util/util"),a=t("../util/evented"),o=t("../util/dom"),s=t("../geo/lng_lat");n.prototype=i.inherit(a,{options:{closeButton:!0,closeOnClick:!0},addTo:function(t){return this._map=t,this._map.on("move",this._update),this.options.closeOnClick&&this._map.on("click",this._onClickClose),this._update(),this},remove:function(){return this._content&&this._content.parentNode&&this._content.parentNode.removeChild(this._content),this._container&&(this._container.parentNode.removeChild(this._container),delete this._container),this._map&&(this._map.off("move",this._update),this._map.off("click",this._onClickClose),delete this._map),this.fire("close"),this},getLngLat:function(){return this._lngLat},setLngLat:function(t){return this._lngLat=s.convert(t),this._update(),this},setText:function(t){return this.setDOMContent(document.createTextNode(t))},setHTML:function(t){var e,r=document.createDocumentFragment(),n=document.createElement("body");for(n.innerHTML=t;;){if(!(e=n.firstChild))break;r.appendChild(e)}return this.setDOMContent(r)},setDOMContent:function(t){return this._createContent(),this._content.appendChild(t),this._update(),this},_createContent:function(){this._content&&this._content.parentNode&&this._content.parentNode.removeChild(this._content),this._content=o.create("div","mapboxgl-popup-content",this._container),this.options.closeButton&&(this._closeButton=o.create("button","mapboxgl-popup-close-button",this._content),this._closeButton.type="button",this._closeButton.innerHTML="×",this._closeButton.addEventListener("click",this._onClickClose))},_update:function(){if(this._map&&this._lngLat&&this._content){this._container||(this._container=o.create("div","mapboxgl-popup",this._map.getContainer()),this._tip=o.create("div","mapboxgl-popup-tip",this._container),this._container.appendChild(this._content));var t=this._map.project(this._lngLat).round(),e=this.options.anchor;if(!e){var r=this._container.offsetWidth,n=this._container.offsetHeight;e=t.ythis._map.transform.height-n?["bottom"]:[],t.xthis._map.transform.width-r/2&&e.push("right"),e=0===e.length?"bottom":e.join("-")}var i={top:"translate(-50%,0)","top-left":"translate(0,0)","top-right":"translate(-100%,0)",bottom:"translate(-50%,-100%)","bottom-left":"translate(0,-100%)","bottom-right":"translate(-100%,-100%)",left:"translate(0,-50%)",right:"translate(-100%,-50%)"},a=this._container.classList;for(var s in i)a.remove("mapboxgl-popup-anchor-"+s);a.add("mapboxgl-popup-anchor-"+e),o.setTransform(this._container,i[e]+" translate("+t.x+"px,"+t.y+"px)")}},_onClickClose:function(){this.remove()}})},{"../geo/lng_lat":339,"../util/dom":428,"../util/evented":434,"../util/util":442}],424:[function(t,e,r){"use strict";function n(t,e){this.target=t,this.parent=e,this.callbacks={},this.callbackID=0,this.receive=this.receive.bind(this),this.target.addEventListener("message",this.receive,!1)}e.exports=n,n.prototype.receive=function(t){function e(t,e,r){this.postMessage({type:"",id:String(i),error:t?String(t):null,data:e},r)}var r,n=t.data,i=n.id;if(""===n.type)r=this.callbacks[n.id],delete this.callbacks[n.id],r&&r(n.error||null,n.data);else if(void 0!==n.id&&this.parent[n.type])this.parent[n.type](n.data,e.bind(this));else if(void 0!==n.id&&this.parent.workerSources){var a=n.type.split(".");this.parent.workerSources[a[0]][a[1]](n.data,e.bind(this))}else this.parent[n.type](n.data)},n.prototype.send=function(t,e,r,n){var i=null;r&&(this.callbacks[i=this.callbackID++]=r),this.postMessage({type:t,id:String(i),data:e},n)},n.prototype.postMessage=function(t,e){this.target.postMessage(t,e)}},{}],425:[function(t,e,r){"use strict";function n(t){var e=document.createElement("a");return e.href=t,e.protocol===document.location.protocol&&e.host===document.location.host}r.getJSON=function(t,e){var r=new XMLHttpRequest;return r.open("GET",t,!0),r.setRequestHeader("Accept","application/json"),r.onerror=function(t){e(t)},r.onload=function(){if(r.status>=200&&r.status<300&&r.response){var t;try{t=JSON.parse(r.response)}catch(t){return e(t)}e(null,t)}else e(new Error(r.statusText))},r.send(),r},r.getArrayBuffer=function(t,e){var r=new XMLHttpRequest;return r.open("GET",t,!0),r.responseType="arraybuffer",r.onerror=function(t){e(t)},r.onload=function(){r.status>=200&&r.status<300&&r.response?e(null,r.response):e(new Error(r.statusText))},r.send(),r},r.getImage=function(t,e){return r.getArrayBuffer(t,function(t,r){if(t)return e(t);var n=new Image;n.onload=function(){e(null,n),(window.URL||window.webkitURL).revokeObjectURL(n.src)};var i=new Blob([new Uint8Array(r)],{type:"image/png"});return n.src=(window.URL||window.webkitURL).createObjectURL(i),n.getData=function(){var t=document.createElement("canvas"),e=t.getContext("2d");return t.width=n.width,t.height=n.height,e.drawImage(n,0,0),e.getImageData(0,0,n.width,n.height).data},n})},r.getVideo=function(t,e){var r=document.createElement("video");r.onloadstart=function(){e(null,r)};for(var i=0;i=s+n?t.call(i,1):(t.call(i,(l-s)/n),r.frame(a)))}if(!n)return t.call(i,1),null;var o=!1,s=e.exports.now();return r.frame(a),function(){o=!0}},r.supported=t("mapbox-gl-supported"),r.hardwareConcurrency=navigator.hardwareConcurrency||4,Object.defineProperty(r,"devicePixelRatio",{get:function(){return window.devicePixelRatio}}),r.supportsWebp=!1;var a=document.createElement("img");a.onload=function(){r.supportsWebp=!0},a.src="data:image/webp;base64,UklGRh4AAABXRUJQVlA4TBEAAAAvAQAAAAfQ//73v/+BiOh/AAA=",r.supportsGeolocation=!!navigator.geolocation},{"mapbox-gl-supported":327}],427:[function(t,e,r){"use strict";function n(t,e){this.canvas=document.createElement("canvas"),t&&e&&(this.canvas.style.position="absolute",this.canvas.classList.add("mapboxgl-canvas"),this.canvas.addEventListener("webglcontextlost",t._contextLost.bind(t),!1),this.canvas.addEventListener("webglcontextrestored",t._contextRestored.bind(t),!1),this.canvas.setAttribute("tabindex",0),e.appendChild(this.canvas))}var i=t("../util"),a=t("mapbox-gl-supported");e.exports=n,n.prototype.resize=function(t,e){var r=window.devicePixelRatio||1;this.canvas.width=r*t,this.canvas.height=r*e,this.canvas.style.width=t+"px",this.canvas.style.height=e+"px"},n.prototype.getWebGLContext=function(t){return t=i.extend({},t,a.webGLContextAttributes),this.canvas.getContext("webgl",t)||this.canvas.getContext("experimental-webgl",t)},n.prototype.getElement=function(){return this.canvas}},{"../util":442,"mapbox-gl-supported":327}],428:[function(t,e,r){"use strict";function n(t){for(var e=0;e1)for(var h=0;h=0&&this._events[t].splice(r,1),this._events[t].length||delete this._events[t]}else delete this._events[t];return this},once:function(t,e){var r=function(n){this.off(t,r),e.call(this,n)}.bind(this);return this.on(t,r),this},fire:function(t,e){if(!this.listens(t))return n.endsWith(t,"error")&&console.error(e&&e.error||e||"Empty error event"),this;e=n.extend({},e),n.extend(e,{type:t,target:this});for(var r=this._events[t].slice(),i=0;i=3)for(var l=0;l1){if(s(t,e))return!0;for(var n=0;n(e.y-t.y)*(r.x-t.x)}function u(t,e,r,n){return l(t,r,n)!==l(e,r,n)&&l(t,e,r)!==l(t,e,n)}function c(t,e,r){var n=r*r;if(1===e.length)return t.distSqr(e[0])1?t.distSqr(r):t.distSqr(r.sub(e)._mult(i)._add(e))}function f(t,e){for(var r,n,i,a=!1,o=0;oe.y!=i.y>e.y&&e.x<(i.x-n.x)*(e.y-n.y)/(i.y-n.y)+n.x&&(a=!a)}return a}function d(t,e){for(var r=!1,n=0,i=t.length-1;ne.y!=o.y>e.y&&e.x<(o.x-a.x)*(e.y-a.y)/(o.y-a.y)+a.x&&(r=!r)}return r}e.exports={multiPolygonIntersectsBufferedMultiPoint:n,multiPolygonIntersectsMultiPolygon:i,multiPolygonIntersectsBufferedMultiLine:a}},{}],438:[function(t,e,r){"use strict";function n(t,e){this.max=t,this.onRemove=e,this.reset()}e.exports=n,n.prototype.reset=function(){for(var t in this.data)this.onRemove(this.data[t]);return this.data={},this.order=[],this},n.prototype.add=function(t,e){if(this.has(t))this.order.splice(this.order.indexOf(t),1),this.data[t]=e,this.order.push(t);else if(this.data[t]=e,this.order.push(t),this.order.length>this.max){var r=this.get(this.order[0]);r&&this.onRemove(r)}return this},n.prototype.has=function(t){return t in this.data},n.prototype.keys=function(){return this.order},n.prototype.get=function(t){if(!this.has(t))return null;var e=this.data[t];return delete this.data[t],this.order.splice(this.order.indexOf(t),1),e},n.prototype.setMaxSize=function(t){for(this.max=t;this.order.length>this.max;){var e=this.get(this.order[0]);e&&this.onRemove(e)}return this}},{}],439:[function(t,e,r){"use strict";function n(t,e,r){if(!(r=r||o.ACCESS_TOKEN)&&o.REQUIRE_ACCESS_TOKEN)throw new Error("An API access token is required to use Mapbox GL. See https://www.mapbox.com/developers/api/#access-tokens");if(t=t.replace(/^mapbox:\/\//,o.API_URL+e), +t+=-1!==t.indexOf("?")?"&access_token=":"?access_token=",o.REQUIRE_ACCESS_TOKEN){if("s"===r[0])throw new Error("Use a public access token (pk.*) with Mapbox GL JS, not a secret access token (sk.*). See https://www.mapbox.com/developers/api/#access-tokens");t+=r}return t}function i(t){return t?"?"+t:""}function a(t){return t.access_token&&"tk."===t.access_token.slice(0,3)?u.extend({},t,{access_token:o.ACCESS_TOKEN}):t}var o=t("./config"),s=t("./browser"),l=t("url"),u=t("./util");e.exports.normalizeStyleURL=function(t,e){var r=l.parse(t);return"mapbox:"!==r.protocol?t:n("mapbox:/"+r.pathname+i(r.query),"/styles/v1/",e)},e.exports.normalizeSourceURL=function(t,e){return"mapbox:"!==l.parse(t).protocol?t:n(t+".json","/v4/",e)+"&secure"},e.exports.normalizeGlyphsURL=function(t,e){var r=l.parse(t);return"mapbox:"!==r.protocol?t:n("mapbox://"+r.pathname.split("/")[1]+"/{fontstack}/{range}.pbf"+i(r.query),"/fonts/v1/",e)},e.exports.normalizeSpriteURL=function(t,e,r,a){var o=l.parse(t);return"mapbox:"!==o.protocol?(o.pathname+=e+r,l.format(o)):n("mapbox:/"+o.pathname+"/sprite"+e+r+i(o.query),"/styles/v1/",a)},e.exports.normalizeTileURL=function(t,e,r){var n=l.parse(t,!0);if(!e)return t;if("mapbox:"!==l.parse(e).protocol)return t;var i=s.supportsWebp?".webp":"$1",o=s.devicePixelRatio>=2||512===r?"@2x":"";return l.format({protocol:n.protocol,hostname:n.hostname,pathname:n.pathname.replace(/(\.(?:png|jpg)\d*)/,o+i),query:a(n.query)})}},{"./browser":426,"./config":431,"./util":442,url:545}],440:[function(t,e,r){"use strict";function n(t){function e(){f.apply(this,arguments)}function r(){d.apply(this,arguments),this.members=e.prototype.members}var n=JSON.stringify(t);if(v[n])return v[n];void 0===t.alignment&&(t.alignment=1),e.prototype=Object.create(f.prototype);var s=0,u=0,g=["Uint8"];return e.prototype.members=t.members.map(function(r){r={name:r.name,type:r.type,components:r.components||1},p(r.name.length),p(r.type in m),g.indexOf(r.type)<0&&g.push(r.type);var n=o(r.type);u=Math.max(u,n),r.offset=s=a(s,Math.max(t.alignment,n));for(var i=0;ithis.capacity){this.capacity=Math.max(t,Math.floor(this.capacity*this.RESIZE_MULTIPLIER),this.DEFAULT_CAPACITY),this.arrayBuffer=new ArrayBuffer(this.capacity*this.bytesPerElement);var e=this.uint8;this._refreshViews(),e&&this.uint8.set(e)}},d.prototype._refreshViews=function(){for(var t=0;t=1)return 1;var e=t*t,r=e*t;return 4*(t<.5?r:3*(t-e)+r-.75)},r.bezier=function(t,e,r,i){var a=new n(t,e,r,i);return function(t){return a.solve(t)}},r.ease=r.bezier(.25,.1,.25,1),r.clamp=function(t,e,r){return Math.min(r,Math.max(e,t))},r.wrap=function(t,e,r){var n=r-e,i=((t-e)%n+n)%n+e;return i===e?r:i},r.coalesce=function(){for(var t=0;t=0)return!0;return!1};var o={};r.warnOnce=function(t){o[t]||("undefined"!=typeof console&&console.warn(t),o[t]=!0)}},{"../geo/coordinate":338,unitbezier:544}],443:[function(t,e,r){"use strict";function n(t,e,r,n){this._vectorTileFeature=t,t._z=e,t._x=r,t._y=n,this.properties=t.properties,null!=t.id&&(this.id=t.id)}e.exports=n,n.prototype={type:"Feature",get geometry(){return void 0===this._geometry&&(this._geometry=this._vectorTileFeature.toGeoJSON(this._vectorTileFeature._x,this._vectorTileFeature._y,this._vectorTileFeature._z).geometry),this._geometry},set geometry(t){this._geometry=t},toJSON:function(){var t={};for(var e in this)"_geometry"!==e&&"_vectorTileFeature"!==e&&"toJSON"!==e&&(t[e]=this[e]);return t}}},{}],444:[function(t,e,r){e.exports={_args:[[{raw:"mapbox-gl@^0.22.0",scope:null,escapedName:"mapbox-gl",name:"mapbox-gl",rawSpec:"^0.22.0",spec:">=0.22.0 <0.23.0",type:"range"},"/home/etienne/Documents/plotly/plotly.js"]],_from:"mapbox-gl@>=0.22.0 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this._validate(t,this.minMonth,this.minDay,o.local.invalidYear),!1},formatYear:function(t){t=this._validate(t,this.minMonth,this.minDay,o.local.invalidYear).year();var e=Math.floor(t/400);return t%=400,t+=t<0?400:0,e+"."+Math.floor(t/20)+"."+t%20},forYear:function(t){if(t=t.split("."),t.length<3)throw"Invalid Mayan year";for(var e=0,r=0;r19||r>0&&n<0)throw"Invalid Mayan year";e=20*e+n}return e},monthsInYear:function(t){return this._validate(t,this.minMonth,this.minDay,o.local.invalidYear),18},weekOfYear:function(t,e,r){return this._validate(t,e,r,o.local.invalidDate),0},daysInYear:function(t){return this._validate(t,this.minMonth,this.minDay,o.local.invalidYear),360},daysInMonth:function(t,e){return this._validate(t,e,this.minDay,o.local.invalidMonth),20},daysInWeek:function(){return 5},dayOfWeek:function(t,e,r){return this._validate(t,e,r,o.local.invalidDate).day()},weekDay:function(t,e,r){return this._validate(t,e,r,o.local.invalidDate),!0},extraInfo:function(t,e,r){var n=this._validate(t,e,r,o.local.invalidDate),i=n.toJD(),a=this._toHaab(i),s=this._toTzolkin(i);return{haabMonthName:this.local.haabMonths[a[0]-1],haabMonth:a[0],haabDay:a[1],tzolkinDayName:this.local.tzolkinMonths[s[0]-1],tzolkinDay:s[0],tzolkinTrecena:s[1]}},_toHaab:function(t){t-=this.jdEpoch;var e=i(t+8+340,365);return[Math.floor(e/20)+1,i(e,20)]},_toTzolkin:function(t){return t-=this.jdEpoch,[a(t+20,20),a(t+4,13)]},toJD:function(t,e,r){var n=this._validate(t,e,r,o.local.invalidDate);return n.day()+20*n.month()+360*n.year()+this.jdEpoch},fromJD:function(t){t=Math.floor(t)+.5-this.jdEpoch;var e=Math.floor(t/360);t%=360,t+=t<0?360:0;var r=Math.floor(t/20),n=t%20;return this.newDate(e,r,n)}}),o.calendars.mayan=n},{"../main":581,"object-assign":470}],575:[function(t,e,r){function n(t){this.local=this.regionalOptions[t||""]||this.regionalOptions[""]}var i=t("../main"),a=t("object-assign");n.prototype=new i.baseCalendar;var o=i.instance("gregorian");a(n.prototype,{name:"Nanakshahi",jdEpoch:2257673.5,daysPerMonth:[31,31,31,31,31,30,30,30,30,30,30,30],hasYearZero:!1,minMonth:1,firstMonth:1,minDay:1,regionalOptions:{"":{name:"Nanakshahi",epochs:["BN","AN"],monthNames:["Chet","Vaisakh","Jeth","Harh","Sawan","Bhadon","Assu","Katak","Maghar","Poh","Magh","Phagun"],monthNamesShort:["Che","Vai","Jet","Har","Saw","Bha","Ass","Kat","Mgr","Poh","Mgh","Pha"],dayNames:["Somvaar","Mangalvar","Budhvaar","Veervaar","Shukarvaar","Sanicharvaar","Etvaar"],dayNamesShort:["Som","Mangal","Budh","Veer","Shukar","Sanichar","Et"],dayNamesMin:["So","Ma","Bu","Ve","Sh","Sa","Et"],digits:null,dateFormat:"dd-mm-yyyy",firstDay:0,isRTL:!1}},leapYear:function(t){var e=this._validate(t,this.minMonth,this.minDay,i.local.invalidYear||i.regionalOptions[""].invalidYear);return o.leapYear(e.year()+(e.year()<1?1:0)+1469)},weekOfYear:function(t,e,r){var n=this.newDate(t,e,r);return n.add(1-(n.dayOfWeek()||7),"d"),Math.floor((n.dayOfYear()-1)/7)+1},daysInMonth:function(t,e){var r=this._validate(t,e,this.minDay,i.local.invalidMonth);return this.daysPerMonth[r.month()-1]+(12===r.month()&&this.leapYear(r.year())?1:0)},weekDay:function(t,e,r){return(this.dayOfWeek(t,e,r)||7)<6},toJD:function(t,e,r){var n=this._validate(t,e,r,i.local.invalidMonth),t=n.year();t<0&&t++;for(var a=n.day(),s=1;s=this.toJD(e+1,1,1);)e++;for(var r=t-Math.floor(this.toJD(e,1,1)+.5)+1,n=1;r>this.daysInMonth(e,n);)r-=this.daysInMonth(e,n),n++;return this.newDate(e,n,r)}}),i.calendars.nanakshahi=n},{"../main":581,"object-assign":470}],576:[function(t,e,r){function n(t){this.local=this.regionalOptions[t||""]||this.regionalOptions[""]}var i=t("../main"),a=t("object-assign");n.prototype=new i.baseCalendar,a(n.prototype,{name:"Nepali",jdEpoch:1700709.5,daysPerMonth:[31,31,32,32,31,30,30,29,30,29,30,30],hasYearZero:!1,minMonth:1,firstMonth:1,minDay:1,daysPerYear:365,regionalOptions:{"":{name:"Nepali",epochs:["BBS","ABS"],monthNames:["Baisakh","Jestha","Ashadh","Shrawan","Bhadra","Ashwin","Kartik","Mangsir","Paush","Mangh","Falgun","Chaitra"],monthNamesShort:["Bai","Je","As","Shra","Bha","Ash","Kar","Mang","Pau","Ma","Fal","Chai"],dayNames:["Aaitabaar","Sombaar","Manglbaar","Budhabaar","Bihibaar","Shukrabaar","Shanibaar"],dayNamesShort:["Aaita","Som","Mangl","Budha","Bihi","Shukra","Shani"],dayNamesMin:["Aai","So","Man","Bu","Bi","Shu","Sha"],digits:null,dateFormat:"dd/mm/yyyy",firstDay:1,isRTL:!1}},leapYear:function(t){return this.daysInYear(t)!==this.daysPerYear},weekOfYear:function(t,e,r){var n=this.newDate(t,e,r);return n.add(-n.dayOfWeek(),"d"),Math.floor((n.dayOfYear()-1)/7)+1},daysInYear:function(t){if(t=this._validate(t,this.minMonth,this.minDay,i.local.invalidYear).year(),void 0===this.NEPALI_CALENDAR_DATA[t])return this.daysPerYear;for(var e=0,r=this.minMonth;r<=12;r++)e+=this.NEPALI_CALENDAR_DATA[t][r];return e},daysInMonth:function(t,e){return t.year&&(e=t.month(),t=t.year()),this._validate(t,e,this.minDay,i.local.invalidMonth),void 0===this.NEPALI_CALENDAR_DATA[t]?this.daysPerMonth[e-1]:this.NEPALI_CALENDAR_DATA[t][e]},weekDay:function(t,e,r){return 6!==this.dayOfWeek(t,e,r)},toJD:function(t,e,r){var n=this._validate(t,e,r,i.local.invalidDate);t=n.year(),e=n.month(),r=n.day();var a=i.instance(),o=0,s=e,l=t;this._createMissingCalendarData(t);var u=t-(s>9||9===s&&r>=this.NEPALI_CALENDAR_DATA[l][0]?56:57);for(9!==e&&(o=r, +s--);9!==s;)s<=0&&(s=12,l--),o+=this.NEPALI_CALENDAR_DATA[l][s],s--;return 9===e?(o+=r-this.NEPALI_CALENDAR_DATA[l][0])<0&&(o+=a.daysInYear(u)):o+=this.NEPALI_CALENDAR_DATA[l][9]-this.NEPALI_CALENDAR_DATA[l][0],a.newDate(u,1,1).add(o,"d").toJD()},fromJD:function(t){var e=i.instance(),r=e.fromJD(t),n=r.year(),a=r.dayOfYear(),o=n+56;this._createMissingCalendarData(o);for(var s=9,l=this.NEPALI_CALENDAR_DATA[o][0],u=this.NEPALI_CALENDAR_DATA[o][s]-l+1;a>u;)s++,s>12&&(s=1,o++),u+=this.NEPALI_CALENDAR_DATA[o][s];var c=this.NEPALI_CALENDAR_DATA[o][s]-(u-a);return this.newDate(o,s,c)},_createMissingCalendarData:function(t){var e=this.daysPerMonth.slice(0);e.unshift(17);for(var r=t-1;r0?474:473))%2820+474+38)%2816<682},weekOfYear:function(t,e,r){var n=this.newDate(t,e,r);return n.add(-(n.dayOfWeek()+1)%7,"d"),Math.floor((n.dayOfYear()-1)/7)+1},daysInMonth:function(t,e){var r=this._validate(t,e,this.minDay,a.local.invalidMonth);return this.daysPerMonth[r.month()-1]+(12===r.month()&&this.leapYear(r.year())?1:0)},weekDay:function(t,e,r){return 5!==this.dayOfWeek(t,e,r)},toJD:function(t,e,r){var n=this._validate(t,e,r,a.local.invalidDate);t=n.year(),e=n.month(),r=n.day();var o=t-(t>=0?474:473),s=474+i(o,2820);return r+(e<=7?31*(e-1):30*(e-1)+6)+Math.floor((682*s-110)/2816)+365*(s-1)+1029983*Math.floor(o/2820)+this.jdEpoch-1},fromJD:function(t){t=Math.floor(t)+.5;var e=t-this.toJD(475,1,1),r=Math.floor(e/1029983),n=i(e,1029983),a=2820;if(1029982!==n){var o=Math.floor(n/366),s=i(n,366);a=Math.floor((2134*o+2816*s+2815)/1028522)+o+1}var l=a+2820*r+474;l=l<=0?l-1:l;var u=t-this.toJD(l,1,1)+1,c=u<=186?Math.ceil(u/31):Math.ceil((u-6)/30),h=t-this.toJD(l,c,1)+1;return this.newDate(l,c,h)}}),a.calendars.persian=n,a.calendars.jalali=n},{"../main":581,"object-assign":470}],578:[function(t,e,r){function n(t){this.local=this.regionalOptions[t||""]||this.regionalOptions[""]}var i=t("../main"),a=t("object-assign"),o=i.instance();n.prototype=new i.baseCalendar,a(n.prototype,{name:"Taiwan",jdEpoch:2419402.5,yearsOffset:1911,daysPerMonth:[31,28,31,30,31,30,31,31,30,31,30,31],hasYearZero:!1,minMonth:1,firstMonth:1,minDay:1,regionalOptions:{"":{name:"Taiwan",epochs:["BROC","ROC"],monthNames:["January","February","March","April","May","June","July","August","September","October","November","December"],monthNamesShort:["Jan","Feb","Mar","Apr","May","Jun","Jul","Aug","Sep","Oct","Nov","Dec"],dayNames:["Sunday","Monday","Tuesday","Wednesday","Thursday","Friday","Saturday"],dayNamesShort:["Sun","Mon","Tue","Wed","Thu","Fri","Sat"],dayNamesMin:["Su","Mo","Tu","We","Th","Fr","Sa"],digits:null,dateFormat:"yyyy/mm/dd",firstDay:1,isRTL:!1}},leapYear:function(t){var e=this._validate(t,this.minMonth,this.minDay,i.local.invalidYear),t=this._t2gYear(e.year());return o.leapYear(t)},weekOfYear:function(t,e,r){var n=this._validate(t,this.minMonth,this.minDay,i.local.invalidYear),t=this._t2gYear(n.year());return 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i.baseCalendar,a(n.prototype,{name:"Thai",jdEpoch:1523098.5,yearsOffset:543,daysPerMonth:[31,28,31,30,31,30,31,31,30,31,30,31],hasYearZero:!1,minMonth:1,firstMonth:1,minDay:1,regionalOptions:{"":{name:"Thai",epochs:["BBE","BE"],monthNames:["January","February","March","April","May","June","July","August","September","October","November","December"],monthNamesShort:["Jan","Feb","Mar","Apr","May","Jun","Jul","Aug","Sep","Oct","Nov","Dec"],dayNames:["Sunday","Monday","Tuesday","Wednesday","Thursday","Friday","Saturday"],dayNamesShort:["Sun","Mon","Tue","Wed","Thu","Fri","Sat"],dayNamesMin:["Su","Mo","Tu","We","Th","Fr","Sa"],digits:null,dateFormat:"dd/mm/yyyy",firstDay:0,isRTL:!1}},leapYear:function(t){var e=this._validate(t,this.minMonth,this.minDay,i.local.invalidYear),t=this._t2gYear(e.year());return o.leapYear(t)},weekOfYear:function(t,e,r){var n=this._validate(t,this.minMonth,this.minDay,i.local.invalidYear),t=this._t2gYear(n.year());return o.weekOfYear(t,n.month(),n.day())},daysInMonth:function(t,e){var r=this._validate(t,e,this.minDay,i.local.invalidMonth);return this.daysPerMonth[r.month()-1]+(2===r.month()&&this.leapYear(r.year())?1:0)},weekDay:function(t,e,r){return(this.dayOfWeek(t,e,r)||7)<6},toJD:function(t,e,r){var n=this._validate(t,e,r,i.local.invalidDate),t=this._t2gYear(n.year());return o.toJD(t,n.month(),n.day())},fromJD:function(t){var e=o.fromJD(t),r=this._g2tYear(e.year());return this.newDate(r,e.month(),e.day())},_t2gYear:function(t){return t-this.yearsOffset-(t>=1&&t<=this.yearsOffset?1:0)},_g2tYear:function(t){return t+this.yearsOffset+(t>=-this.yearsOffset&&t<=-1?1:0)}}),i.calendars.thai=n},{"../main":581,"object-assign":470}],580:[function(t,e,r){function n(t){this.local=this.regionalOptions[t||""]||this.regionalOptions[""]}var i=t("../main"),a=t("object-assign");n.prototype=new i.baseCalendar,a(n.prototype,{name:"UmmAlQura",hasYearZero:!1,minMonth:1,firstMonth:1,minDay:1,regionalOptions:{"":{name:"Umm al-Qura",epochs:["BH","AH"],monthNames:["Al-Muharram","Safar","Rabi' al-awwal","Rabi' Al-Thani","Jumada Al-Awwal","Jumada Al-Thani","Rajab","Sha'aban","Ramadan","Shawwal","Dhu al-Qi'dah","Dhu al-Hijjah"],monthNamesShort:["Muh","Saf","Rab1","Rab2","Jum1","Jum2","Raj","Sha'","Ram","Shaw","DhuQ","DhuH"],dayNames:["Yawm al-Ahad","Yawm al-Ithnain","Yawm al-Thal\u0101th\u0101\u2019","Yawm al-Arba\u2018\u0101\u2019","Yawm al-Kham\u012bs","Yawm al-Jum\u2018a","Yawm al-Sabt"],dayNamesMin:["Ah","Ith","Th","Ar","Kh","Ju","Sa"],digits:null,dateFormat:"yyyy/mm/dd",firstDay:6,isRTL:!0}},leapYear:function(t){var e=this._validate(t,this.minMonth,this.minDay,i.local.invalidYear);return 355===this.daysInYear(e.year())},weekOfYear:function(t,e,r){var n=this.newDate(t,e,r);return n.add(-n.dayOfWeek(),"d"),Math.floor((n.dayOfYear()-1)/7)+1},daysInYear:function(t){for(var e=0,r=1;r<=12;r++)e+=this.daysInMonth(t,r);return e},daysInMonth:function(t,e){for(var r=this._validate(t,e,this.minDay,i.local.invalidMonth),n=r.toJD()-24e5+.5,a=0,s=0;sn)return o[a]-o[a-1];a++}return 30},weekDay:function(t,e,r){return 5!==this.dayOfWeek(t,e,r)},toJD:function(t,e,r){var n=this._validate(t,e,r,i.local.invalidDate),a=12*(n.year()-1)+n.month()-15292;return n.day()+o[a-1]-1+24e5-.5},fromJD:function(t){for(var e=t-24e5+.5,r=0,n=0;ne);n++)r++;var i=r+15292,a=Math.floor((i-1)/12),s=a+1,l=i-12*a,u=e-o[r-1]+1;return this.newDate(s,l,u)},isValid:function(t,e,r){var n=i.baseCalendar.prototype.isValid.apply(this,arguments);return n&&(t=null!=t.year?t.year:t,n=t>=1276&&t<=1500),n},_validate:function(t,e,r,n){var a=i.baseCalendar.prototype._validate.apply(this,arguments);if(a.year<1276||a.year>1500)throw n.replace(/\{0\}/,this.local.name);return a}}),i.calendars.ummalqura=n;var 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n(){this.regionalOptions=[],this.regionalOptions[""]={invalidCalendar:"Calendar {0} not found",invalidDate:"Invalid {0} date",invalidMonth:"Invalid {0} month",invalidYear:"Invalid {0} year",differentCalendars:"Cannot mix {0} and {1} dates"},this.local=this.regionalOptions[""],this.calendars={},this._localCals={}}function i(t,e,r,n){if(this._calendar=t,this._year=e,this._month=r,this._day=n,0===this._calendar._validateLevel&&!this._calendar.isValid(this._year,this._month,this._day))throw(u.local.invalidDate||u.regionalOptions[""].invalidDate).replace(/\{0\}/,this._calendar.local.name)}function a(t,e){return t=""+t,"000000".substring(0,e-t.length)+t}function o(){this.shortYearCutoff="+10"}function s(t){this.local=this.regionalOptions[t]||this.regionalOptions[""]}var l=t("object-assign");l(n.prototype,{instance:function(t,e){t=(t||"gregorian").toLowerCase(),e=e||"";var r=this._localCals[t+"-"+e];if(!r&&this.calendars[t]&&(r=new this.calendars[t](e),this._localCals[t+"-"+e]=r),!r)throw(this.local.invalidCalendar||this.regionalOptions[""].invalidCalendar).replace(/\{0\}/,t);return r},newDate:function(t,e,r,n,i){return n=(null!=t&&t.year?t.calendar():"string"==typeof n?this.instance(n,i):n)||this.instance(),n.newDate(t,e,r)},substituteDigits:function(t){ +return function(e){return(e+"").replace(/[0-9]/g,function(e){return t[e]})}},substituteChineseDigits:function(t,e){return function(r){for(var n="",i=0;r>0;){var a=r%10;n=(0===a?"":t[a]+e[i])+n,i++,r=Math.floor(r/10)}return 0===n.indexOf(t[1]+e[1])&&(n=n.substr(1)),n||t[0]}}}),l(i.prototype,{newDate:function(t,e,r){return this._calendar.newDate(null==t?this:t,e,r)},year:function(t){return 0===arguments.length?this._year:this.set(t,"y")},month:function(t){return 0===arguments.length?this._month:this.set(t,"m")},day:function(t){return 0===arguments.length?this._day:this.set(t,"d")},date:function(t,e,r){if(!this._calendar.isValid(t,e,r))throw(u.local.invalidDate||u.regionalOptions[""].invalidDate).replace(/\{0\}/,this._calendar.local.name);return this._year=t,this._month=e,this._day=r,this},leapYear:function(){return this._calendar.leapYear(this)},epoch:function(){return this._calendar.epoch(this)},formatYear:function(){return this._calendar.formatYear(this)},monthOfYear:function(){return this._calendar.monthOfYear(this)},weekOfYear:function(){return this._calendar.weekOfYear(this)},daysInYear:function(){return this._calendar.daysInYear(this)},dayOfYear:function(){return this._calendar.dayOfYear(this)},daysInMonth:function(){return this._calendar.daysInMonth(this)},dayOfWeek:function(){return this._calendar.dayOfWeek(this)},weekDay:function(){return this._calendar.weekDay(this)},extraInfo:function(){return this._calendar.extraInfo(this)},add:function(t,e){return this._calendar.add(this,t,e)},set:function(t,e){return this._calendar.set(this,t,e)},compareTo:function(t){if(this._calendar.name!==t._calendar.name)throw(u.local.differentCalendars||u.regionalOptions[""].differentCalendars).replace(/\{0\}/,this._calendar.local.name).replace(/\{1\}/,t._calendar.local.name);var e=this._year!==t._year?this._year-t._year:this._month!==t._month?this.monthOfYear()-t.monthOfYear():this._day-t._day;return 0===e?0:e<0?-1:1},calendar:function(){return this._calendar},toJD:function(){return this._calendar.toJD(this)},fromJD:function(t){return this._calendar.fromJD(t)},toJSDate:function(){return this._calendar.toJSDate(this)},fromJSDate:function(t){return this._calendar.fromJSDate(t)},toString:function(){return(this.year()<0?"-":"")+a(Math.abs(this.year()),4)+"-"+a(this.month(),2)+"-"+a(this.day(),2)}}),l(o.prototype,{_validateLevel:0,newDate:function(t,e,r){return null==t?this.today():(t.year&&(this._validate(t,e,r,u.local.invalidDate||u.regionalOptions[""].invalidDate),r=t.day(),e=t.month(),t=t.year()),new i(this,t,e,r))},today:function(){return this.fromJSDate(new Date)},epoch:function(t){return this._validate(t,this.minMonth,this.minDay,u.local.invalidYear||u.regionalOptions[""].invalidYear).year()<0?this.local.epochs[0]:this.local.epochs[1]},formatYear:function(t){var e=this._validate(t,this.minMonth,this.minDay,u.local.invalidYear||u.regionalOptions[""].invalidYear);return(e.year()<0?"-":"")+a(Math.abs(e.year()),4)},monthsInYear:function(t){return this._validate(t,this.minMonth,this.minDay,u.local.invalidYear||u.regionalOptions[""].invalidYear),12},monthOfYear:function(t,e){var r=this._validate(t,e,this.minDay,u.local.invalidMonth||u.regionalOptions[""].invalidMonth);return(r.month()+this.monthsInYear(r)-this.firstMonth)%this.monthsInYear(r)+this.minMonth},fromMonthOfYear:function(t,e){var r=(e+this.firstMonth-2*this.minMonth)%this.monthsInYear(t)+this.minMonth;return 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arguments.length?(t.forEach(function(t,r){e[r]||(e[r]={}),a(e[r],s.PolyChart.defaultConfig()),a(e[r],t)}),this):e},t.getColorScale=function(){},n.rebind(t,r,"on"),t},s.PolyChart.defaultConfig=function(){return{data:{name:"geom1",t:[[1,2,3,4]],r:[[1,2,3,4]],dotType:"circle",dotSize:64,dotVisible:!1,barWidth:20,color:"#ffa500",strokeSize:1,strokeColor:"silver",strokeDash:"solid",opacity:1,index:0,visible:!0,visibleInLegend:!0},geometryConfig:{geometry:"LinePlot",geometryType:"arc",direction:"clockwise",orientation:0,container:"body",radialScale:null,angularScale:null,colorScale:n.scale.category20()}}},s.BarChart=function(){return s.PolyChart()},s.BarChart.defaultConfig=function(){return{geometryConfig:{geometryType:"bar"}}},s.AreaChart=function(){return s.PolyChart()},s.AreaChart.defaultConfig=function(){return{geometryConfig:{geometryType:"arc"}}},s.DotPlot=function(){return s.PolyChart()},s.DotPlot.defaultConfig=function(){return{geometryConfig:{geometryType:"dot",dotType:"circle"}}},s.LinePlot=function(){return s.PolyChart()},s.LinePlot.defaultConfig=function(){return{geometryConfig:{geometryType:"line"}}},s.Legend=function(){function t(){var r=e.legendConfig,i=e.data.map(function(t,e){return[].concat(t).map(function(t,n){var i=a({},r.elements[e]);return i.name=t,i.color=[].concat(r.elements[e].color)[n],i})}),o=n.merge(i);o=o.filter(function(t,e){return r.elements[e]&&(r.elements[e].visibleInLegend||void 0===r.elements[e].visibleInLegend)}),r.reverseOrder&&(o=o.reverse());var s=r.container;("string"==typeof s||s.nodeName)&&(s=n.select(s));var l=o.map(function(t,e){return t.color}),u=r.fontSize,c=null==r.isContinuous?"number"==typeof o[0]:r.isContinuous,h=c?r.height:u*o.length,f=s.classed("legend-group",!0),d=f.selectAll("svg").data([0]),p=d.enter().append("svg").attr({width:300,height:h+u,xmlns:"http://www.w3.org/2000/svg","xmlns:xlink":"http://www.w3.org/1999/xlink",version:"1.1"});p.append("g").classed("legend-axis",!0),p.append("g").classed("legend-marks",!0);var m=n.range(o.length),v=n.scale[c?"linear":"ordinal"]().domain(m).range(l),g=n.scale[c?"linear":"ordinal"]().domain(m)[c?"range":"rangePoints"]([0,h]),y=function(t,e){var r=3*e;return"line"===t?"M"+[[-e/2,-e/12],[e/2,-e/12],[e/2,e/12],[-e/2,e/12]]+"Z":-1!=n.svg.symbolTypes.indexOf(t)?n.svg.symbol().type(t).size(r)():n.svg.symbol().type("square").size(r)()};if(c){var b=d.select(".legend-marks").append("defs").append("linearGradient").attr({id:"grad1",x1:"0%",y1:"0%",x2:"0%",y2:"100%"}).selectAll("stop").data(l);b.enter().append("stop"),b.attr({offset:function(t,e){return e/(l.length-1)*100+"%"}}).style({"stop-color":function(t,e){return t}}),d.append("rect").classed("legend-mark",!0).attr({height:r.height,width:r.colorBandWidth,fill:"url(#grad1)"})}else{var x=d.select(".legend-marks").selectAll("path.legend-mark").data(o);x.enter().append("path").classed("legend-mark",!0),x.attr({transform:function(t,e){return"translate("+[u/2,g(e)+u/2]+")"},d:function(t,e){var r=t.symbol;return y(r,u)},fill:function(t,e){return v(e)}}),x.exit().remove()}var _=n.svg.axis().scale(g).orient("right"),w=d.select("g.legend-axis").attr({transform:"translate("+[c?r.colorBandWidth:u,u/2]+")"}).call(_);return w.selectAll(".domain").style({fill:"none",stroke:"none"}),w.selectAll("line").style({fill:"none",stroke:c?r.textColor:"none"}),w.selectAll("text").style({fill:r.textColor,"font-size":r.fontSize}).text(function(t,e){return o[e].name}),t}var e=s.Legend.defaultConfig(),r=n.dispatch("hover");return t.config=function(t){return arguments.length?(a(e,t),this):e},n.rebind(t,r,"on"),t},s.Legend.defaultConfig=function(t,e){return{data:["a","b","c"],legendConfig:{elements:[{symbol:"line",color:"red"},{symbol:"square",color:"yellow"},{symbol:"diamond",color:"limegreen"}],height:150,colorBandWidth:30,fontSize:12,container:"body",isContinuous:null,textColor:"grey",reverseOrder:!1}}},s.tooltipPanel=function(){var t,e,r,i={container:null,hasTick:!1,fontSize:12,color:"white",padding:5},o="tooltip-"+s.tooltipPanel.uid++,l=function(){t=i.container.selectAll("g."+o).data([0]);var n=t.enter().append("g").classed(o,!0).style({"pointer-events":"none",display:"none"});return r=n.append("path").style({fill:"white","fill-opacity":.9}).attr({d:"M0 0"}),e=n.append("text").attr({dx:i.padding+10,dy:.3*+i.fontSize}),l};return l.text=function(a){var o=n.hsl(i.color).l,s=o>=.5?"#aaa":"white",u=o>=.5?"black":"white",c=a||"";e.style({fill:u,"font-size":i.fontSize+"px"}).text(c);var h=i.padding,f=e.node().getBBox(),d={fill:i.color,stroke:s,"stroke-width":"2px"},p=f.width+2*h+10,m=f.height+2*h;return r.attr({d:"M"+[[10,-m/2],[10,-m/4],[i.hasTick?0:10,0],[10,m/4],[10,m/2],[p,m/2],[p,-m/2]].join("L")+"Z"}).style(d),t.attr({transform:"translate("+[10,-m/2+2*h]+")"}),t.style({display:"block"}),l},l.move=function(e){if(t)return t.attr({transform:"translate("+[e[0],e[1]]+")"}).style({display:"block"}),l},l.hide=function(){if(t)return t.style({display:"none"}),l},l.show=function(){if(t)return t.style({display:"block"}),l},l.config=function(t){return a(i,t),l},l},s.tooltipPanel.uid=1,s.adapter={},s.adapter.plotly=function(){var t={};return t.convert=function(t,e){var r={};if(t.data&&(r.data=t.data.map(function(t,r){var n=a({},t);return[[n,["marker","color"],["color"]],[n,["marker","opacity"],["opacity"]],[n,["marker","line","color"],["strokeColor"]],[n,["marker","line","dash"],["strokeDash"]],[n,["marker","line","width"],["strokeSize"]],[n,["marker","symbol"],["dotType"]],[n,["marker","size"],["dotSize"]],[n,["marker","barWidth"],["barWidth"]],[n,["line","interpolation"],["lineInterpolation"]],[n,["showlegend"],["visibleInLegend"]]].forEach(function(t,r){s.util.translator.apply(null,t.concat(e))}),e||delete n.marker,e&&delete n.groupId,e?("LinePlot"===n.geometry?(n.type="scatter",!0===n.dotVisible?(delete n.dotVisible,n.mode="lines+markers"):n.mode="lines"):"DotPlot"===n.geometry?(n.type="scatter",n.mode="markers"):"AreaChart"===n.geometry?n.type="area":"BarChart"===n.geometry&&(n.type="bar"),delete n.geometry):("scatter"===n.type?"lines"===n.mode?n.geometry="LinePlot":"markers"===n.mode?n.geometry="DotPlot":"lines+markers"===n.mode&&(n.geometry="LinePlot",n.dotVisible=!0):"area"===n.type?n.geometry="AreaChart":"bar"===n.type&&(n.geometry="BarChart"),delete n.mode,delete n.type),n}),!e&&t.layout&&"stack"===t.layout.barmode)){var i=s.util.duplicates(r.data.map(function(t,e){return t.geometry}));r.data.forEach(function(t,e){var n=i.indexOf(t.geometry);-1!=n&&(r.data[e].groupId=n)})}if(t.layout){var o=a({},t.layout);if([[o,["plot_bgcolor"],["backgroundColor"]],[o,["showlegend"],["showLegend"]],[o,["radialaxis"],["radialAxis"]],[o,["angularaxis"],["angularAxis"]],[o.angularaxis,["showline"],["gridLinesVisible"]],[o.angularaxis,["showticklabels"],["labelsVisible"]],[o.angularaxis,["nticks"],["ticksCount"]],[o.angularaxis,["tickorientation"],["tickOrientation"]],[o.angularaxis,["ticksuffix"],["ticksSuffix"]],[o.angularaxis,["range"],["domain"]],[o.angularaxis,["endpadding"],["endPadding"]],[o.radialaxis,["showline"],["gridLinesVisible"]],[o.radialaxis,["tickorientation"],["tickOrientation"]],[o.radialaxis,["ticksuffix"],["ticksSuffix"]],[o.radialaxis,["range"],["domain"]],[o.angularAxis,["showline"],["gridLinesVisible"]],[o.angularAxis,["showticklabels"],["labelsVisible"]],[o.angularAxis,["nticks"],["ticksCount"]],[o.angularAxis,["tickorientation"],["tickOrientation"]],[o.angularAxis,["ticksuffix"],["ticksSuffix"]],[o.angularAxis,["range"],["domain"]],[o.angularAxis,["endpadding"],["endPadding"]],[o.radialAxis,["showline"],["gridLinesVisible"]],[o.radialAxis,["tickorientation"],["tickOrientation"]],[o.radialAxis,["ticksuffix"],["ticksSuffix"]],[o.radialAxis,["range"],["domain"]],[o.font,["outlinecolor"],["outlineColor"]],[o.legend,["traceorder"],["reverseOrder"]],[o,["labeloffset"],["labelOffset"]],[o,["defaultcolorrange"],["defaultColorRange"]]].forEach(function(t,r){s.util.translator.apply(null,t.concat(e))}),e?(void 0!==o.tickLength&&(o.angularaxis.ticklen=o.tickLength,delete o.tickLength),o.tickColor&&(o.angularaxis.tickcolor=o.tickColor,delete o.tickColor)):(o.angularAxis&&void 0!==o.angularAxis.ticklen&&(o.tickLength=o.angularAxis.ticklen),o.angularAxis&&void 0!==o.angularAxis.tickcolor&&(o.tickColor=o.angularAxis.tickcolor)),o.legend&&"boolean"!=typeof o.legend.reverseOrder&&(o.legend.reverseOrder="normal"!=o.legend.reverseOrder),o.legend&&"boolean"==typeof o.legend.traceorder&&(o.legend.traceorder=o.legend.traceorder?"reversed":"normal",delete o.legend.reverseOrder),o.margin&&void 0!==o.margin.t){var l=["t","r","b","l","pad"],u=["top","right","bottom","left","pad"],c={};n.entries(o.margin).forEach(function(t,e){c[u[l.indexOf(t.key)]]=t.value}),o.margin=c}e&&(delete o.needsEndSpacing,delete o.minorTickColor,delete o.minorTicks,delete o.angularaxis.ticksCount,delete o.angularaxis.ticksCount,delete o.angularaxis.ticksStep,delete o.angularaxis.rewriteTicks,delete o.angularaxis.nticks,delete o.radialaxis.ticksCount,delete o.radialaxis.ticksCount,delete o.radialaxis.ticksStep,delete o.radialaxis.rewriteTicks,delete o.radialaxis.nticks),r.layout=o}return r},t}},{"../../constants/alignment":701,"../../lib":728,d3:122}],836:[function(t,e,r){"use strict";var n=t("d3"),i=t("../../lib"),a=t("../../components/color"),o=t("./micropolar"),s=t("./undo_manager"),l=i.extendDeepAll,u=e.exports={};u.framework=function(t){function e(e,i){return i&&(h=i),n.select(n.select(h).node().parentNode).selectAll(".svg-container>*:not(.chart-root)").remove(),r=r?l(r,e):e,a||(a=o.Axis()),c=o.adapter.plotly().convert(r),a.config(c).render(h),t.data=r.data,t.layout=r.layout,u.fillLayout(t),r}var r,i,a,c,h,f=new s;return e.isPolar=!0,e.svg=function(){return a.svg()},e.getConfig=function(){return r},e.getLiveConfig=function(){return o.adapter.plotly().convert(a.getLiveConfig(),!0)},e.getLiveScales=function(){return{t:a.angularScale(),r:a.radialScale()}},e.setUndoPoint=function(){var t=this,e=o.util.cloneJson(r);!function(e,r){f.add({undo:function(){r&&t(r)},redo:function(){t(e)}})}(e,i),i=o.util.cloneJson(e)},e.undo=function(){f.undo()},e.redo=function(){f.redo()},e},u.fillLayout=function(t){var e=n.select(t).selectAll(".plot-container"),r=e.selectAll(".svg-container"),i=t.framework&&t.framework.svg&&t.framework.svg(),o={width:800,height:600,paper_bgcolor:a.background,_container:e,_paperdiv:r,_paper:i};t._fullLayout=l(o,t.layout)}},{"../../components/color":604,"../../lib":728,"./micropolar":835,"./undo_manager":837,d3:122}],837:[function(t,e,r){"use strict";e.exports=function(){function t(t,e){return t?(i=!0,t[e](),i=!1,this):this}var e,r=[],n=-1,i=!1;return{add:function(t){return i?this:(r.splice(n+1,r.length-n),r.push(t),n=r.length-1,this)},setCallback:function(t){e=t},undo:function(){var i=r[n];return i?(t(i,"undo"),n-=1,e&&e(i.undo),this):this},redo:function(){var i=r[n+1];return 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n=t("../../../components/color/attributes"),i=t("./axis_attributes"),a=t("../../../plot_api/edit_types").overrideAll;e.exports=a({domain:{x:{valType:"info_array",items:[{valType:"number",min:0,max:1},{valType:"number",min:0,max:1}],dflt:[0,1]},y:{valType:"info_array",items:[{valType:"number",min:0,max:1},{valType:"number",min:0,max:1}],dflt:[0,1]}},bgcolor:{valType:"color",dflt:n.background},sum:{valType:"number",dflt:1,min:0},aaxis:i,baxis:i,caxis:i},"plot","from-root")},{"../../../components/color/attributes":603,"../../../plot_api/edit_types":756,"./axis_attributes":841}],845:[function(t,e,r){"use strict";function n(t,e){this.id=t.id,this.graphDiv=t.graphDiv,this.init(e),this.makeFramework(e)}function i(t){a.select(t).selectAll(".zoombox,.js-zoombox-backdrop,.js-zoombox-menu,.zoombox-corners").remove()}var a=t("d3"),o=t("tinycolor2"),s=t("../../plotly"),l=t("../../lib"),u=t("../../components/color"),c=t("../../components/drawing"),h=t("../cartesian/set_convert"),f=t("../../lib/extend").extendFlat,d=t("../plots"),p=t("../cartesian/axes"),m=t("../../components/dragelement"),v=t("../../components/fx"),g=t("../../components/titles"),y=t("../cartesian/select"),b=t("../cartesian/constants");e.exports=n;var x=n.prototype;x.init=function(t){this.container=t._ternarylayer,this.defs=t._defs,this.layoutId=t._uid,this.traceHash={},this.layers={}},x.plot=function(t,e){var r=this,n=e[r.id],i=e._size;r._hasClipOnAxisFalse=!1;for(var a=0;a_*b?(a=b,i=a*_):(i=y,a=i/_),o=v*i/y,s=g*a/b,r=e.l+e.w*p-i/2,n=e.t+e.h*(1-m)-a/2,l.x0=r,l.y0=n,l.w=i,l.h=a,l.sum=x,l.xaxis={type:"linear",range:[w+2*k-x,x-w-2*M],domain:[p-o/2,p+o/2],_id:"x"},h(l.xaxis,l.graphDiv._fullLayout),l.xaxis.setScale(),l.xaxis.isPtWithinRange=function(t){return t.a>=l.aaxis.range[0]&&t.a<=l.aaxis.range[1]&&t.b>=l.baxis.range[1]&&t.b<=l.baxis.range[0]&&t.c>=l.caxis.range[1]&&t.c<=l.caxis.range[0]},l.yaxis={type:"linear",range:[w,x-M-k],domain:[m-s/2,m+s/2],_id:"y"},h(l.yaxis,l.graphDiv._fullLayout),l.yaxis.setScale(),l.yaxis.isPtWithinRange=function(){return!0};var A=l.yaxis.domain[0],T=l.aaxis=f({},t.aaxis,{visible:!0,range:[w,x-M-k],side:"left",_counterangle:30,tickangle:(+t.aaxis.tickangle||0)-30,domain:[A,A+s*_],_axislayer:l.layers.aaxis,_gridlayer:l.layers.agrid,_pos:0,_id:"y",_length:i,_gridpath:"M0,0l"+a+",-"+i/2});h(T,l.graphDiv._fullLayout),T.setScale();var S=l.baxis=f({},t.baxis,{visible:!0,range:[x-w-k,M],side:"bottom",_counterangle:30,domain:l.xaxis.domain,_axislayer:l.layers.baxis,_gridlayer:l.layers.bgrid,_counteraxis:l.aaxis,_pos:0,_id:"x",_length:i,_gridpath:"M0,0l-"+i/2+",-"+a});h(S,l.graphDiv._fullLayout),S.setScale(),T._counteraxis=S;var E=l.caxis=f({},t.caxis,{visible:!0,range:[x-w-M,k],side:"right",_counterangle:30,tickangle:(+t.caxis.tickangle||0)+30,domain:[A,A+s*_],_axislayer:l.layers.caxis,_gridlayer:l.layers.cgrid,_counteraxis:l.baxis,_pos:0,_id:"y",_length:i,_gridpath:"M0,0l-"+a+","+i/2});h(E,l.graphDiv._fullLayout),E.setScale();var L="M"+r+","+(n+a)+"h"+i+"l-"+i/2+",-"+a+"Z";l.clipDef.select("path").attr("d",L),l.layers.plotbg.select("path").attr("d",L);var C="M0,"+a+"h"+i+"l-"+i/2+",-"+a+"Z";l.clipDefRelative.select("path").attr("d",C);var I="translate("+r+","+n+")";l.plotContainer.selectAll(".scatterlayer,.maplayer").attr("transform",I),l.clipDefRelative.select("path").attr("transform",null);var z="translate("+r+","+(n+a)+")";l.layers.baxis.attr("transform",z),l.layers.bgrid.attr("transform",z);var D="translate("+(r+i/2)+","+n+")rotate(30)";l.layers.aaxis.attr("transform",D),l.layers.agrid.attr("transform",D);var 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n={};n.attributes=t("./attributes"),n.supplyDefaults=t("./defaults"),n.supplyLayoutDefaults=t("./layout_defaults"),n.layoutAttributes=t("./layout_attributes"),n.calc=t("./calc"),n.plot=t("./plot"),n.style=t("./style"),n.styleOne=t("./style_one"),n.moduleType="trace",n.name="pie",n.basePlotModule=t("./base_plot"),n.categories=["pie","showLegend"],n.meta={},e.exports=n},{"./attributes":1007,"./base_plot":1008,"./calc":1009,"./defaults":1010,"./layout_attributes":1013,"./layout_defaults":1014,"./plot":1015,"./style":1016,"./style_one":1017}],1013:[function(t,e,r){"use strict";e.exports={hiddenlabels:{valType:"data_array",editType:"calc"}}},{}],1014:[function(t,e,r){"use strict";var n=t("../../lib"),i=t("./layout_attributes");e.exports=function(t,e){!function(r,a){n.coerce(t,e,i,r,a)}("hiddenlabels")}},{"../../lib":728,"./layout_attributes":1013}],1015:[function(t,e,r){"use strict";function n(t,e,r){var 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r(t,e){return t.pxmid[1]-e.pxmid[1]}function n(t,e){return e.pxmid[1]-t.pxmid[1]}var i,a,o,s,l,u,c,h,f,d,p,m,v;for(a=0;a<2;a++)for(o=a?r:n,l=a?Math.max:Math.min,c=a?1:-1,i=0;i<2;i++){for(s=i?Math.max:Math.min,u=i?1:-1,h=t[a][i],h.sort(o),f=t[1-a][i],d=f.concat(h),m=[],p=0;p0&&(t.labelExtraY=b),Array.isArray(e.pull))for(i=0;i=e.pull[o.i]||((t.pxmid[1]-o.pxmid[1])*c>0?(h=o.cyFinal+l(o.px0[1],o.px1[1]),(b=h-v-t.labelExtraY)*c>0&&(t.labelExtraY+=b)):(g+t.labelExtraY-y)*c>0&&(n=3*u*Math.abs(i-d.indexOf(t)),f=o.cxFinal+s(o.px0[0],o.px1[0]),(p=f+n-(t.cxFinal+t.pxmid[0])-t.labelExtraX)*u>0&&(t.labelExtraX+=p)))}(m[p],g)}}}function s(t,e){var r,n,i,a,o,s,l,c,h,f,d=[];for(i=0;ic&&(c=s.pull[a]);o.r=Math.min(r/u(s.tilt,Math.sin(l),s.depth),n/u(s.tilt,Math.cos(l),s.depth))/(2+2*c),o.cx=e.l+e.w*(s.domain.x[1]+s.domain.x[0])/2,o.cy=e.t+e.h*(2-s.domain.y[1]-s.domain.y[0])/2,s.scalegroup&&-1===d.indexOf(s.scalegroup)&&d.push(s.scalegroup)}for(a=0;ah.vTotal/2?1:0)}function u(t,e,r){if(!t)return 1;var n=Math.sin(t*Math.PI/180);return Math.max(.01,r*n*Math.abs(e)+2*Math.sqrt(1-n*n*e*e))}var c=t("d3"),h=t("../../components/fx"),f=t("../../components/color"),d=t("../../components/drawing"),p=t("../../lib/svg_text_utils"),m=t("./helpers");e.exports=function(t,e){var r=t._fullLayout;s(e,r._size);var u=r._pielayer.selectAll("g.trace").data(e);u.enter().append("g").attr({"stroke-linejoin":"round",class:"trace"}),u.exit().remove(),u.order(),u.each(function(e){var s=c.select(this),u=e[0],v=u.trace,g=(v.depth||0)*u.r*Math.sin(0)/2,y=v.tiltaxis||0,b=y*Math.PI/180,x=[g*Math.sin(b),g*Math.cos(b)],_=u.r*Math.cos(0),w=s.selectAll("g.part").data(v.tilt?["top","sides"]:["top"]);w.enter().append("g").attr("class",function(t){return t+" part"}),w.exit().remove(),w.order(),l(e),s.selectAll(".top").each(function(){var s=c.select(this).selectAll("g.slice").data(e);s.enter().append("g").classed("slice",!0),s.exit().remove();var l=[[[],[]],[[],[]]],g=!1;s.each(function(e){function o(n){n.originalEvent=c.event;var a=t._fullLayout,o=t._fullData[v.index],s=h.castHoverinfo(o,a,e.i);if("all"===s&&(s="label+text+value+percent+name"),t._dragging||!1===a.hovermode||"none"===s||"skip"===s||!s)return void h.hover(t,n,"pie");var l=i(e,u),f=w+e.pxmid[0]*(1-l),d=M+e.pxmid[1]*(1-l),p=r.separators,g=[];-1!==s.indexOf("label")&&g.push(e.label),-1!==s.indexOf("text")&&(o.hovertext?g.push(Array.isArray(o.hovertext)?o.hovertext[e.i]:o.hovertext):o.text&&o.text[e.i]&&g.push(o.text[e.i])),-1!==s.indexOf("value")&&g.push(m.formatPieValue(e.v,p)),-1!==s.indexOf("percent")&&g.push(m.formatPiePercent(e.v/u.vTotal,p)),h.loneHover({x0:f-l*u.r,x1:f+l*u.r,y:d,text:g.join("
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w=u.cx+x[0],M=u.cy+x[1],k=c.select(this),A=k.selectAll("path.surface").data([e]),T=!1;if(A.enter().append("path").classed("surface",!0).style({"pointer-events":"all"}),k.select("path.textline").remove(),k.on("mouseover",o).on("mouseout",s).on("click",f),v.pull){var S=+(Array.isArray(v.pull)?v.pull[e.i]:v.pull)||0;S>0&&(w+=S*e.pxmid[0],M+=S*e.pxmid[1])}e.cxFinal=w,e.cyFinal=M;var E=v.hole;if(e.v===u.vTotal){var L="M"+(w+e.px0[0])+","+(M+e.px0[1])+b(e.px0,e.pxmid,!0,1)+b(e.pxmid,e.px0,!0,1)+"Z";E?A.attr("d","M"+(w+E*e.px0[0])+","+(M+E*e.px0[1])+b(e.px0,e.pxmid,!1,E)+b(e.pxmid,e.px0,!1,E)+"Z"+L):A.attr("d",L)}else{var C=b(e.px0,e.px1,!0,1);if(E){var I=1-E;A.attr("d","M"+(w+E*e.px1[0])+","+(M+E*e.px1[1])+b(e.px1,e.px0,!1,E)+"l"+I*e.px0[0]+","+I*e.px0[1]+C+"Z")}else A.attr("d","M"+w+","+M+"l"+e.px0[0]+","+e.px0[1]+C+"Z")}var z=Array.isArray(v.textposition)?v.textposition[e.i]:v.textposition,D=k.selectAll("g.slicetext").data(e.text&&"none"!==z?[0]:[]);D.enter().append("g").classed("slicetext",!0),D.exit().remove(),D.each(function(){var r=c.select(this).selectAll("text").data([0]);r.enter().append("text").attr("data-notex",1),r.exit().remove(),r.text(e.text).attr({class:"slicetext",transform:"","text-anchor":"middle"}).call(d.font,"outside"===z?v.outsidetextfont:v.insidetextfont).call(p.convertToTspans,t);var i,o=d.bBox(r.node());"outside"===z?i=a(o,e):(i=n(o,e,u),"auto"===z&&i.scale<1&&(r.call(d.font,v.outsidetextfont),v.outsidetextfont.family===v.insidetextfont.family&&v.outsidetextfont.size===v.insidetextfont.size||(o=d.bBox(r.node())),i=a(o,e)));var s=w+e.pxmid[0]*i.rCenter+(i.x||0),l=M+e.pxmid[1]*i.rCenter+(i.y||0);i.outside&&(e.yLabelMin=l-o.height/2,e.yLabelMid=l,e.yLabelMax=l+o.height/2,e.labelExtraX=0,e.labelExtraY=0,g=!0),r.attr("transform","translate("+s+","+l+")"+(i.scale<1?"scale("+i.scale+")":"")+(i.rotate?"rotate("+i.rotate+")":"")+"translate("+-(o.left+o.right)/2+","+-(o.top+o.bottom)/2+")")})}),g&&o(l,v),s.each(function(t){if(t.labelExtraX||t.labelExtraY){var e=c.select(this),r=e.select("g.slicetext text");r.attr("transform","translate("+t.labelExtraX+","+t.labelExtraY+")"+r.attr("transform"));var n=t.cxFinal+t.pxmid[0],i=t.cyFinal+t.pxmid[1],a="M"+n+","+i,o=(t.yLabelMax-t.yLabelMin)*(t.pxmid[0]<0?-1:1)/4;if(t.labelExtraX){var s=t.labelExtraX*t.pxmid[1]/t.pxmid[0],l=t.yLabelMid+t.labelExtraY-(t.cyFinal+t.pxmid[1]);Math.abs(s)>Math.abs(l)?a+="l"+l*t.pxmid[0]/t.pxmid[1]+","+l+"H"+(n+t.labelExtraX+o):a+="l"+t.labelExtraX+","+s+"v"+(l-s)+"h"+o}else a+="V"+(t.yLabelMid+t.labelExtraY)+"h"+o;e.append("path").classed("textline",!0).call(f.stroke,v.outsidetextfont.color).attr({"stroke-width":Math.min(2,v.outsidetextfont.size/8),d:a,fill:"none"})}})})}),setTimeout(function(){u.selectAll("tspan").each(function(){var t=c.select(this);t.attr("dy")&&t.attr("dy",t.attr("dy"))})},0)}},{"../../components/color":604,"../../components/drawing":628,"../../components/fx":645,"../../lib/svg_text_utils":750,"./helpers":1011,d3:122}],1016:[function(t,e,r){"use strict";var n=t("d3"),i=t("./style_one");e.exports=function(t){t._fullLayout._pielayer.selectAll(".trace").each(function(t){var e=t[0],r=e.trace,a=n.select(this);a.style({opacity:r.opacity}),a.selectAll(".top path.surface").each(function(t){n.select(this).call(i,t,r)})})}},{"./style_one":1017,d3:122}],1017:[function(t,e,r){"use strict";var n=t("../../components/color");e.exports=function(t,e,r){var i=r.marker.line.color;Array.isArray(i)&&(i=i[e.i]||n.defaultLine);var a=r.marker.line.width||0;Array.isArray(a)&&(a=a[e.i]||0),t.style({"stroke-width":a}).call(n.fill,e.color).call(n.stroke,i)}},{"../../components/color":604}],1018:[function(t,e,r){"use strict";var n=t("../scattergl/attributes");e.exports={x:n.x,y:n.y,xy:{valType:"data_array",editType:"calc"},indices:{valType:"data_array",editType:"calc"},xbounds:{valType:"data_array",editType:"calc"},ybounds:{valType:"data_array",editType:"calc"},text:n.text,marker:{color:{valType:"color",arrayOk:!1,editType:"calc"},opacity:{valType:"number",min:0,max:1,dflt:1,arrayOk:!1,editType:"calc"},blend:{valType:"boolean",dflt:null,editType:"calc"},sizemin:{valType:"number",min:.1,max:2,dflt:.5,editType:"calc"},sizemax:{valType:"number",min:.1,dflt:20,editType:"calc"},border:{color:{valType:"color",arrayOk:!1,editType:"calc"},arearatio:{valType:"number",min:0,max:1,dflt:0,editType:"calc"},editType:"calc"},editType:"calc"}}},{"../scattergl/attributes":1077}],1019:[function(t,e,r){"use strict";function n(t,e){this.scene=t,this.uid=e,this.type="pointcloud",this.pickXData=[],this.pickYData=[],this.xData=[],this.yData=[],this.textLabels=[],this.color="rgb(0, 0, 0)",this.name="",this.hoverinfo="all",this.idToIndex=new Int32Array(0),this.bounds=[0,0,0,0],this.pointcloudOptions={positions:new Float32Array(0),idToIndex:this.idToIndex,sizemin:.5,sizemax:12,color:[0,0,0,1],areaRatio:1,borderColor:[0,0,0,1]},this.pointcloud=a(t.glplot,this.pointcloudOptions),this.pointcloud._trace=this}function i(t,e){var r=new n(t,e.uid);return r.update(e),r}var a=t("gl-pointcloud2d"),o=t("../../lib/str2rgbarray"),s=t("../scatter/get_trace_color"),l=["xaxis","yaxis"],u=n.prototype;u.handlePick=function(t){var e=this.idToIndex[t.pointId];return{trace:this,dataCoord:t.dataCoord,traceCoord:this.pickXYData?[this.pickXYData[2*e],this.pickXYData[2*e+1]]:[this.pickXData[e],this.pickYData[e]],textLabel:Array.isArray(this.textLabels)?this.textLabels[e]:this.textLabels,color:this.color,name:this.name,pointIndex:e,hoverinfo:this.hoverinfo}},u.update=function(t){this.index=t.index,this.textLabels=t.text,this.name=t.name,this.hoverinfo=t.hoverinfo,this.bounds=[1/0,1/0,-1/0,-1/0],this.updateFast(t),this.color=s(t,{})},u.updateFast=function(t){var e,r,n,i,a,s,l=this.xData=this.pickXData=t.x,u=this.yData=this.pickYData=t.y,c=this.pickXYData=t.xy,h=t.xbounds&&t.ybounds,f=t.indices,d=this.bounds;if(c){if(n=c,e=c.length>>>1,h)d[0]=t.xbounds[0],d[2]=t.xbounds[1],d[1]=t.ybounds[0],d[3]=t.ybounds[1];else for(s=0;sd[2]&&(d[2]=i),ad[3]&&(d[3]=a);if(f)r=f;else for(r=new Int32Array(e),s=0;sd[2]&&(d[2]=i),ad[3]&&(d[3]=a);this.idToIndex=r,this.pointcloudOptions.idToIndex=r,this.pointcloudOptions.positions=n;var p=o(t.marker.color),m=o(t.marker.border.color),v=t.opacity*t.marker.opacity;p[3]*=v,this.pointcloudOptions.color=p;var g=t.marker.blend;if(null===g){g=l.length<100||u.length<100}this.pointcloudOptions.blend=g,m[3]*=v,this.pointcloudOptions.borderColor=m;var y=t.marker.sizemin,b=Math.max(t.marker.sizemax,t.marker.sizemin);this.pointcloudOptions.sizeMin=y,this.pointcloudOptions.sizeMax=b,this.pointcloudOptions.areaRatio=t.marker.border.arearatio,this.pointcloud.update(this.pointcloudOptions),this.expandAxesFast(d,b/2)},u.expandAxesFast=function(t,e){for(var r,n,i,a=e||.5,o=0;o<2;o++)r=this.scene[l[o]],n=r._min,n||(n=[]),n.push({val:t[o],pad:a}),i=r._max,i||(i=[]),i.push({val:t[o+2],pad:a})},u.dispose=function(){this.pointcloud.dispose()},e.exports=i},{"../../lib/str2rgbarray":749,"../scatter/get_trace_color":1040,"gl-pointcloud2d":230}],1020:[function(t,e,r){"use strict";var n=t("../../lib"),i=t("./attributes");e.exports=function(t,e,r){function a(r,a){return n.coerce(t,e,i,r,a)}a("x"),a("y"),a("xbounds"),a("ybounds"),t.xy&&t.xy instanceof Float32Array&&(e.xy=t.xy),t.indices&&t.indices instanceof Int32Array&&(e.indices=t.indices),a("text"),a("marker.color",r),a("marker.opacity"),a("marker.blend"),a("marker.sizemin"),a("marker.sizemax"),a("marker.border.color",r),a("marker.border.arearatio")}},{"../../lib":728,"./attributes":1018}],1021:[function(t,e,r){"use strict";var n={};n.attributes=t("./attributes"),n.supplyDefaults=t("./defaults"),n.calc=t("../scatter3d/calc"),n.plot=t("./convert"),n.moduleType="trace",n.name="pointcloud",n.basePlotModule=t("../../plots/gl2d"),n.categories=["gl2d","showLegend"],n.meta={},e.exports=n},{"../../plots/gl2d":808,"../scatter3d/calc":1056,"./attributes":1018,"./convert":1019,"./defaults":1020}],1022:[function(t,e,r){"use strict";var n=t("../../plots/font_attributes"),i=t("../../plots/attributes"),a=t("../../components/color/attributes"),o=t("../../components/fx/attributes"),s=t("../../lib/extend").extendFlat,l=t("../../plot_api/edit_types").overrideAll;e.exports=l({hoverinfo:s({},i.hoverinfo,{flags:["label","text","value","percent","name"]}),hoverlabel:o.hoverlabel,domain:{x:{valType:"info_array",items:[{valType:"number",min:0,max:1},{valType:"number",min:0,max:1}],dflt:[0,1]},y:{valType:"info_array",items:[{valType:"number",min:0,max:1},{valType:"number",min:0,max:1}],dflt:[0,1]}},orientation:{valType:"enumerated",values:["v","h"],dflt:"h"},valueformat:{valType:"string",dflt:".3s"},valuesuffix:{valType:"string",dflt:""},arrangement:{valType:"enumerated",values:["snap","perpendicular","freeform","fixed"],dflt:"snap"},textfont:n({}),node:{label:{valType:"data_array",dflt:[]},color:{valType:"color",arrayOk:!0},line:{color:{valType:"color",dflt:a.defaultLine,arrayOk:!0},width:{valType:"number",min:0,dflt:.5,arrayOk:!0}},pad:{valType:"number",arrayOk:!1,min:0,dflt:20},thickness:{valType:"number",arrayOk:!1,min:1,dflt:20}},link:{label:{valType:"data_array",dflt:[]},color:{valType:"color",arrayOk:!0},line:{color:{valType:"color",dflt:a.defaultLine,arrayOk:!0},width:{valType:"number",min:0,dflt:0,arrayOk:!0}},source:{valType:"data_array",dflt:[]},target:{valType:"data_array",dflt:[]},value:{valType:"data_array",dflt:[]}}},"calc","nested")},{"../../components/color/attributes":603,"../../components/fx/attributes":637,"../../lib/extend":717,"../../plot_api/edit_types":756,"../../plots/attributes":770,"../../plots/font_attributes":796}],1023:[function(t,e,r){"use strict";var n=t("../../plot_api/edit_types").overrideAll,i=t("../../plots/plots"),a=t("./plot"),o=t("../../components/fx/layout_attributes");r.name="sankey",r.attr="type",r.baseLayoutAttrOverrides=n({hoverlabel:o.hoverlabel},"plot","nested"),r.plot=function(t){var e=i.getSubplotCalcData(t.calcdata,"sankey","sankey");e.length&&a(t,e)},r.clean=function(t,e,r,n){var i=n._has&&n._has("sankey"),a=e._has&&e._has("sankey");i&&!a&&n._paperdiv.selectAll(".sankey").remove()}},{"../../components/fx/layout_attributes":646,"../../plot_api/edit_types":756,"../../plots/plots":831,"./plot":1028}],1024:[function(t,e,r){"use strict";function n(t,e,r){for(var n=t.map(function(){return[]}),a=0;a1})}var i=t("strongly-connected-components"),a=t("../../lib");e.exports=function(t,e){return n(e.node.label,e.link.source,e.link.target)&&(a.error("Circularity is present in the Sankey data. 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n=t("../../components/colorscale/has_colorscale"),i=t("../../components/colorscale/calc"),a=t("./subtypes");e.exports=function(t){a.hasLines(t)&&n(t,"line")&&i(t,t.line.color,"line","c"),a.hasMarkers(t)&&(n(t,"marker")&&i(t,t.marker.color,"marker","c"),n(t,"marker.line")&&i(t,t.marker.line.color,"marker.line","c"))}},{"../../components/colorscale/calc":610,"../../components/colorscale/has_colorscale":617,"./subtypes":1052}],1036:[function(t,e,r){"use strict";e.exports={PTS_LINESONLY:20,minTolerance:.2,toleranceGrowth:10,maxScreensAway:20}},{}],1037:[function(t,e,r){"use strict";var n=t("../../lib"),i=t("./attributes"),a=t("./constants"),o=t("./subtypes"),s=t("./xy_defaults"),l=t("./marker_defaults"),u=t("./line_defaults"),c=t("./line_shape_defaults"),h=t("./text_defaults"),f=t("./fillcolor_defaults"),d=t("../../components/errorbars/defaults");e.exports=function(t,e,r,p){function m(r,a){return n.coerce(t,e,i,r,a)}var 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block css %} diff --git a/wqflask/wqflask/templates/reference.html b/wqflask/wqflask/templates/reference.html index cc4408e1..49ccd48c 100644 --- a/wqflask/wqflask/templates/reference.html +++ b/wqflask/wqflask/templates/reference.html @@ -2,16 +2,7 @@ {% block title %}References{% endblock %} {% block content %} - - - -
- - - - - -
- -

Papers and References to GeneNetwork

+

Papers and References to GeneNetwork

@@ -23,6 +14,13 @@

+2017 | +2016 | +2015 | +2014 | +2013 | +2012 | +2011 | 2010 | 2009 | 2008 | @@ -41,160 +39,189 @@ Highlighted References
-Please send us citations to articles that we may have missed. +Please send us citations to articles that we may have missed. + +
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+ Google Scholar search for "genenetwork" OR "webqtl" (1430 hits as of September 8, 2016, 1730 as of Oct 18, 2017). + + +
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  1. Mulligan MK, Mozhui K, Prins P, Williams RW (2017) GeneNetwork: A Toolbox for Systems Genetics. In Systems Genetics, Methods in Molecular Biology 1488:75-120 +[An updated primer in using GeneNetwork for molecular analysis of mouse and human cohorts.] +PDF version +

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  2. -Rietman ML, Sommeijer JP; Neuro-Bsik Mouse Phenomics Consortium, Levelt CN, Heimel JA (2012) Candidate genes in ocular dominance plasticity. Front Neurosci 6:11 -
    -From the Abstract: Many studies have been devoted to the identification of genes involved in experience-dependent plasticity in the visual cortex. To discover new candidate genes, we have reexamined data from one such study on ocular dominance (OD) plasticity in recombinant inbred BXD mouse strains. We have correlated the level of plasticity with the gene expression data in the neocortex that have become available for these same strains. PDF version +
  3. Williams RW, Williams EG (2017) Resources for Systems Genetics. In Systems Genetics, Methods in Molecular Biology 1488:3-29. +[This review is intended to help you when making the hard choices about types of resources to use in system genetic studies. The short answer: embrace diversity in your resources. The computational barriers to joint analysis are now minimal.] +PDF version +
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  4. Williams RW (2009) Herding cats: the sociology of data integration. Frontier in Neuroscience 3(2):154-6. +[An short but amusing commentary on predictive (someday perhaps even precision) medicine and how to get there using genetic reference populations such as the BXD and Collaborative Cross families.] +PDF version +

  5. -Moscou MJ, Lauter N, Steffenson B, Wise RP (2011) Quantitative and qualitative stem rust resistance factors in barley are associated with transcriptional suppression of defense regulons. PLoS Genet 7:e1002208 -
    PDF version +Pinelli M, Carissimo A, Cutillo L, Lai CH, Mutarelli M, Moretti MN, Singh MV, Karali M, Carrella D, Pizzo M, Russo F, Ferrari S, Ponzin D, Angelini C, Banfi S, di Bernardo D (2016) An atlas of gene expression and gene co-regulation in the human retina.Nucleic Acids Res. 2016 Jul 8;44(12):5773-84 +RETINA database, and see the PDF. These data are now in GeneNetwork (Species = Human, Group = Retina). +

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  6. -Krebs J, Römer B, Overall RW, Fabel K, Babu H, Brandt MD, Williams RW, Jessberger S, Kempermann G (2011) Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: II. Genetic covariation and identification of Nos1 as linking candidate gene. Front Neurosci 5:106 -
    -This study uses QTL mapping methods to define candidate genes, including NOS1, that may modulate both adult neurogenesis in the hippocampus and the volume of the infrapyramidal mossy fiber projection to CA3. The study also tests whether the genetic basis of variation in adult neurogenesis is linked to variation in the size of the mossy fiber projection to basal dendrites of CA3 pyramidal cells. PDF version +Williams EG, Wu Y, Pooja J, Dubuis S, Blattmann P, Argmann CA, Houten SM, Amariuta T, Wolski W, Zamboni N, Aebersold R, Auwerx J (2016) Systems proteomics and trans-omic integration illuminate new mechanisms in mitochondrial function. Science 352(6291):aad0189 +HTML version, PDF -

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  7. -Alberts R, Chen H, Pommerenke C, Smit AB, Spijker S, Williams RW, Geffers R, Bruder D, Schughart K (2011) Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease. BMC Genomics 12:610. -
    -The first genetic analysis, as well as comparative analysis, of variation in gene expression in T cell subclasses. Please reference this paper when making use of the BXD T help and T regulatory cell data sets generated by Alberts, Schughart and colleagues. + +
  8. +Sloan Z, Arends D, Broman KW, Centeno A, Furlotte N, Nijveen H, Yan L, Zhou X, Williams RW, Prins P (2016) GenetNetwork: framework for web-based genetics. The Journal of Open Source Software http://joss.theoj.org/papers/10.21105/joss.00025 (http://dx.doi.org/10.21105/joss.00025) +HTML version +
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  9. Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC (2016) MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. Neurotoxicology in press +PDF version +

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  10. -Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J (2011) NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell 147:827-39 +
  11. Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, Jordan SD, Quiros PM, Steffen KK, Williams EG, Mouchiroud L, Tronnes SU, Murillo V, Wolff SC, Shaw RJ, Auwerx J, Dillin A (2016) Two conserved histone demethylases regulate mitochondrial stress-induced longevity. Cell 165:1209-1223 +
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    -A high impact article on the role of the Ncor1 gene and a high endurance mouse model (see MedKB). The authors made use of expression data sets in GeneNetwork (see Fig 2 and original data from BXD Lung by Alberts et al. (2011), and BH/HB F2 muscle by Lusis and colleagues). +
  12. Wang X, Pandey AK, Mulligan MK, Williams EG, Mozhui K, Li Z, Jovaisaite V, Quarles LD, Xiao Z, Huang J, Capra JA, Chen Z, Taylor WL, Bastarache L, Niu X, Pollard KS, Ciobanu DC, Reznik AO, Tishkov AV, Zhulin IB, Peng J, Nelson SF, Denny JC, Auwerx J, Lu L, Williams RW (2016). Joint mouse-human phenome-wide association to test gene function and disease risk. Nature Communications 7:10464 +[Best reference on the BXD family of strains and the wide range of phenotypes that have been generated over the past 40 years.] + +PDF version and the + +Supplementary Tables in one Excel file

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  13. -Suwanwela J, Farber CR, Haung B, Song B, Pan C, Lyon KM, Lusis AJ (2011) Systems genetics analysis of mouse chondrocyte differentiation. Journal of Bone and Mineral Research 26:74-760 -PDF version +
  14. Xue Y, Li J, Yan L, Lu L, Liao FF (2015) Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. Behav Brain Res 292:83-94 +
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  15. Chaum E, Winborn CS, Bhattacharya S (2015) Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. Mamm Genome 26:210-221 +
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    -The first analysis of variation in gene expression in cartilage of both the BXD and BXH mouse strain families. These data are now part of GeneNetwork: see UCLA BXD and BXH Cartilage Illumina WG-6 v2. -     +
  16. Cheng Q, Seltzer Z, Sima C, Lakschevitz FS, Glogauer M. (2015) Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. PLoS One 10:e0124117

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  17. Scott RE, Ghule PN, Stein JL, Stein GS (2015) Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis. J Cell Physiol 230:2533-42 +
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  18. -Jansen R, Timmerman J, Loos M, Spijker S, van Ooyen A, Brussaard AB, Mansvelder HD, The Neuro-Bsik Mouse Phenomics Consortium; Smit AB, de Gunst M, Linkenhaer-Hansen K (2011) Novel candidate genes associated with hippocampal oscillations. PLoS One 6: e26586. -HTML and PDF versions +
  19. Williams EG, Auwerx J (2015) The convergence of systems and reductionist approaches in complex trait analysis. Cell 162:23-32.

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  20. -Jackson KJ, Chen X, Miles MF, Harenza J, Damaj MI (2011) The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence. Neuropsychopharmacology 36:2339-2348. -PDF version +
  21. Wu Y, Williams EG, Dubuis S, Mottis A, Jovaisaite V, Houten SM, Argmann CA, Faridi P, Wolski W, Kutalik Z, Zamboni N, Auwerx J, Aebersold R (2014) Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. Cell 158:1415-1430

  22. -Krebs J, Römer D, Overall RW, Fabel K. Babu H, Brandt M, Williams RW, Jessberger S, Kempermann G (2011) Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: II. Genetic covariance and identification of Nos1 as a linking candidate gene. Frontiers in Neuroscience 5:106. -PDF version +Hayes SK, Hager R, Grencis RK (2014) Sex-dependent genetics effects on immune responses to parasitic nematodes. BMC Genomics 15:193

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  23. -Mozhui K, Wang X, Chen J, Mulligan MK, Li Z, Ingles J, Chen X, Lu L and Williams RW (2011) Genetic regulation of Nrxn1 expression: an integrative cross-species analysis of schizophrenia candidate genes. Transl Psychiatry 1: e25; doi:10.1038/tp.2011.24. -PDF version +
  24. Harenza JL, Muldoon PP, De Biasi M, Damaj MI, Miles MF (2014) Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. Genes Brain Behav 13:213-225

  25. -Freeman NE, Templeton JP, Orr WE, Lu L, Williams RW, Geisert EE (2011) Genetic networks in the mouse retina: Growth Associated Protein 43 and Phosphate Tensin Homology network. Molecular Vision 17:1355-1372. -Full Text HTML and PDF versions -
    - -The first expression genetic analysis of the BXD mouse retina based on a total of 80 strains of mice: The HEI Retina Illumina V6.2 (April 2010) RankInv database in GeneNetwork. This is a companion study to Geisert and colleagues (2009), but now instead of an analysis of the entire eye, data were generated exclusively for the retina. - +Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B, Blakely RD (2014) Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain Behav. 13:247-260

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  26. -Di Curzio DL, Goldowitz D (2011) The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice. Mammalian Genome 22:209–234 Full Text PDF version - -
    -The ultimate histogenetics paper on the adrenal gland of mice. A very high level of variation was pared into a set of strong QTLs using 64 of the BXD strains. Precision of most loci is under +/- 2.5 Mb. - +Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, Auwerx J (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497:451-457 PDF version

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  27. -Porcu P, O'Buckley TK, Song SC, Harenza JL, Lu L, Wang X, Williams RW, Miles MF, Morrow AL (2010) Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: Identification of QTLs and downstream gene regulation. PLoS One 6:e18405. Full Text HTML and PDF versions +
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-The first neurogenetic study of deoxycorticosterone, a neuroactive steroid that has a key role in stress biology. Porcu and colleagues detected strong QTLs on Chr 4 and 14 for deoxycorticosterone levels in the brain and circulation. - -
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  • -Alberts R, Schughart K (2010) QTLminer: identifying genes regulating quantitative traits.Full Text PDF version -
    -Innovative new software to help analyze QTL intervals that is currently available at http://genenetwork.helmholtz-hzi.de/ under the Search menu. - -
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  • -Lynch RM, Naswa S, Rogers Jr GL, Kanla SA, Das S, Chesler EJ, Saxton AM, Langston MA, Voy, BH (2010) Identifying genetic loci and spleen gene coexpression networks underlying immunophenotypes in the BXD recombinant inbred mice. Physiological Genomics 41: 244-253 Full Text PDF version -
    -Please cite this publication if you make use of the mouse BXD strain UTK spleen expression databases generated by Voy and colleagues. - -
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  • -Gerrits A, Li Y, Tesson BM, Bystrykh LV, Weersing E, Ausema A, Dontje B, Wang X, Breitling R, Jansen RC, de Haan G (2009) Expression quantitative trait loci are highly sensitive to cellular differentiation state. PLoS Genetics 5: e1000692 Full Text HTML version and -PDF Version +
    + Key References +
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    The first section lists key technical papers that are appropriate references when citing GeneNetwork and WebQTL. The second section lists publications and other resources that have made use of GeneNetwork.

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    -Please cite this publication if you make use of any of the hematopoietic stem cell-associated databases for the BXD strains generated by Gerald de Haan and colleagues. +

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    1. Mulligan MK, Mozhui K, Prins P, Williams RW (2016) GeneNetwork – A toolbox for systems genetics. In Systems Genetics, Methods in Molecular Biology; Schughart K, Williams RW eds.; Humana Press, in press +[This is a currently the most comprehensive protocol and guide (20 Mb) for GeneNetwork.] +PDF version + + +
    2. +Williams RW, Mulligan MK (2012) Genetic and molecular network analysis of behavior. Int Rev Neurobiol. 104:135-57. [Explains the use of GeneNetwork in behavioral neurogenetics] +PDF version -
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    3. Williams EG, Auwerx J (2015) The convergence of systems and reductionist approaches in complex trait analysis. Cell 162:23-32. [Research into the genetic and environmental factors behind complex trait variation has traditionally been segregated into distinct scientific camps. The reductionist approach aims to decrypt phenotypic variability bit by bit, founded on the underlying hypothesis that genome-to-phenome relations are largely constructed from the additive effects of their molecular players. In contrast, the systems approach aims to examine large-scale interactions of many components simultaneously, on the premise that interactions in gene networks can be both linear and non-linear. Both approaches are complementary, and they are becoming increasingly intertwined due to developments in gene editing tools, omics technologies, and population resources. Together, these strategies are beginning to drive the next era in complex trait research, paving the way to improve agriculture and toward more personalized medicine.] PDF version + + +
    4. +Wang J, Williams RW, Manly KF (2003) WebQTL: Web-based complex trait analysis. Neuroinformatics 1: 299-308 Full Text PDF Version. [A good technical reference to WebQTL and GeneNetwork] +
    5. +Williams RW, Gu J, Qi S, Lu L (2003) The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biology 2(11)Full Text Version. [A detailed analysis of the genetics of recombinant inbred strains] +
    6. +Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW (2003) Genetic correlates of gene expression in recombinant inbred strains: a relational model to explore for neurobehavioral phenotypes. Neuroinformatics 1: 343-357. Full Text PDF Version. [Best reference regarding interpretation of genetic correlations.] +
    7. +Chesler EJ, Lu L, Wang J, Williams RW, Manly KF (2004) WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nature Neuroscience 7: 485-486. Full Text PDF Version [A short review] +
    8. +Chesler EJ, Williams RW (2004) Brain gene expression: genomics and genetics. International Review of Neurobiology 60:59-95. (DNA Arrays in Neurobiology, edited by MF Miles, Elsevier, Amsterdam). [A longer discussion, both statistical and conceptual, on the genetic analysis of gene expression and relations to higher order behavioral phenotypes] +
    9. +Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke M, de Haan G (2005) Uncovering regulatory pathways affecting hematopoietic stem cell function using "genetical genomics." Nature Genetics 37:225-232. [Please cite this article if you have used the GNF-Groningen hematopoietic stem cell data set.] +
    10. +Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin N, Langston MA, Threadgill DW, Manly KF, Williams RW (2005) Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nature Genetics 37: 233-242. [Please cite this article if you have used one of the UTHSC brain data sets.] +
    11. +Damerval C, Maurice A, Josse JM, de Vienne D (1994) Quantitative trait loci underlying gene product variation: a novel perspective for analyzing regulation of genome expression. Genetics 137: 289-301 Full Text PDF Version [The first published paper on system genetics. Impressive; before its time.] + +
      [Damerval et al., 1994 abstract] A methodology to dissect the genetic architecture of quantitative variation of numerous gene products simultaneously is proposed. For each individual of a segregating progeny, proteins extracted from a given organ are separated using two-dimensional electrophoresis, and their amounts are estimated with a computer-assisted system for spot quantification. Provided a complete genetic map is available, statistical procedures allow determination of the number, effects and chromosomal locations of factors controlling the amounts of individual proteins. This approach was applied to anonymous proteins of etiolated coleoptiles of maize, in an F(2) progeny between two distant lines. The genetic map included both restriction fragment length polymorphism and protein markers. Minimum estimates of one to five unlinked regulatory factors were found for 42 of the 72 proteins analyzed, with a large diversity of effects. Dominance and epistasis interactions were involved in the control of 38% and 14% of the 72 proteins, respectively. Such a methodology might help understanding the architecture of regulatory networks and the possible adaptive or phenotypic significance of the polymorphism of the genes involved. +
    12. Grisham W, Schottler NA, Valli-Marill J, Beck L, Beatty J (2010) Teaching bioinformatics and neuroinformatics by using free web-based tools. CBE--Life Sciences Education 9: 98-107 Full Text PDF Version @@ -206,257 +233,289 @@ Grisham W, Schottler NA, Valli-Marill J, Beck L, Beatty J (Part 3
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    13. -Li D, Mulligan MK, Wang X, Miles MF, Lu L, Williams RW (2010) A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice. PLoS One. 2010 Aug 17;5(8):e12181. Full Text HTML and PDF Versions -
      -One of the first examples of a sequence variant, in this case a transponson inserted in the 3' UTR of Comt,, that generates both a strong expression QTL and that generates downstream changes in other genes and higher order phenotypes. - -
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    14. Grisham W (2009) Modular digitial course in undergraduate neuroscience education (MDCUNE): A website offering free digital tools for neuroscience educators. Journal of Undergraduate Neuroscience Education 8:A26-A31 Full Text PDF Version
      An excellent example of how resources such as GeneNetwork and the Mouse Brain Library can be used in class room labs. -
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    15. -Webster JA, Gibbs JR, Clarke J, Ray M, Zhang W, Holmans P, Rohrer K, Zhao A, Marlowe L, Kaleem M, McCorquodale DS 3rd, Cuello C, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV; NACC-Neuropathology Group, Heward CB, Reiman EM, Stephan D, Hardy J, Myers AJ (2009) Genetic control of human brain transcript expression in Alzheimer disease. Am J Hum Genet 84:445-58. -
      -One of the first and certainly best human brain eQTL studies. The focus in on late onset Alzheimer's disease, but the data are split between normal and AD cases. All of these data are in GeneNetwork. The cases can be "decoded" by their identifier numbers (see INFO files). - -
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      - +Hübner N, Wallace CA, Zimdahl H, Petretto E, Schulz H, Maciver F, Mueller M, Hummel O, Monti J, Zidek V, Musilova A, Kren V, Causton H, Game L, Born G, Schmidt S, Muller A, Cook SA, Kurtz TW, Whittaker J, Pravenec M, Aitman TJ (2005) Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nature Genetics 37: 243-253. [Please cite this article if you have used one of the rat HXB kidney or peritoneal fat data sets.]
    16. -Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I (2009) Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mamm Genome 20:437-46. -
      -A extremely interesting comparison of using and combining data sets for common inbred strains (so-called Mouse Diversity Panels) with data sets for recombinant inbred strains such as the BXD set. - -
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      - +Kang HM, Ye C, Eskin E (2008) Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots. Genetics 180:1909-1925 +Full Text PDF Version. [An important method that can greatly improve the ability to resolve true genetic interactions in expression genetic studies.]
    17. -Ruden DM, Chen L, Possidente D, Possidente B, Rasouli P, Wang L, Lu X, Garfinkel MD, Hirsch HV, Page GP (2009) Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead. Neurotoxicology 30:898-914 -
      -A landmark study in toxicogenomics using a drosophila genetic reference populations. - -
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      - - +Ljungberg K, Holmgren S, Carlborg O (2004) Simultaneous search for multiple QTL using the global optimization algorithm DIRECT. Bioinformatics 20:1887-1895. [Please review and cite this article if you have exploited the DIRECT pair-scan tool and output graphs in WebQTL.]
    18. -Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Laviviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ (2010) High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. Genes, Brain and Behavior 8:129-159 PMID: 19958391 Full Text HTML Version -
      -A monstrously large (33 pages) and impressive study of many behaviors in more than 60 BXD strains. The design and execution is exemplary; the diversity of data types is unprecedented; the documentation is great. This paper will be a well-spring for a host of other studies on the genetics and epigenetics of behavioral variation in the BXDs for years to come. Over 700 traits (usually in trios of male, female, and combined data) were entered in GeneNetwork. You can read the paper and work with the phenotypes. You can also combine these phenotypes with all of the existing expression data for the BXD strains. - -
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      - - +Manly KF, Wang J, Williams RW (2005) Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression. Genome Biology 6: R27 Full Text HTML and PDF Version. [Please cite this article if you have used one of the HWT (Heritability Weighted Transform) data sets.]
    19. -Wu S, Lusis AJ, Drake TA (2009) A systems-based framework for understanding complex metabolic and cardiovascular disorders. J Lipid Res 50 Suppl:S358-63 Full Text PDF -
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      - - +Manly K, Williams RW (2001) WEBQTL—WWW service for mapping quantitative trait loci. International Mouse Genome Conference 15: 74. [First published abstract on WebQTL, presented Oct 2001, Edinburgh; also see 2002 CTC abstract] +
    20. +Taylor BA, Heiniger HJ, Meier H (1973) Genetic analysis of resistance to cadmium-induced teticular damage in mice. Proc Soc Exp Biol Med 143:629-33 [This is one of the first full paper on the use of recombinant inbred strains in biomedical research and the first paper to use BXD lines of mice. The cdm locus that they mapped to distal Chr 3 was subsequently defined as the Slc38a8 metal testicular metal ion transporter. Full text +
    21. +Webster JA, Gibbs JR, Clarke J, Ray M, Zhang W, Holmans P, Rohrer K, Zhao A, Marlowe L, Kaleem M, McCorquodale DS 3rd, Cuello C, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV; NACC-Neuropathology Group, Heward CB, Reiman EM, Stephan D, Hardy J, Myers AJ (2009) Genetic control of human brain transcript expression in Alzheimer disease. Am J Hum Genet 84:445-58. [Please review and cite this article if you have used the HUMAN data set by Myers and colleagues in GeneNetwork.] +
    22. +Williams RW, Shou S, Lu L, Wang J, Manly KF, Hsu HC, Mountz J, Threadgill DW (2002) Genomic analysis of transcriptional networks: combining microarrays with complex trait analysis. Complex Trait Consortium 1 [One of the first published abstracts on system genetic analysis of microarray data sets, presented May 2002.]
    23. -Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S, Williams RW (2009) Genetics of the hippocampal transcriptome in mice: a systematic survey and online neurogenomic resource. Frontiers in Neuroscience 3:55 -Full Text HTML Version, -Full Text PDF Version +Zhang B, Schmoyer D, Kirov S, Snoddy J (2004) GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies. BMC Bioinformatics 5:16. [This reference describes GOTM--the predecessor of WebGestalt that is now used to analyze sets of covarying transcripts.] -
      -A large expression genetic analysis of the mouse hippocampus (99 strains). This paper is the companion to the the BXD Hippocampus Consortium data sets in GeneNetwork. - -
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  • -Tapocik JD, Letwin N, Mayo CL, Frank B, Luu T, Achinike O, House C, Williams R, Elmer GI, Lee NH (2009) Identification of candidate genes and gene networks specifically associated with analgesic tolerance to morphine. J Neurosci 2:5295-307 Full Text HTML -
    In this study several GeneNetwork data sets were used to study the association of predisposition and tolerance genes with expression QTLs. "The INIA Brain mRNA M430 (Jun06) RMA, VCU BXD PFC Sal M430 2.0 (Dec06) RMA, INIA Brain mRNA M430 (Jun06) RMA, HBP Rosen Striatum M430V2 (Apr05) RMA served as the databases for eQTL searches in the PAG, PFC, TL, and VS, respectively. Significant linkage of eQTL markers to correlated genes was defined by marker regression plots with 1000 permutations. The results from the permutation tests provide LRS (likelihood ratio statistics) scores that are suggestive, significant, or highly significant." - -
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  • -Badea A, Johnson GA, Williams RW (2009) Genetic dissection of the mouse brain using high-field magnetic resonance microscopy. Neuroimaging 45:1067-79 -
    We have generated high field MRIs for a subset of the BXD stains. This paper describes the acquisition and quantitative analysis of many CNS regions and compartments for BXD strains. The summary data are in GeneNetwork and the original MRI data sets are available at the Duke Center for In Vivo Microscopy (CIVM, Al Johnson and colleagues). - -
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    1. -Ciobanu DC, Lu L, Mozhui K, Wang X, Morris JA, Taylor WL, Dietz K, Simon P, Williams RW (2010) Detection, validation, and downstream analysis of allelic variation in gene expression. Genetics 184: 119-128 Full Text PDF -
      Natural allelic variants can cause large differences in gene expression. A problem in microarray-based studies of this phenomenon is that differences in hybridization signal intensity can be due to SNPs in overlapping probes or by isoform variants. The authors develop an approach to this problem that identifies and filters sources of variation and enriches for real differences that can be exploited in downstream functional analyses—essentially reverse complex trait analysis. The authors demonstrate the power of this method by analyzing targets of two validated differences in allelic expression (Stk25 and Rasd2) that segregate in the BXD mouse strains. - -
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      - +Baud A, Mulligan MK, Casale FP, Ingels JF, Bohl CJ, Callebert J, Launay JM, Krohn J, Legarra A, Williams RW, Stegle O (2017) Genetic variation in the social environment contributes to health and disease. PLoS Genet 13(1):e1006498
    2. -Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K (2009) TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 10:167-77 -
      -Schoonjans and colleagues made good use of a liver gene expression data in GeneNetwork (the BXD data set by Gatti et al., 2006) to show a highly significant correlations between expression of TGR5 and COXV1a1 (their figure 1D). - -
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      +Lopez MF, Miles MF, Williams RW, Becker HC (2017) Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort. Alcohol 58:73-82 +
    3. +Porcu P, O'Buckley TK, Lopez MF, Becker HC, Miles MF, Williams RW, Morrow AL (2017) Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains. Alcohol 58:107-125 +
    4. +Rinker JA, Fulmer DB, Trantham-Davidson H, Smith ML, Williams RW, Lopez MF, Randall PK, Chandler LJ, Miles MF, Becker HC, Mulholland PJ (2017) Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. Alcohol 58:33-45 +
    5. +van der Vaart AD, Wolstenholme JT, Smith ML, Harris GM, Lopez MF, Wolen AR, Becker HC, Williams RW, Miles MF (2017) The allostatic impact of chronic ethanol on gene expression: A genetic analysis of chronic intermittent ethanol treatment in the BXD cohort. Alcohol 58:93-106 -
    6. -Davies MN, Lawn S, Whatley S, Fernandes C, Williams RW, Schalkwyk LC (2009) To what extent is blood a reasonable surrogate for brain gene expression studies: estimation from mouse hippocampus and spleen. Front. Neurogen. 1:2. doi:10.3389/neuro.15.002.2009 Full Text HTML -
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    1. -Boon AC, deBeauchamp J, Hollmann A, Luke J, Kotb M, Rowe S, Finkelstein D, Neale G, Lu L, Williams RW, Webby RJ (2009) Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. J Virol 83:10417-26 PMID: 19706712 Full Text PDF Version -
      -There is about a 10,000-fold variation in the susceptibility of BXD strains to H5N1 infection. Sequence variants in Hc gene contribute to this differential vulnerability. - -
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      +Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC (2016) MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. Neurotoxicology 55:40-7 +
    2. +Chintalapudi SR, Wang X, Li H, Lau YH, Williams RW, Jablonski MM (2016) Genetic and immunohistochemical analysis of HSPA5 in mouse and human retinas. Molecular Vision 22:1318-1331 +
    3. +Lu H, Lu L, Williams RW, Jablonski MM (2016) Iris transillumination defect and its gene modulators do not correlate with intraocular pressure in the BXD family of mice. Molecular Vision 22:224-233 +
    4. +Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, Jordan SD, Quiros PM, Steffen KK, Williams EG, Mouchiroud L, Tronnes SU, Murillo V, Wolff SC, Shaw RJ, Auwerx J, Dillin A (2016) Two conserved histone demethylases regulate mitochondrial stress-induced longevity. Cell 165:1209-1223 +
    5. +Neuner SM, Garfinkel BP, Wilmott LA, Ignatowska-Jankowska BM, Citri A, Orly J, Lu L, Overall RW, Mulligan MK, Kempermann G, Williams RW, O'Connell KM, Kaczorowski CC (2016) Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging. Neurobiol Aging 46:58-67 +
    6. +Shi X, Walter NA, Harkness JH, Neve KA, Williams RW, Lu L, Belknap JK, Eshleman AJ, Phillips TJ, Janowsky A (2016) Genetic polymorphisms affect mouse and human Trace Amine-Associated Receptor 1 function. PLoS One 11(3):e0152581 +
    7. +Schultz NG, Ingels J, Hillhouse A, Wardwell K, Chang PL, Cheverud JM, Lutz C, Lu L, Williams RW, Dean MD (2016) The genetic basis of baculum size and shape variation in mice. G3 (Bethesda) 6(5):1141-1151 +
    8. +Sloan Z, Arends D, Broman KW, Centeno A, Furlotte N, Nijveen H, Yan L, Zhou X, Williams RW, Prins P (2016) GenetNetwork: framework for web-based genetics. The Journal of Open Source Software http://joss.theoj.org/papers/10.21105/joss.00025 (http://dx.doi.org/10.21105/joss.00025) +
    9. +Wang X, Pandey AK, Mulligan MK, Williams EG, Mozhui K, Li Z, Jovaisaite V, Quarles LD, Xiao Z, Huang J, Capra JA, Chen Z, Taylor WL, Bastarache L, Niu X, Pollard KS, Ciobanu DC, Reznik AO, Tishkov AV, Zhulin IB, Peng J, Nelson SF, Denny JC, Auwerx J, Lu L, Williams RW (2016) Joint mouse-human phenome-wide association to test gene function and disease risk. Nat Commun 7:10464 +
    10. +Williams EG, Wu Y, Jha P, Dubuis S, Blattmann P, Argmann CA, Houten SM, Amariuta T, Wolski W, Zamboni N, Aebersold R, Auwerx J (2016) Systems proteomics of liver mitochondria function. Science 352(6291):aad0189 -
    11. -Geisert EE, Lu L, Freeman-Anderson ME, Wang X, Gu W, Jiao Y, Williams RW (2009) Gene expression landscape of the mammalian eye: A global survey and database of mRNAs of 103 strains of mice. Molecular Vision 15:1730-1763 PMID:19727342 Full Text HTML Version, -Full Text PDF Version -
      -This is a comprehensive review of the genetics of gene expression in the mouse eye and includes data for mutant and knockout mice, most of the common strains of mice, and 68 BXD strains. This paper is also serves as an excellent tutorial on almost all major analytic and mapping features of GeneNetwork. Finally, this paper has a useful summary table (Table 2) that provides gene expression signatures (genes and probe sets) for all major ocular cell type. - -
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    + GeneNetwork (2015) +
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  • -Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring H, Hansen T, Pedersen,O, Smith U, Hanefel M, Williams RW, Auwerx J (2009) Identification of UBP1 as a critical blood pressure determinant. PLoS Genetics 5:e1000591 -Full Text HTML and PDF Versions -
    -A good example of the rapid "translation" of a mouse blood pressure QTL to a human candidate gene, UBP1. This study made use of the new advanced recombinant inbred BXD strains that are now available from JAX and the University of Tennessee. - -
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    1. -Carneiro AM, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, Erikson KM, Blakely RD (2009) Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Proc Natl Acad Sci USA 106:2047-2052 -Full Text HTML Version, -Full Text PDF Version -
      -A new way to study the impact of sequence variants by exploiting genetic reference populations. In this paper, Blakely and colleagues have analyzed BXD strains that "share specific serotonin receptor (Slc6a4, 5-HT) gene variants against an otherwise randomized genetic background, an advantage over approaches that test allele effects on one or two inbred backgrounds. Perhaps the greatest strength of this approach is the availability of archived, dimensional data across a large number of phenotypes linked to individual BXD lines, including anatomical, neurochemical, and behavioral traits. In this report, we initiate investigation of naturally occurring variation in 5-HT genes via analysis of functional coding polymorphism in mSERT" (Slc6a4). - -
      -
      - +Ashbrook DG, Gini B, Hager R (2015) Genetic variation in offspring indirectly influences the quality of maternal behaviour in mice. eLIFE 4:e11814 +
    2. +Ashbrook DG, Williams RW, Lu L, Hager R (2015) A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder. Frontiers in Behavioral Neuroscience 9:171 +
    3. +Chaum E, Winborn CS, Bhattacharya S (2015) Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. Mammalian Genome 26:210-221 Full text +
    4. +Cheng Q, Seltzer Z, Sima C, Lakschevitz FS, Glogauer M (2015) Quantitative trait loci and candidate genes for neutrophil recruitment in sterile inflammation mapped in AXB-BXA recombinant inbred mice. PLoS One 10:e0124117
    5. -Rosen GD, Pung CJ, Owens CB, Caplow J, Kim H, Mozhui K, Lu L, Williams RW (2009) Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice. Genes Brain Behav. 8: 296–308. Full Text PDF Version. -
      This paper introduces a comprehensive companion microarray data set for the striatum of the BXD strains (see Mouse BXD Striatum mRNA databases in GeneNetwork). +Cook MN, Baker JA, Heldt SA, Williams RW, Hamre KM, Lu L (2015) Identification of candidate genes that underlie the QTL on chromosome 1 that mediates genetic differences in stress-ethanol interactions. Physiol Genomics 47:308-317 +
    6. +Delprato A, Bonheur B, Algéo MP, Rosay P, Lu L, Williams RW, Crusio WE (2015) Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Genes Brain Behav 14(8):591-606 +
    7. +Ferguson B, Ram R, Handoko HY, Mukhopadhyay P, Muller HK, Soyer HP, Morahan G, Walker GJ (2015) Melanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progression. Oncogene 34:2879-86 +
    8. +King R, Lu L, Williams RW, Geisert EE. (2015) Transcriptome networks in the mouse retina: An exon level BXD RI database. Mol Vis 21:1235-1251 +
    9. +Lee J, Seol MY, Jeong S, Kwon HJ, Lee CR, Ku CR, Kang SW, Jeong JJ, Shin DY, Nam KH, Lee EJ, Chung WY, Jo YS (2015) KSR1 is coordinately regulated with Notch signaling and oxidative phosphorylation in thyroid cancer. J Mol Endocrinol 54:115-124 +
    10. +Padula AE, Griffin WC 3rd, Lopez MF, Nimitvilai S, Cannady R, McGuier NS, Chesler EJ, Miles MF, Williams RW, Randall PK, Woodward JJ, Becker HC, Mulholland PJ (2015) KCNN genes that encode small-conductance Ca(2+)-activated K(+) channels influence alcohol and drug addiction. Neuropsychopharmacology 40:1928-1939 +
    11. +Scott RE, Ghule PN, Stein JL, Stein GS (2015) Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis. J Cell Physiol 230:2533-42 +
    12. +Shea CJ, Carhuatanta KA, Wagner J, Bechmann N, Moore R, Herman JP, Jankord R (2015) Variable impact of chronic stress on spatial learning and memory in BXD mice. Physiol Behav. 150:69-77 Full text +
    13. +Xue Y, Li J, Yan L, Lu L, Liao FF (2015) Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. Behav Brain Res 292:83-94 +
    14. +Williams EG, Auwerx J (2015) The convergence of systems and reductionist approaches in complex trait analysis. Cell 162:23-32. PDF version - -
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  • -Whitney IE, Raven MA, Ciobanu DC, Williams RW, Reese BE (2009) Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse. Investigative Ophthalmology & Visual Science 50:1996-2003. -
    In addition to the quantitative genetic analysis of a dopaminergic cell population in the retinas of AXB/BXA strains of mice, this paper also introduces a comprehensive companion microarray data set for the whole eyes of these same strains (see Mouse AXB/BXA Eye mRNA database in GeneNetwork). - -
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  • -Mozhui RT, Ciobanu DC, Schikorski T, Wang XS, Lu L, Williams RW (2008) Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression. PLoS Genetics 4: e1000260. doi:10.1371/journal.pgen.1000260 -Full Text HTML Version. -
    A fine-grained analysis of one of the most intriguing parts of the mouse genome that controls a wide variety of traits. This study highlights sequence variants in formin 2 (Fmn2) as important in translation of mRNA and protein in neurons. - - - -
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    + GeneNetwork (2014) +
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    1. +Ashbrook GN, Delprato A, Grellmann C, Klein M, Wetzel R, Overall RW, Badea A (2014) Transcript co-variance with Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor cell proliferation in the adult hippocampus. Frontiers in Neuroscience in press +
    2. +Ashbrook DG, Williams RW, Lu L, Stein JL, Hibar DP, Nichols TE, Medland SE, Thompson PM, Hager R. (2014) Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease. BMC Genomics 15:850 +
    3. +Carhuatanta KA, Shea CJ, Herman JP, Jankord R (2014) Unique genetic loci identified for emotional behavior in control and chronic stress conditions. Front Behav Neurosci 8:341 +
    4. +Emery FD, Parvathareddy J, Pandey AK, Cui Y, Williams RW, Miller MA (2014) Genetic control of weight loss during pneumonic Burkholderia pseudomallei infection. Pathog Dis 71:249-264 +
    5. +Goldowitz D, Lussier AA, Boyle JK, Wong K, Lattimer SL, Dubose C, Lu L, Kobor MS, Hamre KM (2014) Molecular pathways underpinning ethanol-induced neurodegeneration. Front Genet 5:203 +
    6. +Graybeal C, Bachu M, Mozhui K, Saksida LM, Bussey TJ, Sagalyn E, Williams RW, Holmes A (2014) Strains and stressors: an analysis of touchscreen learning in genetically diverse mouse strains. PLoS One 9(2):e87745 +
    7. +Hall RA, Liebe R, Hochrath K, Kazakov A, Alberts R, Laufs U, Böhm M, Fischer HP, Williams RW, Schughart K, Weber SN, Lammert F (2014) Systems genetics of liver fibrosis: Identification of fibrogenic and expression quantitative trait loci in the BXD murine reference population.PLoS One 9(2):e89279 +
    8. +Harenza JL, Muldoon PP, Biasi MD, Imad Damaj M, Miles MF (2014) Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. Genes, Brain & Behavior 13:213-225 +
    9. +Hayes SK, Hager R, Grencis RK (2014) Sex-dependent genetics effects on immune responses to parasitic nematodes. BMC Genomics 15:193 +
    10. +Huang Y, Zhu X, Wang L, Liu X, Lu L, Gu W, Jiao Y (2014) Genome wide analysis of sex difference in gene expression profiles of bone formations using sfx mice and BXD RI strains. ScientificWorldJournal 2014:584910 +
    11. +Hasenfuss SC, Bakiri L, Thomsen MK, Williams EG, Auwerx J, Wagner EF (2014) Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers. Cell Metab. 2014 Jan 7;19(1):84-95. +
    12. +Jones BC, O'Callaghan JP, Lu L, Williams RW, Alam G, Miller DB (2014) Genetic correlational analysis reveals no association between MPP+ and the severity of striatal dopaminergic damage following MPTP treatment in BXD mouse strains. Neurotoxicol Teratol pii: S0892-0362(14)00159-7 +
    13. +Keeley PW, Whitney IE, Madsen NR, St John AJ, Borhanian S, Leong SA, Williams RW, Reese BE (2014) Independent genomic control of neuronal number across retinal cell types. Dev Cell 30:103-109 +
    14. +Keeley PW, Zhou C, Lu L, Williams RW, Melmed S, Reese BE (2014) Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics. Proc Natl Acad Sci USA 111:9295- +
    15. +Kweon KH, Lee CR, Jung SJ, Ban EJ, Kang SW, Jeong JJ, Nam KH, Jo YS, Lee J, Chung WY (2014) Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers. Int J Oncol 45:2065-2075 +
    16. +Loos M, Mueller T, Gouwenberg Y, Wijnands R, van der Loo RJ, Birchmeier C, Smit AB, Spijker S (2014) Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action. Biol Psychiatry 76:648-655 +
    17. +Lotan A, Fenckova M, Fralten J, Alttoa A, Dixson L, Williams RW, van der Voet M (2014) Neuroinformatic analyses of common and distinct genetic components associate with major neuropsychiatric disorders. Frontiers in Neuroscience 8:331 +
    18. +McLachlan SM, Aliesky H, Banuelos B, Magana J, Williams RW, Rapoport B. (2014) Immunoglobulin heavy chain variable region and major histocompatibility region genes are linked to induced graves' disease in females from two very large families of recombinant inbred mice. Endocrinology 155:4094-4103 +
    19. +McLachlan SM, Hamidi S, Aliesky H, Williams RW, Rapoport B (2014) Sex, genetics and the control of thyroxine and thyrotropin in mice. Thyroid 24:1080-1087 +
    20. +Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R, Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, Damaj MI (2014) The alpha3beta4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies. Br J Pharmacol 171:3845-3857 +
    21. +Nguyen C, Baten A, Morahan G (2014) Comparison of sequence variants in transcriptomic control regions across 17 mouse genomes. Database (Oxford): bau020. doi: 10.1093/database/bau020 +
    22. +Pandey AK, Lu L, Wang X, Homayouni R, Williams RW (2014) Functionally enigmatic genes: a case study of the brain ignorome. PLoS One 9(2):e88889 +
    23. +Pandey AK, Williams RW (2014) Genetics of gene expression in CNS. Int Rev Neurobiol 116:195-231 +
    24. +Pietrzykowski A, Spijker S (2014) Impulsivity and comorbid traits: a multi-step approach for finding putative responsible microRNAs in the amygdala. Frontiers in Neuroscience in press +
    25. +Pirinen E, Cantó C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J (2014) Pharmacological inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metab 19:1034-1041 +
    26. +Poon A, Goldowitz D (2014) Identification of genetic loci that modulate cell proliferation in the adult rostral migratory stream using the expanded panel of BXD mice. BMC Genomics 15:206 +
    27. +Porcu P, Morrow AL (2014) Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: Relevance for human studies. Psychopharmacology (Berl) 231:3257-3272 +
    28. +Ram R, Mehta M, Balmer L, Gatti DM, Morahan G (2014) +Rapid identification of major-effect genes using the collaborative cross. Genetics 198:75-86 +PMID: 25236450 +
    29. +Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J (2014) A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. Cell Metab in press +
    30. +Thompson RL, Williams RW, Kotb M, Sawtell NM. (2014) A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. PLoS One 9(3):e92342 +
    31. +Toth LA, Trammell RA, Williams RW (2014) Mapping complex traits using families of recombinant inbred strains: an overview and example of mapping susceptibility to Candida albicans induced illness phenotypes. Pathog Dis 71:234-248 +
    32. +Unger EL, Jones BC, Bianco LE, Allen RP, Earley CJ (2014) Diurnal variations in brain iron concentrations in BXD RI mice. Neuroscience 263:54-59 +
    33. +van de Lagemaat LN, Nijhof B, Bosch DG, Kohansal-Nodehi M, Keerthikumar S, Heimel JA (2014) Age-related decreased inhibitory versus excitatory gene expression in the adult autistic brain. Frontiers in Neuroscience in press +
    34. +Vied CM, Freudenberg F, Wang Y, Raposo AA, Feng D, Nowakowski RS (2014) A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development. Frontiers in Neuroscience 8:257 +
    35. +Wang L, Lu W, Zhang L, Huang Y, Scheib R, Liu X, Myers L, Lu L, Farber CR, Liu G, Wang CY, Deng H, Williams RW, Wang Y, Gu W, Jiao (2014) Trps1 differentially modulates the bone mineral density between male and female mice and its polymorphism associates with BMD differently between women and men. PLoS One 9(1):e84485 +
    36. +Wu Y, Williams EG, Dubuis S, Mottis A, Jovaisaite V, Houten SM, Argmann CA, Faridi P, Wolski W, Kutalik Z, Zamboni N, Auwerx J, Aebersold R (2014) Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. Cell 158:1415-1430 +
    37. +Williams EG, Mouchiroud L, Frochaux M, Pandey A, Andreux PA, Deplancke B, Auwerx J (2014) An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement. PLoS Genet 10:e1004673 +
    38. +Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B, Blakely RD (2014) Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain Behav. 13:247-260 +
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    -
    - Key References -
    -

    The first section lists key technical papers that are appropriate references when citing GeneNetwork and WebQTL. The second section lists publications and other resources that have made use of GeneNetwork.

    + +

    + GeneNetwork (2013) +
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      1. -Wang J, Williams RW, Manly KF (2003) WebQTL: Web-based complex trait analysis. Neuroinformatics 1: 299-308 Full Text PDF Version. [A good technical reference to WebQTL and GeneNetwork] +Bhandari P, Hill JS, Farris SP, Costin B, Martin I, Chan CL, Alaimo JT, Bettinger JC, Davies AG, Miles MF, Grotewiel M (2013) Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. Genes, Brain & Behavior 11:387-97
      2. -Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW (2003) Genetic correlates of gene expression in recombinant inbred strains: a relational model to explore for neurobehavioral phenotypes. Neuroinformatics 1: 343-357. Full Text PDF Version. [Best reference regarding interpretation of genetic correlations.] +Cheng Y, Gaughan J, Midic U, Han Z, Liang CG, Patel BG, Latham KE (2013) Systems genetics implicates cytoskeletal genes in oocyte control of cloned embryo quality. Genetics 193:877-896 PDF version
      3. -Chesler EJ, Lu L, Wang J, Williams RW, Manly KF (2004) WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nature Neuroscience 7: 485-486. Full Text PDF Version [A short review] +Dogan A, Lasch P, Neuschl C, Millrose MK, Alberts R, Schughart K, Naumann D, Brockmann GA. (2013) ATR-FTIR spectroscopy reveals genomic loci regulating the tissue response in high fat diet fed BXD recombinant inbred mouse strains. BMC Genomics 14:386
      4. -Chesler EJ, Williams RW (2004) Brain gene expression: genomics and genetics. International Review of Neurobiology 60:59-95. (DNA Arrays in Neurobiology, edited by MF Miles, Elsevier, Amsterdam). [A longer discussion, both statistical and conceptual, on the genetic analysis of gene expression and relations to higher order behavioral phenotypes] +DuBose CS, Chesler EJ, Goldowitz D, Hamre KM (2013) Use of the expanded panel of BXD mice narrow QTL regions in ethanol-induced locomotor activation and motor incoordination. Alcohol Clin Exp Res 37:170-83
      5. -Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke M, de Haan G (2005) Uncovering regulatory pathways affecting hematopoietic stem cell function using "genetical genomics." Nature Genetics 37:225-232. [Please cite this article if you have used the GNF-Groningen hematopoietic stem cell data set.] +Farris SP, Miles MF (2013) Fyn-dependent gene networks in acute ethanol sensitivity. PLoS One 8:e82435
      6. -Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin N, Langston MA, Threadgill DW, Manly KF, Williams RW (2005) Genetic dissection of gene expression reveals polygenic and pleiotropic networks modulating brain structure and function. Nature Genetics 37: 233-242. [Please cite this article if you have used one of the UTHSC brain data sets.] - +Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, Auwerx J (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497:451-457 PDF version
      7. -Damerval C, Maurice A, Josse JM, de Vienne D (1994) Quantitative trait loci underlying gene product variation: a novel perspective for analyzing regulation of genome expression. Genetics 137: 289-301 Full Text PDF Version [The first published paper on system genetics. Impressive; before its time.] - -
        [Damerval et al., 1994 abstract] A methodology to dissect the genetic architecture of quantitative variation of numerous gene products simultaneously is proposed. For each individual of a segregating progeny, proteins extracted from a given organ are separated using two-dimensional electrophoresis, and their amounts are estimated with a computer-assisted system for spot quantification. Provided a complete genetic map is available, statistical procedures allow determination of the number, effects and chromosomal locations of factors controlling the amounts of individual proteins. This approach was applied to anonymous proteins of etiolated coleoptiles of maize, in an F(2) progeny between two distant lines. The genetic map included both restriction fragment length polymorphism and protein markers. Minimum estimates of one to five unlinked regulatory factors were found for 42 of the 72 proteins analyzed, with a large diversity of effects. Dominance and epistasis interactions were involved in the control of 38% and 14% of the 72 proteins, respectively. Such a methodology might help understanding the architecture of regulatory networks and the possible adaptive or phenotypic significance of the polymorphism of the genes involved. -
        - +Huang Y, Wang L, Bennett B, Williams RW, Wang YJ, Gu WK, Jiao Y (2013) Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective. Genet Mol Res 12:3662-3674
      8. -Hübner N, Wallace CA, Zimdahl H, Petretto E, Schulz H, Maciver F, Mueller M, Hummel O, Monti J, Zidek V, Musilova A, Kren V, Causton H, Game L, Born G, Schmidt S, Muller A, Cook SA, Kurtz TW, Whittaker J, Pravenec M, Aitman TJ (2005) Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nature Genetics 37: 243-253. [Please cite this article if you have used one of the rat HXB kidney or peritoneal fat data sets.] - +Jellen LC, Lu L, Wang X, Unger EL, Earley CJ, Allen RP, Williams RW, Jones BC (2013) Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience 252:13-23
      9. -Kang HM, Ye C, Eskin E (2008) Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots. Genetics 180:1909-1925 -Full Text PDF Version. [An important method that can greatly improve the ability to resolve true genetic interactions in expression genetic studies.] - - +Jiao Y, Chen H, Yan J, Wang L, Huang Y, Liu X, Williams RW, Lu L, Wang Y, Gu W (2013) Genome-wide gene expression profiles in antioxidant pathways and their potential sex differences and connections to vitamin C in mice. Int J Mol Sci 14:10042-62
      10. -Ljungberg K, Holmgren S, Carlborg O (2004) Simultaneous search for multiple QTL using the global optimization algorithm DIRECT. Bioinformatics 20:1887-1895. [Please review and cite this article if you have exploited the DIRECT pair-scan tool and output graphs in WebQTL.] - +Jones BC, Miller DB, O'Callaghan JP, Lu L, Unger EL, Alam G, Williams RW (2013) Systems analysis of genetic variation in MPTP neurotoxicity in mice. Neurotoxicology 37C:26-34
      11. -Manly KF, Wang J, Williams RW (2005) Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression. Genome Biology 6: R27 Full Text HTML and PDF Version. [Please cite this article if you have used one of the HWT (Heritability Weighted Transform) data sets.] - +Liebe R, Hall RA, Williams RW, Dooley S, Lammert F (2013) Systems genetics of hepatocellular damage in vivo and in vitro: identification of a critical network on chromosome 11 in mouse. Physiological Genomics 45:931-939
      12. -Manly K, Williams RW (2001) WEBQTL—WWW service for mapping quantitative trait loci. International Mouse Genome Conference 15: 74. [First published abstract on WebQTL, presented Oct 2001, Edinburgh; also see 2002 CTC abstract] +Lindblom RP, Aeinehband S, Parso R, Strom M, Al Nimer F, Zhang XM, Domingues CA, Flytzani S, Siez M, Piehl F (2013) Genetic variability in the rat Aplec C-type lectin gene cluster regulates lymphocyte trafficking and motor neuron survival after traumatic nerve root injury. Journal of Neuroinflammation 10:60
      13. -Taylor BA, Heiniger HJ, Meier H (1973) Genetic analysis of resistance to cadmium-induced teticular damage in mice. Proc Soc Exp Biol Med 143:629-33 [This is one of the first full paper on the use of recombinant inbred strains in biomedical research and the first paper to use BXD lines of mice. Full text - - +Mulligan MK, Dubose C, Yue J, Miles MF, Lu L, Hamre KM (2013) Expression, covariation, and genetic regulation of miRNA biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease. Frontiers in Genetics 4:126
      14. -Webster JA, Gibbs JR, Clarke J, Ray M, Zhang W, Holmans P, Rohrer K, Zhao A, Marlowe L, Kaleem M, McCorquodale DS 3rd, Cuello C, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV; NACC-Neuropathology Group, Heward CB, Reiman EM, Stephan D, Hardy J, Myers AJ (2009) Genetic control of human brain transcript expression in Alzheimer disease. Am J Hum Genet 84:445-58. [Please review and cite this article if you have used the HUMAN data set by Myers and colleagues in GeneNetwork.] - +Swaminathan S, Lu H, Williams RW, Lu L, Jablonski MM (2013) Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains. Pigment Cell Melanoma Research 26:487-98
      15. -Williams RW, Shou S, Lu L, Wang J, Manly KF, Hsu HC, Mountz J, Threadgill DW (2002) Genomic analysis of transcriptional networks: combining microarrays with complex trait analysis. Complex Trait Consortium 1 [One of the first published abstracts on system genetic analysis of microarray data sets, presented May 2002.] +Templeton JP, Wang X, Freeman NE, Ma Z, Lu A, Hejtmancik F, Geisert EE (2013) A crystallin gene network in the mouse retina. Exp Eye Res. 116C:129-140 +
      16. +Templeton JP, Freeman NE, Nickerson JM, Jablonski MM, Rex TS, Williams RW, Geisert EE (2013) Innate immune network in the retina activated by optic nerve crush. Invest Ophthalmol Vis Sci. 54:2599-606 +
      17. +Vanderlinden LA, Saba LM, Kechris K, Miles MF, Hoffman PL, Tabakoff B (2013) Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption. PLoS One 8:e68878. + + -
      18. -Zhang B, Schmoyer D, Kirov S, Snoddy J (2004) GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies. BMC Bioinformatics 5:16. [This reference describes GOTM--the predecessor of WebGestalt that is now used to analyze sets of covarying transcripts.]
    @@ -478,6 +537,83 @@ Zhang B, Schmoyer D, Kirov S, Snoddy J ( + GeneNetwork (2012) +
    + +
    +
      + +
    1. +Alberts R, Chen H, Pommerenke C, Smit AB, Spijker S, Williams RW, Geffers R, Bruder D, Schughart K (2011) Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease. BMC Genomics 12:610 PDF version +
    2. +Andreux PA, Williams EG, Koutnikova H, Houtkooper RH, Champy MF, Henry H, Schoonjana K, Williams RW, Auwerx J (2012) Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits. Cell 150:1287-1299 +
    3. +Boughter JD Jr, Mulligan MK, St John SJ, Tokita K, Lu L, Heck DH, Williams RW (2012) Genetic control of a central pattern generator: Rhythmic oromotor movement in mice Is controlled by a major locus near Atp1a2. PLoS One 7:e38169. Full Text version +
    4. +Bubier JA, Chesler EJ (2012) Accelerating discovery for complex neurological and behavioral disorders through systems genetics and integrative genomics in the laboratory mouse. Neurotherapeutics 9:338-348 Full Text version +
    5. +Bryant CD, Kole LA, Guido MA, Sokoloff G, Palmer AA (2012) Congenic dissection of a major QTL for methamphetamine sensitivity implicates epistasis. Genes, Brain and Behavior 11:623-632 PDF version +
    6. +Downing C, Balderrama-Durbin C, Kimball A, Biers J, Wright H, Gilliam D, Johnson TE (2012) Quantitative trait locus mapping for ethanol teratogenesis in BXD recombinant inbred mice. Alcohol Clin Exp Res. 36:1340-1354 +
    7. +Durrant C, Swertz MA, Alberts R, Arends D, Möller S, Mott R, Prins P, van der Velde KJ, Jansen RC, Schughart K.(2012) Bioinformatics tools and database resources for systems genetics analysis in mice--a short review and an evaluation of future needs. Brief Bioinform 13:135-142 HTML version +
    8. +Gini B, Hager R (2012) Recombinant inbred systems can advance research in behavioral ecology. Front. Gene. 3:198 Full Text version +
    9. +Hager R, Lu L, Rosen GD, Williams RW. (2012) Genetic architecture supports mosaic brain evolution and independent brain-body size regulation. Nature Communications 3:1079 PDF version Full Text version +
    10. +Jellen LC, Unger EL, Lu L, Williams RW, Rousseau S, Wang X, Earley CJ, Allen RP, Miles MF, Jones BC (2012) Systems genetic analysis of the effects of iron deficiency in mouse brain. Neurogenetics 13:147-157 +
    11. +McKnite AM, Perez-Munoz ME, Lu L, Williams EG, Brewer S, Andreux PA, Bastiaansen JW, Wang X, Kachman SD, Auwerx J, Williams RW, Benson AK, Peterson DA, Ciobanu DC (2012) Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One 7:e39191 Full Text version +
    12. +Mulligan MK, Wang X, Adler AL, Mozhui K, Lu L, Williams RW (2012) Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation. PLoS One 7:e34586 Full Text version +
    13. +Newbury AJ, Rosen GD (2012) Genetic, morphometric, and behavioral factors linked to the midsagittal area of the corpus callosum. Frontiers in Genetics 3:91 +
      PDF versionFull Text version + + + +
    14. +Parker CC, Cheng R, Sokoloff G, Palmer AA (2012) Genome-wide association for methamphetamine sensitivity in an advanced intercross mouse line. Genes, Brain & Behavior 11:52-61 + +
    15. +Reinius B, Johansson MM, Radomska KJ, Morrow EH, Pandey GK, Kanduri C, Sandberg R, Williams RW, Jazin E (2012) Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome. BMC Genomics 13:607 +
    16. +Rietman ML, Sommeijer JP; Neuro-Bsik Mouse Phenomics Consortium, Levelt CN, Heimel JA (2012) Candidate genes in ocular dominance plasticity. Frontiers in Neuroscience 6:11 PDF version +
    17. +Talishinsky A, Rosen GD (2012) Systems genetics of the lateral septal nucleus in mouse: Heritability, genetic control, and covariation with behavioral and morphological traits. PLoS One 7: e44236 +PDF versionFull Text version + +
    18. +Williams RW, Mulligan MK (2012) Genetic and molecular network analysis of behavior. Int Rev Neurobiol. 104:135-57 +PDF version + +
    19. +Wolen AR, Phillips CA, Langston MA, Vorster PJ, Bruce NA, York TP, Williams RW, Miles MF (2012) Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: Functional and mechanistic implications. PLoS One 7:e33575 +
    20. +Yin L, Unger EL, Jellen LC, Earley CJ, Allen RP, Tomaszewicz A, Fleet JC, Jones BC. (2012) Systems genetic analysis of multivariate response to iron deficiency in mice. Am J Physiol Regul Integr Comp Physiol 302:R1282-96 +PDF version + +
    21. +Ziebarth JD, Cook MN, Wang X, Williams RW, Lu L, Cui Y (2012) Treatment- and population-dependent activity patterns of behavioral and expression QTLs. PLoS One 7:e31805. +PDF versionFull Text version +
    22. +Zumbrun EE, Abdeltawab NF, Bloomfield HA, Chance TB, Nichols DK, Harrison PE, Kotb M, Nalca A (2012) Development of a murine model for aerosolized ebolavirus infection using a panel of recombinant inbred mice. Viruses. 2012 Dec 3;4(12):3468-3493 + + + + + + + + + + + +
    +
    + @@ -496,39 +632,37 @@ Zhang B, Schmoyer D, Kirov S, Snoddy J (2011) Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures. Respir Res 12:61 Full Text version
  • -Alberts R, Chen H, Pommerenke C, Smit AB, Spijker S, Williams RW, Geffers R, Bruder D, Schughart K (2011) Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease. BMC Genomics 12:610. Full Text version +Alberts R, Chen H, Pommerenke C, Smit AB, Spijker S, Williams RW, Geffers R, Bruder D, Schughart K (2011) Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease. BMC Genomics 12:610 Full Text version
  • Di Curzio DL, Goldowitz D (2011) The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice. Mammalian Genome 22:209–234 Full Text PDF version
  • -Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I (2011) MicroRNA expression in the livers of inbred mice. Mutat Res 714:126-133 +Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I (2011) MicroRNA expression in the livers of inbred mice. Mutation Research 714:126-133
  • -Gibson JN, Jellen LC, Unger EL, Morahan G, Mehta M, Earley CJ, Allen RP, Lu L, Jones BC (2011) Genetic analysis of iron-deficiency effects on the mouse spleen. Mamm Genome, in press +Gibson JN, Jellen LC, Unger EL, Morahan G, Mehta M, Earley CJ, Allen RP, Lu L, Jones BC (2011) Genetic analysis of iron-deficiency effects on the mouse spleen. Mammalian Genome 22:556-62
  • Hakvoort TB, Moerland PD, Frijters R, Sokolovic A, Labruyère WT, Vermeulen JL, Ver Loren van Themaat E, Breit TM, Wittink FR, van Kampen AH, Verhoeven AJ, Lamers WH, Sokolovic M (2011) Interorgan coordination of the murine adaptive response to fasting. J Biol Chem 286:16332-43
  • -Freeman NE, Templeton JP, Orr WE, Lu L, Williams RW, Geisert EE (2011) Genetic networks in the mouse retina: Growth Associated Protein 43 and Phosphate Tensin Homology network. Molecular Vision 17:1355-1372. Full Text HTML and PDF versions +Freeman NE, Templeton JP, Orr WE, Lu L, Williams RW, Geisert EE (2011) Genetic networks in the mouse retina: Growth Associated Protein 43 and Phosphate Tensin Homology network. Molecular Vision 17:1355-1372 Full Text HTML and PDF versions
  • Jablonski MM, Freeman NE, Orr WE, Templeton JP, Lu L, Williams RW, Geisert EE (2011) Genetic pathways regulating glutamate levels in retinal Müller cells. Neurochem Res 36:594-603
  • Jackson KJ, Chen X, Miles MF, Harenza J, Damaj MI (2011) The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence. Neuropsychopharmacology 36:2339-2348
  • -Jansen R, Timmerman J, Loos M, Spijker S, van Ooyen A, Brussaard AB, Mansvelder HD, The Neuro-Bsik Mouse Phenomics Consortium; Smit AB, de Gunst M, Linkenhaer-Hansen K (2011) Novel candidate genes associated with hippocampal oscillations. PLoS One 6: e26586. +Jansen R, Timmerman J, Loos M, Spijker S, van Ooyen A, Brussaard AB, Mansvelder HD, The Neuro-Bsik Mouse Phenomics Consortium; Smit AB, de Gunst M, Linkenhaer-Hansen K (2011) Novel candidate genes associated with hippocampal oscillations. PLoS One 6:e26586. HTML and PDF versions
  • Jiao Y, Jiao F, Yan J, Xiong Q, Shriner D, Hasty K, Stuart J, Gu W (2011) Identifying a major locus that regulates spontaneous arthritis in IL-1ra-deficient mice and analysis of potential candidates. Genet Res (Camb) 18:1-9
  • Krebs J, Römer D, Overall RW, Fabel K. Babu H, Brandt M, Williams RW, Jessberger S, Kempermann G (2011)) Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: II. Genetic covariance and identification of Nos1 as a linking candidate gene. Frontiers in Neuroscience 5:106 PDF version +PDF
  • -Jansen R, Timmerman J, Loos M, Spijker S, van Ooyen A, Brussaard AB, Mansvelder HD, The Neuro-Bsik Mouse Phenomics Consortium; Smit AB, de Gunst M, Linkenhaer-Hansen K (2011) Novel candidate genes associated with hippocampal oscillations. PLoS One 6: e26586 -PDF -
  • -Krebs J, Römer B, Overall RW, Fabel K, Babu H, Brandt MD, Williams RW, Jessberger S, Kempermann G (2011) Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: II. Genetic covariation and identification of Nos1 as linking candidate gene. Front Neurosci 5:106 +Krebs J, Römer B, Overall RW, Fabel K, Babu H, Brandt MD, Williams RW, Jessberger S, Kempermann G (2011) Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: II. Genetic covariation and identification of Nos1 as linking candidate gene. Frontiers in Neuroscience 5:106 PDF version
  • -Laughlin RE, Grant TL, Williams RW, Jentsch JD (2011) Genetic dissection of behavioral flexibility: reversal learning in mice. Biol Psychiatry 69:1109-16 +Laughlin RE, Grant TL, Williams RW, Jentsch JD (2011) Genetic dissection of behavioral flexibility: reversal learning in mice. Biological Psychiatry 69:1109-1116
  • -Lu H, Wang X, Pullen M, Guan H, Chen H, Sahu S, Zhang B, Chen H, Williams RW, Geisert EE, Lu L, Jablonski MM (2011) Genetic dissection of the Gpnmb network in the eye. Invest Ophthalmol Vis Sci. 52:4132-42 +Lu H, Wang X, Pullen M, Guan H, Chen H, Sahu S, Zhang B, Chen H, Williams RW, Geisert EE, Lu L, Jablonski MM (2011) Genetic dissection of the Gpnmb network in the eye. Invest Ophthalmol Vis Sci. 52:4132-4142
  • McLachlan SM, Aliesky HA, Chen CR, Williams RW, Rapoport B (2011) Exceptional Hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease. PLoS One 6:e21378
  • @@ -543,9 +677,14 @@ Mozhui K, Wang X, Chen J, Mulligan MK, Li Z, Ingles J, Chen X, Lu L and Williams PDF version
  • Porcu P, O'Buckley TK, Song SC, Harenza JL, Lu L, Wang X, Williams RW, Miles MF, Morrow AL (2010) Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: Identification of QTLs and downstream gene regulation. PLoS One 6:e18405 Full Text HTML and PDF versions +
  • +Sutcliffe JG, Hedlund PB, Thomas EA, Bloom FE, Hilbush BS (2011) Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: implications for Alzheimer's disease. J Neurosci Res. 2011 Jun;89(6):808-14. doi: 10.1002/jnr.22603 +PDF version +
  • Suwanwela J, Farber CR, Haung B, Song B, Pan C, Lyon KM, Lusis AJ (2011) Systems genetics analysis of mouse chondrocyte differentiation. Journal of Bone and Mineral Research 26:74-760 PDF version +
  • Tan T (2011) GeneNetwork: Best of the Web. Genetics Engineering & Biotechnology News 31(3)
  • Whitney IE, Raven MA, Lu L, Williams RW, Reese BE (2011) A QTL on chromosome 10 modulates cone photoreceptor number in the mouse retina. Invest Ophthalmol Vis Sci. 52:3228-36
  • @@ -570,7 +709,7 @@ Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Ba
    1. -Alberts R, Schughart K (2010) QTLminer: identifying genes regulating quantitative traits.Full Text PDF version +Alberts R, Schughart K (2010) QTLminer: identifying genes regulating quantitative traits. BMC Bioinformatics 11:516. Full Text PDF version
    2. Ciobanu DC, Lu L, Mozhui K, Wang X, Morris JA, Taylor WL, Dietz K, Simon P, Williams RW (2010) Detection, validation, and downstream analysis of allelic variation in gene expression. Genetics 184: 119-128 Full Text PDF
    3. @@ -587,9 +726,10 @@ Li D, Mulligan MK, Wang X, Miles MF, Lu L, Williams RW (2010 Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage. Journal of Heredity 2010; doi: 10.1093/jhered/esq023. Full Text PDF Version
    4. -Loguercio S, Overall RW, Michaelson JJ, Wiltshire T, Pletcher MT, Miller BH, Walker JR, Kempermann G, Su AI, Beyer A 2010 Integrative analysis of low- and high-resolution eQTL. PLoS One. 2010 Nov 10;5(11):e13920 Full Text PDF Version +Loguercio S, Overall RW, Michaelson JJ, Wiltshire T, Pletcher MT, Miller BH, Walker JR, Kempermann G, Su AI, Beyer A 2010 Integrative analysis of low- and high-resolution eQTL. PLoS One 5(11):e13920 Full Text PDF Version
    5. -Lynch RM, Naswa S, Rogers Jr GL, Kanla SA, Das S, Chesler EJ, Saxton AM, Langston MA, Voy, BH (2010) Identifying genetic loci and spleen gene coexpression networks underlying immunophenotypes in the BXD recombinant inbred mice. Physiological Genomics 41: 244-253 Full Text PDF version +Lynch RM, Naswa S, Rogers Jr GL, Kanla SA, Das S, Chesler EJ, Saxton AM, Langston MA, Voy, BH (2010) Identifying genetic loci and spleen gene coexpression networks underlying immunophenotypes in the BXD recombinant inbred mice. Physiological Genomics 41:244-253 Full Text PDF version +
    6. Lynch RM (2010) A systems genetics approach to the characterization of differential low dose radiation responses in the BXD recombinant inbred mice. PhD diss., University of Tennessee http://trace.tennessee.edu/utk_graddiss/727
    7. Malkki HA, Donga LA, de Groot SE, Battaglia FP; NeuroBSIK Mouse Phenomics Consortium, Pennartz CM (2010) Appetitive operant conditioning in mice: heritability and dissociability of training stages. Front Behav Neuroscience 4:171 Full Text PDF version
    8. @@ -911,7 +1051,7 @@ Fox JG, Barthold SW, Davisson MT, Newcomer CE (2007) Informatics in neuroscience. Briefings in Bioinformatics 8:446-456
    9. Gatti D, Maki A, Chesler EJ, Kirova R, Kosyk O, Lu L, Manly KF, Williams RW, Perkins A, Langston MA, Threadgill DW, Rusyn I (2007) Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46:548-557 - Full Text PDF Version + Full Text PDF Version
    10. Grice DE, Reenila I, Mannisto PT, Brooks Ai, Smith GG, Golden GT, Buxbaum JD, Berrettini WH (2007) Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine. BMC Genomics 8:76 Full Text PDF Version, @@ -1291,19 +1431,6 @@ Shifman S, Bell JT, Copley BR, Taylor M, Williams RW, Mott R, Flint J ( - - - -
      - -
    • + {% endblock %} diff --git a/wqflask/wqflask/templates/show_trait.html b/wqflask/wqflask/templates/show_trait.html index c2724fea..d41f4dfb 100644 --- a/wqflask/wqflask/templates/show_trait.html +++ b/wqflask/wqflask/templates/show_trait.html @@ -130,6 +130,7 @@ + diff --git a/wqflask/wqflask/templates/show_trait_mapping_tools.html b/wqflask/wqflask/templates/show_trait_mapping_tools.html index eadc7481..77f78415 100644 --- a/wqflask/wqflask/templates/show_trait_mapping_tools.html +++ b/wqflask/wqflask/templates/show_trait_mapping_tools.html @@ -296,6 +296,18 @@
    + {% if genofiles and genofiles|length>0 %} +
    + +
    + +
    +
    + {% endif %}
    @@ -340,6 +352,18 @@ {% if mapping_method == "GEMMA" %}