{% extends "layout.html" %}
{% block content %}
{{ message | safe }}

<h3> <u>R</u>elationship  with <u>A</u>ddiction <u>T</u>hrough <u>S</u>earches of <u>Pub</u>Med </span></a>
</h3>

<table>
	<tr><td >
<p>
			RatsPub searches PubMed to find <i>sentences</i> that contain the query terms (i.e., gene symbols) and  <a href="https://github.com/chen42/RatsPub/blob/master/ratspub_keywords.py">drug addiction-related keywords</a>.  These gene-keyword relationships are presented as an interactive graph that can efficiently  answer the question <b>"What do we know about these genes and addiction?". </b> Data from <a href="https://www.ebi.ac.uk/gwas/">EBI GWAS catalog </a>are also included in the search to better answer this question.

<p> The graph has many interactive elements. For example, clicking gene names will launch a new search for sentences containing the target gene and 200 addiction-related genes. These results help to answer the question <b>"Are there  genes that can link my gene of interest to addiction?"  </b>
		</td>
		<td >
			<div class='img'><img src="/static/ratspub.png" class="img-fluid">
		</td></tr>
		<tr><td colspan=2>

	Up to 100 gene symbols can be searched at a time. Gene symbols can be separated by either a space or a semicolon.  Gene alias will <i>not</i> be automatically included because the large number of false matches associated with gene synonyms retrieved from databases. 
			</td></tr></table>

	<p>
	<b>Example</b>: Rgma Nrxn3; Chrna3

<br> 
    <form action="/progress">
	<textarea name="query" class="form-control form-control-lg" type="search" row="3" id="searchform">
	</textarea>
  <div class="form-group row">
    <div class="col-sm-10">
      <button type="submit" class="btn btn-primary">Submit</button>
    </div>
  </div>

    </form>
{% endblock %}